Results

DNA damage and mutations leading to Metastatic Breast Cancer
Increase Chromosomal Aberrations ; Inadequate DNA repair ; Increase, Mutations ; Antagonism, Estrogen receptor ; Induction, Epithelial Mesenchymal Transition ; Increased, DNA damage and mutation ; Increased activation, Nuclear factor kappa B (NF-kB) ; Increased microRNA expression ; Decreased SIRT1 expression ; metastatic breast cancer
  • 3/21/2022 4:52:30 AM
  • 9/26/2023 10:17:10 AM
Source: https://aopwiki.org/
Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
N/A, Neurodegeneration ; Acetylcholinesterase (AchE) Inhibition ; Increased Mortality ; Decreased, Neuronal network function in adult brain ; Activation of Cyp2E1 ; Oxidative Stress in Brain ; Sensory axonal peripheral neuropathy
  • 5/16/2022 11:28:55 PM
  • 4/29/2023 8:03:06 PM
Source: https://aopwiki.org/
Inhibitor binding to topoisomerase II leading to infant leukaemia
Binding to (interferes with) topoisomerase II enzyme ; MLL chromosomal translocation ; Infant leukaemia ; DNA double-strand break ; Binding to (interferes with) topoisomerase II enzyme ; Increase, DNA double-strand breaks ; MLL chromosomal translocation ; Infant leukaemia
  • 12/16/2016 9:38:16 AM
  • 4/29/2023 8:02:59 PM
  • OECD endorsed (WNT and WPHA)
  • 1.53
  • Review Report
Source: https://aopwiki.org/
Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
Decrease, Population growth rate ; Decrease, ATP production ; Decrease, Photosynthesis ; Decrease, Leaf development ; Decrease, Photosystem II efficiency ; Decrease, Reproduction ; Increase, Oxygen-evolving complex damage
  • 4/11/2021 1:26:04 PM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway
N/A, Mitochondrial dysfunction 1 ; Increase, DNA damage ; ROS formation ; ROS generation from photoactivated chemicals ; Apoptotic cell death ; Activation, PARP1 ; Releasing, Apoptosis-Inducing Factor (AIF)
  • 9/14/2021 12:55:17 AM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) ; Increased, valve movement ; Increased, serotonin (5-HT) ; Increased, oocyte maturation ; induced spawning ; Increased, Reproductive Success ; Increase, cilia movement ; Increased, Population ; Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) ; Increased, valve movement ; Increased, serotonin (5-HT) ; Increased, oocyte maturation ; induced spawning ; Increased, Reproductive Success ; Increase, cilia movement ; Increased, Population
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:59 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation
Increased, predation ; Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) ; Increased, serotonin (5-HT) ; Decreased, anxiety ; Decreased, sheltering ; Increased, predation ; Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) ; Increased, serotonin (5-HT) ; Decreased, anxiety ; Decreased, sheltering
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) ; Increased, muscular waves in foot ; Increased, water retention in foot ; Increased, valve movement ; Depletion, energy reserves ; Increased, foot detachment ; Increased, locomotion ; Increased, serotonin (5-HT) ; Increase, predation ; Decline, Population ; Decrease, Population growth rate ; Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) ; Increased, muscular waves in foot ; Increased, water retention in foot ; Increased, valve movement ; Depletion, energy reserves ; Increased, foot detachment ; Increased, locomotion ; Increased, serotonin (5-HT) ; Increase, predation ; Decline, Population
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) ; Increased, valve movement ; Increased, serotonin (5-HT) ; Decline, Population ; Increase, cilia movement ; increased mantel display ; Induced parturition ; Decreased, Reproductive Success ; Decrease, Population growth rate ; Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) ; Increased, valve movement ; Increased, serotonin (5-HT) ; Decline, Population ; Increase, cilia movement ; increased mantel display ; Induced parturition ; Decreased, Reproductive Success
  • 1/13/2017 5:23:22 PM
  • 4/29/2023 8:02:59 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) ; Increased, valve movement ; Increased, serotonin (5-HT) ; Increased, Reproductive Success ; Increase, cilia movement ; Increased, Population ; increased mantel display ; Induced parturition ; Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) ; Increased, valve movement ; Increased, serotonin (5-HT) ; Increased, Reproductive Success ; Increase, cilia movement ; Increased, Population ; increased mantel display ; Induced parturition
  • 1/13/2017 9:19:04 PM
  • 4/29/2023 8:02:59 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring
Decrease, dihydrotestosterone (DHT) level ; Decrease, androgen receptors (AR) activation ; 5α-reductase, inhibition ; decrease, transcription of genes by AR ; decrease, male anogenital distance ; Altered, Transcription of genes by the androgen receptor ; Decrease, dihydrotestosterone (DHT) level ; Decrease, androgen receptor activation ; Inhibition, 5α-reductase ; decrease, transcription of genes by AR ; anogenital distance (AGD), decreased
  • 8/30/2019 8:02:04 AM
  • 4/29/2023 8:03:02 PM
Source: https://aopwiki.org/
A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
Neuroinflammation ; Decrease of neuronal network function ; Oxidative Stress ; Impaired axonial transport ; Mitochondrial dysfunction ; Hyperphosphorylation of Tau ; Dysfunctional Autophagy ; Accumulation, Cytosolic toxic Tau oligomers ; Synaptic dysfunction ; Memory Loss
  • 10/21/2021 10:22:49 AM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure
Death/Failure, Colony ; Abnormal, Roll change within caste ; Reduced, Brood care ; impaired, Larval development ; Death/Failure, Colony ; Abnormal, Roll change within caste ; Reduced, Brood care ; impaired, Larval development
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
