Inhibitor binding to topoisomerase II leading to infant leukaemia
Binding to (interferes with) topoisomerase II enzyme ; MLL chromosomal translocation ; Infant leukaemia ; DNA double-strand break ; Binding to (interferes with) topoisomerase II enzyme ; DNA double-strand break ; MLL chromosomal translocation ; Infant leukaemia
- 12/16/2016 9:38:16 AM
- 12/25/2020 6:33:36 PM
- EAGMST under review
- 1.53
Source: https://aopwiki.org/
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5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) ; Increased, valve movement ; Increased, serotonin (5-HT) ; Increased, oocyte maturation ; induced spawning ; Increased, Reproductive Success ; Increase, cilia movement ; Increased, Population ; Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) ; Increased, valve movement ; Increased, serotonin (5-HT) ; Increased, oocyte maturation ; induced spawning ; Increased, Reproductive Success ; Increase, cilia movement ; Increased, Population
- 11/29/2016 11:41:17 PM
- 2/7/2020 7:58:15 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation
Increased, predation ; Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) ; Increased, serotonin (5-HT) ; Decreased, anxiety ; Decreased, sheltering ; Increased, predation ; Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) ; Increased, serotonin (5-HT) ; Decreased, anxiety ; Decreased, sheltering
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:36:03 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) ; Increased, muscular waves in foot ; Increased, water retention in foot ; Increased, valve movement ; Depletion, energy reserves ; Increased, foot detachment ; Increased, locomotion ; Increased, serotonin (5-HT) ; Increase, predation ; Decline, Population ; Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) ; Increased, muscular waves in foot ; Increased, water retention in foot ; Increased, valve movement ; Depletion, energy reserves ; Increased, foot detachment ; Increased, locomotion ; Increased, serotonin (5-HT) ; Increase, predation ; Decline, Population
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:35:41 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) ; Increased, valve movement ; Increased, serotonin (5-HT) ; Decline, Population ; Increase, cilia movement ; increased mantel display ; Induced parturition ; Decreased, Reproductive Success ; Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) ; Increased, valve movement ; Increased, serotonin (5-HT) ; Decline, Population ; Increase, cilia movement ; increased mantel display ; Induced parturition ; Decreased, Reproductive Success
- 1/13/2017 5:23:22 PM
- 2/7/2020 7:58:49 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) ; Increased, valve movement ; Increased, serotonin (5-HT) ; Increased, Reproductive Success ; Increase, cilia movement ; Increased, Population ; increased mantel display ; Induced parturition ; Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) ; Increased, valve movement ; Increased, serotonin (5-HT) ; Increased, Reproductive Success ; Increase, cilia movement ; Increased, Population ; increased mantel display ; Induced parturition
- 1/13/2017 9:19:04 PM
- 2/7/2020 7:59:02 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring
Decrease, dihydrotestosterone (DHT) level ; Decrease, androgen receptors (AR) activation ; 5α-reductase, inhibition ; decrease, transcription of genes by AR ; decrease, male anogenital distance ; Altered, Transcription of genes by AR ; Decrease, dihydrotestosterone (DHT) level ; Decrease, androgen receptors (AR) activation ; 5α-reductase, inhibition ; decrease, transcription of genes by AR ; decrease, male anogenital distance
- 8/30/2019 8:02:04 AM
- 11/2/2020 12:49:01 PM
Source: https://aopwiki.org/
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Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure
Death/Failure, Colony ; Abnormal, Roll change within caste ; Reduced, Brood care ; impaired, Larval development ; Death/Failure, Colony ; Abnormal, Roll change within caste ; Reduced, Brood care ; impaired, Larval development
- 11/29/2016 11:41:16 PM
- 4/8/2019 4:34:15 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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ACE2 inhibition leading to lung fibrosis
Accumulation, Collagen ; Lung fibrosis ; ACE2 inhibition ; Increases AngII ; Increase plasma Ang II ; Accumulation, Collagen ; Lung fibrosis ; ACE2 inhibition ; Increases AngII ; Increase plasma Ang II
- 3/1/2020 1:07:54 PM
- 6/25/2020 11:51:21 AM
Source: https://aopwiki.org/
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Acetylcholinesterase inhibition leading to acute mortality
Increased Mortality ; Acetylcholinesterase (AchE) Inhibition ; Acetylcholine accumulation in synapses ; Increased, Atrioventricular block and bradycardia ; Respiratory distress/arrest ; Increased Cholinergic Signaling ; Decreased, Population trajectory ; Decrease, Population trajectory ; Dysregulation of heart rate and vascular tone ; Acetylcholinesterase (AchE) Inhibition ; Acetylcholine accumulation in synapses ; Increased Cholinergic Signaling ; Respiratory distress/arrest ; Dysregulation of heart rate and vascular tone ; Increased Mortality ; Decrease, Population trajectory
- 11/29/2016 11:41:16 PM
- 12/23/2019 7:41:34 PM
- AOP under development
- 1.3
Source: https://aopwiki.org/
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Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement
Increased Mortality ; Acetylcholinesterase (AchE) Inhibition ; Acetylcholine accumulation in synapses ; Increased Cholinergic Signaling ; Decrease, Population trajectory ; Impaired coordination and movement ; Acetylcholinesterase (AchE) Inhibition ; Acetylcholine accumulation in synapses ; Increased Cholinergic Signaling ; Increased Mortality ; Decrease, Population trajectory ; Impaired coordination and movement
- 12/20/2019 8:55:10 PM
- 12/23/2019 7:41:54 PM
Source: https://aopwiki.org/
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Acetylcholinesterase Inhibition Leading to Neurodegeneration
Occurrence, Epileptic seizure ; N/A, Cell injury/death ; N/A, Neurodegeneration ; Acetylcholinesterase (AchE) Inhibition ; Acetylcholine accumulation in synapses ; Overactivation, NMDARs ; Increased, Intracellular Calcium overload ; Desensitization, Nicotinic acetylcholine receptor ; Increase, intracellular calcium ; Increased, glutamate ; Neurodegeneration ; Activation, Muscarinic Acetylcholine Receptors ; Occurrence, Focal Seizure ; Status epilepticus ; Cell injury/death ; N/A, Neurodegeneration ; Acetylcholinesterase (AchE) Inhibition ; Acetylcholine accumulation in synapses ; Overactivation, NMDARs ; Increased, Intracellular Calcium overload ; Activation, Muscarinic Acetylcholine Receptors ; Occurrence, Focal Seizure ; Status epilepticus
- 1/30/2019 5:36:17 PM
- 5/21/2020 10:20:37 PM
Source: https://aopwiki.org/
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AChE binding leading to population reduction
AChE binding ; Seizures ; Death ; Decreased AChE in neurons ; Increased residence time of AChE ; Loss of consciousness ; Headache and fatigue ; Signaling disruption ; Convolutions ; Tremors ; Paralysis ; Population reduction ; AChE binding ; Seizures ; Death ; Decreased AChE in neurons ; Increased residence time of AChE ; Loss of consciousness ; Headache and fatigue ; Signaling disruption ; Convolutions ; Tremors ; Paralysis ; Population reduction
- 10/15/2008 11:30:00 AM
Source: https://www.effectopedia.org/
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AChE binding leading to population reduction
AChE binding ; Seizures ; Death ; Decreased AChE in neurons ; Increased residence time of AChE ; Loss of consciousness ; Headache and fatigue ; Signaling disruption ; Convolutions ; Tremors ; Paralysis ; Population reduction
- 10/15/2008 11:30:00 AM
Source: http://www.effectopedia.org/
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Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
Peptide Oxidation ; Reproductive failure ; Activation, JNK ; Activation, FOXO ; Inhibition, Wnt pathway ; Defect of Embryogenesis ; Peptide Oxidation ; Reproductive failure ; Activation, JNK ; Activation, FOXO ; Inhibition, Wnt pathway ; Defect of Embryogenesis
- 2/15/2017 9:35:06 AM
- 12/16/2019 9:39:39 AM
- EAGMST under review
- 1.8
Source: https://aopwiki.org/
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AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
Formation, Pro-mutagenic DNA Adducts ; Increased, Induced Mutations in Critical Genes ; Metabolism of AFB1, Production of Reactive Electrophiles ; Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) ; Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts ; Tumorigenesis, Hepatocellular carcinoma ; Formation, Pro-mutagenic DNA Adducts ; Increased, Induced Mutations in Critical Genes ; Metabolism of AFB1, Production of Reactive Electrophiles ; Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) ; Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts ; Tumorigenesis, Hepatocellular carcinoma
- 11/29/2016 11:41:16 PM
- 6/6/2017 12:17:56 PM
- EAGMST under review
- 2.8
Source: https://aopwiki.org/
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AhR activation leading to hepatic steatosis
Activation, AHR ; Up Regulation, CD36 ; Accumulation, Triglyceride ; Accumulation, Fatty acid ; Suppression, VLDL secretion ; Inhibition, Mitochondrial fatty acid beta-oxidation ; Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway) ; Increased, SCD-1 ; Increased, FA Influx ; Up Regulation, LDLR (low density lipoprotein receptor) ; Increased, LDL uptake ; Up Regulation, CYP1A1 ; Accumulation, Liver lipid ; Up Regulation, SCD-1 ; Activation, AhR ; Up Regulation, CD36 ; Accumulation, Triglyceride ; Accumulation, Fatty acid ; Suppression, VLDL secretion ; Inhibition, Mitochondrial fatty acid beta-oxidation ; Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway) ; Increased, FA Influx ; Up Regulation, LDLR (low density lipoprotein receptor) ; Increased, LDL uptake ; Up Regulation, CYP1A1 ; Up Regulation, SCD-1 ; Accumulation, Liver lipid
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:15:36 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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AhR activation leading to placental insufficiency
- 11/29/2016 11:41:17 PM
- 11/26/2020 1:31:51 PM
- AOP under development
- 1.42
Source: https://aopwiki.org/
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AKT2 activation leading to hepatic steatosis
Activation, SREBF1 ; Increased, Liver Steatosis ; systemic inflammation leading to hepatic steatosis ; Activation, AKT2 ; Activtation, SREBP-1c ; Increased, Liver Steatosis ; Activation, SREBF1 ; systemic inflammation leading to hepatic steatosis ; Activation, AKT2
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:18:38 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Alkylation of DNA in male prebiotic germ cells leading to heritable mutations
- 8/20/2017 5:22:50 PM
Source: https://aopwiki.org/
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Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations
Alkylation, DNA ; Increase, Mutations ; N/A, Inadequate DNA repair ; Increase, Heritable mutations in offspring ; Alkylation, DNA ; N/A, Inadequate DNA repair ; Increase, Mutations ; Increase, Heritable mutations in offspring
- 11/29/2016 11:41:16 PM
- 4/7/2020 12:56:33 PM
- OECD endorsed (WNT and WPHA)
- 1.11
- Review Report
- i-Library
Source: https://aopwiki.org/
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Alkylation of DNA leading to cancer 1
Alkylation, DNA ; Increase, Mutations ; N/A, Inadequate DNA repair ; Increase, Cancer ; Alkylation, DNA ; N/A, Inadequate DNA repair ; Increase, Mutations ; Increase, Cancer
- 11/29/2016 11:41:16 PM
- 3/5/2020 2:39:52 PM
Source: https://aopwiki.org/
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Alkylation of DNA leading to reduced sperm count
Alkylation, DNA ; N/A, Inadequate DNA repair ; Increase, Apoptosis ; Increase, DNA strand breaks ; Reduce, Sperm count ; Alkylation, DNA ; N/A, Inadequate DNA repair ; Increase, Apoptosis ; Increase, DNA strand breaks ; Reduce, Sperm count
- 3/31/2020 7:19:28 PM
- 4/6/2020 3:57:25 PM
Source: https://aopwiki.org/
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Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
Increased, Binding of chemicals to 2u (serum) ; Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium) ; Increase, Cytotoxicity (renal tubular cell) ; Increase, Regenerative cell proliferation (tubular epithelial cells) ; Increase, Hyperplasia (renal tubular cells) ; Increase, Adenomas/carcinomas (renal tubular) ; Increased, Binding of chemicals to 2u (serum) ; Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium) ; Increase, Cytotoxicity (renal tubular cell) ; Increase, Regenerative cell proliferation (tubular epithelial cells) ; Increase, Hyperplasia (renal tubular cells) ; Increase, Adenomas/carcinomas (renal tubular)
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:38:16 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
Decreased, GnRH cfos activity ; Decreased, GnRH pulsatility/release ; Decreased, LH Surge ; Delayed, Ovulation ; Decreased, Cortical granule release/distribution upon fertilization ; Altered, Formation of cortical envelope ; Abnormal, Sperm penetration (polyspermy) ; Altered, Chromosome number (polyploid) zygote ; Decreased, Decreased fecundity ; Inhibition, Antgonism of NE receptor ; Decreased, Binding of NE to NE receptors on GnRH neurons ; Decreased, GnRH cfos activity ; Decreased, GnRH pulsatility/release ; Decreased, LH Surge ; Delayed, Ovulation ; Decreased, Cortical granule release/distribution upon fertilization ; Altered, Formation of cortical envelope ; Abnormal, Sperm penetration (polyspermy) ; Altered, Chromosome number (polyploid) zygote ; Decreased, Decreased fecundity ; Inhibition, Antgonism of NE receptor ; Decreased, Binding of NE to NE receptors on GnRH neurons
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:44:04 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Altered ion channel activity leading impaired heart function
Increased Mortality ; impaired, ion channels ; Altered, Action Potential ; Increased, cardiac arrthymia ; Increased Mortality ; impaired, ion channels ; Altered, Action Potential ; Increased, cardiac arrthymia
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:37:59 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Androgen receptor (AR) antagonism leading to decreased fertility in females
Decreased, Transcription of genes by AR ; Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation ; Decreased fertility, Reduced number of oocytes ovulated ; Antagonism, Androgen receptor ; Altered, Transcription of genes by AR ; Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation ; Decreased fertility, Reduced number of oocytes ovulated ; Antagonism, Androgen receptor ; Granulosa cell proliferation of gonadotropin-independent follicles, Reduced
- 5/19/2020 8:32:18 PM
- 11/2/2020 12:51:38 PM
Source: https://aopwiki.org/
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Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring
Decreased, Transcription of genes by AR ; Decrease, androgen receptors (AR) activation ; Antagonism, Androgen receptor ; increase, retained nipples in males ; Altered, Transcription of genes by AR ; Decrease, androgen receptors (AR) activation ; Antagonism, Androgen receptor ; increase, retained nipples in males
- 5/11/2020 2:14:48 PM
- 9/8/2020 6:50:27 PM
Source: https://aopwiki.org/
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Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring
Decrease, androgen receptors (AR) activation ; decrease, transcription of genes by AR ; decrease, male anogenital distance ; Antagonism, Androgen receptor ; Decrease, androgen receptors (AR) activation ; decrease, transcription of genes by AR ; decrease, male anogenital distance ; Antagonism, Androgen receptor
- 8/30/2019 8:27:36 AM
- 10/13/2020 3:41:46 PM
Source: https://aopwiki.org/
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Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat)
Increase, Mitogenic cell proliferation (hepatocytes) ; Increase, Adenomas/carcinomas (hepatocellular) ; Increase, Preneoplastic foci (hepatocytes) ; Activation, Androgen receptor ; Increase, cell proliferation (hepatocytes) ; Increase, hepatocellular adenomas and carcinomas ; Increase, Preneoplastic foci (hepatocytes) ; Activation, Androgen receptor
- 11/29/2016 11:41:16 PM
- 6/16/2020 1:14:47 PM
- AOP under development
- 1.26
Source: https://aopwiki.org/
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Androgen receptor agonism leading to reproductive dysfunction
Androgen receptor, agonism ; Gonadotropins, circulating concentrations, reduction ; Testosterone synthesis by ovarian theca cells, reduction ; 17beta-estradiol synthesis by ovarian granulosa cells, reduction
- 4/18/2015 2:24:17 PM
Source: http://www.effectopedia.org/
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Androgen receptor agonism leading to reproductive dysfunction
Androgen receptor, agonism ; Gonadotropins, circulating concentrations, reduction ; Testosterone synthesis by ovarian theca cells, reduction ; 17beta-estradiol synthesis by ovarian granulosa cells, reduction ; Androgen receptor, agonism ; Gonadotropins, circulating concentrations, reduction ; Testosterone synthesis by ovarian theca cells, reduction ; 17beta-estradiol synthesis by ovarian granulosa cells, reduction
- 4/18/2015 2:24:17 PM
Source: https://www.effectopedia.org/
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Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
Reduction, Plasma 17beta-estradiol concentrations ; Reduction, 17beta-estradiol synthesis by ovarian granulosa cells ; Agonism, Androgen receptor ; Reduction, Testosterone synthesis by ovarian theca cells ; Reduction, Vitellogenin synthesis in liver ; Reduction, Cumulative fecundity and spawning ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Reduction, Gonadotropins, circulating concentrations ; Decrease, Population trajectory ; Reduction, Plasma 17beta-estradiol concentrations ; Reduction, 17beta-estradiol synthesis by ovarian granulosa cells ; Decrease, Population trajectory ; Agonism, Androgen receptor ; Reduction, Gonadotropins, circulating concentrations ; Reduction, Testosterone synthesis by ovarian theca cells ; Reduction, Vitellogenin synthesis in liver ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Reduction, Cumulative fecundity and spawning
- 11/29/2016 11:41:16 PM
- 5/13/2019 2:47:03 PM
- OECD endorsed (WNT and WPHA)
- 1.12
- Review Report
- i-Library
Source: https://aopwiki.org/
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Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
N/A, Androgen receptor, Antagonism ; Alteration, Wnt pathway ; Feminisation or incomplete development, Primary and accessory male sex organs ; Decreased, Transcription of genes by AR ; N/A, Impairment of reproductive capacity ; N/A, Androgen receptor, Antagonism ; Alteration, Wnt pathway ; Feminisation or incomplete development, Primary and accessory male sex organs ; Altered, Transcription of genes by AR ; N/A, Impairment of reproductive capacity
- 11/29/2016 11:41:16 PM
- 6/15/2020 8:35:02 PM
Source: https://aopwiki.org/
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Antagonism of the androgen receptor
Antagonism of the androgen receptor ; Decrease in transcription of androgen dependent genes ; Repression of Wnt signalling ; Alteration of cell proliferation and differentiation of androgen dependent organs ; Developmental toxicity by antagonism of the androgen receptor ; Antagonism of the androgen receptor ; Decrease in transcription of androgen dependent genes ; Repression of Wnt signalling ; Alteration of cell proliferation and differentiation of androgen dependent organs ; Developmental toxicity by antagonism of the androgen receptor
- 4/11/2010 10:00:00 AM
Source: https://www.effectopedia.org/
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Antagonism of the androgen receptor
Antagonism of the androgen receptor ; Decrease in transcription of androgen dependent genes ; Repression of Wnt signalling ; Alteration of cell proliferation and differentiation of androgen dependent organs ; Developmental toxicity by antagonism of the androgen receptor
- 4/11/2010 10:00:00 AM
Source: http://www.effectopedia.org/
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Antagonist binding to PPARα leading to body-weight loss
Binding of antagonist, PPAR alpha ; Decreased, PPARalpha transactivation of gene expression ; Decreased, Mitochondrial Fatty Acid Beta Oxidation ; Decreased, Ketogenesis (production of ketone bodies) ; Not Increased, Circulating Ketone Bodies ; Decreased, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids ; Increased, Catabolism of Muscle Protein ; stabilization, PPAR alpha co-repressor ; Decreased, Body Weight ; Fatty Acid Beta Oxidation, Decreased ; Binding of antagonist, PPAR alpha ; stabilization, PPAR alpha co-repressor ; Decreased, PPARalpha transactivation of gene expression ; Fatty Acid Beta Oxidation, Decreased ; Decreased, Ketogenesis (production of ketone bodies) ; Not Increased, Circulating Ketone Bodies ; Increased, Catabolism of Muscle Protein ; Decreased, Body Weight
- 11/29/2016 11:41:15 PM
- 8/16/2019 2:18:20 PM
- OECD endorsed (WNT and WPHA)
- 2.3
- Review Report
- i-Library
Source: https://aopwiki.org/
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Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone ; Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP ; Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin ; Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failure of secondary hemostasis ; Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage) ; Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin) ; Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal ; Hemostasis, Depletion from blood of fully functional carboxylated clotting factors ; Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction ; Osteoporosis and vascular calcification, Bone deterioration ; Impaired recruitment , Population trajectory ; Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone ; Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP ; Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin ; Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failure of secondary hemostasis ; Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage) ; Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin) ; Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal ; Hemostasis, Depletion from blood of fully functional carboxylated clotting factors ; Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction ; Osteoporosis and vascular calcification, Bone deterioration ; Impaired recruitment , Population trajectory
- 11/29/2016 11:41:17 PM
- 4/14/2020 1:34:09 PM
- AOP under development
- 1.31
Source: https://aopwiki.org/
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Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
Increased, latency period ; Increased, Adenomas/carcinomas (mammary) ; Decreased, Dopaminergic activity ; Increased, prolactin secretion ; Increased, hyperplasia (mammary gland) ; Increased, latency period ; Increased, Adenomas/carcinomas (mammary) ; Decreased, Dopaminergic activity ; Increased, prolactin secretion ; Increased, hyperplasia (mammary gland)
- 11/29/2016 11:41:17 PM
- 2/7/2020 7:49:08 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
Decreased, Ovarian E2 ; Suppression, Estrogen receptor (ER) activity ; Increased, secretion of GnRH from hypothalamus ; Increased, secrection of FSH from anterior pituitary ; Increased, secretion of LH from anterior pituitary ; Hyperplasia, ovarian stromal cells ; Hyperplasia, ovarian epithelium ; Decrease, E2 blood concentrations at hypothalamus ; Promotion, ovarian adenomas ; Promotion, ovarian granular cell tumors ; Decreased, Ovarian E2 ; Suppression, Estrogen receptor (ER) activity ; Increased, secretion of GnRH from hypothalamus ; Increased, secrection of FSH from anterior pituitary ; Increased, secretion of LH from anterior pituitary ; Hyperplasia, ovarian stromal cells ; Hyperplasia, ovarian epithelium ; Decrease, E2 blood concentrations at hypothalamus ; Promotion, ovarian adenomas ; Promotion, ovarian granular cell tumors
- 11/29/2016 11:41:17 PM
- 2/7/2020 7:46:48 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
Increase, Regenerative cell proliferation (urothelial cells) ; Increase, Hyperplasia (urothelial) ; Mitochondrial impairment ; Urothelial cell injury/death ; Urothelial Tumor ; Increase, Regenerative cell proliferation (urothelial cells) ; Increase, Hyperplasia (urothelial) ; Mitochondrial impairment ; Urothelial cell injury/death ; Urothelial Tumor
- 4/21/2020 8:26:59 PM
- 4/21/2020 11:41:01 PM
Source: https://aopwiki.org/
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AOP from chemical insult to cell death
Decompartmentalization ; Direct mitochondrial inhibition ; narcosis ; Mitochondrial impairment ; Apoptosis ; Necrosis ; Decompartmentalization ; Direct mitochondrial inhibition ; narcosis ; Mitochondrial impairment ; Apoptosis ; Necrosis
- 2/6/2017 7:58:57 PM
- 2/7/2017 6:44:31 PM
Source: https://aopwiki.org/
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Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female
reduction in ovarian granulosa cells, Aromatase (Cyp19a1) ; Reduction, Plasma 17beta-estradiol concentrations ; Reduction, 17beta-estradiol synthesis by ovarian granulosa cells ; impaired, Fertility ; irregularities, ovarian cycle ; reduction in ovarian granulosa cells, Aromatase (Cyp19a1) ; Reduction, Plasma 17beta-estradiol concentrations ; Reduction, 17beta-estradiol synthesis by ovarian granulosa cells ; impaired, Fertility ; irregularities, ovarian cycle
- 11/29/2016 11:41:15 PM
- 11/30/2016 6:11:36 PM
- EAGMST under review
- 1.21
Source: https://aopwiki.org/
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Aromatase inhibition
Inhibition of the aromatase enzyme ; Decrease in conversion of testosterone to oestradiol ; Decrease in transcription of oestrogen receptor genes ; Developmental toxicity by inhibition of the aromatase enzyme with letrozole
- 4/11/2010 10:00:00 AM
Source: http://www.effectopedia.org/
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Aromatase inhibition
Inhibition of the aromatase enzyme ; Decrease in conversion of testosterone to oestradiol ; Decrease in transcription of oestrogen receptor genes ; Developmental toxicity by inhibition of the aromatase enzyme with letrozole ; Inhibition of the aromatase enzyme ; Decrease in conversion of testosterone to oestradiol ; Decrease in transcription of oestrogen receptor genes ; Developmental toxicity by inhibition of the aromatase enzyme with letrozole
- 4/11/2010 10:00:00 AM
Source: https://www.effectopedia.org/
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Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol ; reduction in ovarian granulosa cells synthesis of estradiol, Reduced steroidogenic production of estradiol in granulosa cells ; Reduced Estradiol in Circulation, Reduced steroidogenic production of estradiol in granulosa cells leading to decreased estradiol in circulation ; Decreased positive estrogenic feedback on hypothalamus, Reduced estradiol in circulation decreases estrogen concentration at hypothalamus ; Decreased Kisspeptin release from neurons in AVPV, Decreased hypothalamic estrogen reduces kisspeptinergic neuron response ; Decreased GnRH Release, Decreased Kisspeptin stimulation of GnRH neurons ; Decreased LH release from Anterior Pituitary, Decreased GnRH stimulation of Anterior Pituitary Gonadotrophs ; Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation ; Decreased fertility, Reduced number of oocytes ovulated ; Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol ; reduction in ovarian granulosa cells synthesis of estradiol, Reduced steroidogenic production of estradiol in granulosa cells ; Reduced Estradiol in Circulation, Reduced steroidogenic production of estradiol in granulosa cells leading to decreased estradiol in circulation ; Decreased positive estrogenic feedback on hypothalamus, Reduced estradiol in circulation decreases estrogen concentration at hypothalamus ; Decreased Kisspeptin release from neurons in AVPV, Decreased hypothalamic estrogen reduces kisspeptinergic neuron response ; Decreased GnRH Release, Decreased Kisspeptin stimulation of GnRH neurons ; Decreased LH release from Anterior Pituitary, Decreased GnRH stimulation of Anterior Pituitary Gonadotrophs ; Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation ; Decreased fertility, Reduced number of oocytes ovulated
