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Binding to Thyroid Peroxidase (TPO) mediated Learning impairment
Binding to Thyroid Peroxidase (TPO) ; Decreased levels of TPO ; Decrease levels of serum T4 and T3 ; Altered TR mediated proteints ; Synaptic malformation and altered function ; Learning impairment
- 10/15/2008 11:30:00 AM
Source: http://www.effectopedia.org/
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Binding to Thyroid Peroxidase (TPO) mediated Learning impairment
Binding to Thyroid Peroxidase (TPO) ; Decreased levels of TPO ; Decrease levels of serum T4 and T3 ; Altered TR mediated proteints ; Synaptic malformation and altered function ; Learning impairment ; Binding to Thyroid Peroxidase (TPO) ; Decreased levels of TPO ; Decrease levels of serum T4 and T3 ; Altered TR mediated proteints ; Synaptic malformation and altered function ; Learning impairment
- 10/15/2008 11:30:00 AM
Source: https://www.effectopedia.org/
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Glutathione conjugation leading to reproductive dysfunction via oxidative stress
Depletion, GSH ; impaired, Fertility ; Increased, Reactive oxygen species ; Increased, Lipid peroxidation ; Conjugation, GSH
- 4/4/2023 5:20:47 PM
- 9/14/2023 1:47:17 PM
Source: https://aopwiki.org/
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Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)
Thyroperoxidase, Inhibition ; Increase, Hypertrophy and proliferation (follicular cell) ; Increase, Hyperplasia (follicular cells) ; Increase, Thyroid-stimulating hormone (TSH) ; Decrease, Serum thyroid hormone (T4/T3) ; Increase, Adenomas/carcinomas (follicular cell) ; Decrease, Incorporation of active iodide into iodotyrosines ; Thyroxine (T4) in serum, Decreased ; Thyroperoxidase, Inhibition ; Thyroid hormone synthesis, Decreased ; Increase, Hypertrophy and proliferation (follicular cell) ; Increase, Hyperplasia (follicular cells) ; Increase, Thyroid-stimulating hormone (TSH) ; Decrease, Serum thyroid hormone (T4/T3) ; Increase, Adenomas/carcinomas (follicular cell) ; Decrease, Incorporation of active iodide into iodotyrosines ; Increased, Thyroid-stimulating hormone (TSH)
- 11/29/2016 11:41:16 PM
- 4/29/2023 8:02:57 PM
- AOP under development
- 1.29
Source: https://aopwiki.org/
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Inhibition of thyroid peroxidase leading to impaired fertility in fish
Reduction, Plasma 17beta-estradiol concentrations ; Reduction, Cumulative fecundity and spawning ; Reduction, Plasma vitellogenin concentrations ; Thyroperoxidase, Inhibition ; Thyroid hormone synthesis, Decreased ; reduction in ovarian granulosa cells, Aromatase (Cyp19a1) ; Reduction, Plasma 17beta-estradiol concentrations ; Reduction, Vitellogenin synthesis in liver ; Reduction, Plasma vitellogenin concentrations ; Reduction, Cumulative fecundity and spawning ; Thyroperoxidase, Inhibition ; Thyroid hormone synthesis, Decreased
- 9/19/2018 12:33:14 AM
- 6/7/2023 9:33:54 AM
Source: https://aopwiki.org/
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Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
Increase, Mortality ; Increased Mortality ; Decrease, Population growth rate ; Increased, Kidney Failure ; Increased, Reactive oxygen species ; Increase, Apoptosis ; Increase, Necrosis ; Oxidation, Glutathione (To be considered with MIE) ; Increased, Lipid peroxidation
- 8/5/2021 5:59:48 PM
- 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
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Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
Up Regulation, SREBF2 ; Up Regulation, Unsaturated fatty acid ; Down Regulation, GSS and GSTs gene ; Glutathione synthesis ; Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene ; Perturbation of cholesterol ; Glutathione homeostasis ; Hepatotoxicity ; Up Regulation, SREBF2 ; Up Regulation, Unsaturated fatty acid ; Down Regulation, GSS and GSTs gene ; Glutathione synthesis ; Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene ; Perturbation of cholesterol ; Glutathione homeostasis ; Hepatotoxicity
- 2/15/2017 8:56:47 AM
- 4/29/2023 8:02:59 PM
Source: https://aopwiki.org/
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Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain
Thyroperoxidase, Inhibition ; Thyroid hormone synthesis, Decreased ; Decrease, Serum thyroid hormone (T4/T3) ; Increase, seizure ; Altered, Thyroid hormone-dependent gene expression ; Brain thyroid hormone (T4/T3) decreased ; Abnormal, neuroblast migration ; Periventricular heterotopia formation
- 6/22/2021 3:22:22 PM
- 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
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