Heart failure ; Binding to ACE2 ; Downregulation, ACE2 ; Induced, Angiotensin (Ang) II accumulation ; Hyperactivation of ACE/Ang-II/AT1R axis ; Angiotensin (1-7) levels diminished ; Angiotensin II degradation reduced ; ADAM17 expression induction ; ACE2 increased shedding
  • 10/15/2021 5:54:54 PM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
Acetylcholinesterase inhibition leading to acute mortality
Increased Mortality ; Acetylcholinesterase (AchE) Inhibition ; Acetylcholine accumulation in synapses ; Increased, Atrioventricular block and bradycardia ; Respiratory distress/arrest ; Increased Cholinergic Signaling ; Decreased, Population trajectory ; Decrease, Population trajectory ; Dysregulation of heart rate and vascular tone ; Acetylcholinesterase (AchE) Inhibition ; Acetylcholine accumulation in synapses ; Increased Cholinergic Signaling ; Respiratory distress/arrest ; Dysregulation of heart rate and vascular tone ; Increased Mortality ; Decrease, Population growth rate
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:55 PM
  • AOP under development
  • 1.3
Source: https://aopwiki.org/
Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement​
Increased Mortality ; Acetylcholinesterase (AchE) Inhibition ; Acetylcholine accumulation in synapses ; Increased Cholinergic Signaling ; Decrease, Population trajectory ; Impaired coordination and movement ; Acetylcholinesterase (AchE) Inhibition ; Acetylcholine accumulation in synapses ; Increased Cholinergic Signaling ; Increased Mortality ; Decrease, Population growth rate ; Impaired coordination and movement
  • 12/20/2019 8:55:10 PM
  • 4/29/2023 8:03:02 PM
Source: https://aopwiki.org/
Acetylcholinesterase Inhibition Leading to Neurodegeneration
Occurrence, Epileptic seizure ; N/A, Cell injury/death ; N/A, Neurodegeneration ; Acetylcholinesterase (AchE) Inhibition ; Acetylcholine accumulation in synapses ; Overactivation, NMDARs ; Increased, Intracellular Calcium overload ; Desensitization, Nicotinic acetylcholine receptor ; Increase, intracellular calcium ; Increased, glutamate ; Neurodegeneration ; Activation, Muscarinic Acetylcholine Receptors ; Occurrence, Focal Seizure ; Status epilepticus ; Cell injury/death ; N/A, Neurodegeneration ; Acetylcholinesterase (AchE) Inhibition ; Acetylcholine accumulation in synapses ; Overactivation, NMDARs ; Increased, Intracellular Calcium overload ; Increased, glutamate ; Activation, Muscarinic Acetylcholine Receptors ; Occurrence, Focal Seizure ; Status epilepticus
  • 1/30/2019 5:36:17 PM
  • 9/3/2023 9:47:47 AM
Source: https://aopwiki.org/
AChE binding leading to population reduction
AChE binding ; Seizures ; Death ; Decreased AChE in neurons ; Increased residence time of AChE ; Loss of consciousness ; Headache and fatigue ; Signaling disruption ; Convolutions ; Tremors ; Paralysis ; Population reduction ; AChE binding ; Seizures ; Death ; Decreased AChE in neurons ; Increased residence time of AChE ; Loss of consciousness ; Headache and fatigue ; Signaling disruption ; Convolutions ; Tremors ; Paralysis ; Population reduction
  • 10/15/2008 11:30:00 AM
Source: https://www.effectopedia.org/
AChE binding leading to population reduction
AChE binding ; Seizures ; Death ; Decreased AChE in neurons ; Increased residence time of AChE ; Loss of consciousness ; Headache and fatigue ; Signaling disruption ; Convolutions ; Tremors ; Paralysis ; Population reduction
  • 10/15/2008 11:30:00 AM
Source: http://www.effectopedia.org/
Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
Peptide Oxidation ; Reproductive failure ; Activation, JNK ; Activation, FOXO ; Inhibition, Wnt pathway ; Defect of Embryogenesis ; Peptide Oxidation ; Reproductive failure ; Activation, JNK ; Activation, FOXO ; Inhibition, Wnt pathway ; Defect of Embryogenesis
  • 2/15/2017 9:35:06 AM
  • 4/29/2023 8:02:59 PM
  • EAGMST under review
  • 1.8
Source: https://aopwiki.org/
Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release
Impairment, Learning and memory ; Increase, intracellular calcium ; Disruption, neurotransmitter release ; Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2
  • 6/20/2023 8:18:02 PM
  • 8/23/2023 2:11:22 PM
Source: https://aopwiki.org/
Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
N/A, Neurodegeneration ; Impairment, Learning and memory ; Increased, Reactive oxygen species ; Apoptosis ; Increase, intracellular calcium ; Increase, Mitochondrial Dysfunction ; Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2
  • 6/20/2023 8:29:51 PM
  • 8/23/2023 2:22:07 PM
Source: https://aopwiki.org/
Activation of reactive oxygen species leading the atherosclerosis
  • 7/19/2022 7:38:23 AM
  • 4/29/2023 8:03:06 PM
Source: https://aopwiki.org/
Activation of the AhR leading to breast cancer
Activation, AhR ; Increase, Inflammation ; Increased, Migration (Endothelial Cells) ; Increased, Invasion ; Increased, Motility ; N/A, Breast Cancer ; Apoptosis ; Increase, angiogenesis ; Increased, tumor growth
  • 2/15/2022 8:06:25 PM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation
Increase, Hyperplasia (glandular epithelial cells of endometrium) ; Activation, estrogen receptor alpha ; Genomic instability ; Epigenetic modification process ; Expression of factors ruling proliferation, modified ; Uterine adenocarcinoma (endometrioid adenocarcinoma Type I)
  • 7/27/2023 9:24:54 AM
  • 7/27/2023 10:21:43 AM
Source: https://aopwiki.org/
Adverse outcome pathway of PM-induced respiratory toxicity
Oxidative Stress ; Apoptosis ; Epithelial-mesenchymal transition ; Dysfunctional Autophagy ; Non-coding RNA expression profile alteration ; Activation of inflammation pathway ; Pulmonary inflammation ; Emphysema ; Fibroblast proliferation and differentiation ; Airway remodeling ; Chronic obstructive pulmonary disease
  • 5/31/2022 6:27:45 AM
  • 4/29/2023 8:03:06 PM
Source: https://aopwiki.org/
Adverse outcome pathway on photochemical toxicity initiated by light exposure