- 11/29/2016 11:41:17 PM
- 2/7/2020 7:45:51 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Aromatase inhibition leading to reproductive dysfunction
Reduction, Plasma 17beta-estradiol concentrations ; Reduction, 17beta-estradiol synthesis by ovarian granulosa cells ; Reduction, Vitellogenin synthesis in liver ; Reduction, Cumulative fecundity and spawning ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Decrease, Population trajectory ; Inhibition, Aromatase ; Reduction, Plasma 17beta-estradiol concentrations ; Reduction, 17beta-estradiol synthesis by ovarian granulosa cells ; Decrease, Population trajectory ; Reduction, Vitellogenin synthesis in liver ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Reduction, Cumulative fecundity and spawning ; Inhibition, Aromatase
- 11/29/2016 11:41:16 PM
- 4/18/2017 6:27:39 PM
- OECD endorsed (WNT and WPHA)
- 1.12
- Review Report
- i-Library
Source: https://aopwiki.org/
|
Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
Decrease, Population trajectory ; Inhibition, Aromatase ; Reduction, 17beta-estradiol synthesis by the undifferentiated gonad ; Increased, Differentiation to Testis ; Increased, Male Biased Sex Ratio ; Decrease, Population trajectory ; Inhibition, Aromatase ; Reduction, 17beta-estradiol synthesis by the undifferentiated gonad ; Increased, Differentiation to Testis ; Increased, Male Biased Sex Ratio
- 6/15/2020 1:54:44 PM
- 12/29/2020 1:37:17 PM
Source: https://aopwiki.org/
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Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2
Increased Mortality ; Decreased, Population trajectory ; Activation, AHR ; dimerization, AHR/ARNT ; Increase, COX-2 expression ; Altered, Cardiovascular development/function ; Increase, Mortality ; Increase, Early Life Stage Mortality ; Activation, AhR ; dimerization, AHR/ARNT ; Increase, COX-2 expression ; Altered, Cardiovascular development/function ; Increase, Early Life Stage Mortality
- 11/29/2016 11:41:16 PM
- 10/30/2019 8:57:29 PM
- OECD endorsed (WNT and WPHA)
- 1.27
- Review Report
- i-Library
Source: https://aopwiki.org/
|
Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
Activation, AHR ; dimerization, AHR/ARNT ; Altered, Cardiovascular development/function ; Impairment, Endothelial network ; reduced dimerization, ARNT/HIF1-alpha ; Increase, Pericardial edema ; reduced production, VEGF ; Increase, Early Life Stage Mortality ; Activation, AhR ; dimerization, AHR/ARNT ; Altered, Cardiovascular development/function ; Increase, Early Life Stage Mortality ; Impairment, Endothelial network ; reduced dimerization, ARNT/HIF1-alpha ; reduced production, VEGF
- 11/29/2016 11:41:17 PM
- 12/18/2019 3:07:36 PM
- OECD endorsed (WNT and WPHA)
- 1.7
- Review Report
- i-Library
Source: https://aopwiki.org/
|
Aryl hydrocarbon receptor activation leading to uroporphyria
Activation, AHR ; Oxidation, Uroporphyrinogen ; Inhibition, UROD ; Accumulation, Highly carboxylated porphyrins ; Induction, CYP1A2/CYP1A5 ; Uroporphyria ; Activation, AhR ; Induction, CYP1A2/CYP1A5 ; Oxidation, Uroporphyrinogen ; Inhibition, UROD ; Accumulation, Highly carboxylated porphyrins ; Uroporphyria
- 11/29/2016 11:41:16 PM
- 12/6/2019 9:42:03 PM
- OECD endorsed (WNT and WPHA)
- 1.7
- Review Report
- i-Library
Source: https://aopwiki.org/
|
Axonal sodium channel modulation leading to acute mortality
Increased Mortality ; modulation, sodium channel ; prolonged, Depolarization of neuronal membrane ; Overactivation, Neuronotransmitter release ; Overactivation, muscle contraction ; Increased, Ataxia, paralysis, or hyperactivity ; Increased Mortality ; modulation, sodium channel ; prolonged, Depolarization of neuronal membrane ; Overactivation, Neuronotransmitter release ; Overactivation, muscle contraction ; Increased, Ataxia, paralysis, or hyperactivity
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:35:26 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
Activation, beta-2 adrenergic receptor ; Increased activity, beta-2 adrenergic receptor ; relaxation, smooth muscle ; Proliferation/Clonal Expansion, smooth muscle ; Hypertrophy/hyperplasia, smooth muscle ; Promotion, mesovarian leiomyomas ; Activation, beta-2 adrenergic receptor ; Increased activity, beta-2 adrenergic receptor ; relaxation, smooth muscle ; Proliferation/Clonal Expansion, smooth muscle ; Hypertrophy/hyperplasia, smooth muscle ; Promotion, mesovarian leiomyomas
- 11/29/2016 11:41:17 PM
- 2/7/2020 7:46:33 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
N/A, Mitochondrial dysfunction 1 ; N/A, Neuroinflammation ; N/A, Cell injury/death ; N/A, Neurodegeneration ; Impairment, Learning and memory ; Binding of agonist, Ionotropic glutamate receptors ; Overactivation, NMDARs ; Increased, Intracellular Calcium overload ; Decreased, Neuronal network function in adult brain ; N/A, Mitochondrial dysfunction 1 ; Neuroinflammation ; Cell injury/death ; N/A, Neurodegeneration ; Impairment, Learning and memory ; Binding of agonist, Ionotropic glutamate receptors ; Overactivation, NMDARs ; Increased, Intracellular Calcium overload ; Decreased, Neuronal network function in adult brain
- 11/29/2016 11:41:16 PM
- 4/4/2019 1:48:15 PM
- OECD endorsed (WNT and WPHA)
- 1.23
- Review Report
- i-Library
Source: https://aopwiki.org/
|
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
N/A, Mitochondrial dysfunction 1 ; N/A, Neuroinflammation ; N/A, Cell injury/death ; N/A, Neurodegeneration ; Impairment, Learning and memory ; Decrease of neuronal network function ; Binding, SH-/selen-proteins ; N/A, Interferences with SH-/selen-proteins ; Depletion, GSH ; N/A, Oxidative stress ; N/A, Neuronal dysfunction ; Oxidative Stress ; Binding, Thiol/seleno-proteins involved in protection against oxidative stress ; Glutamate dyshomeostasis ; Tissue resident cell activation ; Increased Pro-inflammatory mediators ; Decreased protection against oxidative stress ; Neuroinflammation ; Cell injury/death ; Impairment, Learning and memory ; Decrease of neuronal network function ; Binding, Thiol/seleno-proteins involved in protection against oxidative stress ; Decreased protection against oxidative stress ; Oxidative Stress ; Glutamate dyshomeostasis ; Tissue resident cell activation ; Increased Pro-inflammatory mediators
- 11/29/2016 11:41:16 PM
- 2/7/2020 10:32:43 AM
- AOP under development
- 1.13
Source: https://aopwiki.org/
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Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease
Disruption, Mitochondrial electron transport chain ; Increase, Cytotoxicity ; Oxidation, Glutathione (To be considered with MIE) ; Oxidative Stress ; Binding, Thiol/seleno-proteins involved in protection against oxidative stress ; Decreased protection against oxidative stress ; Chronic kidney disease ; Binding, Thiol/seleno-proteins involved in protection against oxidative stress ; Decreased protection against oxidative stress ; Oxidative Stress ; Disruption, Mitochondrial electron transport chain ; Increase, Cytotoxicity ; Oxidation, Glutathione (To be considered with MIE) ; Chronic kidney disease
- 2/18/2019 2:42:55 PM
- 2/18/2019 3:02:37 PM
Source: https://aopwiki.org/
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Binding of nicotine to nicotinic receptors leading to adverse development
Binding of nicotine to nicotinic receptors alpha4Beta2 and alpha7 (agonism) ; Activation of Voltage operated calcium channels (pre-synaptic) and direct depolarisation (post-synaptic) ; Alteration of neurotrasmitter release such as dopamine, norepinephrine, serotonin ; Apoptosis ; Nicotine exposure developmental outcome ; Binding of nicotine to nicotinic receptors alpha4Beta2 and alpha7 (agonism) ; Activation of Voltage operated calcium channels (pre-synaptic) and direct depolarisation (post-synaptic) ; Alteration of neurotrasmitter release such as dopamine, norepinephrine, serotonin ; Apoptosis ; Nicotine exposure developmental outcome
- 4/11/2010 10:00:00 AM
Source: https://www.effectopedia.org/
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Binding of nicotine to nicotinic receptors leading to adverse development
Binding of nicotine to nicotinic receptors alpha4Beta2 and alpha7 (agonism) ; Activation of Voltage operated calcium channels (pre-synaptic) and direct depolarisation (post-synaptic) ; Alteration of neurotrasmitter release such as dopamine, norepinephrine, serotonin ; Apoptosis ; Nicotine exposure developmental outcome ; Binding of nicotine to nicotinic receptors alpha4Beta2 and alpha7 (agonism) ; Activation of Voltage operated calcium channels (pre-synaptic) and direct depolarisation (post-synaptic) ; Alteration of neurotrasmitter release such as dopamine, norepinephrine, serotonin ; Apoptosis ; Nicotine exposure developmental outcome
- 4/11/2010 10:00:00 AM
Source: https://www.effectopedia.org/
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Binding of nicotine to nicotinic receptors leading to adverse development
Binding of nicotine to nicotinic receptors alpha4Beta2 and alpha7 (agonism) ; Activation of Voltage operated calcium channels (pre-synaptic) and direct depolarisation (post-synaptic) ; Alteration of neurotrasmitter release such as dopamine, norepinephrine, serotonin ; Apoptosis ; Nicotine exposure developmental outcome
- 4/11/2010 10:00:00 AM
Source: http://www.effectopedia.org/
|
Binding of nicotine to nicotinic receptors leading to adverse development
Binding of nicotine to nicotinic receptors alpha4Beta2 and alpha7 (agonism) ; Activation of Voltage operated calcium channels (pre-synaptic) and direct depolarisation (post-synaptic) ; Alteration of neurotrasmitter release such as dopamine, norepinephrine, serotonin ; Apoptosis ; Nicotine exposure developmental outcome
- 4/11/2010 10:00:00 AM
Source: http://www.effectopedia.org/
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Binding of viral S-glycoprotein to ACE2 receptor leading to acute respiratory distress associated mortality
Increased Mortality ; Increased, secretion of proinflammatory and profibrotic mediators ; Binding of S protein to ACE receptor ; Enhanced viral entry and gene expression ; Increase inflammatory immune responses ; Increase, the risk of acute respiratory failure ; Increased Mortality ; Increased, secretion of proinflammatory and profibrotic mediators ; ACE2 binding to viral S-protein ; Increased viral entry and gene expression ; Increased inflammatory immune responses ; Increase, the risk of acute respiratory failure
- 3/1/2020 3:04:20 PM
- 1/22/2021 9:56:10 AM
Source: https://aopwiki.org/
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Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
Activation of estrogen receptor in immune cells ; Induction of GATA3 expression by STAT6:ER fusion protein ; Overproduction of IL-4 from Th2 cell ; Increase of anti-single/double-stranded DNA antibody from autoreactive B cell ; Exacerbation of systemic lupus erythematosus ; Binding to estrogen receptor (ER)-α in immune cells ; Induction of GATA3 expression ; Increase of Th2 cells producing IL-4 ; Increase of anti-DNA antibody from autoreactive B cell ; Exacerbation of systemic lupus erythematosus (SLE)
- 12/29/2019 10:57:40 PM
- 9/8/2020 11:29:11 PM
Source: https://aopwiki.org/
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Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
Binding at picrotoxin site, iGABAR chloride channel ; Reduction, Ionotropic GABA receptor chloride channel conductance ; Occurrence, A paroxysmal depolarizing shift ; Reduction, Neuronal synaptic inhibition ; Generation, Amplified excitatory postsynaptic potential (EPSP) ; Occurrence, Epileptic seizure ; Binding at picrotoxin site, iGABAR chloride channel ; Reduction, Ionotropic GABA receptor chloride channel conductance ; Reduction, Neuronal synaptic inhibition ; Generation, Amplified excitatory postsynaptic potential (EPSP) ; Occurrence, A paroxysmal depolarizing shift ; Occurrence, Epileptic seizure
- 11/29/2016 11:41:16 PM
- 8/16/2019 2:16:27 PM
- OECD endorsed (WNT and WPHA)
- 1.15
- Review Report
- i-Library
Source: https://aopwiki.org/
|
Binding to Thyroid Peroxidase (TPO) mediated Learning impairment
Binding to Thyroid Peroxidase (TPO) ; Decreased levels of TPO ; Decrease levels of serum T4 and T3 ; Altered TR mediated proteints ; Synaptic malformation and altered function ; Learning impairment ; Binding to Thyroid Peroxidase (TPO) ; Decreased levels of TPO ; Decrease levels of serum T4 and T3 ; Altered TR mediated proteints ; Synaptic malformation and altered function ; Learning impairment
- 10/15/2008 11:30:00 AM
Source: https://www.effectopedia.org/
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Binding to Thyroid Peroxidase (TPO) mediated Learning impairment
Binding to Thyroid Peroxidase (TPO) ; Decreased levels of TPO ; Decrease levels of serum T4 and T3 ; Altered TR mediated proteints ; Synaptic malformation and altered function ; Learning impairment
- 10/15/2008 11:30:00 AM
Source: http://www.effectopedia.org/
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Calcium-mediated neuronal ROS production and energy imbalance
Inhibition, Ca++ ATPase ; Increase, Ca++ (intracellular) ; Disruption, Mitochondrial electron transport chain ; Decrease, Mitochondrial ATP production ; Increase, Reactive oxygen species production ; Decreased, Nitric Oxide ; Decreased, Long-term potentiation (LTP) ; Increased, Oxidative damage ; Inhibition, Ca++ ATPase ; Increase, Ca++ (intracellular) ; Disruption, Mitochondrial electron transport chain ; Decrease, Mitochondrial ATP production ; Increase, Reactive oxygen species production ; Decreased, Nitric Oxide ; Decreased, Long-term potentiation (LTP) ; Increased, Oxidative damage
- 11/29/2016 11:41:16 PM
- 6/15/2020 7:54:51 PM
Source: https://aopwiki.org/
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Chemical binding to tubulin in oocytes leading to aneuploid offspring
Binding, Tubulin ; Disruption, Microtubule dynamics ; Disorganization, Spindle ; Altered, Meiotic chromosome dynamics ; Altered, Chromosome number ; Increase, Aneuploid offspring ; Binding, Tubulin ; Disruption, Microtubule dynamics ; Disorganization, Spindle ; Altered, Meiotic chromosome dynamics ; Altered, Chromosome number ; Increase, Aneuploid offspring
- 11/29/2016 11:41:16 PM
- 2/24/2020 3:10:42 PM
Source: https://aopwiki.org/
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Chitin synthase 1 inhibition leading to mortality
Increase, Mortality ; Increase, Chitin synthase 1 inhibition ; Decrease, Cuticular chitin content ; Increase, Premature molting
- 10/22/2020 8:11:08 PM
- 11/11/2020 8:18:38 AM
Source: https://aopwiki.org/
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Chitinase inhibition leading to mortality
Increase, Mortality ; Increase, Premature molting ; Increase, Chitinase inhibition ; Decrease, Digestion of old cuticle
- 10/21/2020 6:01:42 AM
- 10/23/2020 7:53:56 AM
Source: https://aopwiki.org/
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Chitobiase inhibition leading to mortality
Increase, Mortality ; Increase, Premature molting ; Decrease, Digestion of old cuticle ; Increase, Chitobiase inhibition
- 10/21/2020 6:07:06 AM
- 10/23/2020 7:55:33 AM
Source: https://aopwiki.org/
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Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
Inhibition, Bile Salt Export Pump (ABCB11) ; Activation of specific nuclear receptors, Transcriptional change ; Bile accumulation, Pathological condition ; Release, Cytokine ; Increase, Inflammation ; Production, Reactive oxygen species ; Peptide Oxidation ; Cholestasis, Pathology ; Inhibition, Bile Salt Export Pump (ABCB11) ; Activation of specific nuclear receptors, Transcriptional change ; Bile accumulation, Pathological condition ; Release, Cytokine ; Increase, Inflammation ; Production, Reactive oxygen species ; Peptide Oxidation ; Cholestasis, Pathology
- 11/29/2016 11:41:16 PM
- 12/3/2016 9:37:43 PM
- AOP under development
- 1.19
Source: https://aopwiki.org/
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Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
Binding of antagonist, NMDA receptors ; Inhibition, NMDARs ; Decreased, Calcium influx ; Reduced levels of BDNF ; N/A, Cell injury/death ; Impairment, Learning and memory ; Aberrant, Dendritic morphology ; Decrease of synaptogenesis ; Decrease of neuronal network function ; Reduced, Presynaptic release of glutamate ; Binding of antagonist, NMDA receptors ; Inhibition, NMDARs ; Decreased, Calcium influx ; Reduced levels of BDNF ; Cell injury/death ; Impairment, Learning and memory ; Aberrant, Dendritic morphology ; Decrease of synaptogenesis ; Decrease of neuronal network function ; Reduced, Presynaptic release of glutamate
- 11/29/2016 11:41:16 PM
- 4/4/2019 2:00:53 PM
- OECD endorsed (WNT and WPHA)
- 1.22
- Review Report
- i-Library
Source: https://aopwiki.org/
|
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
NMDARs, Binding of antagonist ; NMDARs, Inhibition ; Calcium influx, Decreased ; Release of BDNF, Reduced ; Presynaptic release of glutamate, Reduced ; Cell death, N/A ; Dendritic morphology, Aberrant ; Synaptogenesis, Decreased ; Neuronal network function, Decreased ; Learning and memory, Impairment
- 10/15/2016 9:00:00 AM
Source: http://www.effectopedia.org/
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Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
NMDARs, Binding of antagonist ; NMDARs, Inhibition ; Calcium influx, Decreased ; Release of BDNF, Reduced ; Presynaptic release of glutamate, Reduced ; Cell death, N/A ; Dendritic morphology, Aberrant ; Synaptogenesis, Decreased ; Neuronal network function, Decreased ; Learning and memory, Impairment ; NMDARs, Binding of antagonist ; NMDARs, Inhibition ; Calcium influx, Decreased ; Release of BDNF, Reduced ; Presynaptic release of glutamate, Reduced ; Cell death, N/A ; Dendritic morphology, Aberrant ; Synaptogenesis, Decreased ; Neuronal network function, Decreased ; Learning and memory, Impairment
- 10/15/2016 9:00:00 AM
Source: https://www.effectopedia.org/
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Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
N/A, Neuroinflammation ; Binding of antagonist, NMDA receptors ; Inhibition, NMDARs ; Decreased, Calcium influx ; Reduced levels of BDNF ; N/A, Cell injury/death ; N/A, Neurodegeneration ; Impairment, Learning and memory ; Neuroinflammation ; Binding of antagonist, NMDA receptors ; Inhibition, NMDARs ; Decreased, Calcium influx ; Reduced levels of BDNF ; Cell injury/death ; N/A, Neurodegeneration ; Impairment, Learning and memory
- 11/29/2016 11:41:16 PM
- 1/17/2019 3:22:07 PM
- OECD endorsed (WNT and WPHA)
- 1.13
- Review Report
- i-Library
Source: https://aopwiki.org/
|
Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)
Increase, Adenomas/carcinomas (hepatocellular) ; Increase, Preneoplastic foci (hepatocytes) ; Increase, Cytotoxicity (hepatocytes) ; Increase, Regenerative cell proliferation (hepatocytes) ; Increase, hepatocellular adenomas and carcinomas ; Increase, Preneoplastic foci (hepatocytes) ; Increase, Cytotoxicity (hepatocytes) ; Increase, Regenerative cell proliferation (hepatocytes)
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:41:43 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
Increased, Oxidative Stress ; Increased, secretion of local growth factors ; persistent, cytotoxicity (pleura or peritoneum) ; Increased, inflammation ; Increased, Cell Proliferation (mesothelium) ; Increased, mesotheliomas ; Increased, Oxidative Stress ; Increased, secretion of local growth factors ; persistent, cytotoxicity (pleura or peritoneum) ; Increased, inflammation ; Increased, Cell Proliferation (mesothelium) ; Increased, mesotheliomas
- 11/29/2016 11:41:17 PM
- 2/7/2020 7:49:27 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
Chronic reactive oxygen species leading to human treatment-resistant gastric cancer
Increased, Reactive oxygen species ; Oxidative Stress ; Wnt ligand stimulation ; Frizzled activation ; GSK3beta inactivation ; β-catenin activation ; Snail, Zeb, Twist activation ; Epithelial-mesenchymal transition ; Treatment-resistant gastric cancer ; Chronic reactive oxygen species ; Sustained tissue damage / macrophage activation/ porcupine-induced Wnt secretion ; Proliferation/ beta-catenin activation ; Chronic reactive oxygen species ; Sustained tissue damage / macrophage activation/ porcupine-induced Wnt secretion ; Proliferation/ beta-catenin activation ; Epithelial-mesenchymal transition ; Treatment-resistant gastric cancer
- 5/29/2019 2:10:22 AM
- 10/13/2020 9:35:59 AM
Source: https://aopwiki.org/
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Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
Increase, Biliary excretion TH glucuronide ; Thyroxine (T4) in serum, Decreased ; Increased, Free serum thyroxine (T4) ; Altered, Amphibian metamorphosis ; Increased, Hepatic thyroid hormone uptake/transport ; Displacement, Serum thyroxine (T4) from carrier protein ; Binding, Thyroid binding globulin in serum
- 12/9/2020 8:22:16 PM
- 12/9/2020 8:32:23 PM
Source: https://aopwiki.org/
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Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis
Increase, Biliary excretion TH glucuronide ; Thyroxine (T4) in serum, Decreased ; Binding, Transthyretin in serum ; Increased, Free serum thyroxine (T4) ; Altered, Amphibian metamorphosis ; Increased, Hepatic thyroid hormone uptake/transport ; Displacement, Serum thyroxine (T4) from carrier protein
- 12/9/2020 7:43:30 PM
- 12/9/2020 8:23:45 PM
Source: https://aopwiki.org/
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Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat
Increase, Mitogenic cell proliferation (hepatocytes) ; Increase, Adenomas/carcinomas (hepatocellular) ; Activation, Constitutive androstane receptor ; Altered gene expression specific to CAR activation, Hepatocytes ; Increase, Preneoplastic foci (hepatocytes) ; Increase, cell proliferation (hepatocytes) ; Increase, hepatocellular adenomas and carcinomas ; Activation, Constitutive androstane receptor ; Altered gene expression specific to CAR activation, Hepatocytes ; Increase, Preneoplastic foci (hepatocytes)
- 11/29/2016 11:41:16 PM
- 1/7/2020 3:26:44 PM
- AOP under development
- 1.18
Source: https://aopwiki.org/
|
Covalent Binding of Low Molecular Weight Organic Chemicals to Proteins leads to Sensitisation (Sensitization) of the Respiratory Tract
N/A, Covalent binding to protein, possibly lysine residue ; Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways ; Increase, Allergic Respiratory Hypersensitivity Response ; Activation, Dendritic Cells ; Activation/Proliferation, T-cells ; N/A, Covalent binding to protein, possibly lysine residue ; Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways ; Activation, Dendritic Cells ; Activation/Proliferation, T-cells ; Increase, Allergic Respiratory Hypersensitivity Response ; Covalent Binding, Protein
- 11/29/2016 11:41:16 PM
- 12/4/2020 5:06:18 AM
- AOP under development
- 1.20
Source: https://aopwiki.org/
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Covalent Protein binding leading to Skin Sensitisation
Covalent Binding, Protein ; Activation, Keratinocytes ; Activation, Dendritic Cells ; Activation/Proliferation, T-cells ; sensitisation, skin ; Activation, Dendritic Cells ; Activation/Proliferation, T-cells ; Covalent Binding, Protein ; Activation, Keratinocytes ; sensitisation, skin
- 11/29/2016 11:41:16 PM
- 4/30/2019 5:03:05 PM
- OECD endorsed (WNT and WPHA)
- 1.1
- i-Library
Source: https://aopwiki.org/
|
Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
Increased Mortality ; Decline, Population ; Increased, blood uric acid concentration ; Occurrence, renal proximal tubular necrosis ; Increased, blood potassium concentration ; Occurrence, tophi (urate) deposition ; Occurrence, cardiac arrhythmia ; Increased, Oxidative Stress ; Inhibition, Cyclooxygenase 1 activity ; Decreased, Prostaglandin F2alpha concentration, plasma ; Occurrence, renal ischemia ; Increased Mortality ; Decline, Population ; Increased, blood uric acid concentration ; Occurrence, renal proximal tubular necrosis ; Increased, blood potassium concentration ; Occurrence, tophi (urate) deposition ; Occurrence, cardiac arrhythmia ; Increased, Oxidative Stress ; Inhibition, Cyclooxygenase 1 activity ; Decreased, Prostaglandin F2alpha concentration, plasma ; Occurrence, renal ischemia
- 11/29/2016 11:41:17 PM
- 2/7/2020 7:50:29 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
Cyclooxygenase inhibition leading reproductive failure
Inhibition, Cyclooxygenase activity ; Reduction, Prostaglandin E2 concentration ; Reduction, Ca and HCO3 transport to shell gland ; Reduction, Eggshell thickness ; N/A, Gap ; N/A, Reproductive failure ; Inhibition, Cyclooxygenase activity ; Reduction, Prostaglandin E2 concentration ; Reduction, Ca and HCO3 transport to shell gland ; Reduction, Eggshell thickness ; N/A, Gap ; N/A, Reproductive failure
- 11/29/2016 11:41:16 PM
- 11/26/2019 3:56:13 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
Cyclooxygenase inhibition leading to reproductive dysfunction
Decrease, Population trajectory ; Inhibition, Cyclooxygenase activity ; Decrease, Ovulation ; Reduced, Prostaglandins, ovary ; Reduced, Reproductive Success ; Declining, Population trajectory ; Decrease, Population trajectory ; Inhibition, Cyclooxygenase activity ; Decrease, Ovulation ; Reduced, Prostaglandins, ovary ; Reduced, Reproductive Success
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:19:19 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
Decrease, Population trajectory ; Inhibition, Cyclooxygenase activity ; Reduced, Reproductive Success ; Reduced, Prostaglandin F2alpha concentration, plasma ; Reduced, Prostaglandin F2alpha synthesis, ovary ; Reduced, Spawning behavior ; Reduced, Ability to attract spawning mates ; Decrease, Population trajectory ; Inhibition, Cyclooxygenase activity ; Reduced, Reproductive Success ; Reduced, Prostaglandin F2alpha concentration, plasma ; Reduced, Prostaglandin F2alpha synthesis, ovary ; Reduced, Spawning behavior ; Reduced, Ability to attract spawning mates
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:36:34 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
Decrease, Population trajectory ; Inhibition, Cyclooxygenase activity ; Reduced, Reproductive Success ; Reduced, Prostaglandin F2alpha concentration, plasma ; Reduced, Ability to attract spawning mates ; Reduced, Pheromone release ; Decreased, Prostaglandin F2alpha synthesis, ovary ; Decline, Population trajectory ; Decrease, Population trajectory ; Inhibition, Cyclooxygenase activity ; Reduced, Reproductive Success ; Reduced, Prostaglandin F2alpha concentration, plasma ; Reduced, Ability to attract spawning mates ; Reduced, Pheromone release ; Decreased, Prostaglandin F2alpha synthesis, ovary
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:36:51 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
Decrease, Population trajectory ; Inhibition, Cyclooxygenase activity ; Reduced, Reproductive Success ; Decline, Population trajectory ; Reduced, Prostaglandin E2 concentration, hypothalamus ; Reduced, Gonadotropin releasing hormone, hypothalamus ; Reduced, Luteinizing hormone (LH), plasma ; Reduced, Maturation inducing steroid, plasma ; Reduced, Maturation inducing steroid receptor signalling, oocyte ; Reduced, Meiotic prophase I/metaphase I transition, oocyte ; Increased, cyclic adenosine monophosphate ; Decrease, Population trajectory ; Inhibition, Cyclooxygenase activity ; Reduced, Reproductive Success ; Reduced, Prostaglandin E2 concentration, hypothalamus ; Reduced, Gonadotropin releasing hormone, hypothalamus ; Reduced, Luteinizing hormone (LH), plasma ; Reduced, Maturation inducing steroid, plasma ; Reduced, Maturation inducing steroid receptor signalling, oocyte ; Reduced, Meiotic prophase I/metaphase I transition, oocyte ; Increased, cyclic adenosine monophosphate
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:37:22 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
Decrease, Population trajectory ; Inhibition, Cyclooxygenase activity ; Reduced, Reproductive Success ; Declining, Population trajectory ; Reduced, Prostaglandin E2 concentration, hypothalamus ; Reduced, Gonadotropin releasing hormone, hypothalamus ; Reduced, Luteinizing hormone (LH), plasma ; Reduced, Maturation inducing steroid, plasma ; Reduced, Maturation inducing steroid receptor signalling, oocyte ; Upregulated, Spindle assembly checkpoint protein Mad2-oocyte ; Increased, Chromosome misseggregation ; Decrease, Population trajectory ; Inhibition, Cyclooxygenase activity ; Reduced, Reproductive Success ; Reduced, Prostaglandin E2 concentration, hypothalamus ; Reduced, Gonadotropin releasing hormone, hypothalamus ; Reduced, Luteinizing hormone (LH), plasma ; Reduced, Maturation inducing steroid, plasma ; Reduced, Maturation inducing steroid receptor signalling, oocyte ; Upregulated, Spindle assembly checkpoint protein Mad2-oocyte ; Increased, Chromosome misseggregation
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:37:38 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
CYP2E1 activation and formation of protein adducts leading to neurodegeneration
CYP2E1 Activation ; Protein Adduct Formation ; Oxidative Stress in Brain ; Lipid Peroxidation ; Unfolded Protein Response ; General Apoptosis ; Neurodegeneration ; CYP2E1 Activation ; Protein Adduct Formation ; Oxidative Stress in Brain ; Lipid Peroxidation ; Unfolded Protein Response ; General Apoptosis ; Neurodegeneration
- 3/26/2018 1:02:49 PM
- 4/9/2018 3:53:06 PM
Source: https://aopwiki.org/
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Cyp2E1 Activation Leading to Liver Cancer
Activation of Cyp2E1 ; Oxidative Stress ; Hepatocytotoxicity ; Induction, persistant proliferation/sustained proliferation ; Liver Cancer ; Oxidative Stress ; Activation of Cyp2E1 ; Hepatocytotoxicity ; Induction, persistent proliferation/sustained proliferation ; Liver Cancer
- 5/30/2017 5:25:04 PM
- 10/9/2020 6:02:34 PM
- AOP under development
- 1.24
Source: https://aopwiki.org/
|
Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
Increase, Cytotoxicity (club cells) ; Increase, Necrosis (terminal bronchiolar cells) ; Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells) ; Increase, Hyperplasia (terminal bronchiolar cells) ; Increase, Adenomas/carcinomas (bronchioloalveolar) ; Increase, Cytotoxicity (club cells) ; Increase, Necrosis (terminal bronchiolar cells) ; Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells) ; Increase, Hyperplasia (terminal bronchiolar cells) ; Increase, Adenomas/carcinomas (bronchioloalveolar)
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:39:04 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
Increase, Regenerative cell proliferation (tubular epithelial cells) ; Increase, Adenomas/carcinomas (renal tubular) ; Increase, Cytotoxicity (tubular epithelial cells) ; Increase, Hyperplasia (tubular epithelial cells) ; Increase, Regenerative cell proliferation (tubular epithelial cells) ; Increase, Adenomas/carcinomas (renal tubular) ; Increase, Cytotoxicity (tubular epithelial cells) ; Increase, Hyperplasia (tubular epithelial cells)
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:41:30 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
Death/Failure, Colony ; Abnormal, Roll change within caste ; impaired, Larval development ; Decreased, Glucose oxidase enzyme activity ; Decreased, Hydrogen peroxide production ; Reduced, Antiseptic incorporated in food ; Reduced, Food storage ; Death/Failure, Colony ; Abnormal, Roll change within caste ; impaired, Larval development ; Decreased, Glucose oxidase enzyme activity ; Decreased, Hydrogen peroxide production ; Reduced, Antiseptic incorporated in food ; Reduced, Food storage
- 11/29/2016 11:41:16 PM
- 4/8/2019 4:39:30 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)
Decreased, Androgen receptor activity ; Decreased, Testosterone binding to androgen receptor (hypothalamus) ; Increase, Hyperplasia (Leydig cells) ; Increased, Luteinizing hormone (LH) ; Increase, Leydig cell tumors ; Decreased, Androgen receptor activity ; Decreased, Testosterone binding to androgen receptor (hypothalamus) ; Increase, Hyperplasia (Leydig cells) ; Increased, Luteinizing hormone (LH) ; Increase, Leydig cell tumors
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:39:59 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
Reduction, Testosterone synthesis in Leydig cells ; Decreased, Transcription of genes by AR ; Decrease, dihydrotestosterone (DHT) level ; Decrease, androgen receptors (AR) activation ; decrease, male anogenital distance ; reduction, testosterone levels ; Reduction, Testosterone synthesis in Leydig cells ; Altered, Transcription of genes by AR ; Decrease, dihydrotestosterone (DHT) level ; Decrease, androgen receptors (AR) activation ; decrease, male anogenital distance ; reduction, testosterone levels
- 8/30/2019 8:36:36 AM
- 10/13/2020 3:53:55 PM
Source: https://aopwiki.org/
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Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation
Decrease, Population trajectory ; Decreased, Triiodothyronine (T3) in serum ; Reduced, Swimming performance ; Reduced, Young of year survival ; Reduced, Anterior swim bladder inflation ; Reduced, Hearing ; Inhibition, Deiodinase 1 ; Increased Mortality ; Decrease, Population trajectory ; Decreased, Triiodothyronine (T3) in serum ; Reduced, Swimming performance ; Reduced, Young of year survival ; Reduced, Anterior swim bladder inflation ; Inhibition, Deiodinase 1
- 11/29/2016 11:41:17 PM
- 1/18/2021 2:36:17 PM
- AOP under development
- 1.35
Source: https://aopwiki.org/
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Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation
Decrease, Population trajectory ; Decreased, Triiodothyronine (T3) in serum ; Reduced, Posterior swim bladder inflation ; Reduced, Swimming performance ; Reduced, Young of year survival ; Reduced, Anterior swim bladder inflation ; Reduced, Hearing ; Inhibition, Deiodinase 1 ; Increased Mortality ; Decrease, Population trajectory ; Decreased, Triiodothyronine (T3) in serum ; Reduced, Posterior swim bladder inflation ; Reduced, Swimming performance ; Reduced, Young of year survival ; Reduced, Anterior swim bladder inflation ; Inhibition, Deiodinase 1
- 11/29/2016 11:41:17 PM
- 1/18/2021 2:35:56 PM
- AOP under development
- 1.35
Source: https://aopwiki.org/
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Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation
Decrease, Population trajectory ; Inhibition, Deiodinase 2 ; Decreased, Triiodothyronine (T3) in serum ; Reduced, Swimming performance ; Reduced, Young of year survival ; Reduced, Anterior swim bladder inflation ; Reduced, Hearing ; Increased Mortality ; Decrease, Population trajectory ; Inhibition, Deiodinase 2 ; Decreased, Triiodothyronine (T3) in serum ; Reduced, Swimming performance ; Reduced, Young of year survival ; Reduced, Anterior swim bladder inflation
- 11/29/2016 11:41:17 PM
- 1/18/2021 2:59:18 PM
- AOP under development
- 1.35
Source: https://aopwiki.org/
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Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation
Decrease, Population trajectory ; Inhibition, Deiodinase 2 ; Decreased, Triiodothyronine (T3) in serum ; Reduced, Posterior swim bladder inflation ; Reduced, Swimming performance ; Reduced, Young of year survival ; Reduced, Anterior swim bladder inflation ; Reduced, Hearing ; Increased Mortality ; Decrease, Population trajectory ; Inhibition, Deiodinase 2 ; Decreased, Triiodothyronine (T3) in serum ; Reduced, Posterior swim bladder inflation ; Reduced, Swimming performance ; Reduced, Young of year survival ; Reduced, Anterior swim bladder inflation
- 11/29/2016 11:41:17 PM
- 1/18/2021 2:58:14 PM
- AOP under development
- 1.35
Source: https://aopwiki.org/
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Direct deposition of ionizing energy leading to lung cancer
Increase, Mutations ; N/A, Inadequate DNA repair ; Increase, Cell Proliferation ; Direct Deposition of ionizing energy ; Increase DNA Double Strand Breaks ; Inadequate DNA repair ; Increase mutations ; Increase Chromosomal Aberrations ; Increase cell proliferation ; Increase, lung cancer ; Increase, DNA strand breaks ; Increase, Chromosomal aberrations ; Direct Deposition of Energy ; N/A, Inadequate DNA repair ; Increase, Mutations ; Increase, Cell Proliferation ; Direct Deposition of Energy ; Increase, DNA strand breaks ; Increase, Chromosomal aberrations ; Increase, lung cancer
- 12/18/2018 9:25:49 PM
- 6/5/2020 2:01:22 AM
Source: https://aopwiki.org/
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Disruption of VEGFR Signaling Leading to Developmental Defects
Inhibition, VegfR2 ; Reduction, Angiogenesis ; Impairment, Endothelial network ; Insufficiency, Vascular ; Increased, Developmental Defects ; Inhibition, VegfR2 ; Reduction, Angiogenesis ; Impairment, Endothelial network ; Insufficiency, Vascular ; Increased, Developmental Defects
- 11/29/2016 11:41:16 PM
- 12/21/2020 3:20:27 PM
- EAGMST under review
- 1.6
Source: https://aopwiki.org/
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DNA Adducts Leading to Liver Hemangiosarcoma
- 7/14/2017 5:38:40 PM
- 1/29/2018 4:51:03 AM
Source: https://aopwiki.org/
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DNA Intercalation Mediated Cardiomyopathy
Intercalation with Nuclear and mt DNA ; Heart Failure ; Respiratory Failure ; Inhibition of Topoisomerase II ; Altered Expression of ETC Proteins ; Deregulation and Increase of mt Calcium Loading ; Reduced Calcium Loading Capacity of Mitochondria ; Calcium-Induced MPT ; Inhibited DNA Replication ; Altered Sychronization of Calcium in Myocytes ; Calcium-Induced Cell Death in Myocytes ; Altered Calicium Signaling ; Tumor Cell Death and Regression ; Congestive Heart Failure ; Increased Sensitivity to Calcium Loading/ROS in Myocytes ; Dialated CardioMyopathy ; Accumulating Risk for Cardiopathy
- 4/11/2010 10:00:00 AM
Source: http://www.effectopedia.org/
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DNA Intercalation Mediated Cardiomyopathy
Intercalation with Nuclear and mt DNA ; Heart Failure ; Respiratory Failure ; Inhibition of Topoisomerase II ; Altered Expression of ETC Proteins ; Deregulation and Increase of mt Calcium Loading ; Reduced Calcium Loading Capacity of Mitochondria ; Calcium-Induced MPT ; Inhibited DNA Replication ; Altered Sychronization of Calcium in Myocytes ; Calcium-Induced Cell Death in Myocytes ; Altered Calicium Signaling ; Tumor Cell Death and Regression ; Congestive Heart Failure ; Increased Sensitivity to Calcium Loading/ROS in Myocytes ; Dialated CardioMyopathy ; Accumulating Risk for Cardiopathy ; Intercalation with Nuclear and mt DNA ; Heart Failure ; Respiratory Failure ; Inhibition of Topoisomerase II ; Altered Expression of ETC Proteins ; Deregulation and Increase of mt Calcium Loading ; Reduced Calcium Loading Capacity of Mitochondria ; Calcium-Induced MPT ; Inhibited DNA Replication ; Altered Sychronization of Calcium in Myocytes ; Calcium-Induced Cell Death in Myocytes ; Altered Calicium Signaling ; Tumor Cell Death and Regression ; Congestive Heart Failure ; Increased Sensitivity to Calcium Loading/ROS in Myocytes ; Dialated CardioMyopathy ; Accumulating Risk for Cardiopathy
- 4/11/2010 10:00:00 AM
Source: https://www.effectopedia.org/
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DNA methyltransferase inhibition leading to population decline (1)
Decrease, Population trajectory ; Decrease, Oogenesis ; Decrease, Fecundity ; Increase, DNA methyltransferase inhibition ; Increase, Oocyte apoptosis ; Decrease, Global DNA methylation ; Increase, Caspase transcription ; Decrease, Population trajectory ; Decrease, Oogenesis ; Decrease, Fecundity ; Increase, Oocyte apoptosis ; Increase, DNA methyltransferase inhibition ; Decrease, Global DNA methylation ; Increase, Caspase transcription
- 4/26/2020 10:07:35 AM
- 10/27/2020 7:41:21 AM
Source: https://aopwiki.org/
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DNA methyltransferase inhibition leading to population decline (2)
Decrease, Population trajectory ; Decrease, Oogenesis ; Decrease, Fecundity ; Increase, DNA methyltransferase inhibition ; Increase, Ovarian follicle breakdown ; Decrease, Global DNA methylation ; Increase, Caspase transcription ; Increase, Ovarian somatic cell apoptosis ; Decrease, Population trajectory ; Decrease, Oogenesis ; Decrease, Fecundity ; Increase, Ovarian follicle breakdown ; Increase, DNA methyltransferase inhibition ; Decrease, Global DNA methylation ; Increase, Caspase transcription ; Increase, Ovarian somatic cell apoptosis
- 4/26/2020 10:08:36 AM
- 10/27/2020 7:41:49 AM
Source: https://aopwiki.org/
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DNA methyltransferase inhibition leading to population decline (3)
Decrease, Population trajectory ; Decrease, Oogenesis ; Decrease, Fecundity ; Increase, DNA methyltransferase inhibition ; Increase, Oocyte apoptosis ; Increase, DNA double-strand break ; Increase, Caspase transcription ; Decrease, Population trajectory ; Decrease, Oogenesis ; Decrease, Fecundity ; Increase, Oocyte apoptosis ; Increase, DNA methyltransferase inhibition ; Increase, DNA double-strand break ; Increase, Caspase transcription
- 4/26/2020 10:09:06 AM
- 10/27/2020 7:42:42 AM
Source: https://aopwiki.org/
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DNA methyltransferase inhibition leading to population decline (4)
Decrease, Population trajectory ; Decrease, Oogenesis ; Decrease, Fecundity ; Increase, DNA methyltransferase inhibition ; Increase, Ovarian follicle breakdown ; Increase, DNA double-strand break ; Increase, Caspase transcription ; Increase, Ovarian somatic cell apoptosis ; Decrease, Population trajectory ; Decrease, Oogenesis ; Decrease, Fecundity ; Increase, Ovarian follicle breakdown ; Increase, DNA methyltransferase inhibition ; Increase, DNA double-strand break ; Increase, Caspase transcription ; Increase, Ovarian somatic cell apoptosis
- 4/26/2020 10:09:30 AM
- 10/27/2020 7:42:09 AM
Source: https://aopwiki.org/
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DNA methyltransferase inhibition leading to transgenerational effects (1)
Decrease, Population trajectory ; Increase, DNA methyltransferase inhibition ; Decrease, Global DNA methylation ; Decrease, Heritable DNA methylation (F3) ; Increase, Caspase transcription (F3) ; Increase, Oocyte apoptosis (F3) ; Decrease, Oogenesis (F3) ; Decrease, Fecundity (F3) ; Decrease, Population trajectory ; Increase, DNA methyltransferase inhibition ; Decrease, Global DNA methylation ; Decrease, Heritable DNA methylation (F3) ; Increase, Caspase transcription (F3) ; Increase, Oocyte apoptosis (F3) ; Decrease, Oogenesis (F3) ; Decrease, Fecundity (F3)
- 4/26/2020 10:09:53 AM
- 10/27/2020 8:02:44 AM
Source: https://aopwiki.org/
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DNA methyltransferase inhibition leading to transgenerational effects (2)
Decrease, Population trajectory ; Increase, DNA methyltransferase inhibition ; Decrease, Global DNA methylation ; Decrease, Heritable DNA methylation (F3) ; Increase, Caspase transcription (F3) ; Decrease, Oogenesis (F3) ; Decrease, Fecundity (F3) ; Increase, Ovarian somatic cell apoptosis (F3) ; Increase, Ovarian follicle breakdown (F3) ; Decrease, Population trajectory ; Increase, DNA methyltransferase inhibition ; Decrease, Global DNA methylation ; Decrease, Heritable DNA methylation (F3) ; Increase, Caspase transcription (F3) ; Decrease, Oogenesis (F3) ; Decrease, Fecundity (F3) ; Increase, Ovarian somatic cell apoptosis (F3) ; Increase, Ovarian follicle breakdown (F3)
- 4/26/2020 10:10:16 AM
- 10/27/2020 8:03:16 AM
Source: https://aopwiki.org/
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Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis
Thyroid hormone synthesis, Decreased ; Decreased, Thyroxine (T4) in serum ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Inhibition, Dual oxidase ; Thyroid hormone synthesis, Decreased ; Decreased, Thyroxine (T4) in serum ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Inhibition, Dual oxidase
- 11/29/2016 11:41:17 PM
- 12/9/2020 5:39:21 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.
prepubertal increase, Estrogen receptor (ER) activity ; Activation, estrogen receptor alpha ; Promotion, SIX-1 postive basal-type progenitor cells ; Proliferation/Clonal Expansion, aberrant basal cells ; squamous metaplasia, aberrant basal cells ; Increased, Hyperplasia (glandular epithelial cells of endometrium) ; Increased, adenosquamous carcinomas of endometrium ; prepubertal increase, Estrogen receptor (ER) activity ; Activation, estrogen receptor alpha ; Promotion, SIX-1 postive basal-type progenitor cells ; Proliferation/Clonal Expansion, aberrant basal cells ; squamous metaplasia, aberrant basal cells ; Increased, Hyperplasia (glandular epithelial cells of endometrium) ; Increased, adenosquamous carcinomas of endometrium
- 11/29/2016 11:41:17 PM
- 2/7/2020 7:47:20 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk
- 5/9/2019 2:47:16 PM
- 1/9/2020 1:10:09 PM
Source: https://aopwiki.org/
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Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
Increase, Ecdysone receptor agonism ; Increase, Nuclear receptor E75b gene expression ; Increase, Fushi tarazu factor-1 gene expression ; Decrease, Circulating ecdysis triggering hormone ; Decrease, Circulating crustacean cardioactive peptide ; Decrease, Ecdysis motoneuron bursts ; Decrease, Excitatory postsynaptic potential ; Decrease, Abdominal muscle contraction ; Increase, Incomplete ecdysis ; Increased Mortality ; Increase, Mortality ; Increase, Ecdysone receptor agonism ; Increase, Nuclear receptor E75b gene expression ; Increase, Fushi tarazu factor-1 gene expression ; Decrease, Circulating ecdysis triggering hormone ; Decrease, Circulating crustacean cardioactive peptide ; Decrease, Ecdysis motoneuron bursts ; Decrease, Excitatory postsynaptic potential ; Decrease, Abdominal muscle contraction ; Increase, Incomplete ecdysis ; Increase, Mortality
- 11/29/2016 11:41:15 PM
- 5/24/2018 8:51:38 PM
Source: https://aopwiki.org/
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EGFR Activation Leading to Decreased Lung Function
Activation, EGFR ; Occurrence, Transdifferentiation of ciliated epithelial cells ; Occurrence, Metaplasia of goblet cells ; Occurrence, Hyperplasia of goblet cells ; Increase, Proliferation of goblet cells ; Activation, SP1 ; Decrease, Apoptosis of ciliated epithelial cells ; Increase, Mucin production ; Chronic, Mucus hypersecretion ; Decrease, Lung function ; Activation, EGFR ; Occurrence, Transdifferentiation of ciliated epithelial cells ; Occurrence, Metaplasia of goblet cells ; Occurrence, Hyperplasia of goblet cells ; Increase, Proliferation of goblet cells ; Activation, Sp1 ; Decrease, Apoptosis of ciliated epithelial cells ; Increase, Mucin production ; Chronic, Mucus hypersecretion ; Decrease, Lung function
- 11/29/2016 11:41:17 PM
- 5/17/2018 8:21:50 AM
- AOP under development
- 1.51
Source: https://aopwiki.org/
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Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development
- 8/4/2018 12:50:00 AM
- 8/4/2018 12:54:24 AM
Source: https://aopwiki.org/
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Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity
- 8/4/2018 12:55:30 AM
- 8/4/2018 12:56:59 AM
Source: https://aopwiki.org/
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Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
Reduction, Plasma 17beta-estradiol concentrations ; Reduction, 17beta-estradiol synthesis by ovarian granulosa cells ; Activation, AHR ; dimerization, AHR/ARNT ; Reduction, Vitellogenin synthesis in liver ; Reduction, Cumulative fecundity and spawning ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Decrease, Population trajectory ; Increase, DNA methyltransferase expression ; Increase, hypermethylation of the promotor region of gonadotropin releasing hormone receptor ; Decrease, expression of gonadotropin releasing hormone receptor ; Reduction, Plasma 17beta-estradiol concentrations ; Reduction, 17beta-estradiol synthesis by ovarian granulosa cells ; Decrease, Population trajectory ; Activation, AhR ; dimerization, AHR/ARNT ; Reduction, Vitellogenin synthesis in liver ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Reduction, Cumulative fecundity and spawning ; Increase, DNA methyltransferase expression ; Increase, hypermethylation of the promotor region of gonadotropin releasing hormone receptor ; Decrease, expression of gonadotropin releasing hormone receptor
- 10/30/2019 8:09:12 PM
- 10/30/2019 8:55:49 PM
Source: https://aopwiki.org/
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Endocytic lysosomal uptake leading to liver fibrosis
N/A, Mitochondrial dysfunction 1 ; N/A, Cell injury/death ; Release, Cytokine ; Peptide Oxidation ; Activation, Stellate cells ; Accumulation, Collagen ; N/A, Liver fibrosis ; Disruption, Lysosome ; Infiltration, Inflammatory cells ; Inflammation, Liver ; Increased Pro-inflammatory mediators ; Endocytotic lysosomal uptake ; Leukocyte recruitment/activation ; N/A, Mitochondrial dysfunction 1 ; Cell injury/death ; Increased Pro-inflammatory mediators ; Activation, Stellate cells ; Accumulation, Collagen ; N/A, Liver fibrosis ; Endocytotic lysosomal uptake ; Disruption, Lysosome ; Leukocyte recruitment/activation
- 11/29/2016 11:41:16 PM
- 12/20/2019 1:26:55 PM
- AOP under development
- 1.47
Source: https://aopwiki.org/
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Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
Increased, induction of UDPGT's in liver ; Increased, T4/T3 catabolism ; Decreased, serum T4/T3 ; Increased, Thyroid-stimulating hormone (TSH) ; Increased, Hypertrophy and proliferation (follicular cell) ; Increased, Hyperplasia (follicular cells) ; Increased Apoptosis, Adenomas/carcinomas (follicular cell) ; Increased, induction of UDPGT's in liver ; Increased, T4/T3 catabolism ; Decreased, serum T4/T3 ; Increased, Thyroid-stimulating hormone (TSH) ; Increased, Hypertrophy and proliferation (follicular cell) ; Increased, Hyperplasia (follicular cells) ; Increased Apoptosis, Adenomas/carcinomas (follicular cell)
- 11/29/2016 11:41:17 PM
- 2/7/2020 7:46:07 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Epigenetic modification of PPARG leading to adipogenesis
peroxisome proliferator activated receptor promoter demethylation ; Activation of specific nuclear receptors, PPAR-gamma activation ; chronic high fat diet ; activation of CCAAT/enhancer-binding protein alpha ; increased adipogenesis ; decreased dopamine ; decreased reward ; decreased DNA methylation of tyrosine hydroxylase ; decreased methylation of dopamine transporter promoter ; obesity ; peroxisome proliferator activated receptor promoter demethylation ; chronic high fat diet ; Activation of specific nuclear receptors, PPAR-gamma activation ; activation of CCAAT/enhancer-binding protein alpha ; increased adipogenesis ; decreased dopamine ; decreased reward ; decreased DNA methylation of tyrosine hydroxylase ; decreased methylation of dopamine transporter promoter ; obesity
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:32:34 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
Increase, Inflammation ; Increase, Papillomas/carcinomas (squamous cells) ; Increase, Cytotoxicity (epithelial cells) ; Increase, Regenerative cell proliferation (forestomach epithelial cells) ; Increase, Hyperplasia (forestomach epithelial cells) ; Increase, Inflammation ; Increase, Papillomas/carcinomas (squamous cells) ; Increase, Cytotoxicity (epithelial cells) ; Increase, Regenerative cell proliferation (forestomach epithelial cells) ; Increase, Hyperplasia (forestomach epithelial cells)
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:41:05 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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ER agonism leading to reduced survival due to renal failure
Agonism, Estrogen receptor ; Increase, Plasma vitellogenin concentrations ; Increased, Vitellogenin synthesis ; Increased, renal vitellogenin deposition ; Increased, glomerular rupture and renal hemorrhaging ; Increased, nephropathy ; Agonism, Estrogen receptor ; Increase, Plasma vitellogenin concentrations ; Increased, Vitellogenin synthesis ; Increased, renal vitellogenin deposition ; Increased, glomerular rupture and renal hemorrhaging ; Increased, nephropathy
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:14:57 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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ER agonism leading to skewed sex ratios due to altered sexual differentiation in males
Agonism, Estrogen receptor ; skewed, sex ratio ; Agonism, Estrogen receptor ; skewed, sex ratio
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:14:19 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
ER mediated breast cancer AOP
- 11/29/2016 11:41:17 PM
- 12/3/2016 9:37:49 PM
Source: https://aopwiki.org/
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Estrogen Binding Mediated Population Reduction
Binding to ER ; ER Transcription Factors ; Upreregulated Gene Transcription in the liver tissue ; Gene expression for Vtg production ; Alteration of Anal fin papillae ; Alteration of Gonadal morphology ; Reduced Growth ; Reduced eggs per female ; Reduced Fertility ; Mixed sex gonads ; Sex reversal ; Delayed adult mail mortality ; Altered sex ratios ; Population reduction ; Binding to ER ; ER Transcription Factors ; Upreregulated Gene Transcription in the liver tissue ; Gene expression for Vtg production ; Alteration of Anal fin papillae ; Alteration of Gonadal morphology ; Reduced Growth ; Reduced eggs per female ; Reduced Fertility ; Mixed sex gonads ; Sex reversal ; Delayed adult mail mortality ; Altered sex ratios ; Population reduction
- 10/15/2008 11:30:00 AM
Source: https://www.effectopedia.org/
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Estrogen Binding Mediated Population Reduction
Binding to ER ; ER Transcription Factors ; Upreregulated Gene Transcription in the liver tissue ; Gene expression for Vtg production ; Alteration of Anal fin papillae ; Alteration of Gonadal morphology ; Reduced Growth ; Reduced eggs per female ; Reduced Fertility ; Mixed sex gonads ; Sex reversal ; Delayed adult mail mortality ; Altered sex ratios ; Population reduction
- 10/15/2008 11:30:00 AM
Source: http://www.effectopedia.org/
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Estrogen Receptor Activation and Female Precocious Puberty
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:45:29 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
Estrogen receptor activation leading to breast cancer
N/A, Mitochondrial dysfunction 1 ; Increased, Oxidative Stress ; Activation, Estrogen receptor ; Increase, Cell Proliferation (Epithelial Cells) ; Decreased, Apoptosis (Epithelial Cells) ; Increased, ER binding to DNA (classical pathway) ; Increased, ER binding to T.F. to DNA (non-classical pathway) ; Increased, Proliferation (Endothelial cells) ; Increased, Migration (Endothelial Cells) ; Increased, Non-genomic signaling ; Increased, Ductal Hyperplasia ; Increase, DNA damage ; modulation, Extracellular Matrix Composition ; Increased, Invasion ; Activation, Fibroblasts ; Activation, Macrophages ; Increased, Angiogenesis ; Altered, Gene Expression ; Altered, Protein Production ; Increased, Motility ; Increased, Second Messenger Production ; N/A, Breast Cancer ; N/A, Mitochondrial dysfunction 1 ; Increased, Oxidative Stress ; Activation, Estrogen receptor ; Increase, Cell Proliferation (Epithelial Cells) ; Decreased, Apoptosis (Epithelial Cells) ; Increased, ER binding to DNA (classical pathway) ; Increased, ER binding to T.F. to DNA (non-classical pathway) ; Increased, Proliferation (Endothelial cells) ; Increased, Migration (Endothelial Cells) ; Increased, Non-genomic signaling ; Increased, Ductal Hyperplasia ; Increase, DNA damage ; modulation, Extracellular Matrix Composition ; Increased, Invasion ; Activation, Fibroblasts ; Activation, Macrophages ; Increased, Angiogenesis ; Altered, Gene Expression ; Altered, Protein Production ; Increased, Motility ; Increased, Second Messenger Production ; N/A, Breast Cancer
- 11/29/2016 11:41:17 PM
- 3/6/2020 10:48:25 PM
Source: https://aopwiki.org/
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Estrogen receptor agonism leading to reproductive dysfunction
Reduction, Cumulative fecundity and spawning ; Decrease, Population trajectory ; Agonism, Estrogen receptor ; Increase, Plasma vitellogenin concentrations ; Increase, Vitellogenin synthesis in liver ; Increase, Renal pathology due to VTG deposition ; Altered, Reproductive behaviour ; Altered, Larval development ; Impaired development of, Reproductive organs ; Decrease, Population trajectory ; Reduction, Cumulative fecundity and spawning ; Agonism, Estrogen receptor ; Increase, Plasma vitellogenin concentrations ; Increase, Vitellogenin synthesis in liver ; Increase, Renal pathology due to VTG deposition ; Altered, Reproductive behaviour ; Altered, Larval development ; Impaired development of, Reproductive organs
- 11/29/2016 11:41:16 PM
- 2/7/2020 8:20:40 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Estrogen receptor antagonism leading to reproductive dysfunction