Systemic or topycal administration of chemicals ; Distribution and deposition of chemicals to skin and/or eyes ; Absorption of photon energy ; ROS generation from photoactivated chemicals ; Radicals of target chemicals ; Oxidation of membrane lipids ; Oxidation/denatuation of membrane proteins ; Oxidation of DNA ; Formation of DNA photo-adducts ; Formation of protein photo-adducts ; Inflamatory events in light-exposed tissues ; ROS generation from photoactivated chemicals ; Oxidation of membrane lipids ; Oxidation/denatuation of membrane proteins ; Inflamatory events in light-exposed tissues
  • 2/3/2019 5:29:48 AM
  • 4/29/2023 8:03:01 PM
Source: https://aopwiki.org/
Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
Reduction, fetal/adult testosterone ; Damaging, Mitochondria ; Increased apoptosis, decreased fetal/adult Leydig Cells ; Decreased sperm quantity or quality in the adult, Decreased fertility ; Increased, Oxidative Stress ; Activation, estrogen receptor alpha ; Increased, Reactive oxygen species ; Increase, DNA damage ; Apoptosis ; Malformation, cryptorchidism - maldescended testis ; anogenital distance (AGD), decreased ; Antagonism, Androgen receptor ; Decrease, Reproduction ; Increased, glycolipid levels ; Impaired, blood testis barrier ; Disruption, Estrogen receptor ; Depletion, Ectoplasmic specialization (ES)
  • 12/14/2022 2:19:44 AM
  • 5/17/2023 12:59:01 PM
Source: https://aopwiki.org/
AFB1: Mutagenic Mode-of-Action leading to Hepatocellular Carcinoma (HCC)
Formation, Pro-mutagenic DNA Adducts ; Increased, Induced Mutations in Critical Genes ; Metabolism of AFB1, Production of Reactive Electrophiles ; Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) ; Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts ; Tumorigenesis, Hepatocellular carcinoma ; Formation, Pro-mutagenic DNA Adducts ; Increased, Induced Mutations in Critical Genes ; Metabolism of AFB1, Production of Reactive Electrophiles ; Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) ; Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts ; Tumorigenesis, Hepatocellular carcinoma
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • EAGMST under review
  • 2.8
Source: https://aopwiki.org/
AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
Induction, Upregulation of glucuronyltransferase activity ; Thyroxine (T4) in serum, Decreased ; Thyroxine (T4) in neuronal tissue, Decreased ; Hippocampal gene expression, Altered ; Hippocampal Physiology, Altered ; Activation, AhR ; Cognitive Function, Decreased ; Increased, Clearance of thyroxine from serum ; Increase, Glucuronidation of T4
  • 6/30/2022 10:07:58 PM
  • 6/6/2023 2:30:49 PM
Source: https://aopwiki.org/
AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
Thyroxine (T4) in serum, Decreased ; Thyroxine (T4) in neuronal tissue, Decreased ; Hippocampal gene expression, Altered ; Hippocampal Physiology, Altered ; Activation, AhR ; Increase, Reactive oxygen species production ; Thyroid hormone synthesis, Decreased ; Cognitive Function, Decreased ; Induction, CYP1A2/CYP1A5 ; Increase, Oxidative Stress
  • 6/30/2022 10:12:04 PM
  • 6/6/2023 2:32:06 PM
Source: https://aopwiki.org/
AhR activation leading to hepatic steatosis
Activation, AHR ; Up Regulation, CD36 ; Accumulation, Triglyceride ; Accumulation, Fatty acid ; Suppression, VLDL secretion ; Inhibition, Mitochondrial fatty acid beta-oxidation ; Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway) ; Increased, SCD-1 ; Increased, FA Influx ; Up Regulation, LDLR (low density lipoprotein receptor) ; Increased, LDL uptake ; Up Regulation, CYP1A1 ; Accumulation, Liver lipid ; Up Regulation, SCD-1 ; Activation, AhR ; Up Regulation, CD36 ; Accumulation, Triglyceride ; Accumulation, Fatty acid ; Suppression, VLDL secretion ; Inhibition, Mitochondrial fatty acid beta-oxidation ; Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway) ; Increased, FA Influx ; Up Regulation, LDLR (low density lipoprotein receptor) ; Increased, LDL uptake ; Up Regulation, CYP1A1 ; Up Regulation, SCD-1 ; Accumulation, Liver lipid
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
AhR activation leading to liver fibrosis
Cell injury/death ; Activation, AhR ; N/A, Liver Steatosis ; Activation, Stellate cells ; N/A, Liver fibrosis ; Up Regulation, CYP1A1 ; Leukocyte recruitment/activation ; Increased, extracellular matrix deposition ; Increase, Reactive oxygen species
  • 4/13/2023 12:31:32 PM
  • 4/29/2023 8:03:07 PM
Source: https://aopwiki.org/
AhR activation leading to preeclampsia
Activation, AhR ; dimerization, AHR/ARNT ; reduced dimerization, ARNT/HIF1-alpha ; reduced production, VEGF ; abnormal, placental labyrinth vasculature morphology ; increase, placental insufficiency ; increase, Preeclampsia
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:58 PM
  • AOP under development
  • 1.42
Source: https://aopwiki.org/
AKT2 activation leading to hepatic steatosis
Activation, SREBF1 ; Increased, Liver Steatosis ; systemic inflammation leading to hepatic steatosis ; Activation, AKT2 ; Activtation, SREBP-1c ; Increased, Liver Steatosis ; Activation, SREBF1 ; systemic inflammation leading to hepatic steatosis ; Activation, AKT2
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Alcohol dehydrogenase leading to reproductive dysfunction
Increase, Mortality ; Increased, Estrogen receptor (ER) activity ; Increase, Alcohol dehydrogenase ; Increase, Vitellogenin mRNA ; Delay, Ovarian maturation ; Increase, Body volume of female adults ; Increase, sex ratio (F/M) ; Increase, developmental abnormalities
  • 8/29/2022 12:07:22 AM
  • 5/25/2023 7:25:45 AM
Source: https://aopwiki.org/
Alkylation of DNA in male prebiotic germ cells leading to heritable mutations
  • 8/20/2017 5:22:50 PM
Source: https://aopwiki.org/
Alkylation of DNA in male pre-meiotic germ cells leading to heritable mutations
Alkylation, DNA ; Increase, Mutations ; N/A, Inadequate DNA repair ; Increase, Heritable mutations in offspring ; Alkylation, DNA ; Inadequate DNA repair ; Increase, Mutations ; Increase, Heritable mutations in offspring
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:55 PM
  • OECD endorsed (WNT and WPHA)
  • 1.11