Reduction, Vitellogenin synthesis in liver ; Reduction, Cumulative fecundity and spawning ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Decrease, Population trajectory ; Antagonism, Estrogen receptor ; Decrease, Population trajectory ; Reduction, Vitellogenin synthesis in liver ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Reduction, Cumulative fecundity and spawning ; Antagonism, Estrogen receptor
- 11/29/2016 11:41:16 PM
- 11/30/2016 5:22:47 PM
- EAGMST under review
- 1.12
Source: https://aopwiki.org/
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Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
Decreased, Sodium conductance 1 ; Reduced, swimming speed ; Reduced, feeding 1 ; Increased, predation ; Reduced, survival ; Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel ; Decreased, Sodium conductance 1 ; Reduced, swimming speed ; Reduced, feeding 1 ; Increased, predation ; Reduced, survival ; Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:35:08 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Example6 Neurotoxicity
Interaction (VSGCs) ; chloride-permeable ion channels ; voltage-gated calcium channels ; ligand-gated chloride channels ; Seizures ; Death ; Loss of consciousness ; Signaling disruption ; Convolutions ; Tremors ; Paralysis ; Neuronal membrane potential disruption ; Disruption of homeostasis of neuronal networks ; Movement Impariment ; Behavioral Changes ; Population reduction
- 10/15/2008 11:30:00 AM
Source: http://www.effectopedia.org/
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Example6 Neurotoxicity
Interaction (VSGCs) ; chloride-permeable ion channels ; voltage-gated calcium channels ; ligand-gated chloride channels ; Seizures ; Death ; Loss of consciousness ; Signaling disruption ; Convolutions ; Tremors ; Paralysis ; Neuronal membrane potential disruption ; Disruption of homeostasis of neuronal networks ; Movement Impariment ; Behavioral Changes ; Population reduction ; Interaction (VSGCs) ; chloride-permeable ion channels ; voltage-gated calcium channels ; ligand-gated chloride channels ; Seizures ; Death ; Loss of consciousness ; Signaling disruption ; Convolutions ; Tremors ; Paralysis ; Neuronal membrane potential disruption ; Disruption of homeostasis of neuronal networks ; Movement Impariment ; Behavioral Changes ; Population reduction
- 10/15/2008 11:30:00 AM
Source: https://www.effectopedia.org/
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Excessive reactive oxygen species production leading to mortality (1)
Increase, Mortality ; Increase, Reactive oxygen species production ; Increase, Protein oxidation ; Decrease, Osmoregulation ; Increase, Body fluid overload ; Increase, Mortality ; Increase, Reactive oxygen species production ; Increase, Protein oxidation ; Increase, Abnormal osmoregulation ; Increase, Body fluid overload
- 4/19/2020 8:48:12 AM
- 10/27/2020 7:38:53 AM
Source: https://aopwiki.org/
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Excessive reactive oxygen species production leading to mortality (2)
Increase, Mortality ; Increase, Reactive oxygen species production ; Decrease, Oxidative phosphorylation ; Decrease, ATP production ; Decrease, Mitochondrial membrane potential ; Increase, Mortality ; Increase, Reactive oxygen species production ; Decrease, Oxidative phosphorylation ; Decrease, Adenosine triphosphate pool ; Decrease, Mitochondrial membrane potential
- 4/19/2020 8:48:39 AM
- 10/27/2020 7:39:11 AM
Source: https://aopwiki.org/
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Excessive reactive oxygen species production leading to mortality (3)
Increase, Mortality ; Increase, Reactive oxygen species production ; Increase, Lipid peroxidation ; Decrease, ATP production ; Decrease, Neutral lipids ; Increase, Mortality ; Increase, Reactive oxygen species production ; Decrease, Adenosine triphosphate pool ; Increase, Lipid peroxidation ; Decrease, Neutral lipids
- 4/19/2020 8:49:00 AM
- 10/27/2020 7:39:31 AM
Source: https://aopwiki.org/
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Excessive reactive oxygen species production leading to mortality (4)
Increase, Mortality ; Increase, Reactive oxygen species production ; Increase, Apoptosis ; Increase, Oxidative DNA damage ; Increase, DNA double-strand break ; Increase, Mortality ; Increase, Reactive oxygen species production ; Increase, Apoptosis ; Increase, Oxidative DNA damage ; Increase, DNA double-strand break
- 4/19/2020 8:49:22 AM
- 10/27/2020 7:39:47 AM
Source: https://aopwiki.org/
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Excessive reactive oxygen species production leading to population decline via follicular atresia
Decrease, Population trajectory ; Increase, Reactive oxygen species production ; Peptide Oxidation ; Decrease, Ovulation ; Decrease, Fertility ; Increase, DNA damage ; Increase, Reactive oxygen species ; Increase, Apoptosis ; Decrease, Oogenesis ; Increase, Follicular atresia ; Decrease, Fecundity ; Decrease, Population trajectory ; Increase, Reactive oxygen species production ; Decrease, Ovulation ; Increase, DNA damage ; Increase, Apoptosis ; Decrease, Oogenesis ; Increase, Follicular atresia ; Decrease, Fecundity ; Increase, Oxidative DNA damage
- 4/15/2017 8:00:03 PM
- 11/25/2020 4:22:20 PM
Source: https://aopwiki.org/
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Excessive reactive oxygen species production leading to population decline via lipid peroxidation
Decrease, Mitochondrial ATP production ; Increase, Reactive oxygen species production ; Decrease, Ovulation ; Decrease, Fertility ; Decrease, Oogenesis ; Increase, Lipid peroxidation ; Increase, Uncoupling of oxidative phosphorylation ; Decrease, Fecundity ; Decrease, Population trajectory ; Decrease, Mitochondrial ATP production ; Increase, Reactive oxygen species production ; Decrease, Ovulation ; Increase, Apoptosis ; Decrease, Oogenesis ; Increase, Follicular atresia ; Decrease, Fecundity ; Decrease, Coupling of oxidative phosphorylation ; Increase, Lipid peroxidation
- 6/29/2017 12:00:09 PM
- 11/25/2020 4:27:08 PM
- AOP under development
Source: https://aopwiki.org/
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Excessive reactive oxygen species production leading to population decline via mitochondrial dysfunction
Decrease, Population trajectory ; Increase, Reactive oxygen species production ; Decrease, Oogenesis ; Decrease, Fecundity ; Decrease, Oxidative phosphorylation ; Decrease, Adenosine triphosphate pool ; Decrease, Mitochondrial membrane potential
- 11/18/2019 9:01:38 AM
- 11/25/2020 4:14:56 PM
Source: https://aopwiki.org/
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Excessive reactive oxygen species production leading to population decline via reduced fatty acid beta-oxidation
Decrease, Fecundity ; Increase, DNA hypomethylation ; Increase, Gene expression ; Increase, S-adenosylmethionine depletion ; Decrease, Population trajectory ; Increase, Reactive oxygen species production ; Decrease, Oogenesis ; Decrease, Fecundity ; Decrease, Adenosine triphosphate pool ; Increase, DNA hypomethylation ; Increase, Gene expression ; Increase, S-adenosylmethionine depletion ; Increase, Lipid peroxidation ; Decrease, Lipid storage ; Decrease, Fatty acid β-oxidation
- 5/30/2019 12:08:59 PM
- 11/25/2020 3:36:07 PM
Source: https://aopwiki.org/
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Formation of DNA photoproducts leading to growth inhibition (1)
Increase, Mortality ; Increase, Apoptosis ; Increase, DNA double-strand break ; Increase, Formation of DNA photoproducts ; Increase, Mortality ; Increase, Apoptosis ; Increase, DNA double-strand break ; Increase, Formation of DNA photoproducts
- 4/19/2020 8:50:03 AM
- 10/27/2020 8:05:48 AM
Source: https://aopwiki.org/
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Formation of DNA photoproducts leading to growth inhibition (2)
- 4/19/2020 8:52:14 AM
- 10/27/2020 8:06:14 AM
Source: https://aopwiki.org/
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Formation of DNA photoproducts leading to growth inhibition (3)
- 4/19/2020 8:52:38 AM
- 10/27/2020 8:06:39 AM
Source: https://aopwiki.org/
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Frustrated phagocytosis-induced lung cancer
Release, Cytokine ; Increase, Cell Proliferation ; Increased, Reactive oxygen species ; Increased, recruitment of inflammatory cells ; Frustrated phagoytosis ; Increased, DNA damage and mutation ; Lung cancer ; Release, Cytokine ; Increase, Cell Proliferation ; Increased, recruitment of inflammatory cells ; Increased, Reactive oxygen species ; Frustrated phagoytosis ; Increased, DNA damage and mutation ; Lung cancer
- 7/3/2019 3:26:45 PM
- 1/9/2020 1:48:25 PM
Source: https://aopwiki.org/
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Gastric ulcer formation
Inhibition, PTGS-1 (Prostaglandin-endoperoxide synthase 1) ; Activation, PTGS-1 (Prostaglandin-endoperoxide synthase 1) ; Activation, PTGS-2 (Prostaglandin-endoperoxide synthase 2) ; Inhibition, PTGS-2 (Prostaglandin-endoperoxide synthase 2) ; Increase, bicarbonate ; Increase, mucous ; Increase, mucosal blood flow ; Increase, platelet aggregation ; Increase, angiogenesis ; Decrease, leukocyte adherence ; Increase, leukocyte adherence ; Activate, leukocyte ; Activate, mucosal defense ; Increase, surfactant ; Decrease, surfactant ; Activate, phospholipase ; Increase, ammonium (NH4+) ; Inhibit, gastric ulcer formation ; Activated, gastric ulcer formation ; Inhibition, PTGS-1 (Prostaglandin-endoperoxide synthase 1) ; Activation, PTGS-1 (Prostaglandin-endoperoxide synthase 1) ; Activation, PTGS-2 (Prostaglandin-endoperoxide synthase 2) ; Inhibition, PTGS-2 (Prostaglandin-endoperoxide synthase 2) ; Increase, bicarbonate ; Increase, mucous ; Increase, mucosal blood flow ; Increase, platelet aggregation ; Increase, angiogenesis ; Decrease, leukocyte adherence ; Increase, leukocyte adherence ; Activate, leukocyte ; Activate, mucosal defense ; Increase, surfactant ; Decrease, surfactant ; Activate, phospholipase ; Increase, ammonium (NH4+) ; Inhibit, gastric ulcer formation ; Activated, gastric ulcer formation
- 4/17/2017 2:11:46 PM
- 6/15/2020 8:11:39 PM
Source: https://aopwiki.org/
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Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
impaired, Fertility ; Reduction, Testosterone synthesis in Leydig cells ; Reduction, testosterone level ; Glucocorticoid Receptor Agonist, Activation ; Repressed expression of steroidogenic enzymes ; Increased apoptosis, decreased number of adult Leydig Cells ; Decreased Sperm Number, Reduced Fertility ; Accelerated Epididymal Sperm Transit, Reduced Fertility ; Abnormal Sperm Maturation, Reduced Fertility ; Decreased sperm quantity or quality in the adult, Decreased fertility ; impaired, Fertility ; Reduction, Testosterone synthesis in Leydig cells ; Reduction, testosterone level ; Glucocorticoid Receptor Agonist, Activation ; Repressed expression of steroidogenic enzymes ; Increased apoptosis, decreased number of adult Leydig Cells ; Decreased sperm quantity or quality in the adult, Decreased fertility
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:21:10 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Glucocorticoid Receptor activation leading to hepatic steatosis
Decreased, Mitochondrial Fatty Acid Beta Oxidation ; Activation, Glucocorticoid Receptor ; Decreased, PPAR-alpha activation ; Increased, Liver Steatosis ; Activation, Glucocorticoid Receptor ; Accumulation, Triglyceride ; Decreased, PPAR-alpha activation ; Increased, Liver Steatosis ; Decreased, Mitochondrial Fatty Acid Beta Oxidation ; Decrease, Acyl-CoA dehydrogenases
- 2/22/2020 1:39:30 PM
- 1/15/2021 4:45:40 PM
Source: https://aopwiki.org/
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Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
Activation, Glucocorticoid Receptor ; Inhibition, Nuclear factor kappa B (NF-kB) ; Suppression, Inflammatory cytokines ; Decreased, Lymphocytes ; Induction, IKB inhibitory protein ; Suppression, Immune system ; Increased, Disease susceptibility ; Activation, Glucocorticoid Receptor ; Inhibition, Nuclear factor kappa B (NF-kB) ; Suppression, Inflammatory cytokines ; Decreased, Lymphocytes ; Induction, IKB inhibitory protein ; Suppression, Immune system ; Increased, Disease susceptibility
- 11/29/2016 11:41:16 PM
- 1/7/2020 3:38:57 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
Activation, Glucocorticoid Receptor ; Decrease, Population trajectory ; Reduced, Swimming performance ; Increase, Cripto-1 expression ; Inhibition, Activin signaling ; Inhibition, Fin regeneration ; Activation, Glucocorticoid Receptor ; Decrease, Population trajectory ; Reduced, Swimming performance ; Increase, Cripto-1 expression ; Inhibition, Activin signaling ; Inhibition, Fin regeneration
- 4/20/2020 8:16:51 PM
- 7/27/2020 4:54:31 PM
Source: https://aopwiki.org/
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Glutamate-gated chloride channel activation leading to acute mortality
Increased Mortality ; Activation, Glutamate-gated chloride channel ; Increased, Chloride conductance ; hyperpolarisation, neuron ; N/A, Ataxia, paralysis, or hyperactivity ; Decreased, population 1 ; Increased Mortality ; Activation, Glutamate-gated chloride channel ; Increased, Chloride conductance ; hyperpolarisation, neuron ; N/A, Ataxia, paralysis, or hyperactivity ; Decreased, population 1
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:40:32 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
Increased Mortality ; Increased, Chloride conductance ; Increased, Inhibitory postsynaptic potential ; Increased, Neuronal synaptic inhibition ; Inhibition, Feeding ; Activation, Glutamate-gated chloride channels ; Induction, pharyngeal muscle paralysis ; Increased Mortality ; Increased, Chloride conductance ; Increased, Inhibitory postsynaptic potential ; Increased, Neuronal synaptic inhibition ; Inhibition, Feeding ; Activation, Glutamate-gated chloride channels ; Induction, pharyngeal muscle paralysis
- 11/29/2016 11:41:17 PM
- 12/3/2016 9:37:47 PM
Source: https://aopwiki.org/
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GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
Decreased, GnRH pulsatility/release in hypothalamus ; Decreased, LH Surge from anterior pituitary ; interruption, Ovulation ; prolonged, estrus ; Increased, circulating estrogen levels ; Increased, prolactin exposure ; Hyperplasia, Mammary gland ; Increased, latency period ; Increased, Adenomas/carcinomas (mammary) ; Decreased, GnRH pulsatility/release in hypothalamus ; Decreased, LH Surge from anterior pituitary ; interruption, Ovulation ; prolonged, estrus ; Increased, circulating estrogen levels ; Increased, prolactin exposure ; Hyperplasia, Mammary gland ; Increased, latency period ; Increased, Adenomas/carcinomas (mammary)
- 11/29/2016 11:41:17 PM
- 2/7/2020 7:47:42 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
Decreased, GnRH pulsatility/release in hypothalamus ; Decreased, LH Surge from anterior pituitary ; interruption, Ovulation ; prolonged, estrus ; Increased, circulating estrogen levels ; Increased, lactotroph hyperplasia and hypertrophy ; Increased, adenomas (pituitary) ; Decreased, GnRH pulsatility/release in hypothalamus ; Decreased, LH Surge from anterior pituitary ; interruption, Ovulation ; prolonged, estrus ; Increased, circulating estrogen levels ; Increased, lactotroph hyperplasia and hypertrophy ; Increased, adenomas (pituitary)
- 11/29/2016 11:41:17 PM
- 2/7/2020 7:48:44 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Handbook development AOP
- 2/16/2017 4:26:17 PM
- 2/7/2020 7:59:20 PM
Source: https://aopwiki.org/
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Helicobacter pylori to gastric ulcer
Decrease, surfactant ; Activate, phospholipase ; Increase, ammonium (NH4+) ; Activated, gastric ulcer formation ; Reduced, mucosal defense ; Helicobacter pylori infection ; Decrease, surfactant ; Activate, phospholipase ; Increase, ammonium (NH4+) ; Activated, gastric ulcer formation ; Reduced, mucosal defense ; Helicobacter pylori infection
- 6/2/2017 3:06:41 PM
- 6/15/2020 8:17:10 PM
- AOP under development
Source: https://aopwiki.org/
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Hepatic nuclear receptor activation leading to altered amphibian metamorphosis
Thyroxine (T4) in serum, Decreased ; Induction, Upregulation of glucuronyltransferase activity ; Increase, Biliary excretion TH glucuronide ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Activation, Hepatic nuclear receptor(s) ; Increased, Hepatic thyroid hormone uptake/transport ; Induction, Upregulation of glucuronyltransferase activity ; Increase, Biliary excretion TH glucuronide ; Thyroxine (T4) in serum, Decreased ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Activation, Hepatic nuclear receptor(s) ; Increased, Hepatic thyroid hormone uptake/transport
- 11/29/2016 11:41:17 PM
- 12/9/2020 8:04:49 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Histamine (H2) receptor antagonism leading to reduced survival
Impairment, Learning and memory ; Increased, predation ; Antagonism, Histamine Receptor (H2) ; Decrease, histaminergic neuron excitation ; N/A, sedation ; Decreased, locomotion ; impaired, Learning and memory ; Decreased, survival ; Impairment, Learning and memory ; Increased, predation ; Antagonism, Histamine Receptor (H2) ; Decrease, histaminergic neuron excitation ; N/A, sedation ; Decreased, locomotion ; Decreased, survival
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:36:19 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Histone deacetylase inhibition leading to testicular atrophy
Apoptosis ; Histone deacetylase inhibition ; Histone acetylation, increase ; p21 (CDKN1A) expression, increase ; cell cycle, disrupted ; testicular atrophy ; spermatocyte depletion ; Apoptosis ; Histone deacetylase inhibition ; Histone acetylation, increase ; Cell cycle, disrupted ; Spermatocyte depletion ; Testicular atrophy
- 3/10/2017 11:45:47 AM
- 2/10/2020 7:33:43 AM
- AOP under development
- 1.52
Source: https://aopwiki.org/
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Histone deacetylase inhibition leads to impeded craniofacial development
Histone deacetylase inhibition ; Neural crest cell migration, reduced ; Collagen production, reduced ; Facial cartilage structures are reduced in size and morphologically distorted ; Histone deacetylase inhibition ; Neural crest cell migration, reduced ; Collagen production, reduced ; Facial cartilage structures are reduced in size and morphologically distorted
- 12/20/2018 8:45:23 AM
- 12/20/2018 9:39:49 AM
Source: https://aopwiki.org/
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Histone deacetylase inhibition leads to neural tube defects
Altered, Gene Expression ; Histone deacetylase inhibition ; Histone acetylation, increase ; Altered differentiation ; Neural tube defects ; Altered, Gene Expression ; Histone deacetylase inhibition ; Histone acetylation, increase ; Altered differentiation ; Neural tube defects
- 12/20/2018 1:24:47 PM
- 12/20/2018 1:33:26 PM
Source: https://aopwiki.org/
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HMG-CoA reductase inhibition leading to decreased fertility
Inhibition, HMG-CoA reductase ; Decreased, mevalonate ; Decreased, cholesterol ; Decreased, Testosterone ; malformed, Male reproductive tract ; Decrease, Fertility ; Inhibition, HMG-CoA reductase ; Decreased, mevalonate ; Decreased, cholesterol ; Decreased, Testosterone ; malformed, Male reproductive tract ; Decrease, Fertility
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:43:34 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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HNF4alpha suppression leading to hepatic steatosis
Suppression, HNF4alpha ; Suppression, HNF4alpha
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:16:53 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme ; Increased, Plasma tyrosine ; Increase, Cytotoxicity (corneal cells) ; Increase, Inflammation (corneal cells) ; Increase, Regenerative cell proliferation (corneal cells) ; Increase, Papillomas/carcinomas (squamous cells) ; Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme ; Increased, Plasma tyrosine ; Increase, Cytotoxicity (corneal cells) ; Increase, Inflammation (corneal cells) ; Increase, Regenerative cell proliferation (corneal cells) ; Increase, Papillomas/carcinomas (squamous cells)
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:40:47 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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IKK complex inhibition leading to liver injury
N/A, Cell injury/death ; Inhibition, Nuclear factor kappa B (NF-kB) ; Necrotic Tissue ; Liver Injury ; Inhibition, IKK complex ; Activation, Caspase 8 pathway ; Activation, Tissue resident cells (Kuppfer cells) ; Increased, proinflammatory mediators (TNFalpha) ; Increase, proinflammatory mediators (TNFalpha) ; Cell injury/death ; Inhibition, Nuclear factor kappa B (NF-kB) ; Necrotic Tissue ; Liver Injury ; Inhibition, IKK complex ; Activation, Caspase 8 pathway ; Activation, Tissue resident cells (Kuppfer cells) ; Increase, proinflammatory mediators (TNFalpha)
- 1/7/2019 1:00:15 PM
- 1/7/2019 3:48:02 PM
Source: https://aopwiki.org/
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Immune mediated hepatitis
Increase in inflammation ; benzoquinone imine and acylglucuronide metabolites ; Mitochondrial dysfunction ; Activation of ER stress ; Apoptotic cell death ; Immune cell activation ; IFNγ signaling ; Immune mediated hepatitis
- 11/2/2020 11:16:30 AM
- 11/2/2020 12:34:07 PM
Source: https://aopwiki.org/
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Impaired IL-1R1 signaling leading to increased susceptibility to infection
Inhibition, Nuclear factor kappa B (NF-kB) ; Increase, Increased susceptibility to infection ; Blocking of IL-1R ; Decreased IL-1 production ; Impaired IL-1 signaling ; Suppressed AP-1 ; Suppressed NF-kB ; Suppressed DC activation ; Impaired antigen presentation ; Impaired T cell activation ; Suppression, Suppression of T-cell dependent antibody response (TDAR) ; Suppressed MyD88 ; Impaired Ab production ; Inhibition of IL-1 binding to IL-1 receptor ; Suppression of T cell activation ; Inhibition, Nuclear factor kappa B (NF-kB) ; Impaired IL-1R1 signaling ; Suppression of T cell activation ; Increase, Increased susceptibility to infection
- 12/21/2018 1:02:52 AM
- 12/22/2020 2:47:56 AM
Source: https://aopwiki.org/
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Increased DNA damage leading to increased risk of breast cancer
Increase, Mutations ; Increase, Cell Proliferation (Epithelial Cells) ; Increased, Ductal Hyperplasia ; Increase, DNA damage ; N/A, Breast Cancer ; Tissue resident cell activation ; Increased Pro-inflammatory mediators ; Leukocyte recruitment/activation ; Increase mutations ; Increase in reactive oxygen and nitrogen species (RONS) ; Increase in inflammation ; Increase, Mutations ; Tissue resident cell activation ; Increased Pro-inflammatory mediators ; Leukocyte recruitment/activation ; Increase, Cell Proliferation (Epithelial Cells) ; Increased, Ductal Hyperplasia ; Increase, DNA damage ; N/A, Breast Cancer ; Increase in reactive oxygen and nitrogen species (RONS)
- 5/3/2019 2:20:11 PM
- 1/9/2020 1:17:11 PM
Source: https://aopwiki.org/
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Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
Increase, Dopaminergic activity ; Decreased, Prolactin ; Increased, Estrogen receptor (ER) activity ; Decreased, Progesterone from corpus luteum ; Increase, Hyperplasia (glandular epithelial cells of endometrium) ; Increase, Endometrial adenocarcinomas ; Increase, Dopaminergic activity ; Decreased, Prolactin ; Increased, Estrogen receptor (ER) activity ; Decreased, Progesterone from corpus luteum ; Increase, Hyperplasia (glandular epithelial cells of endometrium) ; Increase, Endometrial adenocarcinomas
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:40:17 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure
Abnormal, Foraging activity and behavior ; Death/Failure, Colony ; Decrease, Number of worker bees ; Increase, Energetic demands and therefore metabolic stress ; Increased, Appetite and hunger ; Abnormal, Foraging activity and behavior ; Death/Failure, Colony ; Decrease, Number of worker bees ; Increase, Energetic demands and therefore metabolic stress ; Increased, Appetite and hunger
- 11/29/2016 11:41:16 PM
- 4/8/2019 4:37:25 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
Increase, Mutations ; Increase, Cell Proliferation (Epithelial Cells) ; Increased, Ductal Hyperplasia ; Increase, DNA damage ; N/A, Breast Cancer ; Tissue resident cell activation ; Increased Pro-inflammatory mediators ; Leukocyte recruitment/activation ; Increase in reactive oxygen and nitrogen species (RONS) ; Increase, Mutations ; Tissue resident cell activation ; Increased Pro-inflammatory mediators ; Leukocyte recruitment/activation ; Increase, Cell Proliferation (Epithelial Cells) ; Increased, Ductal Hyperplasia ; Increase, DNA damage ; N/A, Breast Cancer ; Increase in reactive oxygen and nitrogen species (RONS)
- 5/7/2019 6:03:51 PM
- 1/9/2020 1:18:05 PM
Source: https://aopwiki.org/
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Inhibition of 11β-HSD leading to impaired spermatogenesis in fish
Decrease, Fertility ; Decreased, 11-ketotestosterone ; Impaired, Spermatogenesis ; Decreased plasma 11-KT level ; Inhibition of 11β-HSD ; Decrease, Fertility ; Decreased, 11-ketotestosterone ; Impaired, Spermatogenesis ; Inhibition of 11β-HSD
- 7/3/2020 4:44:29 PM
- 7/21/2020 1:51:31 PM
Source: https://aopwiki.org/
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Inhibition of 11β-hydroxylase leading to infertility in male fish
impaired, Fertility ; Decreased, 11-ketotestosterone ; 11β-hydroxylase inhibition ; Decreased plasma 11-KT level ; Decreased size and sperm volume ; impaired, Fertility ; Decreased, 11-ketotestosterone ; 11β-hydroxylase inhibition ; Decreased size and sperm volume
- 7/12/2020 2:16:17 PM
- 1/26/2021 2:54:48 PM
Source: https://aopwiki.org/
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Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
Inhibition, Cytochrome P450 enzyme (CYP17A1) activity ; Reduction, 17-OH-pregnenolone conversion in DHEA ; Reduction, 17-OH-progesterone conversion in androstenedione ; Decrease, testosterone synthesis/level ; Decrease, dihydrotestosterone (DHT) level ; Decrease, androgen receptors (AR) activation ; Impaired inguinoscrotal testicular descent phase ; Malformation, cryptorchidism - maldescended testis ; Inhibition, Cytochrome P450 enzyme (CYP17A1) activity ; Reduction, 17-OH-pregnenolone conversion in DHEA ; Reduction, 17-OH-progesterone conversion in androstenedione ; Decrease, testosterone synthesis/level ; Decrease, dihydrotestosterone (DHT) level ; Decrease, androgen receptors (AR) activation ; Impaired inguinoscrotal testicular descent phase ; Malformation, cryptorchidism - maldescended testis
- 4/10/2019 8:22:51 AM
- 2/24/2020 8:09:23 AM
Source: https://aopwiki.org/
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Inhibition of 5α-reductase leading to impaired fecundity in female fish
Reduction, Plasma 17beta-estradiol concentrations ; Reduction, Cumulative fecundity and spawning ; Reduction, Plasma vitellogenin concentrations ; Decrease, Population trajectory ; Decrease, dihydrotestosterone (DHT) level ; 5α-reductase, inhibition ; Reduction, egg production and spawning ; Reduction, Plasma 17beta-estradiol concentrations ; Decrease, Population trajectory ; Reduction, Plasma vitellogenin concentrations ; Reduction, Cumulative fecundity and spawning ; Decrease, dihydrotestosterone (DHT) level ; 5α-reductase, inhibition
- 4/18/2019 9:45:58 PM
- 7/27/2020 10:09:28 AM
Source: https://aopwiki.org/
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Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)
Increase, Hyperplasia (Leydig cells) ; Increase, Leydig cell tumors ; Inhibition, 5α-reductase activity ; Increased, Leutinizing hormone (LH) ; Decrease, Bioactivation of testosterone ; Increase, Hyperplasia (Leydig cells) ; Increase, Leydig cell tumors ; Inhibition, 5α-reductase activity ; Increased, Leutinizing hormone (LH) ; Decrease, Bioactivation of testosterone
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:42:16 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
Inhibition of ATP synthase
Inhibition of ATP synthase ; Death ; Reduced ATP formation ; Inhibition of ATP-dependent cellular functions ; Reduced ATP-depndent functions ; Heart Failure ; Respiratory Failure ; Increased metabolism ; Reduced mitochondrial oxygen consumption ; Increased mitochondrial reactive oxygen species formation ; Necrosis ; Apoptosis ; Hyperpolarized mitochondrial membrane potential ; Population reduction
- 4/11/2010 10:00:00 AM
Source: http://www.effectopedia.org/
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Inhibition of ATP synthase
Inhibition of ATP synthase ; Death ; Reduced ATP formation ; Inhibition of ATP-dependent cellular functions ; Reduced ATP-depndent functions ; Heart Failure ; Respiratory Failure ; Increased metabolism ; Reduced mitochondrial oxygen consumption ; Increased mitochondrial reactive oxygen species formation ; Necrosis ; Apoptosis ; Hyperpolarized mitochondrial membrane potential ; Population reduction ; Inhibition of ATP synthase ; Death ; Reduced ATP formation ; Inhibition of ATP-dependent cellular functions ; Reduced ATP-depndent functions ; Heart Failure ; Respiratory Failure ; Increased metabolism ; Reduced mitochondrial oxygen consumption ; Increased mitochondrial reactive oxygen species formation ; Necrosis ; Apoptosis ; Hyperpolarized mitochondrial membrane potential ; Population reduction
- 4/11/2010 10:00:00 AM
Source: https://www.effectopedia.org/
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Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
Binding, Immunophilins ; Inhibition, Calcineurin Activity ; Interference, nuclear localization of NFAT ; Reduction, NFAT/AP-1 complex formation ; Suppression, IL-2 and IL-4 production ; Suppression, Suppression of production of cytotoxic T-cells ; Suppression, Suppression of T-cell dependent antibody production ; Impairment, T-cell dependent antibody response ; Relief, Relief of atopic dermatitis ; Increase, Increased susceptibility to infection ; Inhibition, Calcineurin Activity ; Interference, nuclear localization of NFAT ; Reduction, NFAT/AP-1 complex formation ; Suppression, IL-2 and IL-4 production ; Impairment, T-cell dependent antibody response
- 11/29/2016 11:41:17 PM
- 9/17/2020 11:11:34 PM
- EAGMST under review
- 1.38
Source: https://aopwiki.org/
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Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome
Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) ; Inhibition, NADH-ubiquinone oxidoreductase (complex I) ; Decrease, Oxidative phosphorylation ; Decreased Na/K ATPase activity ; Decreased proximal tubular vectorial transport ; Chemical induced Fanconi syndrome ; Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) ; Inhibition, NADH-ubiquinone oxidoreductase (complex I) ; Decrease, Oxidative phosphorylation ; Decreased Na/K ATPase activity ; Decreased proximal tubular vectorial transport ; Chemical induced Fanconi syndrome
- 12/20/2018 2:40:37 PM
- 1/29/2019 1:44:35 PM
Source: https://aopwiki.org/
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Inhibition of complexes I-IV
Inhibition of complex I ; Inhibition of complex II ; Inhibition of complex III ; Inhibition of complex IV ; Death ; Reduced ATP formation ; Inhibition of ATP-dependent cellular functions ; Reduced ATP-depndent functions ; Heart Failure ; Respiratory Failure ; Increased metabolism ; Inhibition of the electron transport chain ; Reduced mitochondrial oxygen consumption ; Reduced mitochondrial membrane potential ; Increased mitochondrial reactive oxygen species formation ; Necrosis ; Apoptosis ; Population reduction ; Inhibition of complex I ; Inhibition of complex II ; Inhibition of complex III ; Inhibition of complex IV ; Death ; Reduced ATP formation ; Inhibition of ATP-dependent cellular functions ; Reduced ATP-depndent functions ; Heart Failure ; Respiratory Failure ; Increased metabolism ; Inhibition of the electron transport chain ; Reduced mitochondrial oxygen consumption ; Reduced mitochondrial membrane potential ; Increased mitochondrial reactive oxygen species formation ; Necrosis ; Apoptosis ; Population reduction
- 4/11/2010 10:00:00 AM
Source: https://www.effectopedia.org/
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Inhibition of complexes I-IV
Inhibition of complex I ; Inhibition of complex II ; Inhibition of complex III ; Inhibition of complex IV ; Death ; Reduced ATP formation ; Inhibition of ATP-dependent cellular functions ; Reduced ATP-depndent functions ; Heart Failure ; Respiratory Failure ; Increased metabolism ; Inhibition of the electron transport chain ; Reduced mitochondrial oxygen consumption ; Reduced mitochondrial membrane potential ; Increased mitochondrial reactive oxygen species formation ; Necrosis ; Apoptosis ; Population reduction
- 4/11/2010 10:00:00 AM
Source: http://www.effectopedia.org/
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Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity
Decreased, Population trajectory ; Decreased, Reproductive Success ; CYP7B activity, inhibition ; 7α-hydroxypregnenolone synthesis in the brain, decreased ; Dopamine release in the brain, decreased ; Locomotor activity, decreased ; Decreased, Reproductive Success ; CYP7B activity, inhibition ; 7α-hydroxypregnenolone synthesis in the brain, decreased ; Dopamine release in the brain, decreased ; Locomotor activity, decreased ; Decreased, Population trajectory
- 5/2/2017 2:41:02 PM
- 6/15/2020 7:09:00 PM
Source: https://aopwiki.org/
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Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
Decreased, Population trajectory ; Decreased, Reproductive Success ; CYP7B activity, inhibition ; 7α-hydroxypregnenolone synthesis in the brain, decreased ; Dopamine release in the brain, decreased ; Sexual behavior, decreased ; Decreased, Reproductive Success ; CYP7B activity, inhibition ; 7α-hydroxypregnenolone synthesis in the brain, decreased ; Dopamine release in the brain, decreased ; Decreased, Population trajectory ; Sexual behavior, decreased
- 5/3/2017 3:40:04 PM
- 6/15/2020 7:09:20 PM
Source: https://aopwiki.org/
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Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
Inhibition of cystathionine beta-synthase ; Inhibition of Methylenetetrahydrofolate reductase ; Inhibition of Methionine synthase ; Inhibition of betaine-homocysteine methyltransferase ; Increased Homocysteine level ; Increased plasma Homocysteine level ; Increased brain Homocysteine level ; Induce Neuronal dysfunctions ; Increased, Plasma HCY level ; Induced, dysfunction of microcirculation ; Impaired,anterior-posterior axis development ; Inhibition of cystathionine beta-synthase ; Increased Homocysteine level ; Increased, Plasma HCY level ; Induced, dysfunction of microcirculation ; Impaired,anterior-posterior axis development
- 6/14/2019 12:41:37 PM
- 12/3/2019 3:04:45 PM
Source: https://aopwiki.org/
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Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
Activation, PPARα ; Activation, LXR ; peroxisome proliferator activated receptor promoter demethylation ; Activation, FAS ; Activation, SCD-1 ; Inhibition, Mitochondrial fatty acid beta-oxidation ; Inhibition, PPAR alpha ; Increased, Liver Steatosis ; Activation, NRF2 ; Activation, SHP ; Increased, Reactive oxygen species ; Increase, insulin ; Activation, insulin receptor ; Activation, mTORC2 ; Activation, AKT ; Activation, mTORC1 ; Activation, SREBP-1 ; Activation, L-FABP ; Increase, cytosolic fatty acid ; Increased, lipogenesis ; Activation, FXR ; Activation, HSD17B4 ; Inhibition, LXR ; Inhibition, LRH-1 ; Activation, aPKC ; Activation, PI3K ; Inhibition, Steatosis ; Increase, Fatty acid beta-oxidation ; Decrease, cytosolic fatty acid ; Activation, LRH-1 ; Inhibition, Fatty Acid Beta Oxidation ; N/A, Steatohepatisis ; Increased, Oncotic Necrosis ; Increased, Liver Steatosis ; Increased, Reactive oxygen species ; Inhibition, Fatty Acid Beta Oxidation ; Increase, cytosolic fatty acid ; Increased, Oncotic Necrosis ; N/A, Steatohepatisis
- 4/12/2017 5:28:27 PM
- 6/15/2020 7:55:44 PM
Source: https://aopwiki.org/
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Inhibition of histone deacetylases class I
Inhibition of histone deacetylases (HDACs) class I ; De-repression of the Wnt/beta-catenin signalling pathway ; Accumulation of beta-catenin ; Activation of Wnt target genes ; Valproic acid exposure developmental outcome ; Inhibition of histone deacetylases (HDACs) class I ; De-repression of the Wnt/beta-catenin signalling pathway ; Accumulation of beta-catenin ; Activation of Wnt target genes ; Valproic acid exposure developmental outcome
- 4/11/2010 10:00:00 AM
Source: https://www.effectopedia.org/
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Inhibition of histone deacetylases class I
Inhibition of histone deacetylases (HDACs) class I ; De-repression of the Wnt/beta-catenin signalling pathway ; Accumulation of beta-catenin ; Activation of Wnt target genes ; Valproic acid exposure developmental outcome
- 4/11/2010 10:00:00 AM
Source: http://www.effectopedia.org/
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Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
Production, Critical Metabolites (CGA 330050 and CGA 265307) ; Induction, Liver “Dysfunctional” Changes by CGA 330050 ; Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307 ; Induction, Sustained Hepatotoxicity ; Induction, Sustained Cell Proliferation ; Formation, Liver tumor ; Production, Critical Metabolites (CGA 330050 and CGA 265307) ; Induction, Liver “Dysfunctional” Changes by CGA 330050 ; Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307 ; Induction, Sustained Hepatotoxicity ; Induction, Sustained Cell Proliferation ; Formation, Liver tumor
- 11/29/2016 11:41:16 PM
- 6/15/2020 8:38:44 PM
Source: https://aopwiki.org/
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Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)
Decreased, Uptake of inorganic iodide ; Increase, Hypertrophy and proliferation (follicular cell) ; Increase, Hyperplasia (follicular cells) ; Increase, Thyroid-stimulating hormone (TSH) ; Decrease, Serum thyroid hormone (T4/T3) ; Increase, Adenomas/carcinomas (follicular cell) ; Decreased, Uptake of inorganic iodide ; Increase, Hypertrophy and proliferation (follicular cell) ; Increase, Hyperplasia (follicular cells) ; Increase, Thyroid-stimulating hormone (TSH) ; Decrease, Serum thyroid hormone (T4/T3) ; Increase, Adenomas/carcinomas (follicular cell)
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:39:24 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
Inhibition of JAK3 ; Blockade of STAT5 phosphorylation ; Suppression of STAT5 binding to cytokine gene promoters ; Suppression of IL-2 production ; Impairment of T-cell dependent antibody response ; Inhibition of JAK3 ; Blockade of STAT5 phosphorylation ; Suppression of STAT5 binding to cytokine gene promoters ; Suppression of IL-4 production ; Impairment of T-cell dependent antibody response
- 1/5/2020 10:55:25 PM
- 9/24/2020 3:08:43 PM
Source: https://aopwiki.org/
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Inhibition of JAK3 leading to impairment of TDAR
- 9/14/2019 12:03:50 AM
Source: https://aopwiki.org/
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Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
Decreased, survival ; Reduced, Swimming performance ; Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts ; Inhibition of lysyl oxidase ; Reduction of collagen crosslinking ; Weak collagen matrix ; Notochord distortion or malformations ; Growth, reduction ; Decreased, survival ; Reduced, Swimming performance ; Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts ; Inhibition of lysyl oxidase ; Reduction of collagen crosslinking ; Weak collagen matrix ; Notochord distortion or malformations ; Growth, reduction
- 8/3/2017 1:52:03 PM
- 3/5/2020 8:45:41 AM
Source: https://aopwiki.org/
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Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
Increase, Cytotoxicity (renal tubular cell) ; Occurrence, Kidney toxicity ; Inhibition of mitochondrial DNA polymerase gamma (Pol gamma) ; Depletion, mtDNA ; Dysfunction, Mitochondria ; Increase, Cytotoxicity (renal tubular cell) ; Occurrence, Kidney toxicity ; Inhibition of mitochondrial DNA polymerase gamma (Pol gamma) ; Depletion, mtDNA ; Dysfunction, Mitochondria
- 10/25/2017 11:15:19 AM
- 10/12/2020 4:39:19 PM
Source: https://aopwiki.org/
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Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
Thyroxine (T4) in neuronal tissue, Decreased ; Thyroxine (T4) in serum, Decreased ; Reduced levels of BDNF ; Impairment, Learning and memory ; Decrease of synaptogenesis ; Decrease of neuronal network function ; Thyroid hormone synthesis, Decreased ; Inhibition, Na+/I- symporter (NIS) ; Decrease of Thyroidal iodide ; Decrease of GABAergic interneurons ; Thyroxine (T4) in serum, Decreased ; Thyroxine (T4) in neuronal tissue, Decreased ; Reduced levels of BDNF ; Impairment, Learning and memory ; Decrease of synaptogenesis ; Decrease of neuronal network function ; Thyroid hormone synthesis, Decreased ; Inhibition, Na+/I- symporter (NIS) ; Decrease of Thyroidal iodide ; Decrease of GABAergic interneurons
- 11/29/2016 11:41:16 PM
- 8/16/2019 1:42:52 PM
- OECD endorsed (WNT and WPHA)
- 1.28
- Review Report
- i-Library
Source: https://aopwiki.org/
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Inhibition of N-linked glycosylation leads to liver injury
Increased, Liver Steatosis ; Apoptosis ; Unfolded Protein Response ; Liver Injury ; Inhibition of N-linked glycosylation ; Accumulation of misfolded proteins ; Activation of hepatic stellate cells ; Increased, Liver Steatosis ; Apoptosis ; Unfolded Protein Response ; Liver Injury ; Inhibition of N-linked glycosylation ; Accumulation of misfolded proteins ; Activation of hepatic stellate cells
- 3/6/2019 12:18:36 PM
- 3/6/2019 12:32:49 PM
Source: https://aopwiki.org/
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Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
Peptide Oxidation ; Increase, Adenomas/carcinomas (hepatocellular) ; Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme ; Increase, Cytotoxicity ; Increased, Induction of pyruvate dehydrogenase (PDH) ; Increase, Oxidative metabolism ; Peptide Oxidation ; Increase, hepatocellular adenomas and carcinomas ; Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme ; Increase, Cytotoxicity ; Increased, Induction of pyruvate dehydrogenase (PDH) ; Increase, Oxidative metabolism
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:38:43 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Inhibition of retinaldehyde dehydrogenase leads to population decline
Decrease, Population trajectory ; Decline, Population ; Retinaldehyde dehydrogenase inhibition ; Decreased optical elements of the eye ; Decreased retinoic acid (RA) synthesis ; Decreased plasma RA level ; Increased visual impairment ; Decrease, Population trajectory ; Retinaldehyde dehydrogenase inhibition ; Decreased optical elements of the eye ; Decreased retinoic acid (RA) synthesis ; Decreased plasma RA level ; Increased visual impairment
- 5/22/2019 8:45:03 AM
- 5/25/2020 2:51:44 PM
Source: https://aopwiki.org/
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Inhibition of the enzyme 5-alpha reductase type 2
Inhibition of the enzyme 5-alpha reductase type 2 ; Decrease in dihydrotestosterone conversion from testosterone ; Decrease in transcription of androgen-dependent genes ; Alteration of proliferation and differentiation of several androgen dependent tissues ; Developmental toxicity by inhibition of the 5-alpha reductase enzyme ; Inhibition of the enzyme 5-alpha reductase type 2 ; Decrease in dihydrotestosterone conversion from testosterone ; Decrease in transcription of androgen-dependent genes ; Alteration of proliferation and differentiation of several androgen dependent tissues ; Developmental toxicity by inhibition of the 5-alpha reductase enzyme
- 4/11/2010 10:00:00 AM
Source: https://www.effectopedia.org/
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Inhibition of the enzyme 5-alpha reductase type 2
Inhibition of the enzyme 5-alpha reductase type 2 ; Decrease in dihydrotestosterone conversion from testosterone ; Decrease in transcription of androgen-dependent genes ; Alteration of proliferation and differentiation of several androgen dependent tissues ; Developmental toxicity by inhibition of the 5-alpha reductase enzyme
- 4/11/2010 10:00:00 AM
Source: http://www.effectopedia.org/
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Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) ; Inhibition, NADH-ubiquinone oxidoreductase (complex I) ; N/A, Mitochondrial dysfunction 1 ; impaired, Proteostasis ; N/A, Neuroinflammation ; Degeneration of dopaminergic neurons of the nigrostriatal pathway ; Parkinsonian motor deficits ; Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) ; Inhibition, NADH-ubiquinone oxidoreductase (complex I) ; N/A, Mitochondrial dysfunction 1 ; Impaired, Proteostasis ; Neuroinflammation ; Degeneration of dopaminergic neurons of the nigrostriatal pathway ; Parkinsonian motor deficits
- 11/29/2016 11:41:15 PM
- 5/13/2019 2:45:51 PM
- OECD endorsed (WNT and WPHA)
- 1.33
- Review Report
- i-Library
Source: https://aopwiki.org/
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Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)
Thyroperoxidase, Inhibition ; Increase, Hypertrophy and proliferation (follicular cell) ; Increase, Hyperplasia (follicular cells) ; Increase, Thyroid-stimulating hormone (TSH) ; Decrease, Serum thyroid hormone (T4/T3) ; Increase, Adenomas/carcinomas (follicular cell) ; Decrease, Incorporation of active iodide into iodotyrosines ; Thyroperoxidase, Inhibition ; Increase, Hypertrophy and proliferation (follicular cell) ; Increase, Hyperplasia (follicular cells) ; Increase, Thyroid-stimulating hormone (TSH) ; Decrease, Serum thyroid hormone (T4/T3) ; Increase, Adenomas/carcinomas (follicular cell) ; Decrease, Incorporation of active iodide into iodotyrosines
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:42:02 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Inhibition of thyroid peroxidase leading to impaired fertility in fish
Reduction, Plasma 17beta-estradiol concentrations ; Reduction, Cumulative fecundity and spawning ; Reduction, Plasma vitellogenin concentrations ; Thyroperoxidase, Inhibition ; Thyroid hormone synthesis, Decreased ; Reduction, Plasma 17beta-estradiol concentrations ; Reduction, Plasma vitellogenin concentrations ; Reduction, Cumulative fecundity and spawning ; Thyroperoxidase, Inhibition ; Thyroid hormone synthesis, Decreased
- 9/19/2018 12:33:14 AM
- 10/16/2020 1:12:04 AM
Source: https://aopwiki.org/
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Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
Thyroxine (T4) in neuronal tissue, Decreased ; Thyroxine (T4) in serum, Decreased ; Hippocampal anatomy, Altered ; Hippocampal Physiology, Altered ; Hippocampal gene expression, Altered ; Thyroperoxidase, Inhibition ; Thyroid hormone synthesis, Decreased ; Cognitive Function, Decreased ; Thyroxine (T4) in serum, Decreased ; Thyroxine (T4) in neuronal tissue, Decreased ; Hippocampal gene expression, Altered ; Hippocampal anatomy, Altered ; Hippocampal Physiology, Altered ; Thyroperoxidase, Inhibition ; Thyroid hormone synthesis, Decreased ; Cognitive Function, Decreased
- 11/29/2016 11:41:16 PM
- 8/16/2019 2:11:05 PM
- OECD endorsed (WNT and WPHA)
- 1.10
- Review Report
- i-Library
Source: https://aopwiki.org/
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Inhibition of tyrosinase leads to decreased population in fish
Decrease, Population trajectory ; Inhibition of tyrosinase ; Reduction of L-Dopaquinone ; Reduction in melanin level ; Reduction of melanosome level ; Reduction fo Pigmentation pattern ; Decrease, Population trajectory ; Inhibition of tyrosinase ; Reduction of L-Dopaquinone ; Reduction in melanin level ; Reduction of melanosome level ; Reduction fo Pigmentation pattern
- 5/3/2019 12:02:43 PM
- 7/27/2020 4:04:11 PM
Source: https://aopwiki.org/
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Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
Thyroxine (T4) in neuronal tissue, Decreased ; Thyroxine (T4) in serum, Decreased ; Hippocampal anatomy, Altered ; Hippocampal Physiology, Altered ; Hippocampal gene expression, Altered ; Cognitive Function, Decreased ; Binding, Transthyretin in serum ; Displacement, Serum thyroxine (T4) from transthyretin ; Increased, Free serum thyroxine (T4) ; Increased, Uptake of thyroxine into tissue ; Increased, Clearance of thyroxine from tissues ; Thyroxine (T4) in serum, Decreased ; Thyroxine (T4) in neuronal tissue, Decreased ; Hippocampal gene expression, Altered ; Hippocampal anatomy, Altered ; Hippocampal Physiology, Altered ; Cognitive Function, Decreased ; Binding, Transthyretin in serum ; Displacement, Serum thyroxine (T4) from transthyretin ; Increased, Free serum thyroxine (T4) ; Increased, Uptake of thyroxine into tissue ; Increased, Clearance of thyroxine from serum
- 11/29/2016 11:41:17 PM
- 1/26/2021 4:06:30 PM
- AOP under development
- 1.41
Source: https://aopwiki.org/
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Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
Increase, Cytotoxicity ; Decrease, Intracellular pH ; Increase, Tissue Degeneration, Necrosis & Atrophy ; Increase, Cell Proliferation ; Increase, Respiratory or Squamous Metaplasia ; Increase, Mutations in Critical Genes ; Increase, Site of Contact Nasal Tumors ; Increase, Cytotoxicity ; Decrease, Intracellular pH ; Increase, Tissue Degeneration, Necrosis & Atrophy ; Increase, Cell Proliferation ; Increase, Respiratory or Squamous Metaplasia ; Increase, Mutations in Critical Genes ; Increase, Site of Contact Nasal Tumors
- 11/29/2016 11:41:16 PM
- 3/20/2017 10:31:11 AM
- EAGMST under review
- 2.7
Source: https://aopwiki.org/
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Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis
Thyroid hormone synthesis, Decreased ; Decrease of Thyroidal iodide ; Decreased, Thyroxine (T4) in serum ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Inhibition, Iodotyrosine deiodinase (IYD) ; Thyroid hormone synthesis, Decreased ; Decrease of Thyroidal iodide ; Decreased, Thyroxine (T4) in serum ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Inhibition, Iodotyrosine deiodinase (IYD)
- 11/29/2016 11:41:17 PM
- 12/9/2020 5:29:11 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality
Increased Mortality ; Increased, Chloride conductance ; Activation, ionotropic GABA Receptor chloride channel ; Increased, Inhibitory postsynaptic potential ; Induction, Somatic muscle paralysis ; Increased, Neuronal synaptic inhibition ; Inhibition, Feeding ; Increased Mortality ; Increased, Chloride conductance ; Activation, ionotropic GABA Receptor chloride channel ; Increased, Inhibitory postsynaptic potential ; Induction, Somatic muscle paralysis ; Increased, Neuronal synaptic inhibition ; Inhibition, Feeding
- 11/29/2016 11:41:17 PM
- 12/3/2016 9:37:47 PM
Source: https://aopwiki.org/
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Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure
Reproductive failure ; Activation, JAK/STAT pathway ; Activation, TGF-beta pathway ; Reproductive failure ; Activation, JAK/STAT pathway ; Activation, TGF-beta pathway
- 2/15/2017 8:44:35 AM
- 7/3/2018 2:12:22 AM
Source: https://aopwiki.org/
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Juvenile hormone receptor agonism leading to male offspring induction associated population decline
Decline, Population ; Activation, Juvenile hormone receptor ; Induction, Doublesex1 gene ; Induction, Male reproductive tract ; Increased, Male offspring ; Alteration, Food-web structures ; Decline, Population ; Activation, Juvenile hormone receptor ; Induction, Doublesex1 gene ; Induction, Male reproductive tract ; Increased, Male offspring ; Alteration, Food-web structures
- 11/29/2016 11:41:17 PM
- 11/29/2016 11:55:10 PM
Source: https://aopwiki.org/
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Kidney dysfunction by decreased thyroid hormone
Thyroid hormone synthesis, Decreased ; Decreased, Thyroxine (T4) in serum ; Decreased, Glomerular filtration ; Decreased, Renal plasma flow ; Decreased, Sodium reabsorption ; Increased, Serum creatinine ; Occurrence, Cystic dilatation (renal tubule) ; Occurrence, Cytoplasmic vacuolization (podocyte) ; Occurrence, Cytoplasmic vacuolization (Renal tubule) ; Decreased, Renal ability to dilute urine ; Occurrence, Kidney toxicity ; Thyroid hormone synthesis, Decreased ; Decreased, Thyroxine (T4) in serum ; Decreased, Glomerular filtration ; Decreased, Renal plasma flow ; Decreased, Sodium reabsorption ; Increased, Serum creatinine ; Occurrence, Cystic dilatation (renal tubule) ; Occurrence, Cytoplasmic vacuolization (podocyte) ; Occurrence, Cytoplasmic vacuolization (Renal tubule) ; Decreased, Renal ability to dilute urine ; Occurrence, Kidney toxicity
- 11/29/2016 11:41:16 PM
- 6/23/2020 2:12:44 AM
- AOP under development
- 1.40
Source: https://aopwiki.org/
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Kidney toxicity induced by activation of 5HT2C
Activation, 5HT2c ; N/A, Unknown ; Increased, Kidney Failure ; Activation, 5HT2c ; N/A, Unknown ; Increased, Kidney Failure
- 11/29/2016 11:41:16 PM
- 8/19/2019 2:31:42 PM
Source: https://aopwiki.org/
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Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis
Increase, Reactive oxygen species production ; Accumulation, Collagen ; Increased, secretion of local growth factors ; Expression of Collagen ; Collagen Deposition ; Induction, Cell damage sensing ; Incudtion, Sustained inflammatory cytokine release ; Increase, Differentiation of fibroblasts ; Induction, Epithelial Mesenchymal Transition ; Pulmonary fibrosis ; Activation, Latent Transforming Growth Factor Beta 1 ; Activation, Transforming Growth Factor beta pathway ; Accumulation, Collagen ; Pulmonary fibrosis ; Induction, Epithelial Mesenchymal Transition ; Activation, Latent Transforming Growth Factor Beta 1 ; Increase, Differentiation of fibroblasts ; Activation, Transforming Growth Factor beta pathway
- 7/26/2017 10:54:43 PM
- 8/16/2017 11:53:39 AM
Source: https://aopwiki.org/
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L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
Blockade, L-Type Calcium Channels ; Decrease, Calcium currents ; Decrease, Calcium binding to Troponin C ; Decrease, Cardiac contractility ; Decrease, Cardiac ejection fraction ; Decrease, Blood pressure ; Heart failure ; Disruption, Intracellular calcium mobilization ; Disruption, Sarcomere assembly ; Blockade, L-Type Calcium Channels ; Decrease, Calcium currents ; Decrease, Calcium binding to Troponin C ; Decrease, Cardiac contractility ; Decrease, Cardiac ejection fraction ; Disruption, Intracellular calcium mobilization ; Disruption, Sarcomere assembly ; Heart failure
- 5/10/2018 12:37:07 PM
- 10/12/2020 4:28:56 PM
Source: https://aopwiki.org/
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L-type calcium channel blockade leading to hypotension
- 2/11/2019 1:12:06 PM
- 10/12/2020 4:55:02 PM
Source: https://aopwiki.org/
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L-type calcium channel blockade leading to the disruption of cardiac electrophysiology
- 5/10/2018 12:46:24 PM
- 10/12/2020 4:29:52 PM
Source: https://aopwiki.org/
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Lung surfactant function inhibition leading to immediate adverse lung effects
Substance - lung surfactant interaction ; Disruption of lung surfactant function ; Alveolar collapse ; Alveolar reopening ; Loss of barrier function ; Blood extravasation into the lungs ; Reduced lung volume ; Impaired oxygenation of the blood ; Acute inhalation toxicity ; Loss of alveolar capillary membrane integrity ; Substance - lung surfactant interaction ; Inhibition of lung surfactant function ; Alveolar collapse ; Alveolar reopening ; Loss of barrier function ; Blood extravasation into the lungs ; Reduced lung volume ; Impaired oxygenation of the blood ; Acute inhalation toxicity ; Immediate adverse lung effects
- 6/19/2019 10:49:33 AM
- 1/8/2021 12:11:31 PM
Source: https://aopwiki.org/
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Luteinizing hormone receptor antagonism leading to reproductive dysfunction
Decline, Population trajectory ; Antagonism,LH receptor ; Reduction, Progesterone synthesis ; Reduction, Plasma progesterone concentration ; Reduction, progesterone uptake, decresed maturation ; Impaired ovulation ; Decrease of egg production and cummulative fecundity ; Antagonism,LH receptor ; Reduction, Progesterone synthesis ; Reduction, Plasma progesterone concentration ; Reduction, progesterone uptake, decresed maturation ; Impaired ovulation ; Decrease of egg production and cummulative fecundity ; Decline, Population trajectory
- 10/3/2019 2:43:37 PM