  • Review Report
  • i-Library
Source: https://aopwiki.org/
Alkylation of DNA leading to cancer 1
Alkylation, DNA ; Increase, Mutations ; N/A, Inadequate DNA repair ; Increase, Cancer ; Alkylation, DNA ; Inadequate DNA repair ; Increase, Mutations ; Increase, Cancer
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:58 PM
Source: https://aopwiki.org/
Alkylation of DNA leading to reduced sperm count
Alkylation, DNA ; N/A, Inadequate DNA repair ; Increase, Apoptosis ; Increase, DNA strand breaks ; Reduce, Sperm count ; Alkylation, DNA ; Inadequate DNA repair ; Increase, Apoptosis ; Increase, DNA strand breaks ; Reduce, Sperm count
  • 3/31/2020 7:19:28 PM
  • 4/29/2023 8:03:02 PM
Source: https://aopwiki.org/
Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
Increased, Binding of chemicals to 2u (serum) ; Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium) ; Increase, Cytotoxicity (renal tubular cell) ; Increase, Regenerative cell proliferation (tubular epithelial cells) ; Increase, Hyperplasia (renal tubular cells) ; Increase, Adenomas/carcinomas (renal tubular) ; Increased, Binding of chemicals to 2u (serum) ; Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium) ; Increase, Cytotoxicity (renal tubular cell) ; Increase, Regenerative cell proliferation (tubular epithelial cells) ; Increase, Hyperplasia (renal tubular cells) ; Increase, Adenomas/carcinomas (renal tubular)
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Alpha-noradrenergic antagonism leads to reduced fecundity via delayed ovulation
Decreased, GnRH cfos activity ; Decreased, GnRH pulsatility/release ; Decreased, LH Surge ; Delayed, Ovulation ; Decreased, Cortical granule release/distribution upon fertilization ; Altered, Formation of cortical envelope ; Abnormal, Sperm penetration (polyspermy) ; Altered, Chromosome number (polyploid) zygote ; Decreased, Decreased fecundity ; Inhibition, Antgonism of NE receptor ; Decreased, Binding of NE to NE receptors on GnRH neurons ; Decreased, GnRH cfos activity ; Decreased, GnRH pulsatility/release ; Decreased, LH Surge ; Delayed, Ovulation ; Decreased, Cortical granule release/distribution upon fertilization ; Altered, Formation of cortical envelope ; Abnormal, Sperm penetration (polyspermy) ; Altered, Chromosome number (polyploid) zygote ; Decreased, Decreased fecundity ; Inhibition, Antgonism of NE receptor ; Decreased, Binding of NE to NE receptors on GnRH neurons
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Altered ion channel activity leading impaired heart function
Increased Mortality ; impaired, ion channels ; Altered, Action Potential ; Increased, cardiac arrthymia ; Increased Mortality ; impaired, ion channels ; Altered, Action Potential ; Increased, cardiac arrthymia
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
An overview of adverse outcome pathway linked between PM2.5 exposure and congenital heart defects
  • 11/12/2023 1:59:28 PM
  • 11/12/2023 1:59:28 PM
Source: https://aopwiki.org/
Androgen receptor (AR) antagonism leading to decreased fertility in females
Decreased, Transcription of genes by AR ; Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation ; Decreased fertility, Reduced number of oocytes ovulated ; Antagonism, Androgen receptor ; Altered, Transcription of genes by the androgen receptor ; Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation ; Decreased fertility, Reduced number of oocytes ovulated ; Antagonism, Androgen receptor ; Granulosa cell proliferation of gonadotropin-independent follicles, Reduced
  • 5/19/2020 8:32:18 PM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
Androgen receptor (AR) antagonism leading to hypospadias in male offspring
Decrease, androgen receptor activation ; Antagonism, Androgen receptor ; Hypospadias, increased
  • 12/18/2022 3:45:51 PM
  • 4/29/2023 8:03:07 PM
Source: https://aopwiki.org/
Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring
Decreased, Transcription of genes by AR ; Decrease, androgen receptors (AR) activation ; Antagonism, Androgen receptor ; increase, retained nipples in males ; Altered, Transcription of genes by the androgen receptor ; Decrease, androgen receptor activation ; Antagonism, Androgen receptor ; Nipple retention (NR), increased
  • 5/11/2020 2:14:48 PM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring
Decrease, androgen receptors (AR) activation ; decrease, transcription of genes by AR ; decrease, male anogenital distance ; Antagonism, Androgen receptor ; Decrease, androgen receptor activation ; decrease, transcription of genes by AR ; anogenital distance (AGD), decreased ; Antagonism, Androgen receptor
  • 8/30/2019 8:27:36 AM
  • 4/29/2023 8:03:02 PM
Source: https://aopwiki.org/
Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat)
Increase, Mitogenic cell proliferation (hepatocytes) ; Increase, Adenomas/carcinomas (hepatocellular) ; Increase, Preneoplastic foci (hepatocytes) ; Activation, Androgen receptor ; Increase, cell proliferation (hepatocytes) ; Increase, hepatocellular adenomas and carcinomas ; Increase, Preneoplastic foci (hepatocytes) ; Activation, Androgen receptor
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.26
Source: https://aopwiki.org/
Androgen receptor activation leading to prostate cancer
Altered, Transcription of genes by the androgen receptor ; Alterations, Cellular proliferation / hyperplasia ; Activation, Androgen receptor ; Decreased, Apoptosis (Epithelial Cells) ; Increased, Invasion ; Inflamatory events in light-exposed tissues ; Increase, Androgen receptor ; prostatic intraepithelial neoplasia ; Prostate cancer
  • 5/11/2023 3:10:36 PM
  • 5/11/2023 3:42:34 PM
Source: https://aopwiki.org/
Androgen receptor agonism leading to male-biased sex ratio
Decrease, Population growth rate ; Agonism, Androgen receptor ; Reduction, 17beta-estradiol synthesis by the undifferentiated gonad ; Increased, Differentiation to Testis ; Increased, Male Biased Sex Ratio
  • 3/10/2021 2:35:37 PM
  • 10/17/2023 8:52:10 AM