- 11/29/2019 4:43:20 PM
Source: https://aopwiki.org/
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LXR activation leading to hepatic steatosis
Activation, LXR ; peroxisome proliferator activated receptor promoter demethylation ; Up Regulation, CD36 ; Increase, FA Influx ; Activation, ChREBP ; Activation, SREBP-1c ; Activation, FAS ; Activation, SCD-1 ; Synthesis, De Novo FA ; Accumulation, Triglyceride ; Damaging, Mitochondria ; N/A, Liver Steatosis ; Activation, LXR ; peroxisome proliferator activated receptor promoter demethylation ; Up Regulation, CD36 ; Increase, FA Influx ; Activation, ChREBP ; Activation, SREBP-1c ; Activation, FAS ; Activation, SCD-1 ; Synthesis, De Novo FA ; Accumulation, Triglyceride ; Damaging, Mitochondria ; N/A, Liver Steatosis
- 11/29/2016 11:41:16 PM
- 6/15/2020 8:18:45 PM
Source: https://aopwiki.org/
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Mental stress to agitation
Activation, Glucocorticoid Receptor ; Decreased, serotonin transporter activity ; Increased, extracellular serotonin ; Decreased, intracellular serotonin ; Decreased, packaged serotonin ; Decreased, synaptic release ; Inactivated, 5-HTR (serotonin receptors) ; Reduce expression, BDNF (Brain-derived neurotrophic factor) ; Decreased, neuroplasticity ; Increase, cortisone ; Reduced, BDNF (Brain-derived neurotrophic factor) ; Increased, agitation ; Decreased, extracellular serotonin ; Increased, glucocorticoid receptor activity ; Decreased, serotonin transporter activity ; Increased, extracellular serotonin ; Decreased, extracellular serotonin ; Decreased, intracellular serotonin ; Decreased, packaged serotonin ; Decreased, synaptic release ; Inactivated, 5-HTR (serotonin receptors) ; Reduce expression, BDNF (Brain-derived neurotrophic factor) ; Decreased, neuroplasticity ; Reduced, BDNF (Brain-derived neurotrophic factor) ; Increased, agitation ; Increased, glucocorticoid receptor activity
- 5/30/2017 7:12:23 PM
- 6/15/2020 8:12:27 PM
- AOP under development
Source: https://aopwiki.org/
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Microtubule interacting drugs lead to peripheral neuropathy
Binding of microtubule stabilizing agents (MSA) to microtubules ; Disturbance in microtubule dynamic instability ; Impaired axonial transport ; Sensory axonal peripheral neuropathy ; Binding of microtubule stabilizing agents (MSA) to microtubules ; Disturbance in microtubule dynamic instability ; Impaired axonial transport ; Sensory axonal peripheral neuropathy
- 1/29/2019 1:39:38 PM
- 1/29/2019 1:51:08 PM
Source: https://aopwiki.org/
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Mitochondrial ATP synthase antagonism leading to growth inhibition (1)
Decrease, Population trajectory ; Decrease, Fecundity ; Increase, DNA methyltransferase inhibition ; Increase, DNA hypomethylation ; Increase, Gene expression ; Decrease, Population trajectory ; Decrease, Fecundity ; Increase, Mitochondrial ATP synthase antagonism ; Decrease, Adenosine triphosphate pool ; Decrease, Growth ; Increase, DNA methyltransferase inhibition ; Increase, DNA hypomethylation ; Increase, Gene expression ; Decrease, Cell proliferation
- 4/22/2019 8:44:30 AM
- 12/4/2020 10:14:40 PM
Source: https://aopwiki.org/
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Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
Decrease, Population trajectory ; Decrease, Fecundity ; Increase, DNA methyltransferase inhibition ; Increase, DNA hypomethylation ; Increase, Gene expression ; Decrease, Transgenerational DNA methylation ; Decrease, Population trajectory ; Decrease, Fecundity ; Increase, Mitochondrial ATP synthase antagonism ; Decrease, Adenosine triphosphate pool ; Decrease, Growth ; Increase, DNA methyltransferase inhibition ; Increase, DNA hypomethylation ; Increase, Gene expression ; Decrease, Transgenerational DNA methylation ; Increase, Cell death
- 4/22/2019 8:45:23 AM
- 12/4/2020 10:17:23 PM
Source: https://aopwiki.org/
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Mitochondrial complex III antagonism leading to growth inhibition (1)
Increase, Mortality ; Decrease, Mitochondrial ATP production ; Decrease, Oxidative phosphorylation ; Mitochondrial Complex III inhibition ; Increase, Necrosis ; Increase, Mortality ; Decrease, Mitochondrial ATP production ; Decrease, Oxidative phosphorylation ; Decrease, Adenosine triphosphate pool ; Increase, Necrosis ; Decrease, Growth ; Increase, Mitochondrial complex III antagonism ; Decrease, Cell proliferation
- 3/19/2019 12:35:17 PM
- 12/4/2020 10:27:14 PM
Source: https://aopwiki.org/
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Mitochondrial complex III antagonism leading to growth inhibition (2)
Increase, Mortality ; Increase, Reactive oxygen species ; Increase, Apoptosis ; Mitochondrial Complex III inhibition ; Increase, Oxidative DNA damage ; Increase, Mortality ; Increase, Apoptosis ; Decrease, Adenosine triphosphate pool ; Decrease, Growth ; Increase, Reactive oxygen species ; Increase, Mitochondrial complex III antagonism ; Increase, Oxidative DNA damage ; Increase, Cell death
- 3/19/2019 12:35:59 PM
- 12/4/2020 10:28:42 PM
Source: https://aopwiki.org/
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Mitochondrial complex inhibition leading to liver injury
Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) ; Inhibition, NADH-ubiquinone oxidoreductase (complex I) ; N/A, Mitochondrial dysfunction 1 ; impaired, Proteostasis ; N/A, Cell injury/death ; Mitochondrial Complex I inhibition ; Mitochondrial Complex III inhibition ; Mitochondrial Complex IV inhibition ; Mitochondrial Complex V inhibition ; Decrease in mitochondrial oxidative phosphorylation ; Increased reactive oxygen species (in the mitochondria) ; Mitochondrial Injury ; Necrotic Tissue ; Liver Injury ; Binding of inhibitor to mitochondrial complex III ; Binding of inhibitor to mitochondrial complex IV ; Binding of inhibitor to mitochondrial complex V ; Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) ; Inhibition, NADH-ubiquinone oxidoreductase (complex I) ; N/A, Mitochondrial dysfunction 1 ; Impaired, Proteostasis ; Cell injury/death ; Increase, Mitochondrial complex III antagonism ; Mitochondrial Complex IV inhibition ; Mitochondrial Complex V inhibition ; Binding of inhibitor to mitochondrial complex III ; Binding of inhibitor to mitochondrial complex IV ; Binding of inhibitor to mitochondrial complex V ; Decrease in mitochondrial oxidative phosphorylation ; Increased reactive oxygen species (in the mitochondria) ; Mitochondrial Injury ; Necrotic Tissue ; Liver Injury
- 12/19/2018 2:14:24 PM
- 6/15/2019 3:09:24 PM
Source: https://aopwiki.org/
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Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis
Decreased testosterone by the fetal Leydig cells, Increased corticosterone ; Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists ; Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells ; Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells ; Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells ; Decreased sperm quantity / quality in the adult, Decreased fertility ; Decreased testosterone by the fetal Leydig cells, Increased corticosterone ; Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists ; Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells ; Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells ; Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells ; Decreased sperm quantity / quality in the adult, Decreased fertility
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:30:15 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome
Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells ; Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells ; Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells ; Decreased sperm quantity / quality in the adult, Decreased fertility ; Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome ; Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells ; Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells ; Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells ; Decreased sperm quantity / quality in the adult, Decreased fertility ; Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:31:19 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell
Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol ; Decreased Cholesterol, Decreased Uptake of Lipoproteins ; Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane ; Decreased Cholesterol, Decreased Testosterone Production by Adult Leydig Cells ; Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis ; Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol ; Decreased Cholesterol, Decreased Uptake of Lipoproteins ; Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane ; Decreased Cholesterol, Decreased Testosterone Production by Adult Leydig Cells ; Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:31:39 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis
Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells ; Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells ; Decreased sperm quantity / quality in the adult, Decreased fertility ; Decreased testosterone by the fetal Leydig cells, Increased estradiol ; Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists ; decreased testosterone by fetal Leydig cells, Dysgenesis of fetal Leydig cells ; Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells ; Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells ; Decreased sperm quantity / quality in the adult, Decreased fertility ; Decreased testosterone by the fetal Leydig cells, Increased estradiol ; Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists ; decreased testosterone by fetal Leydig cells, Dysgenesis of fetal Leydig cells
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:31:02 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation
Decreased sperm quantity or quality in the adult, Decreased fertility ; Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid ; Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells ; Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells ; Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells ; Decreased sperm quantity or quality in the adult, Decreased fertility ; Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid ; Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells ; Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells ; Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:32:17 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells ; Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis ; Decreased testosterone by the fetal Leydig cells, Dysgensis of fetal Leydig cells ; Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells ; Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis ; Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells ; Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis ; Decreased testosterone by the fetal Leydig cells, Dysgensis of fetal Leydig cells ; Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells ; Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:33:15 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell
Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell ; Decreased steroidogenesis, Decreased Activity of Steroidogenic Enzymes in Adult Leydig cells ; Decreased steroidogenesis, Increased Apoptosis of Adult Leydig Cells ; Decreased steroidogenesis, Alterations in the Leydig Cell Cytoskeleton ; Decreased sperm quantity or quality in the adult, Decreased fertility ; Decreased sperm quantity or quality in the adult, Decreased fertility ; Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell ; Decreased steroidogenesis, Decreased Activity of Steroidogenic Enzymes in Adult Leydig cells ; Decreased steroidogenesis, Increased Apoptosis of Adult Leydig Cells ; Decreased steroidogenesis, Alterations in the Leydig Cell Cytoskeleton
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:31:58 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Molecular events lead to epilepsy
Increased, intracellular sodium (Na+) ; Increased, intracellular chloride (Cl-) ; Activated, presynaptic neuron 1 ; Increased, glutamate ; Activated, NMDA receptor ; Activated, voltage-gated sodium channel ; Inhibit, voltage-gated sodium channel ; Treat, carbamazepine ; Activated, membrane depolarization ; Inactive, membrane depolarization ; Increased, RDX dose ; Repress, GABA-A receptor ; Activate, GABA-A receptor ; Activate, presynaptic neuron 2 ; Increase, GABA ; Increase, seizure ; Increased, hippocampal hyperdepolarization ; Increased, epilepsy ; Increased, intracellular sodium (Na+) ; Increased, intracellular chloride (Cl-) ; Activated, presynaptic neuron 1 ; Increased, glutamate ; Activated, NMDA receptor ; Activated, voltage-gated sodium channel ; Inhibit, voltage-gated sodium channel ; Treat, carbamazepine ; Activated, membrane depolarization ; Inactive, membrane depolarization ; Increased, RDX dose ; Repress, GABA-A receptor ; Activate, GABA-A receptor ; Activate, presynaptic neuron 2 ; Increase, GABA ; Increase, seizure ; Increased, hippocampal hyperdepolarization ; Increased, epilepsy
- 4/14/2017 6:58:30 PM
- 6/15/2020 8:01:31 PM
Source: https://aopwiki.org/
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Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition
Mu Opioid Receptor Agonism ; Release of G Proteins ; Analgesia ; Inhibition of N-type Ca ion channels ; Inhibition of neurotransmitter vesicle release ; Mu Opioid Receptor Agonism ; Release of G Proteins ; Analgesia ; Inhibition of N-type Ca ion channels ; Inhibition of neurotransmitter vesicle release
- 6/23/2017 10:33:09 AM
- 6/15/2020 8:29:28 PM
- AOP under development
Source: https://aopwiki.org/
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Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening
hyperpolarisation, neuron ; Mu Opioid Receptor Agonism ; Release of G Proteins ; Opening of G protein gated inward rectifying K channels ; Analgesia ; hyperpolarisation, neuron ; Mu Opioid Receptor Agonism ; Release of G Proteins ; Opening of G protein gated inward rectifying K channels ; Analgesia
- 6/8/2017 3:54:18 PM
- 6/15/2020 8:29:15 PM
- AOP under development
Source: https://aopwiki.org/
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NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
Damaging, Mitochondria ; Apoptosis ; Activation, NADPH Oxidase ; ROS formation ; Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK ; Activation, HIF-1 ; Increased, DNA Damage-Repair ; Reproductive failure ; Damaging, Mitochondria ; Apoptosis ; Activation, NADPH Oxidase ; ROS formation ; Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK ; Activation, HIF-1 ; Increased, DNA Damage-Repair ; Reproductive failure
- 2/15/2017 8:09:24 AM
- 7/3/2018 3:04:58 AM
Source: https://aopwiki.org/
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Narcosis leading to respiratory failure
Accumulation, Biological membranes ; Disruption, Membrane integrity ; Accumulation, Biological membranes ; Disruption, Membrane integrity
- 11/29/2016 11:41:16 PM
- 2/19/2019 10:02:59 PM
- AOP under development
- 1.2
Source: https://aopwiki.org/
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Network of SSRIs (selective serotonin reuptake inhibitors)
Activation, Glucocorticoid Receptor ; Inhibit, serotonin transporter activity ; Decreased, serotonin transporter activity ; Decreased, extracellular sodium (Na+) ; Decreased, extracellular chloride (Cl-) ; Increased, extracellular serotonin ; Increased, intracellular sodium (Na+) ; Increased, intracellular chloride (Cl-) ; Decreased, intracellular serotonin ; Decreased, packaged serotonin ; Decreased, synaptic release ; Increased, 5-HT3 (5-hydroxytryptamine) ; Inactivated, 5-HTR (serotonin receptors) ; Reduce expression, BDNF (Brain-derived neurotrophic factor) ; Decreased, neuroplasticity ; Increase, cortisone ; Reduced, BDNF (Brain-derived neurotrophic factor) ; Activation, 5-HT2A (Serotonin 2A) ; Activate, PLC (Phospholipase C) ; Increase, inositol triphosphate ; Increase, intracellular calcium ; Activate, calmodulin ; Increase, myosin light chain phosphorylation ; Increase, vascular smooth muscle contraction ; Increased, seizure ; Increased, agitation ; Increased, depression ; Increase, hypertension ; Decreased, extracellular serotonin ; Activation, Glucocorticoid Receptor ; Inhibit, serotonin transporter activity ; Decreased, serotonin transporter activity ; Decreased, extracellular sodium (Na+) ; Decreased, extracellular chloride (Cl-) ; Increased, extracellular serotonin ; Decreased, extracellular serotonin ; Increased, intracellular sodium (Na+) ; Increased, intracellular chloride (Cl-) ; Decreased, intracellular serotonin ; Decreased, packaged serotonin ; Decreased, synaptic release ; Increased, 5-HT3 (5-hydroxytryptamine) ; Inactivated, 5-HTR (serotonin receptors) ; Reduce expression, BDNF (Brain-derived neurotrophic factor) ; Decreased, neuroplasticity ; Increase, cortisone ; Reduced, BDNF (Brain-derived neurotrophic factor) ; Activation, 5-HT2A (Serotonin 2A) ; Activate, PLC (Phospholipase C) ; Increase, inositol triphosphate ; Increase, intracellular calcium ; Activate, calmodulin ; Increase, myosin light chain phosphorylation ; Increase, vascular smooth muscle contraction ; Increased, seizure ; Increased, agitation ; Increased, depression ; Increase, hypertension
- 4/13/2017 6:11:48 PM
- 6/15/2020 7:56:04 PM
Source: https://aopwiki.org/
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NFE2/Nrf2 repression to steatosis
NFE2/Nrf2 repression ; Reduced, FXR activity ; Reduced, SHP activity ; Activated, LXR ; Reduced, PPARalpha ; Reduced, HSD17B4 activity ; Reduced, fatty acid beta oxidation ; Increased, steatosis ; NFE2/Nrf2 repression ; Reduced, FXR activity ; Reduced, SHP activity ; Activated, LXR ; Reduced, PPARalpha ; Reduced, HSD17B4 activity ; Reduced, fatty acid beta oxidation ; Increased, steatosis
- 6/2/2017 8:26:43 PM
- 6/15/2020 8:18:14 PM
- AOP under development
Source: https://aopwiki.org/
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NFE2L2/FXR activation leading to hepatic steatosis
Activation, PPARα ; Inhibition, Mitochondrial fatty acid beta-oxidation ; Increased, De Novo FA synthesis ; Increased, Liver Steatosis ; Activation, NRF2 ; Activation, NR1H4 ; Activation, SHP ; Decreased, DHB4/HSD17B4 ; Activation, LXR alpha ; Inhibition, SREBP1c ; Activation, MTTP ; Increased, ApoB100 ; Increased, Triglyceride ; FA synthesis ; Activation, PPARα ; Increased, Liver Steatosis ; Inhibition, Mitochondrial fatty acid beta-oxidation ; Increased, De Novo FA synthesis ; Activation, NRF2 ; Activation, NR1H4 ; Activation, SHP ; Decreased, DHB4/HSD17B4 ; Activation, LXR alpha ; Inhibition, SREBP1c ; Activation, MTTP ; Increased, ApoB100 ; Increased, Triglyceride
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:17:56 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1
N/A, Mitochondrial dysfunction 1 ; Impairment, Learning and memory ; Activation, Nicotinic acetylcholine receptor ; Abnormal, Foraging activity and behavior ; Weakened, Colony ; Altered, Ca2+-calmodulin activated signal transduction ; Death/Failure, Colony ; N/A, Mitochondrial dysfunction 1 ; Impairment, Learning and memory ; Activation, Nicotinic acetylcholine receptor ; Abnormal, Foraging activity and behavior ; Weakened, Colony ; Altered, Ca2+-calmodulin activated signal transduction ; Death/Failure, Colony
- 11/29/2016 11:41:16 PM
- 4/4/2019 6:55:06 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
N/A, Mitochondrial dysfunction 1 ; Impairment, Learning and memory ; Activation, Nicotinic acetylcholine receptor ; Abnormal, Foraging activity and behavior ; Weakened, Colony ; Altered, Ca2+-calmodulin activated signal transduction ; Death/Failure, Colony ; Abnormal, Role change within caste ; N/A, Mitochondrial dysfunction 1 ; Impairment, Learning and memory ; Activation, Nicotinic acetylcholine receptor ; Abnormal, Foraging activity and behavior ; Weakened, Colony ; Altered, Ca2+-calmodulin activated signal transduction ; Death/Failure, Colony ; Abnormal, Role change within caste
- 11/29/2016 11:41:16 PM
- 4/8/2019 4:39:02 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste
Impairment, Learning and memory ; Activation, Nicotinic acetylcholine receptor ; Abnormal, Foraging activity and behavior ; Weakened, Colony ; Altered, Ca2+-calmodulin activated signal transduction ; Death/Failure, Colony ; Desensitization, Nicotinic acetylcholine receptor ; Impairment, Learning and memory ; Activation, Nicotinic acetylcholine receptor ; Abnormal, Foraging activity and behavior ; Weakened, Colony ; Altered, Ca2+-calmodulin activated signal transduction ; Death/Failure, Colony ; Desensitization, Nicotinic acetylcholine receptor
- 11/29/2016 11:41:16 PM
- 4/8/2019 4:36:46 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
N/A, Mitochondrial dysfunction 1 ; Impairment, Learning and memory ; Decrease of neuronal network function ; Activation, Nicotinic acetylcholine receptor ; Death/Failure, Colony ; Abnormal, Roll change within caste ; Reduced, Brood care ; impaired, Larval development ; N/A, Mitochondrial dysfunction 1 ; Impairment, Learning and memory ; Decrease of neuronal network function ; Activation, Nicotinic acetylcholine receptor ; Death/Failure, Colony ; Abnormal, Roll change within caste ; Reduced, Brood care ; impaired, Larval development
- 11/29/2016 11:41:16 PM
- 4/8/2019 4:33:10 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
Impairment, Learning and memory ; Decrease of neuronal network function ; Activation, Nicotinic acetylcholine receptor ; Death/Failure, Colony ; Abnormal, Roll change within caste ; Reduced, Brood care ; impaired, Larval development ; Desensitization, Nicotinic acetylcholine receptor ; Impairment, Learning and memory ; Decrease of neuronal network function ; Activation, Nicotinic acetylcholine receptor ; Death/Failure, Colony ; Abnormal, Roll change within caste ; Reduced, Brood care ; impaired, Larval development ; Desensitization, Nicotinic acetylcholine receptor
- 11/29/2016 11:41:16 PM
- 4/4/2019 6:54:17 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
N/A, Mitochondrial dysfunction 1 ; Activation, Nicotinic acetylcholine receptor ; Death/Failure, Colony ; impaired, Hive thermoregulation ; Accumulation, Damaged mitochondrial DNA ; Accelerated, Aging ; Overwhelmed, Mitochondrial DNA repair mechanisms ; Decrease, Number of worker bees ; N/A, Mitochondrial dysfunction 1 ; Activation, Nicotinic acetylcholine receptor ; Death/Failure, Colony ; impaired, Hive thermoregulation ; Accumulation, Damaged mitochondrial DNA ; Accelerated, Aging ; Overwhelmed, Mitochondrial DNA repair mechanisms ; Decrease, Number of worker bees
- 11/29/2016 11:41:16 PM
- 4/8/2019 4:33:41 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure
N/A, Mitochondrial dysfunction 1 ; Activation, Nicotinic acetylcholine receptor ; Weakened, Colony ; Death/Failure, Colony ; impaired, Hive thermoregulation ; N/A, Mitochondrial dysfunction 1 ; Activation, Nicotinic acetylcholine receptor ; Weakened, Colony ; Death/Failure, Colony ; impaired, Hive thermoregulation
- 11/29/2016 11:41:16 PM
- 4/8/2019 4:35:19 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure
N/A, Mitochondrial dysfunction 1 ; Activation, Nicotinic acetylcholine receptor ; Weakened, Colony ; Death/Failure, Colony ; N/A, Mitochondrial dysfunction 1 ; Activation, Nicotinic acetylcholine receptor ; Weakened, Colony ; Death/Failure, Colony
- 11/29/2016 11:41:17 PM
- 2/7/2020 7:50:44 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure
Impairment, Learning and memory ; Activation, Nicotinic acetylcholine receptor ; Abnormal, Foraging activity and behavior ; Weakened, Colony ; Altered, Ca2+-calmodulin activated signal transduction ; Death/Failure, Colony ; Abnormal, Role change within caste ; Desensitization, Nicotinic acetylcholine receptor ; Impairment, Learning and memory ; Activation, Nicotinic acetylcholine receptor ; Abnormal, Foraging activity and behavior ; Weakened, Colony ; Altered, Ca2+-calmodulin activated signal transduction ; Death/Failure, Colony ; Abnormal, Role change within caste ; Desensitization, Nicotinic acetylcholine receptor
- 11/29/2016 11:41:16 PM
- 4/8/2019 4:36:06 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
Nosema infection causes abnormal role change that leads to colony loss/failure
Weakened, Colony ; Death/Failure, Colony ; Abnormal, Role change within caste ; Weakened, Colony ; Death/Failure, Colony ; Abnormal, Role change within caste
- 11/29/2016 11:41:17 PM
- 2/7/2020 7:53:41 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Nosema infection increases energetic demands leading to colony loss/failure
Abnormal, Foraging activity and behavior ; Weakened, Colony ; Death/Failure, Colony ; Increased, Energetic demands and therefore metabolic stress ; Abnormal, Foraging activity and behavior ; Weakened, Colony ; Death/Failure, Colony ; Increased, Energetic demands and therefore metabolic stress
- 11/29/2016 11:41:17 PM
- 2/7/2020 7:53:26 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
Activation, PXR/SXR ; Up Regulation, CD36 ; Accumulation, Fatty acid ; Decreased, Mitochondrial fatty acid beta-oxidation ; Increased, FA Influx ; Increased, Triglyceride formation ; Up Regulation, SCD-1 ; Increased, Liver Steatosis ; Inhibition, FoxA2 ; Down Regulation, CPT1A ; Down Regulation, HMGCS2 ; Increased, Hepatic Triglycerides ; Accumulation, Hepatic FA ; Decreased, Ketogenesis ; Activation, PXR/SXR ; Up Regulation, CD36 ; Accumulation, Fatty acid ; Decreased, Mitochondrial fatty acid beta-oxidation ; Increased, Liver Steatosis ; Increased, FA Influx ; Up Regulation, SCD-1 ; Increased, Triglyceride formation ; Inhibition, FoxA2 ; Down Regulation, CPT1A ; Down Regulation, HMGCS2 ; Decreased, Ketogenesis
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:17:28 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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NR1I3 (CAR) suppression leading to hepatic steatosis
Activation, LXR ; peroxisome proliferator activated receptor promoter demethylation ; Up Regulation, CD36 ; Activation, ChREBP ; Accumulation, Fatty acid ; Inhibition, Mitochondrial fatty acid beta-oxidation ; Increased, FA Influx ; Suppression, Constitutive androstane receptor, NR1l3 ; Inhibition, PPAR alpha ; Activation, SREBF1 ; Increased, De Novo FA synthesis ; Increased, Fatty acid uptake ; Increased, Triglyceride formation ; Up Regulation, SCD-1 ; Up Regulation, FAS ; Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1) ; Increased, Liver Steatosis ; Activation, LXR ; peroxisome proliferator activated receptor promoter demethylation ; Up Regulation, CD36 ; Activation, ChREBP ; Accumulation, Fatty acid ; Increased, Liver Steatosis ; Inhibition, Mitochondrial fatty acid beta-oxidation ; Increased, FA Influx ; Up Regulation, SCD-1 ; Suppression, Constitutive androstane receptor, NR1l3 ; Inhibition, PPAR alpha ; Activation, SREBF1 ; Increased, De Novo FA synthesis ; Increased, Triglyceride formation ; Up Regulation, FAS ; Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1)
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:16:10 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
NSAID induced PTGS1 inactivation to gastric ulcer
Activated, gastric ulcer formation ; Reduced, PTGS1 function ; Reduced, platelet aggregation ; Decreased, mucosal blood flow ; Reduced, mucosal defense ; Decreased, mucous ; Decreased, bicarbonate ; Activated, gastric ulcer formation ; Reduced, PTGS1 function ; Reduced, platelet aggregation ; Decreased, mucosal blood flow ; Reduced, mucosal defense ; Decreased, mucous ; Decreased, bicarbonate
- 6/2/2017 2:20:27 PM
- 6/15/2020 8:15:55 PM
- AOP under development
Source: https://aopwiki.org/
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NSAID induced PTGS2 inactivation to gastric ulcer
Activated, gastric ulcer formation ; Reduced, PTGS2 function ; Decreased, angiogenesis ; Increased, leukocyte adherence ; Increased, leukocyte activation ; Activated, gastric ulcer formation ; Reduced, PTGS2 function ; Decreased, angiogenesis ; Increased, leukocyte adherence ; Increased, leukocyte activation
- 6/2/2017 2:50:59 PM
- 6/15/2020 8:16:13 PM
- AOP under development
Source: https://aopwiki.org/
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Organic anion transporter (OAT1) inhibition leading to renal failure and mortality
Increased Mortality ; Decline, Population ; Inhibition, organic anion transporter 1 (OAT1) ; Increased, blood uric acid concentration ; Occurrence, renal proximal tubular necrosis ; Increased, blood potassium concentration ; Occurrence, tophi (urate) deposition ; Occurrence, cardiac arrhythmia ; Increased, Oxidative Stress ; Increased Mortality ; Decline, Population ; Inhibition, organic anion transporter 1 (OAT1) ; Increased, blood uric acid concentration ; Occurrence, renal proximal tubular necrosis ; Increased, blood potassium concentration ; Occurrence, tophi (urate) deposition ; Occurrence, cardiac arrhythmia ; Increased, Oxidative Stress