Source: https://aopwiki.org/
Androgen receptor agonism leading to reproduction dysfunction (in zebrafish)
Reduction, Plasma 17beta-estradiol concentrations ; Agonism, Androgen receptor ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Reduction, Cumulative fecundity and spawning ; Decreased, Population trajectory ; Increase, Gonadotropins concentration in plasma ; Reduction,Testosterone concentration in plasma ; Reduction, the ratio of 17beta-estradiol/11-Keto Testosterone in plasma ; Decreased spawning and cumulative fecundity, decreased gonadosomatic index ; Increased, gene expression of AR
  • 5/17/2023 1:08:20 AM
  • 5/23/2023 9:13:53 AM
Source: https://aopwiki.org/
Androgen receptor agonism leading to reproductive dysfunction
Androgen receptor, agonism ; Gonadotropins, circulating concentrations, reduction ; Testosterone synthesis by ovarian theca cells, reduction ; 17beta-estradiol synthesis by ovarian granulosa cells, reduction ; Androgen receptor, agonism ; Gonadotropins, circulating concentrations, reduction ; Testosterone synthesis by ovarian theca cells, reduction ; 17beta-estradiol synthesis by ovarian granulosa cells, reduction
  • 4/18/2015 2:24:17 PM
Source: https://www.effectopedia.org/
Androgen receptor agonism leading to reproductive dysfunction
Androgen receptor, agonism ; Gonadotropins, circulating concentrations, reduction ; Testosterone synthesis by ovarian theca cells, reduction ; 17beta-estradiol synthesis by ovarian granulosa cells, reduction
  • 4/18/2015 2:24:17 PM
Source: http://www.effectopedia.org/
Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
Reduction, Plasma 17beta-estradiol concentrations ; Reduction, 17beta-estradiol synthesis by ovarian granulosa cells ; Agonism, Androgen receptor ; Reduction, Testosterone synthesis by ovarian theca cells ; Reduction, Vitellogenin synthesis in liver ; Reduction, Cumulative fecundity and spawning ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Reduction, Gonadotropins, circulating concentrations ; Decrease, Population trajectory ; Reduction, Plasma 17beta-estradiol concentrations ; Reduction, 17beta-estradiol synthesis by ovarian granulosa cells ; Decrease, Population growth rate ; Agonism, Androgen receptor ; Reduction, Gonadotropins, circulating concentrations ; Reduction, Testosterone synthesis by ovarian theca cells ; Reduction, Vitellogenin synthesis in liver ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Reduction, Cumulative fecundity and spawning
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:55 PM
  • OECD endorsed (WNT and WPHA)
  • 1.12
  • Review Report
  • i-Library
Source: https://aopwiki.org/
Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
N/A, Androgen receptor, Antagonism ; Alteration, Wnt pathway ; Feminisation or incomplete development, Primary and accessory male sex organs ; Decreased, Transcription of genes by AR ; N/A, Impairment of reproductive capacity ; N/A, Androgen receptor, Antagonism ; Alteration, Wnt pathway ; Feminisation or incomplete development, Primary and accessory male sex organs ; Altered, Transcription of genes by the androgen receptor ; N/A, Impairment of reproductive capacity
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:55 PM
Source: https://aopwiki.org/
Androgen receptor antagonism leading to testicular cancer
Decrease, androgen receptor activation ; Malformation, cryptorchidism - maldescended testis ; decrease, transcription of genes by AR ; Antagonism, Androgen receptor ; Testicular Cancer
  • 2/12/2021 5:12:19 PM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis
Accumulation, Collagen ; Increased, secretion of proinflammatory mediators ; Increased, Reactive oxygen species ; Lung fibrosis ; Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R) ; Increased activation, Nuclear factor kappa B (NF-kB)
  • 3/30/2021 4:00:28 PM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
Antagonism of Smoothened receptor leading to orofacial clefting
Apoptosis ; Increase, Apoptosis ; Decrease, Cell proliferation ; Antagonism, Smoothened receptor ; Decrease, GLI1/2 translocation to nucleus ; Decrease, GLI1/2 target gene expression ; Decrease, palatal shelf outgrowth ; Orofacial clefting ; Decrease, Sonic Hedgehog second messenger production ; Decrease, Smoothend relocation and activation
  • 7/13/2022 7:09:57 PM
  • 11/14/2023 6:47:12 PM
Source: https://aopwiki.org/
Antagonism of the androgen receptor
Antagonism of the androgen receptor ; Decrease in transcription of androgen dependent genes ; Repression of Wnt signalling ; Alteration of cell proliferation and differentiation of androgen dependent organs ; Developmental toxicity by antagonism of the androgen receptor ; Antagonism of the androgen receptor ; Decrease in transcription of androgen dependent genes ; Repression of Wnt signalling ; Alteration of cell proliferation and differentiation of androgen dependent organs ; Developmental toxicity by antagonism of the androgen receptor
  • 4/11/2010 10:00:00 AM
Source: https://www.effectopedia.org/
Antagonism of the androgen receptor
Antagonism of the androgen receptor ; Decrease in transcription of androgen dependent genes ; Repression of Wnt signalling ; Alteration of cell proliferation and differentiation of androgen dependent organs ; Developmental toxicity by antagonism of the androgen receptor
  • 4/11/2010 10:00:00 AM
Source: http://www.effectopedia.org/
Antagonist binding to PPARα leading to body-weight loss
Binding of antagonist, PPAR alpha ; Decreased, PPARalpha transactivation of gene expression ; Decreased, Mitochondrial Fatty Acid Beta Oxidation ; Decreased, Ketogenesis (production of ketone bodies) ; Not Increased, Circulating Ketone Bodies ; Decreased, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids ; Increased, Catabolism of Muscle Protein ; stabilization, PPAR alpha co-repressor ; Decreased, Body Weight ; Fatty Acid Beta Oxidation, Decreased ; Binding of antagonist, PPAR alpha ; stabilization, PPAR alpha co-repressor ; Decreased, PPARalpha transactivation of gene expression ; Fatty Acid Beta Oxidation, Decreased ; Decreased, Ketogenesis (production of ketone bodies) ; Not Increased, Circulating Ketone Bodies ; Increased, Catabolism of Muscle Protein ; Decreased, Body Weight
  • 11/29/2016 11:41:15 PM
  • 4/29/2023 8:02:54 PM
  • OECD endorsed (WNT and WPHA)
  • 2.3
  • Review Report
  • i-Library
Source: https://aopwiki.org/
Anticoagulant rodenticide inhibition of vitamin K epoxide reductase resulting coagulopathy and hemorrhage
Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone ; Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP ; Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin ; Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failure of secondary hemostasis ; Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage) ; Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin) ; Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal ; Hemostasis, Depletion from blood of fully functional carboxylated clotting factors ; Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction ; Osteoporosis and vascular calcification, Bone deterioration ; Impaired recruitment , Population trajectory ; Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone ; Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP ; Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin ; Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failure of secondary hemostasis ; Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage) ; Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin) ; Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal ; Hemostasis, Depletion from blood of fully functional carboxylated clotting factors ; Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction ; Osteoporosis and vascular calcification, Bone deterioration ; Impaired recruitment , Population trajectory
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:59 PM
  • AOP under development
  • 1.31
Source: https://aopwiki.org/
Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
Increased, latency period ; Increased, Adenomas/carcinomas (mammary) ; Decreased, Dopaminergic activity ; Increased, prolactin secretion ; Increased, hyperplasia (mammary gland) ; Increased, latency period ; Increased, Adenomas/carcinomas (mammary) ; Decreased, Dopaminergic activity ; Increased, prolactin secretion ; Increased, hyperplasia (mammary gland)
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:58 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse
Decreased, Ovarian E2 ; Suppression, Estrogen receptor (ER) activity ; Increased, secretion of GnRH from hypothalamus ; Increased, secrection of FSH from anterior pituitary ; Increased, secretion of LH from anterior pituitary ; Hyperplasia, ovarian stromal cells ; Hyperplasia, ovarian epithelium ; Decrease, E2 blood concentrations at hypothalamus ; Promotion, ovarian adenomas ; Promotion, ovarian granular cell tumors ; Decreased, Ovarian E2 ; Suppression, Estrogen receptor (ER) activity ; Increased, secretion of GnRH from hypothalamus ; Increased, secrection of FSH from anterior pituitary ; Increased, secretion of LH from anterior pituitary ; Hyperplasia, ovarian stromal cells ; Hyperplasia, ovarian epithelium ; Decrease, E2 blood concentrations at hypothalamus ; Promotion, ovarian adenomas ; Promotion, ovarian granular cell tumors
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:58 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation
Increase cell proliferation ; Increased, Hepatic thyroid hormone uptake/transport ; Apoptosis ; Cell cycle, disrupted ; Altered, Thyroid hormone-dependent gene expression ; systemic inflammatory response syndrome
  • 4/22/2021 1:08:37 AM
  • 5/26/2023 7:22:45 AM
Source: https://aopwiki.org/
AOP for urothelial carcinogenesis due to chemical cytotoxicity by mitochondrial impairment
Increase, Regenerative cell proliferation (urothelial cells) ; Increase, Hyperplasia (urothelial) ; Mitochondrial impairment ; Urothelial cell injury/death ; Urothelial Tumor ; Increase, Regenerative cell proliferation (urothelial cells) ; Increase, Hyperplasia (urothelial) ; Mitochondrial impairment ; Urothelial cell injury/death ; Urothelial Tumor
  • 4/21/2020 8:26:59 PM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
AOP from chemical insult to cell death
Decompartmentalization ; Direct mitochondrial inhibition ; narcosis ; Mitochondrial impairment ; Apoptosis ; Necrosis ; Decompartmentalization ; Direct mitochondrial inhibition ; narcosis ; Mitochondrial impairment ; Apoptosis ; Necrosis
  • 2/6/2017 7:58:57 PM
  • 4/29/2023 8:02:59 PM
Source: https://aopwiki.org/
AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
Oxidative Stress ; Pulmonary fibrosis ; Activation, Fibroblasts ; Activation, Macrophages ; Increase, Reactive oxygen species ; Airway epithelial injury ; Mitochondrial dysfunction ; Pulmonary inflammation ; Pulmonary epithelial injury ; Airway inflammation ; Increased incidence of respiratory disease ; Dysfunction of respiratory system
  • 1/9/2023 4:14:58 PM
  • 4/29/2023 8:03:07 PM
Source: https://aopwiki.org/
Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female
reduction in ovarian granulosa cells, Aromatase (Cyp19a1) ; Reduction, Plasma 17beta-estradiol concentrations ; Reduction, 17beta-estradiol synthesis by ovarian granulosa cells ; impaired, Fertility ; irregularities, ovarian cycle ; reduction in ovarian granulosa cells, Aromatase (Cyp19a1) ; Reduction, Plasma 17beta-estradiol concentrations ; Reduction, 17beta-estradiol synthesis by ovarian granulosa cells ; impaired, Fertility ; irregularities, ovarian cycle
  • 11/29/2016 11:41:15 PM
  • 4/29/2023 8:02:54 PM
  • EAGMST under review
  • 1.21
Source: https://aopwiki.org/
Aromatase inhibition
Inhibition of the aromatase enzyme ; Decrease in conversion of testosterone to oestradiol ; Decrease in transcription of oestrogen receptor genes ; Developmental toxicity by inhibition of the aromatase enzyme with letrozole
  • 4/11/2010 10:00:00 AM