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:45:13 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Oxidation of hemoglobin Mediated Population Reduction
Oxidation of hemoglobin (methemoglobin) ; Oxidative stress in red blood cells ; Reduced oxygen supply and hypoxia ; Respiration changes ; Headache and fatigue ; Seizures ; Death ; Population reduction
- 10/15/2008 11:30:00 AM
Source: http://www.effectopedia.org/
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Oxidation of hemoglobin Mediated Population Reduction
Oxidation of hemoglobin (methemoglobin) ; Oxidative stress in red blood cells ; Reduced oxygen supply and hypoxia ; Respiration changes ; Headache and fatigue ; Seizures ; Death ; Population reduction ; Oxidation of hemoglobin (methemoglobin) ; Oxidative stress in red blood cells ; Reduced oxygen supply and hypoxia ; Respiration changes ; Headache and fatigue ; Seizures ; Death ; Population reduction
- 10/15/2008 11:30:00 AM
Source: https://www.effectopedia.org/
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Oxidation of iron in hemoglobin leading to hematotoxicity
N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III) ; Altered regulation, Alpha hemoglobin ; Propagation, Oxidative stress ; Damaging, Red blood cells; hemolysis ; Formation, Formation of hemoglobin adducts ; Down Regulation, Gulcose-6-phosphate dehydrogenase ; Increase, RBC congestion in liver ; Increase, Liver and splenic hemosiderosis ; N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number ; N/A, Cyanosis occurs ; N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III) ; Altered regulation, Alpha hemoglobin ; Propagation, Oxidative stress ; Damaging, Red blood cells; hemolysis ; Formation, Formation of hemoglobin adducts ; Down Regulation, Gulcose-6-phosphate dehydrogenase ; Increase, RBC congestion in liver ; Increase, Liver and splenic hemosiderosis ; N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number ; N/A, Cyanosis occurs
- 11/29/2016 11:41:16 PM
- 6/16/2020 1:14:22 PM
- AOP under development
- 1.16
Source: https://aopwiki.org/
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Oxidative DNA damage leading to chromosomal aberrations and mutations
Increase, Mutations ; N/A, Inadequate DNA repair ; Increase, Oxidative damage to DNA ; Increase, DNA strand breaks ; Increase, Chromosomal aberrations ; N/A, Inadequate DNA repair ; Increase, Mutations ; Increase, DNA strand breaks ; Increase, Chromosomal aberrations ; Increase, Oxidative damage to DNA
- 5/19/2019 8:13:15 PM
- 10/12/2020 1:57:17 PM
Source: https://aopwiki.org/
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Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling
- 7/14/2017 5:34:19 PM
- 1/29/2018 4:52:17 AM
Source: https://aopwiki.org/
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Pathway newrok: NMDA, nACh, GABA A, receptor binding leading to population reduction
Binding to the NMDA receptor ; Binding to the nACh receptor ; Binding to the GABA A receptor ; Hydrophobic binding to proteins and membranes ; Death ; Reduced membrane current ; Decreased channel open time ; Increased channel open time ; Reduction of all cell functions ; Reduced Excitatory Transmition ; Reduced Excitatory of the Hippocampus ; Facilitated Inhibitory Transmission Cortex-Thalamus ; Reversible decrease of organ functions ; Sedation ; Excitability ; Population reduction ; Binding to the NMDA receptor ; Binding to the nACh receptor ; Binding to the GABA A receptor ; Hydrophobic binding to proteins and membranes ; Death ; Reduced membrane current ; Decreased channel open time ; Increased channel open time ; Reduction of all cell functions ; Reduced Excitatory Transmition ; Reduced Excitatory of the Hippocampus ; Facilitated Inhibitory Transmission Cortex-Thalamus ; Reversible decrease of organ functions ; Sedation ; Excitability ; Population reduction
- 10/15/2008 11:30:00 AM
Source: https://www.effectopedia.org/
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Pathway newrok: NMDA, nACh, GABA A, receptor binding leading to population reduction
Binding to the NMDA receptor ; Binding to the nACh receptor ; Binding to the GABA A receptor ; Hydrophobic binding to proteins and membranes ; Death ; Reduced membrane current ; Decreased channel open time ; Increased channel open time ; Reduction of all cell functions ; Reduced Excitatory Transmition ; Reduced Excitatory of the Hippocampus ; Facilitated Inhibitory Transmission Cortex-Thalamus ; Reversible decrease of organ functions ; Sedation ; Excitability ; Population reduction
- 10/15/2008 11:30:00 AM
Source: http://www.effectopedia.org/
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Pendrin inhibition leading to altered amphibian metamorphosis
Thyroid hormone synthesis, Decreased ; Decreased, Thyroxine (T4) in serum ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Inhibition, Pendrin ; Thyroid hormone synthesis, Decreased ; Decreased, Thyroxine (T4) in serum ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Inhibition, Pendrin
- 11/29/2016 11:41:17 PM
- 12/9/2020 5:35:08 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Peptide Oxidation Leading to Hypertension
Peptide Oxidation ; Oxidation, Glutathione (To be considered with MIE) ; KE1 : S-Glutathionylation, eNOS ; KE2 : Decrease, GTPCH-1 ; KE3 : Decrease, Tetrahydrobiopterin ; KE4 : Uncoupling, eNOS ; KE6 : Depletion, Nitric Oxide ; KE7 : Impaired, Vasodilation ; KE8 : Increase, Vascular Resistance ; KE5 : Decrease, AKT/eNOS activity ; Hypertension ; Peptide Oxidation ; KE1 : S-Glutathionylation, eNOS ; KE2 : Decrease, GTPCH-1 ; KE3 : Decrease, Tetrahydrobiopterin ; KE4 : Uncoupling, eNOS ; KE6 : Depletion, Nitric Oxide ; KE7 : Impaired, Vasodilation ; KE8 : Increase, Vascular Resistance ; KE5 : Decrease, AKT/eNOS activity ; Hypertension
- 11/29/2016 11:41:17 PM
- 6/17/2020 5:42:43 PM
- AOP under development
- 1.50
Source: https://aopwiki.org/
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Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol
Activation, PXR/SXR ; Activation, PXR/SXR
- 11/29/2016 11:41:16 PM
- 6/17/2020 5:44:43 PM
- AOP under development
- 2.5
Source: https://aopwiki.org/
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Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
Decreased, PPAR-alpha activation ; Decreased, PPAR-beta activation ; Decreased, PPAR-gamma activation ; Accumulation, Fatty acid ; Decreased, HSD17B10 expression ; Decreased, Mitochondrial fatty acid beta-oxidation ; Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity ; Undefined, Liver Steatosis ; Increased, Liver Steatosis ; Decreased, PPAR-alpha activation ; Decreased, PPAR-beta activation ; Decreased, PPAR-gamma activation ; Accumulation, Fatty acid ; Decreased, HSD17B10 expression ; Decreased, Mitochondrial fatty acid beta-oxidation ; Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity ; Increased, Liver Steatosis
- 11/29/2016 11:41:16 PM
- 2/7/2020 6:42:32 PM
Source: https://aopwiki.org/
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Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis
Increase, Inflammation ; Inactivation of PPARγ ; Activation of TGF-β signaling ; Differentiation of Myofibroblast ; Production of α-smooth muscle actin ; Expression of Collagen ; Collagen Deposition ; Lung fibrosis ; Induction, Epithelial Mesenchymal Transition ; Activation of PPARγ ; Increase, Inflammation ; Inactivation of PPARγ ; Activation of TGF-β signaling ; Collagen Deposition ; Induction, Epithelial Mesenchymal Transition ; Lung fibrosis
- 2/15/2017 7:34:56 AM
- 12/16/2019 9:38:24 AM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
Up Regulation, SREBF2 ; Up Regulation, Unsaturated fatty acid ; Down Regulation, GSS and GSTs gene ; Glutathione synthesis ; Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene ; Perturbation of cholesterol ; Glutathione homeostasis ; Hepatotoxicity ; Up Regulation, SREBF2 ; Up Regulation, Unsaturated fatty acid ; Down Regulation, GSS and GSTs gene ; Glutathione synthesis ; Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene ; Perturbation of cholesterol ; Glutathione homeostasis ; Hepatotoxicity
- 2/15/2017 8:56:47 AM
- 7/3/2018 2:10:26 AM
Source: https://aopwiki.org/
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Phospholipase A inhibitors lead to hepatotoxicity
Inhibition, Phospholipase A ; Damage, Lipid bilayer ; Disturbance, Lysosomal function ; Injury, Mitochondria ; Occurrence, Cytoplasmic vacuolization (hepatocyte) ; Occurrence, Ballooning degeneration (hepatocyte) ; Occurrence, Cytoplasmic vacuolization (kupffer cell) ; Induction, Microvesicular fat ; Formation, Mallory body ; Occurrence, Cytoplasmic vacuolization (Bile duct cell) ; Formation, Liver fibrosis ; Inhibition, Phospholipase A ; Damage, Lipid bilayer ; Disturbance, Lysosomal function ; Injury, Mitochondria ; Occurrence, Cytoplasmic vacuolization (hepatocyte) ; Occurrence, Ballooning degeneration (hepatocyte) ; Occurrence, Cytoplasmic vacuolization (kupffer cell) ; Induction, Microvesicular fat ; Formation, Mallory body ; Occurrence, Cytoplasmic vacuolization (Bile duct cell) ; Formation, Liver fibrosis
- 11/29/2016 11:41:16 PM
- 9/10/2020 11:46:03 PM
- AOP under development
- 1.39
Source: https://aopwiki.org/
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PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
Increased, PPAR-alpha activation ; Decreased, bile flow ; Increased, cholestasis ; Alteration, lipid metabolism ; prolonged, elevation of serun CCK ; Increased, Cellular proliferation / hyperplasia of acinar cells ; Increased, Pancreatic acinar tumors ; Increased, PPAR-alpha activation ; Decreased, bile flow ; Increased, cholestasis ; Alteration, lipid metabolism ; prolonged, elevation of serun CCK ; Increased, Cellular proliferation / hyperplasia of acinar cells ; Increased, Pancreatic acinar tumors
- 11/29/2016 11:41:17 PM
- 2/7/2020 7:47:05 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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PPARalpha Agonism Impairs Fish Reproduction
Activation, PPARα ; Decreased, cholesterol ; Decreased, 11-ketotestosterone ; Impaired, Spermatogenesis ; Activation, PPARα ; Decreased, cholesterol ; Decreased, 11-ketotestosterone ; Impaired, Spermatogenesis
- 4/9/2020 2:47:50 PM
- 5/11/2020 8:37:26 PM
Source: https://aopwiki.org/
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PPARgamma activation leading to sarcomas in rats, mice, and hamsters
Activation of specific nuclear receptors, PPAR-gamma activation ; Increased, adipogenesis ; Increased, secretion of local growth factors ; Increased, proliferation of mesenchymal cells ; Increased, IGF-1 (mouse) ; Increased, Firbrosarcoma ; Increased, liposarcoma ; Increased, hemagiosarcoma ; Activation of specific nuclear receptors, PPAR-gamma activation ; Increased, adipogenesis ; Increased, secretion of local growth factors ; Increased, proliferation of mesenchymal cells ; Increased, IGF-1 (mouse) ; Increased, Firbrosarcoma ; Increased, liposarcoma ; Increased, hemagiosarcoma
- 11/29/2016 11:41:17 PM
- 2/7/2020 7:46:20 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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PPARα activation in utero leading to impaired fertility in males
impaired, Fertility ; Activation, PPARα ; Decrease, Steroidogenic acute regulatory protein (STAR) ; Reduction, Cholesterol transport in mitochondria ; Reduction, Testosterone synthesis in Leydig cells ; Reduction, testosterone level ; Decrease, Translocator protein (TSPO) ; Malformation, Male reproductive tract ; impaired, Fertility ; Activation, PPARα ; Decrease, Steroidogenic acute regulatory protein (STAR) ; Reduction, Cholesterol transport in mitochondria ; Reduction, Testosterone synthesis in Leydig cells ; Reduction, testosterone level ; Decrease, Translocator protein (TSPO) ; Malformation, Male reproductive tract
- 11/29/2016 11:41:16 PM
- 12/2/2016 3:31:51 PM
- EAGMST under review
- 1.21
Source: https://aopwiki.org/
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PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
Activation, PPARα ; modulation, Genes/proteins that regulate hepatocyte fate ; Increase, Mitogenic cell proliferation (hepatocytes) ; Increase, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci ; Increase, Adenomas/carcinomas (hepatocellular) ; Activation, PPARα ; Increase, Phenotypic enzyme activity ; Increase, cell proliferation (hepatocytes) ; Increase, Clonal Expansion of Altered Hepatic Foci ; Increase, hepatocellular adenomas and carcinomas
- 11/29/2016 11:41:16 PM
- 12/31/2020 2:47:07 PM
- AOP under development
- 1.17
Source: https://aopwiki.org/
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PPARα activation leading to impaired fertility in adult male rodents
impaired, Fertility ; Activation, PPARα ; Reduction, Cholesterol transport in mitochondria ; Reduction, Testosterone synthesis in Leydig cells ; Reduction, testosterone level ; Increase, Luteinizing hormone (LH) ; Hyperplasia, Leydig cell ; Increase proliferation, Leydig cell ; impaired, Fertility ; Activation, PPARα ; Reduction, Cholesterol transport in mitochondria ; Reduction, Testosterone synthesis in Leydig cells ; Reduction, testosterone level ; Increase, Luteinizing hormone (LH) ; Hyperplasia, Leydig cell ; Increase proliferation, Leydig cell
- 11/29/2016 11:41:16 PM
- 6/15/2020 7:08:19 PM
- AOP under development
- 1.21
Source: https://aopwiki.org/
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presynaptic neuron 1 activation to epilepsy
Increased, intracellular sodium (Na+) ; Increased, seizure ; Activated, presynaptic neuron 1 ; Increased, glutamate ; Activated, NMDA receptor ; Activated, voltage-gated sodium channel ; Inhibit, voltage-gated sodium channel ; Treat, carbamazepine ; Activated, membrane depolarization ; Increased, hippocampal hyperdepolarization ; Increased, epilepsy ; Increased, intracellular sodium (Na+) ; Increased, seizure ; Activated, presynaptic neuron 1 ; Increased, glutamate ; Activated, NMDA receptor ; Activated, voltage-gated sodium channel ; Inhibit, voltage-gated sodium channel ; Treat, carbamazepine ; Activated, membrane depolarization ; Increased, hippocampal hyperdepolarization ; Increased, epilepsy
- 6/2/2017 3:27:37 PM
- 6/15/2020 8:17:40 PM
- AOP under development
Source: https://aopwiki.org/
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presynaptic neuron 2 repression to epilepsy
Increased, seizure ; Activated, membrane depolarization ; Increased, RDX dose ; Increased, hippocampal hyperdepolarization ; Increased, epilepsy ; Reduced, presynaptic neuron 2 activity ; Decreased, GABA ; Reduced, GABA-A receptor activation ; Decreased, intracellular chloride ; Increased, seizure ; Activated, membrane depolarization ; Increased, RDX dose ; Increased, hippocampal hyperdepolarization ; Increased, epilepsy ; Reduced, presynaptic neuron 2 activity ; Decreased, GABA ; Reduced, GABA-A receptor activation ; Decreased, intracellular chloride
- 6/2/2017 4:07:00 PM
- 6/15/2020 8:17:56 PM
- AOP under development
Source: https://aopwiki.org/
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Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation
Reduction, Plasma 17beta-estradiol concentrations ; Reduction, 17beta-estradiol synthesis by ovarian granulosa cells ; Reduction, Vitellogenin synthesis in liver ; Reduction, Cumulative fecundity and spawning ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Decrease, Population trajectory ; Inhibition, Prolyl hydroxylases ; Increased, HIF-1 heterodimer ; Decreased, Aromatase (Cyp19a1) mRNA ; Reduction, Plasma 17beta-estradiol concentrations ; Reduction, 17beta-estradiol synthesis by ovarian granulosa cells ; Decrease, Population trajectory ; Reduction, Vitellogenin synthesis in liver ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Reduction, Cumulative fecundity and spawning ; Inhibition, Prolyl hydroxylases ; Increased, HIF-1 heterodimer ; Decreased, Aromatase (Cyp19a1) mRNA
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:42:54 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Protein Alkylation leading to Liver Fibrosis
N/A, Cell injury/death ; Alkylation, Protein ; Increased, Activation and Recruitment of Hepatic macrophages (Kupffer Cells) ; Up Regulation, TGFbeta1 expression ; Activation, Stellate cells ; Accumulation, Collagen ; N/A, Liver fibrosis ; Tissue resident cell activation ; Increased Pro-inflammatory mediators ; Cell injury/death ; Tissue resident cell activation ; Increased Pro-inflammatory mediators ; Alkylation, Protein ; Activation, Stellate cells ; Accumulation, Collagen ; N/A, Liver fibrosis
- 11/29/2016 11:41:16 PM
- 4/30/2019 4:53:51 PM
- OECD endorsed (WNT and WPHA)
- 1.14
- Review Report
- i-Library
Source: https://aopwiki.org/
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Queen egg-laying decrease leads to colony loss/failure
Weakened, Colony ; Death/Failure, Colony ; Weakened, Colony ; Death/Failure, Colony
- 11/29/2016 11:41:17 PM
- 2/7/2020 7:53:55 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Reactive oxygen species generated from photoreactive chemicals leading to phototoxic reactions
Systemic or topycal administration of chemicals ; Distribution and deposition of chemicals to skin and/or eyes ; Absorption of photon energy ; ROS generation from photoactivated chemicals ; Radicals of target chemicals ; Oxidation of membrane lipids ; Oxidation/denatuation of membrane proteins ; Oxidation of DNA ; Formation of DNA photo-adducts ; Formation of protein photo-adducts ; Inflamatory events in light-exposed tissues ; ROS generation from photoactivated chemicals ; Oxidation of membrane lipids ; Oxidation/denatuation of membrane proteins ; Inflamatory events in light-exposed tissues
- 2/3/2019 5:29:48 AM
- 1/7/2020 3:28:34 PM
Source: https://aopwiki.org/
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Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
Increase, Cytotoxicity (renal tubular cell) ; Occurrence, Kidney toxicity ; Disturbance, Lysosomal function ; Disruption, Lysosome ; Binding of substrate, endocytic receptor ; Increase, Cytotoxicity (renal tubular cell) ; Occurrence, Kidney toxicity ; Disturbance, Lysosomal function ; Disruption, Lysosome ; Binding of substrate, endocytic receptor
- 10/25/2017 12:13:54 PM
- 10/12/2020 4:40:03 PM
Source: https://aopwiki.org/
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Reduced environmental pH leading to thinner shells in Mytilus edulis
- 3/16/2020 6:15:26 AM
- 3/17/2020 5:15:43 AM
Source: https://aopwiki.org/
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Reduction in photophosphorylation leading to growth inhibition in aquatic plants
Decrease, Mitochondrial ATP production ; Increase, Uncoupling of photophosphorylation ; Decrease, Chloroplast ATP production ; Decrease, Chlorophyll synthesis ; Decrease, Light harvest capacity ; Decrease, Photosynthesis ; Decrease, Glycolysis ; Decrease, Oxidative phosphorylation ; Decrease, Leaf cell mitosis ; Decrease, Leaf development ; Increase, Growth inhibition ; Decrease, Mitochondrial ATP production ; Increase, Uncoupling of photophosphorylation ; Decrease, Chloroplast ATP production ; Decrease, Chlorophyll synthesis ; Decrease, Light harvest capacity ; Decrease, Photosynthesis ; Decrease, Glycolysis ; Decrease, Oxidative phosphorylation ; Decrease, Leaf cell mitosis ; Decrease, Leaf development ; Increase, Growth inhibition
- 10/10/2017 11:43:35 AM
- 11/2/2020 11:24:58 AM
Source: https://aopwiki.org/
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Renal protein alkylation leading to kidney toxicity
Decrease, Mitochondrial ATP production ; Alkylation, Protein ; Increase, Cytotoxicity (renal tubular cell) ; Occurrence, Kidney toxicity ; Dysfunction, Mitochondria ; Decrease, Mitochondrial ATP production ; Alkylation, Protein ; Increase, Cytotoxicity (renal tubular cell) ; Occurrence, Kidney toxicity ; Dysfunction, Mitochondria
- 10/25/2017 1:03:32 PM
- 10/12/2020 4:47:32 PM
Source: https://aopwiki.org/
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Retinoic acid signalling leading to developmental toxicity
Binding to the retinoic acid receptor (agonism) ; Transcription of retinoic acid regulated genes ; Repression of the Wnt signalling pathway ; Developmental toxicity of retinoic acid ; Binding to the retinoic acid receptor (agonism) ; Transcription of retinoic acid regulated genes ; Repression of the Wnt signalling pathway ; Developmental toxicity of retinoic acid
- 4/11/2010 10:00:00 AM
Source: https://www.effectopedia.org/
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Retinoic acid signalling leading to developmental toxicity
Binding to the retinoic acid receptor (agonism) ; Transcription of retinoic acid regulated genes ; Repression of the Wnt signalling pathway ; Developmental toxicity of retinoic acid
- 4/11/2010 10:00:00 AM
Source: http://www.effectopedia.org/
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S-adenosylmethionine depletion leading to population decline (1)
Increase, Mortality ; Increase, Chitin synthase inhibition ; Decrease, Cuticular chitin synthesis ; Increase, Premature molting ; Increase, Mortality ; Increase, Chitin synthase 1 inhibition ; Decrease, Cuticular chitin content ; Increase, Premature molting
- 5/8/2020 11:10:27 AM
- 10/27/2020 7:46:33 AM
Source: https://aopwiki.org/
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S-adenosylmethionine depletion leading to population decline (2)
Increase, Mortality ; Decrease, Cuticular chitin synthesis ; Increase, Premature molting ; Increase, Sulfonylurea receptor binding ; Increase, Opening of voltage-dependent calcium channel ; Increase, Cell membrane depolarization ; Increase, Mortality ; Decrease, Cuticular chitin content ; Increase, Premature molting ; Increase, Sulfonylurea receptor binding ; Increase, Cell membrane depolarization ; Increase, Opening of voltage-dependent calcium channel
- 5/8/2020 11:10:57 AM
- 10/27/2020 7:46:47 AM
Source: https://aopwiki.org/
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Secretion of inflammatory cytokines after cellular sensing of the stressor leading to plaque progression
Sensing of the stressor by pulmonary cells ; Increased production of pulmonary, pro-inflammatory cytokines ; Increased production of pulmonary SAA ; Formation of HDL-SAA ; Increased systemic total cholesterol pool ; Foam cell formation ; Plaque progression in arteries ; Sensing of the stressor by pulmonary cells ; Increased production of pulmonary, pro-inflammatory cytokines ; Increased production of pulmonary SAA ; Formation of HDL-SAA ; Increased systemic total cholesterol pool ; Foam cell formation ; Plaque progression in arteries
- 6/29/2017 5:37:35 AM
- 10/13/2020 9:16:49 AM
- AOP under development
Source: https://aopwiki.org/
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Sensitization induction of the intestinal tract by food proteins
- 2/2/2018 1:13:59 PM
- 2/2/2018 2:22:05 PM
Source: https://aopwiki.org/
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Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
Release of G Proteins ; Inhibition of N-type Ca ion channels ; Inhibition of neurotransmitter vesicle release ; Serotonin 1A Receptor Agonism ; Anti-depressant Activity ; Release of G Proteins ; Inhibition of N-type Ca ion channels ; Inhibition of neurotransmitter vesicle release ; Serotonin 1A Receptor Agonism ; Anti-depressant Activity
- 6/23/2017 11:21:13 AM
- 6/15/2020 8:30:10 PM
- AOP under development
Source: https://aopwiki.org/
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Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening
hyperpolarisation, neuron ; Release of G Proteins ; Opening of G protein gated inward rectifying K channels ; Serotonin 1A Receptor Agonism ; Anti-depressant Activity ; hyperpolarisation, neuron ; Release of G Proteins ; Opening of G protein gated inward rectifying K channels ; Serotonin 1A Receptor Agonism ; Anti-depressant Activity
- 6/23/2017 11:02:54 AM
- 6/15/2020 8:29:50 PM
- AOP under development
Source: https://aopwiki.org/
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Serotonin transporter activation to agitation
Decreased, serotonin transporter activity ; Increased, extracellular serotonin ; Decreased, intracellular serotonin ; Decreased, packaged serotonin ; Decreased, synaptic release ; Inactivated, 5-HTR (serotonin receptors) ; Reduce expression, BDNF (Brain-derived neurotrophic factor) ; Decreased, neuroplasticity ; Increased, agitation ; Decreased, extracellular serotonin ; Increased, serotonin transporter activity ; Increased, intracellular serotonin ; Increased, packaged serotonin ; Increased, synaptic release ; Increased, extracellular serotonin ; Decreased, extracellular serotonin ; Inactivated, 5-HTR (serotonin receptors) ; Reduce expression, BDNF (Brain-derived neurotrophic factor) ; Decreased, neuroplasticity ; Increased, agitation ; Increased, serotonin transporter activity ; Increased, intracellular serotonin ; Increased, packaged serotonin ; Increased, synaptic release
- 5/31/2017 12:08:34 AM
- 6/15/2020 8:13:27 PM
- AOP under development
Source: https://aopwiki.org/
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Serotonin transporter activation to depression
Inhibit, serotonin transporter activity ; Decreased, serotonin transporter activity ; Increased, extracellular serotonin ; Decreased, intracellular serotonin ; Decreased, packaged serotonin ; Decreased, synaptic release ; Inactivated, 5-HTR (serotonin receptors) ; Reduce expression, BDNF (Brain-derived neurotrophic factor) ; Decreased, neuroplasticity ; Reduced, BDNF (Brain-derived neurotrophic factor) ; Increased, depression ; Decreased, extracellular serotonin ; Increased, serotonin transporter activity ; Increased, intracellular serotonin ; Increased, packaged serotonin ; Increased, synaptic release ; Increased, extracellular serotonin ; Decreased, extracellular serotonin ; Inactivated, 5-HTR (serotonin receptors) ; Reduce expression, BDNF (Brain-derived neurotrophic factor) ; Decreased, neuroplasticity ; Increased, depression ; Increased, serotonin transporter activity ; Increased, intracellular serotonin ; Increased, packaged serotonin ; Increased, synaptic release
- 5/30/2017 7:58:08 PM
- 6/15/2020 8:13:06 PM
- AOP under development
Source: https://aopwiki.org/
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Serotonin transporter activation to seizure
Decreased, serotonin transporter activity ; Increased, extracellular serotonin ; Decreased, intracellular serotonin ; Decreased, packaged serotonin ; Decreased, synaptic release ; Increased, 5-HT3 (5-hydroxytryptamine) ; Increased, seizure ; Decreased, extracellular serotonin ; Increased, serotonin transporter activity ; Increased, intracellular serotonin ; Increased, packaged serotonin ; Increased, synaptic release ; Decreased, 5-HT3 ; Increased, extracellular serotonin ; Decreased, extracellular serotonin ; Increased, seizure ; Increased, serotonin transporter activity ; Increased, intracellular serotonin ; Increased, packaged serotonin ; Increased, synaptic release ; Decreased, 5-HT3
- 5/30/2017 7:45:53 PM
- 6/15/2020 8:12:45 PM
- AOP under development
Source: https://aopwiki.org/
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Sodium channel (Nav1.1) inhibition leading to population decline
Inhibition, sodium channel ; Decreased, sodium conductance 2 ; Decreased, GABA release ; Inhibition, sodium channel ; Decreased, sodium conductance 2 ; Decreased, GABA release
- 11/29/2016 11:41:17 PM
- 2/7/2020 7:58:29 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Sodium channel inhibition leading to congenital malformations
Increased, Atrioventricular block and bradycardia ; Respiratory distress/arrest ; Inhibition, sodium channel ; Decreased, Sodium conductance 1 ; N/A, hypoxia ; Increased, amputations ; Respiratory distress/arrest ; Inhibition, sodium channel ; Decreased, Sodium conductance 1 ; Increased, Atrioventricular block and bradycardia ; N/A, hypoxia ; Increased, amputations
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:34:48 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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sodium channel inhibition leading to increased predation
Inhibition, sodium channel ; Decreased, Sodium conductance 1 ; Reduced, swimming speed ; Increased, predation ; Inhibition, sodium channel ; Decreased, Sodium conductance 1 ; Reduced, swimming speed ; Increased, predation