Source: http://www.effectopedia.org/
Aromatase inhibition
Inhibition of the aromatase enzyme ; Decrease in conversion of testosterone to oestradiol ; Decrease in transcription of oestrogen receptor genes ; Developmental toxicity by inhibition of the aromatase enzyme with letrozole ; Inhibition of the aromatase enzyme ; Decrease in conversion of testosterone to oestradiol ; Decrease in transcription of oestrogen receptor genes ; Developmental toxicity by inhibition of the aromatase enzyme with letrozole
  • 4/11/2010 10:00:00 AM
Source: https://www.effectopedia.org/
Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats
Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol ; reduction in ovarian granulosa cells synthesis of estradiol, Reduced steroidogenic production of estradiol in granulosa cells ; Reduced Estradiol in Circulation, Reduced steroidogenic production of estradiol in granulosa cells leading to decreased estradiol in circulation ; Decreased positive estrogenic feedback on hypothalamus, Reduced estradiol in circulation decreases estrogen concentration at hypothalamus ; Decreased Kisspeptin release from neurons in AVPV, Decreased hypothalamic estrogen reduces kisspeptinergic neuron response ; Decreased GnRH Release, Decreased Kisspeptin stimulation of GnRH neurons ; Decreased LH release from Anterior Pituitary, Decreased GnRH stimulation of Anterior Pituitary Gonadotrophs ; Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation ; Decreased fertility, Reduced number of oocytes ovulated ; Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol ; reduction in ovarian granulosa cells synthesis of estradiol, Reduced steroidogenic production of estradiol in granulosa cells ; Reduced Estradiol in Circulation, Reduced steroidogenic production of estradiol in granulosa cells leading to decreased estradiol in circulation ; Decreased positive estrogenic feedback on hypothalamus, Reduced estradiol in circulation decreases estrogen concentration at hypothalamus ; Decreased Kisspeptin release from neurons in AVPV, Decreased hypothalamic estrogen reduces kisspeptinergic neuron response ; Decreased GnRH Release, Decreased Kisspeptin stimulation of GnRH neurons ; Decreased LH release from Anterior Pituitary, Decreased GnRH stimulation of Anterior Pituitary Gonadotrophs ; Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation ; Decreased fertility, Reduced number of oocytes ovulated
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:58 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Aromatase inhibition leading to reproductive dysfunction
Reduction, Plasma 17beta-estradiol concentrations ; Reduction, 17beta-estradiol synthesis by ovarian granulosa cells ; Reduction, Vitellogenin synthesis in liver ; Reduction, Cumulative fecundity and spawning ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Decrease, Population trajectory ; Inhibition, Aromatase ; Reduction, Plasma 17beta-estradiol concentrations ; Reduction, 17beta-estradiol synthesis by ovarian granulosa cells ; Decrease, Population growth rate ; Reduction, Vitellogenin synthesis in liver ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Reduction, Cumulative fecundity and spawning ; Inhibition, Aromatase
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:55 PM
  • OECD endorsed (WNT and WPHA)
  • 1.12
  • Review Report
  • i-Library
Source: https://aopwiki.org/
Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
Decrease, Population trajectory ; Inhibition, Aromatase ; Reduction, 17beta-estradiol synthesis by the undifferentiated gonad ; Increased, Differentiation to Testis ; Increased, Male Biased Sex Ratio ; Decrease, Population growth rate ; Inhibition, Aromatase ; Reduction, 17beta-estradiol synthesis by the undifferentiated gonad ; Increased, Differentiation to Testis ; Increased, Male Biased Sex Ratio
  • 6/15/2020 1:54:44 PM
  • 10/17/2023 8:51:27 AM
Source: https://aopwiki.org/
Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced cardiovascular toxicity
Activation, AhR ; dimerization, AHR/ARNT ; Altered, Cardiovascular development/function ; Increase, Early Life Stage Mortality ; Increase, slincR expression ; Decrease, sox9 expression
  • 6/28/2022 6:54:26 PM
  • 6/16/2023 4:57:37 PM
Source: https://aopwiki.org/
Aryl hydrocarbon receptor activation leading to early life stage mortality via sox9 repression induced impeded craniofacial development
Activation, AhR ; dimerization, AHR/ARNT ; Increase, Early Life Stage Mortality ; Facial cartilage structures are reduced in size and morphologically distorted ; Increase, slincR expression ; Decrease, sox9 expression
  • 6/28/2022 5:22:12 PM
  • 6/16/2023 4:57:03 PM
Source: https://aopwiki.org/
Aryl hydrocarbon receptor activation leading to early life stage mortality, via increased COX-2
Increased Mortality ; Decreased, Population trajectory ; Activation, AHR ; dimerization, AHR/ARNT ; Increase, COX-2 expression ; Altered, Cardiovascular development/function ; Increase, Mortality ; Increase, Early Life Stage Mortality ; Activation, AhR ; dimerization, AHR/ARNT ; Increase, COX-2 expression ; Altered, Cardiovascular development/function ; Increase, Early Life Stage Mortality
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:55 PM
  • OECD endorsed (WNT and WPHA)
  • 1.27
  • Review Report
  • i-Library
Source: https://aopwiki.org/
Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
Activation, AHR ; dimerization, AHR/ARNT ; Altered, Cardiovascular development/function ; Impairment, Endothelial network ; reduced dimerization, ARNT/HIF1-alpha ; Increase, Pericardial edema ; reduced production, VEGF ; Increase, Early Life Stage Mortality ; Activation, AhR ; dimerization, AHR/ARNT ; Altered, Cardiovascular development/function ; Increase, Early Life Stage Mortality ; Impairment, Endothelial network ; reduced dimerization, ARNT/HIF1-alpha ; reduced production, VEGF
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:58 PM
  • OECD endorsed (WNT and WPHA)
  • 1.7