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:34:32 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Sodium channel inhibition leading to reduced survival
Inhibition, sodium channel ; Decreased, Sodium conductance 1 ; Reduced, swimming speed ; Reduced, feeding 1 ; Increased, predation ; Reduced, survival ; Inhibition, sodium channel ; Decreased, Sodium conductance 1 ; Reduced, swimming speed ; Reduced, feeding 1 ; Increased, predation ; Reduced, survival
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:34:00 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
Thyroxine (T4) in neuronal tissue, Decreased ; Thyroxine (T4) in serum, Decreased ; Hippocampal anatomy, Altered ; Hippocampal Physiology, Altered ; Hippocampal gene expression, Altered ; Thyroid hormone synthesis, Decreased ; Cognitive Function, Decreased ; Inhibition, Na+/I- symporter (NIS) ; Decrease of Thyroidal iodide ; Decreased, Thyroxine (T4) in serum ; Thyroxine (T4) in serum, Decreased ; Thyroxine (T4) in neuronal tissue, Decreased ; Hippocampal gene expression, Altered ; Hippocampal anatomy, Altered ; Hippocampal Physiology, Altered ; Thyroid hormone synthesis, Decreased ; Cognitive Function, Decreased ; Inhibition, Na+/I- symporter (NIS) ; Decrease of Thyroidal iodide ; Decreased, Thyroxine (T4) in serum
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:44:59 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis
Thyroxine (T4) in serum, Decreased ; Thyroid hormone synthesis, Decreased ; Inhibition, Na+/I- symporter (NIS) ; Decrease of Thyroidal iodide ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Thyroxine (T4) in serum, Decreased ; Thyroid hormone synthesis, Decreased ; Inhibition, Na+/I- symporter (NIS) ; Decrease of Thyroidal iodide ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis
- 11/29/2016 11:41:17 PM
- 12/9/2020 5:23:21 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
SSRI (Selective serotonin reuptake inhibitor) to hypertension
Decreased, serotonin transporter activity ; Increased, extracellular serotonin ; Decreased, intracellular serotonin ; Decreased, packaged serotonin ; Decreased, synaptic release ; Activation, 5-HT2A (Serotonin 2A) ; Activate, PLC (Phospholipase C) ; Increase, inositol triphosphate ; Increase, intracellular calcium ; Activate, calmodulin ; Increase, myosin light chain phosphorylation ; Increase, vascular smooth muscle contraction ; Increase, hypertension ; Decreased, extracellular serotonin ; Decreased, serotonin transporter activity ; Increased, extracellular serotonin ; Decreased, extracellular serotonin ; Decreased, intracellular serotonin ; Decreased, packaged serotonin ; Decreased, synaptic release ; Activation, 5-HT2A (Serotonin 2A) ; Activate, PLC (Phospholipase C) ; Increase, inositol triphosphate ; Increase, intracellular calcium ; Activate, calmodulin ; Increase, myosin light chain phosphorylation ; Increase, vascular smooth muscle contraction ; Increase, hypertension
- 5/31/2017 12:30:22 AM
- 6/15/2020 8:14:16 PM
- AOP under development
Source: https://aopwiki.org/
|
Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease
Stimulation, TLR7/8 in dendritic cells ; Overproduction of IL-23, matured dendritic cells ; Overproduction of IL-17 from Th17 cells ; Psoriatic skin disease ; Stimulation, TLR7/8 ; Increase, IL-23 from matured dendritic cells ; Th17 cell migration and inflammation induction ; Psoriatic skin disease ; Maturation of TNF/iNOS-Producing Dendritic Cells
- 12/27/2019 9:09:57 AM
- 1/26/2021 12:31:40 AM
Source: https://aopwiki.org/
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Substance interaction with the lung resident cell membrane components leading to lung fibrosis
Pulmonary fibrosis ; Interaction with the lung resident cell membrane components ; Increased, secretion of proinflammatory and profibrotic mediators ; Increased, recruitment of inflammatory cells ; Loss of alveolar capillary membrane integrity ; Increased, activation of T (T) helper (h) type 2 cells ; Increased, fibroblast proliferation and myofibroblast differentiation ; Increased, extracellular matrix deposition ; Interaction with the lung resident cell membrane components ; Increased, secretion of proinflammatory and profibrotic mediators ; Increased, recruitment of inflammatory cells ; Loss of alveolar capillary membrane integrity ; Increased, activation of T (T) helper (h) type 2 cells ; Increased, fibroblast proliferation and myofibroblast differentiation ; Increased, extracellular matrix deposition ; Pulmonary fibrosis
- 11/29/2016 11:41:17 PM
- 11/12/2019 2:59:43 AM
- AOP under development
- 1.32
Source: https://aopwiki.org/
|
Sulfonylureareceptor binding leading to mortality
Increase, Mortality ; Decrease, Cuticular chitin content ; Increase, Premature molting ; Increase, Sulfonylurea receptor binding ; Increase, Cell membrane depolarization ; Increase, Opening of voltage-dependent calcium channel
- 10/22/2020 8:15:52 PM
- 10/23/2020 7:52:05 AM
Source: https://aopwiki.org/
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Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure
Suppression, Immune system ; Abnormal, Foraging activity and behavior ; Death/Failure, Colony ; Decrease, Number of worker bees ; Increased, Viral susceptibility ; Suppression, Immune system ; Abnormal, Foraging activity and behavior ; Death/Failure, Colony ; Decrease, Number of worker bees ; Increased, Viral susceptibility
- 11/29/2016 11:41:16 PM
- 4/8/2019 4:38:24 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
Suppression of immune system contributes to impaired development and leads to colony loss/failure
Suppression, Immune system ; Death/Failure, Colony ; impaired, Hive thermoregulation ; Decrease, Number of worker bees ; Increased, Viral susceptibility ; impaired, Development ; Suppression, Immune system ; Death/Failure, Colony ; impaired, Hive thermoregulation ; Decrease, Number of worker bees ; Increased, Viral susceptibility ; impaired, Development
- 11/29/2016 11:41:16 PM
- 4/8/2019 4:37:50 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
Sustained AhR Activation leading to Rodent Liver Tumours
Activation, Long term AHR receptor driven direct and indirect gene expression changes ; N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects ; Changes/Inhibition, Cellular Homeostasis and Apoptosis ; Alterations, Cellular proliferation / hyperplasia ; Formation, Hepatocellular and Bile duct tumors ; Activation, Long term AHR receptor driven direct and indirect gene expression changes ; N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects ; Changes/Inhibition, Cellular Homeostasis and Apoptosis ; Alterations, Cellular proliferation / hyperplasia ; Formation, Hepatocellular and Bile duct tumors
- 11/29/2016 11:41:16 PM
- 12/2/2016 4:59:32 PM
- EAGMST under review
- 1.7
Source: https://aopwiki.org/
|
TBX1 inhibition leading to congenital cardiac conotruncal anomalies
Inhibition, TBX1 ; Disruption, Neural crest cell migration ; Disruption, Progenitor cells of second heart field ; Impairment, Fourth pharyngeal arch development ; Abnormalities, Cardiac outflow tract formation ; Anomalies, Congenital cardiac conotruncal ; Inhibition, TBX1 ; Disruption, Neural crest cell migration ; Disruption, Progenitor cells of second heart field ; Impairment, Fourth pharyngeal arch development ; Abnormalities, Cardiac outflow tract formation ; Anomalies, Congenital cardiac conotruncal
- 8/6/2019 7:03:26 AM
- 11/2/2020 1:38:39 PM
Source: https://aopwiki.org/
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Thermal stress leading to population decline (1)
N/A, Mitochondrial dysfunction 1 ; Decrease, Population trajectory ; Decrease, Oogenesis ; Decrease, Fecundity ; Decrease, Adenosine triphosphate pool
- 4/18/2020 9:18:10 AM
- 12/4/2020 9:55:47 PM
Source: https://aopwiki.org/
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Thermal stress leading to population decline (2)
N/A, Mitochondrial dysfunction 1 ; Decrease, Population trajectory ; Increase, Apoptosis ; Decrease, Oogenesis ; Decrease, Fecundity ; Increase, Reactive oxygen species ; Increase, Oxidative DNA damage
- 4/18/2020 9:18:37 AM
- 12/4/2020 9:53:38 PM
Source: https://aopwiki.org/
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Thermal stress leading to population decline (3)
N/A, Mitochondrial dysfunction 1 ; Decrease, Population trajectory ; Increase, Reactive oxygen species production ; Increase, Apoptosis ; Decrease, Oogenesis ; Decrease, Fecundity ; Increase, Global DNA methylation
- 4/18/2020 9:19:06 AM
- 12/4/2020 9:50:31 PM
Source: https://aopwiki.org/
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Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
Hippocampal anatomy, Altered ; Hippocampal Physiology, Altered ; Hippocampal gene expression, Altered ; Cognitive Function, Decreased ; Antagonism, Thyroid Receptor ; Hippocampal gene expression, Altered ; Hippocampal anatomy, Altered ; Hippocampal Physiology, Altered ; Cognitive Function, Decreased ; Antagonism, Thyroid Receptor
- 6/8/2019 9:12:01 PM
- 6/25/2020 2:41:05 PM
Source: https://aopwiki.org/
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Thyroperoxidase inhibition leading to altered amphibian metamorphosis
Thyroxine (T4) in serum, Decreased ; Thyroperoxidase, Inhibition ; Thyroid hormone synthesis, Decreased ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Thyroxine (T4) in serum, Decreased ; Thyroperoxidase, Inhibition ; Thyroid hormone synthesis, Decreased ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis
- 11/29/2016 11:41:17 PM
- 12/9/2020 5:22:50 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
Thyroperoxidase inhibition leading to increased mortality via altered eye structure
Thyroxine (T4) in serum, Decreased ; Increased Mortality ; Decrease, Population trajectory ; Thyroperoxidase, Inhibition ; Thyroid hormone synthesis, Decreased ; Decreased, Triiodothyronine (T3) in serum
- 12/9/2020 12:45:26 PM
- 12/10/2020 9:59:52 AM
Source: https://aopwiki.org/
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Thyroperoxidase inhibition leading to increased mortality via altered photoreceptor patterning
- 12/9/2020 12:47:23 PM
- 12/9/2020 12:47:23 PM
Source: https://aopwiki.org/
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Thyroperoxidase inhibition leading to increased mortality via decreased eye size
- 12/9/2020 12:46:57 PM
- 12/9/2020 12:46:57 PM
Source: https://aopwiki.org/
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Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
Thyroxine (T4) in serum, Decreased ; Decrease, Population trajectory ; Thyroperoxidase, Inhibition ; Thyroid hormone synthesis, Decreased ; Decreased, Triiodothyronine (T3) in serum ; Reduced, Swimming performance ; Reduced, Young of year survival ; Reduced, Anterior swim bladder inflation ; Reduced, Hearing ; Thyroxine (T4) in serum, Decreased ; Increased Mortality ; Decrease, Population trajectory ; Thyroperoxidase, Inhibition ; Thyroid hormone synthesis, Decreased ; Decreased, Triiodothyronine (T3) in serum ; Reduced, Swimming performance ; Reduced, Young of year survival ; Reduced, Anterior swim bladder inflation
- 11/29/2016 11:41:17 PM
- 1/18/2021 2:36:38 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
Inactivation of PPARγ ; Activation, TGF-beta pathway ; Activation, JNK ; Induction, Epithelial Mesenchymal Transition ; Pulmonary fibrosis ; Toll-like receptor 4 activation ; Activator protein 1 activation ; Pin-1 activation ; Latent Transforming growth Factor beta expression ; Pulmonary fibrosis ; Inactivation of PPARγ ; Induction, Epithelial Mesenchymal Transition ; Activation, TGF-beta pathway ; Activation, JNK ; Toll-like receptor 4 activation ; Activator protein 1 activation ; Pin-1 activation ; Latent Transforming growth Factor beta expression
- 6/29/2020 6:57:02 AM
- 12/23/2020 5:58:14 AM
Source: https://aopwiki.org/
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Trypsin inhibition leading to pancreatic acinar cell tumors
Trypsin inhibition ; Increased intestinal monitor peptide level ; Increased blood CCK level ; Increased exocrine secretion from pancreatic acinar cells ; Acinar cell proliferation ; Pancreatic acinar cell tumors ; Trypsin inhibition ; Increased intestinal monitor peptide level ; Increased blood CCK level ; Increased exocrine secretion from pancreatic acinar cells ; Acinar cell proliferation ; Pancreatic acinar cell tumors
- 1/8/2020 5:45:04 AM
- 1/9/2020 12:28:41 PM
Source: https://aopwiki.org/
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Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis
Decreased, Triiodothyronine (T3) in serum ; Inhibition, Deiodinase 1 ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Decreased, Triiodothyronine (T3) in serum ; Inhibition, Deiodinase 1 ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis
- 11/29/2016 11:41:17 PM
- 2/7/2020 7:54:49 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis
Inhibition, Deiodinase 2 ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Inhibition, Deiodinase 2 ; Increased, Thyroid-stimulating hormone (TSH) ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Increased, Thyroxine (T4) in serum ; Altered, Thyroid hormone-dependent gene expression
- 11/29/2016 11:41:17 PM
- 12/9/2020 7:27:26 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis
Altered, Amphibian metamorphosis ; Inhibition, Deiodinase 3 ; Increased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Inhibition, Deiodinase 3 ; Increased, Triiodothyronine (T3) in tissues ; Altered, Thyroid hormone-dependent gene expression
- 11/29/2016 11:41:17 PM
- 12/9/2020 7:38:09 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
Uncoupling of oxidative phosphorylation leading to growth inhibition (1)
Increase, Mortality ; Decrease, Oogenesis ; Decrease, Oxidative phosphorylation ; Increase, Chitin synthase inhibition ; Decrease, Cuticular chitin synthesis ; Increase, Premature molting ; Decrease, Fecundity ; Increase, ATP synthase inhibition ; Decrease, ATP production ; Increase, Oocyte apoptosis ; Decrease, Oogenesis ; Decrease, Fecundity ; Decrease, Coupling of oxidative phosphorylation ; Decrease, Oxidative phosphorylation ; Increase, Mitochondrial ATP synthase antagonism ; Decrease, Adenosine triphosphate pool ; Increase, Oocyte apoptosis ; Increase, Necrosis ; Decrease, Growth ; Decrease, ATP synthase activity ; Increase, Tissue/organ damage ; Decrease, Cell proliferation
- 5/24/2018 4:15:32 PM
- 12/7/2020 1:05:19 PM
Source: https://aopwiki.org/
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Uncoupling of oxidative phosphorylation leading to growth inhibition (2)
Increase, Mortality ; Decrease, Oogenesis ; Decrease, Oxidative phosphorylation ; Decrease, Cuticular chitin synthesis ; Increase, Premature molting ; Increase, Sulfonylurea receptor binding ; Increase, Opening of voltage-dependent calcium channel ; Increase, Cell membrane depolarization ; Decrease, Fecundity ; Increase, Necrosis ; Increase, ATP synthase inhibition ; Decrease, ATP production ; Increase, Ovarian follicle breakdown ; Decrease, Oogenesis ; Decrease, Fecundity ; Decrease, Coupling of oxidative phosphorylation ; Decrease, Oxidative phosphorylation ; Increase, Mitochondrial ATP synthase antagonism ; Decrease, Adenosine triphosphate pool ; Increase, Necrosis ; Increase, Ovarian follicle breakdown ; Decrease, Growth ; Increase, Abnormal osmoregulation ; Decrease, ATP synthase activity ; Increase, Tissue/organ damage ; Decrease, Plasma membrane ATPase activity ; Increase, Cell death
- 5/24/2018 6:16:25 PM
- 12/4/2020 8:14:11 PM
Source: https://aopwiki.org/
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Uncoupling of oxidative phosphorylation leading to growth inhibition (3)
Decrease, Mitochondrial ATP production ; Increase, Fatty acid beta-oxidation ; Decrease, Photosynthesis ; Decrease, Glycolysis ; Increase, D1 protein blockage ; Decrease, Photosystem II activity ; Decrease, Growth ; Decrease, Population trajectory ; Decrease, Mitochondrial ATP production ; Increase, Apoptosis ; Decrease, Coupling of oxidative phosphorylation ; Decrease, Photosynthesis ; Decrease, Glycolysis ; Decrease, Oxidative phosphorylation ; Decrease, Adenosine triphosphate pool ; Increase, D1 protein antagonism ; Decrease, Photosystem II activity ; Decrease, Growth ; Increase, Tissue/organ damage ; Increase, Mitochondrial complex III dysfunction ; Increase, Cytochrome c release ; Decrease, Lipid storage
- 5/24/2018 6:46:35 PM
- 12/4/2020 8:46:02 PM
Source: https://aopwiki.org/
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Uncoupling of oxidative phosphorylation leading to growth inhibition (4)
Increase, DNA damage ; Increase, Reactive oxygen species ; Increase, Apoptosis ; Increase, D1 protein blockage ; Decrease, Photosystem II activity ; Decrease, Growth ; Increase, Reactive oxygen species production ; Increase, DNA damage ; Increase, Apoptosis ; Decrease, Coupling of oxidative phosphorylation ; Increase, D1 protein antagonism ; Decrease, Photosystem II activity ; Decrease, Growth ; Increase, Reactive oxygen species ; Increase, Oxidative DNA damage ; Increase, Tissue/organ damage ; Increase, Mitochondrial complex III dysfunction ; Increase, Cell death ; Increase, Oxygen consumption
- 5/24/2018 7:31:11 PM
- 12/4/2020 8:46:54 PM
Source: https://aopwiki.org/
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Uncoupling of oxidative phosphorylation leading to growth inhibition (5)
Increase, Mortality ; Decrease, Mitochondrial ATP production ; Increase, Apoptosis ; Increase, Uncoupling of oxidative phosphorylation ; Increase, Mortality ; Decrease, Mitochondrial ATP production ; Increase, Reactive oxygen species production ; Increase, Apoptosis ; Decrease, Coupling of oxidative phosphorylation ; Decrease, Growth ; Increase, Lipid peroxidation ; Increase, Tissue/organ damage ; Increase, Mitochondrial complex I dysfunction ; Increase, Cell death ; Increase, Oxygen consumption
- 6/12/2018 8:23:10 AM
- 12/4/2020 8:40:00 PM
Source: https://aopwiki.org/
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Uncoupling of oxidative phosphorylation leading to growth inhibition (6)
Decrease, Mitochondrial ATP production ; Decrease, Ovulation ; Decrease, Oogenesis ; Increase, Uncoupling of oxidative phosphorylation ; Decrease, Fecundity ; Decrease, Mitochondrial ATP production ; Increase, Reactive oxygen species production ; Decrease, Ovulation ; Apoptosis ; Decrease, Oogenesis ; Decrease, Fecundity ; Decrease, Coupling of oxidative phosphorylation ; Decrease, Growth ; Increase, Oxidative DNA damage ; Increase, Protein oxidation ; Increase, Tissue/organ damage ; Increase, Mitochondrial complex I dysfunction ; Increase, Cell death ; Increase, Oxygen consumption
- 6/12/2018 8:33:44 AM
- 12/4/2020 8:45:03 PM
Source: https://aopwiki.org/
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unknown MIE leading to renal failure and mortality
Increased Mortality ; Occurrence, renal proximal tubular necrosis ; Increased, blood potassium concentration ; Occurrence, cardiac arrhythmia ; Increased, Oxidative Stress ; Unknown, MIE ; Increased, Reactive oxygen species ; Increased Mortality ; Occurrence, renal proximal tubular necrosis ; Increased, blood potassium concentration ; Occurrence, cardiac arrhythmia ; Increased, Oxidative Stress ; Unknown, MIE ; Increased, Reactive oxygen species
- 11/29/2016 11:41:17 PM
- 2/7/2020 7:54:14 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
Reduction, Plasma 17beta-estradiol concentrations ; Reduction, 17beta-estradiol synthesis by ovarian granulosa cells ; Reduction, Vitellogenin synthesis in liver ; Reduction, Cumulative fecundity and spawning ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Decrease, Population trajectory ; Increased, HIF-1 heterodimer ; Decreased, Aromatase (Cyp19a1) mRNA ; modulation, Unknown ; Increased, HIF-1 alpha transcription ; Reduction, Plasma 17beta-estradiol concentrations ; Reduction, 17beta-estradiol synthesis by ovarian granulosa cells ; Decrease, Population trajectory ; Reduction, Vitellogenin synthesis in liver ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Reduction, Cumulative fecundity and spawning ; Increased, HIF-1 heterodimer ; Decreased, Aromatase (Cyp19a1) mRNA ; modulation, Unknown ; Increased, HIF-1 alpha transcription
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:43:16 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
Activation, Pregnane-X receptor, NR1l2 ; Thyroxine (T4) in neuronal tissue, Decreased ; Thyroxine (T4) in serum, Decreased ; Induction, Upregulation of glucuronyltransferase activity ; Increase, Biliary excretion TH glucuronide ; Hippocampal anatomy, Altered ; Hippocampal Physiology, Altered ; Hippocampal gene expression, Altered ; Loss, Cochlear function ; Activation, Pregnane-X receptor, NR1l2 ; Induction, Upregulation of glucuronyltransferase activity ; Increase, Biliary excretion TH glucuronide ; Thyroxine (T4) in serum, Decreased ; Thyroxine (T4) in neuronal tissue, Decreased ; Hippocampal gene expression, Altered ; Hippocampal anatomy, Altered ; Hippocampal Physiology, Altered ; Loss, Cochlear function
- 11/29/2016 11:41:16 PM
- 6/17/2020 5:45:45 PM
- AOP under development
- 1.9
Source: https://aopwiki.org/
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Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat)
Increase, Urinary bladder calculi ; Increase, Cytotoxicity (urothelial cells) ; Increase, Regenerative cell proliferation (urothelial cells) ; Increase, Hyperplasia (urothelial) ; Increase, Adenomas/carcinomas (urothelial) ; Increase, Urinary bladder calculi ; Increase, Cytotoxicity (urothelial cells) ; Increase, Regenerative cell proliferation (urothelial cells) ; Increase, Hyperplasia (urothelial) ; Increase, Adenomas/carcinomas (urothelial)
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:42:40 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure
Abnormal, Foraging activity and behavior ; Weakened, Colony ; Death/Failure, Colony ; Abnormal, Foraging activity and behavior ; Weakened, Colony ; Death/Failure, Colony
- 11/29/2016 11:41:17 PM
- 2/7/2020 7:52:37 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
Varroa mite infestation increases virus levels leading to colony loss/failure
Weakened, Colony ; Death/Failure, Colony ; Increased, Deformed Wing Virus levels ; Weakened, Colony ; Death/Failure, Colony ; Increased, Deformed Wing Virus levels
- 11/29/2016 11:41:17 PM
- 2/7/2020 7:52:23 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
Vinclozoline case study
Binding to ER ; Nonspecific Protein Binding ; Binding to AR ; Binding to PR ; Binding to GR ; Binding to MR ; ER Transcription Factors ; Upreregulated Gene Transcription in the liver tissue ; Gene expression for Vtg production ; Alteration of Anal fin papillae ; Alteration of Gonadal morphology ; Reduced Growth ; Reduced eggs per female ; Reduced Fertility ; Mixed sex gonads ; Sex reversal ; Delayed adult mail mortality ; Altered sex ratios ; Population reduction
- 10/15/2008 11:30:00 AM
Source: http://www.effectopedia.org/
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Vinclozoline case study
Binding to ER ; Nonspecific Protein Binding ; Binding to AR ; Binding to PR ; Binding to GR ; Binding to MR ; ER Transcription Factors ; Upreregulated Gene Transcription in the liver tissue ; Gene expression for Vtg production ; Alteration of Anal fin papillae ; Alteration of Gonadal morphology ; Reduced Growth ; Reduced eggs per female ; Reduced Fertility ; Mixed sex gonads ; Sex reversal ; Delayed adult mail mortality ; Altered sex ratios ; Population reduction ; Binding to ER ; Nonspecific Protein Binding ; Binding to AR ; Binding to PR ; Binding to GR ; Binding to MR ; ER Transcription Factors ; Upreregulated Gene Transcription in the liver tissue ; Gene expression for Vtg production ; Alteration of Anal fin papillae ; Alteration of Gonadal morphology ; Reduced Growth ; Reduced eggs per female ; Reduced Fertility ; Mixed sex gonads ; Sex reversal ; Delayed adult mail mortality ; Altered sex ratios ; Population reduction
- 10/15/2008 11:30:00 AM
Source: https://www.effectopedia.org/
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Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
TRPA1 activation, TRPA1 Receptor ; TRPV1 activation, TRPV1 ; Activation of oxidative stress pathway ; Opening of calcium channel, Calcium influx ; Trigeminal nerve activation ; SP (Substance P) release, Local increase of SP ; Non-neuronal production of TNF, Epithelial irritation ; Immune system inflammation ; Production of nerve growth factor , Epithelial irritation ; Non-neuronal production of IL-8/CXCL1, Epithelial irritation ; Generation of novel epitopes , Antigen presentation ; Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea ; Increased Respiratory irritability and Chronic Cough, ; Sensitization, Immune system ; Increase, hypertension ; Increased CGRP, neuronal release of CGRP ; Increased neurokinin A (NKA) by neuronal cells ; Irritation of nasal mucosa inducing sneeze reflex ; TRPA1 activation, TRPA1 Receptor ; Opening of calcium channel, Calcium influx ; Trigeminal nerve activation ; SP (Substance P) release, Local increase of SP ; Increased CGRP, neuronal release of CGRP ; Increased neurokinin A (NKA) by neuronal cells ; Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea ; Irritation of nasal mucosa inducing sneeze reflex ; Increased Respiratory irritability and Chronic Cough,
- 11/29/2016 11:41:17 PM
- 11/1/2018 2:33:16 PM
Source: https://aopwiki.org/
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Weak acid respiratory uncoupling leading to death
Interaction with inner mitochondrial membrane & non-covalent perturbation ; Death ; Reduced ATP formation ; Inhibition of ATP-dependent cellular functions ; Reduced ATP-depndent functions ; Heart Failure ; Respiratory Failure ; Increased metabolism ; Population reduction ; Interaction with inner mitochondrial membrane & non-covalent perturbation ; Death ; Reduced ATP formation ; Inhibition of ATP-dependent cellular functions ; Reduced ATP-depndent functions ; Heart Failure ; Respiratory Failure ; Increased metabolism ; Population reduction
- 10/15/2008 11:30:00 AM
Source: https://www.effectopedia.org/
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Weak acid respiratory uncoupling leading to death
Interaction with inner mitochondrial membrane & non-covalent perturbation ; Death ; Reduced ATP formation ; Inhibition of ATP-dependent cellular functions ; Reduced ATP-depndent functions ; Heart Failure ; Respiratory Failure ; Increased metabolism ; Population reduction
- 10/15/2008 11:30:00 AM
Source: http://www.effectopedia.org/
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Weather event contributes abnormal foraging leading to colony loss/failure
Abnormal, Foraging activity and behavior ; Weakened, Colony ; Death/Failure, Colony ; Abnormal, Foraging activity and behavior ; Weakened, Colony ; Death/Failure, Colony
- 11/29/2016 11:41:17 PM
- 2/7/2020 7:53:08 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
Weather event contributes to colony loss/failure
Weakened, Colony ; Death/Failure, Colony ; Weakened, Colony ; Death/Failure, Colony
- 11/29/2016 11:41:17 PM
- 2/7/2020 7:52:55 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity
Inhibition, Inhibition of Dopamine-beta-hydroxylase ; Decreased, Synthesis of NE ; Decreased, GnRH cfos activity ; Decreased, GnRH pulsatility/release ; Decreased, LH Surge ; Delayed, Ovulation ; Decreased, Cortical granule release/distribution upon fertilization ; Altered, Formation of cortical envelope ; Abnormal, Sperm penetration (polyspermy) ; Altered, Chromosome number (polyploid) zygote ; Decreased, Decreased fecundity ; Inhibition, Inhibition of Dopamine-beta-hydroxylase ; Decreased, Synthesis of NE ; Decreased, GnRH cfos activity ; Decreased, GnRH pulsatility/release ; Decreased, LH Surge ; Delayed, Ovulation ; Decreased, Cortical granule release/distribution upon fertilization ; Altered, Formation of cortical envelope ; Abnormal, Sperm penetration (polyspermy) ; Altered, Chromosome number (polyploid) zygote ; Decreased, Decreased fecundity
- 11/29/2016 11:41:16 PM
- 2/7/2020 7:32:55 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
|
α-diketone-induced bronchiolitis obliterans
Increase, Inflammation ; Induction, Epithelial Mesenchymal Transition ; Interaction of α-diketones with arginine residues ; Proteasomal dysfunction ; Airway epithelial injury ; Fibroproliferative airway lesions ; Bronchiolitis obliterans ; Increase, Inflammation ; Induction, Epithelial Mesenchymal Transition ; Interaction of α-diketones with arginine residues ; Proteasomal dysfunction ; Airway epithelial injury ; Fibroproliferative airway lesions ; Bronchiolitis obliterans
- 1/30/2019 2:26:02 PM
- 1/30/2019 3:00:08 PM
Source: https://aopwiki.org/
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