  • Review Report
  • i-Library
Source: https://aopwiki.org/
Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway
Activation, AhR ; Decrease, Lung function ; Increased, Reactive oxygen species ; Increase, Cell death ; Altered gene expression, AHR nuclear translocator (ARNT)-dependent pathway
  • 8/14/2021 5:58:13 AM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway
Activation, AhR ; Decrease, Lung function ; Apoptosis ; Altered gene expression, P53 dependent apoptosis pathway
  • 8/14/2021 6:00:31 AM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
Aryl hydrocarbon receptor activation leading to lung cancer through AHR-ARNT toxicity pathway
Activation, AhR ; Increased, DNA damage and mutation ; Lung cancer ; Altered gene expression, AHR nuclear translocator (ARNT)-dependent pathway ; Increased, Reactive metabolites production
  • 8/14/2021 5:57:36 AM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
Aryl hydrocarbon receptor activation leading to lung cancer through IL-6 toxicity pathway
Activation, AhR ; Increased, Reactive oxygen species ; Increased, DNA damage and mutation ; Lung cancer ; Altered gene expression, NF-kB dependent Interleukin-6 pathway ; Increased, Interleukin-6 production
  • 8/14/2021 5:50:20 AM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
Aryl hydrocarbon receptor activation leading to lung cancer through sustained NRF2 toxicity pathway
Activation, AhR ; Increase, Cell Proliferation ; Lung cancer ; Altered gene expression, NRF2 dependent antioxidant pathway
  • 8/14/2021 6:01:32 AM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway
Activation, AhR ; Increased, extracellular matrix deposition ; Induction, Epithelial Mesenchymal Transition ; Lung fibrosis ; Altered gene expression, NF-kB dependent Interleukin-6 pathway
  • 8/14/2021 5:25:23 AM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway
Activation, AhR ; Increase, Inflammation ; Increased, extracellular matrix deposition ; Activation of TGF-β signaling ; Induction, Epithelial Mesenchymal Transition ; Lung fibrosis ; Altered gene expression, TGF-β dependent fibrosis pathway
  • 8/14/2021 4:03:18 AM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
Aryl hydrocarbon receptor activation leading to uroporphyria
Activation, AHR ; Oxidation, Uroporphyrinogen ; Inhibition, UROD ; Accumulation, Highly carboxylated porphyrins ; Induction, CYP1A2/CYP1A5 ; Uroporphyria ; Activation, AhR ; Induction, CYP1A2/CYP1A5 ; Oxidation, Uroporphyrinogen ; Inhibition, UROD ; Accumulation, Highly carboxylated porphyrins ; Uroporphyria
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • OECD endorsed (WNT and WPHA)
  • 1.7
  • Review Report
  • i-Library
Source: https://aopwiki.org/
Axonal sodium channel modulation leading to acute mortality
Increased Mortality ; modulation, sodium channel ; prolonged, Depolarization of neuronal membrane ; Overactivation, Neuronotransmitter release ; Overactivation, muscle contraction ; Increased, Ataxia, paralysis, or hyperactivity ; Increased Mortality ; modulation, sodium channel ; prolonged, Depolarization of neuronal membrane ; Overactivation, Neuronotransmitter release ; Overactivation, muscle contraction ; Increased, Ataxia, paralysis, or hyperactivity
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Beta-2 adrenergic agonist activity leading to mesovarian leiomyomas in the rat and mouse
Activation, beta-2 adrenergic receptor ; Increased activity, beta-2 adrenergic receptor ; relaxation, smooth muscle ; Proliferation/Clonal Expansion, smooth muscle ; Hypertrophy/hyperplasia, smooth muscle ; Promotion, mesovarian leiomyomas ; Activation, beta-2 adrenergic receptor ; Increased activity, beta-2 adrenergic receptor ; relaxation, smooth muscle ; Proliferation/Clonal Expansion, smooth muscle ; Hypertrophy/hyperplasia, smooth muscle ; Promotion, mesovarian leiomyomas
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:58 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment.
N/A, Mitochondrial dysfunction 1 ; N/A, Neuroinflammation ; N/A, Cell injury/death ; N/A, Neurodegeneration ; Impairment, Learning and memory ; Binding of agonist, Ionotropic glutamate receptors ; Overactivation, NMDARs ; Increased, Intracellular Calcium overload ; Decreased, Neuronal network function in adult brain ; N/A, Mitochondrial dysfunction 1 ; Neuroinflammation ; Cell injury/death ; N/A, Neurodegeneration ; Impairment, Learning and memory ; Binding of agonist, Ionotropic glutamate receptors ; Overactivation, NMDARs ; Increased, Intracellular Calcium overload ; Decreased, Neuronal network function in adult brain
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • OECD endorsed (WNT and WPHA)
  • 1.23
  • Review Report
  • i-Library
Source: https://aopwiki.org/
Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
Impairment, Learning and memory ; Decrease of neuronal network function ; Binding of agonist, Ionotropic glutamate receptors ; Overactivation, NMDARs ; Increased, Intracellular Calcium overload ; Synaptic dysfunction ; Loss of drebrin
  • 12/12/2022 2:00:02 AM
  • 10/19/2023 12:01:19 AM
Source: https://aopwiki.org/
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
N/A, Mitochondrial dysfunction 1 ; N/A, Neuroinflammation ; N/A, Cell injury/death ; N/A, Neurodegeneration ; Impairment, Learning and memory ; Decrease of neuronal network function ; Binding, SH-/selen-proteins ; N/A, Interferences with SH-/selen-proteins ; Depletion, GSH ; N/A, Oxidative stress ; Neuronal dysfunction ; Oxidative Stress ; Binding, Thiol/seleno-proteins involved in protection against oxidative stress ; Glutamate dyshomeostasis ; Tissue resident cell activation ; Increased Pro-inflammatory mediators ; Decreased protection against oxidative stress ; Neuroinflammation ; Cell injury/death ; Impairment, Learning and memory ; Decrease of neuronal network function ; Binding, Thiol/seleno-proteins involved in protection against oxidative stress ; Decreased protection against oxidative stress ; Oxidative Stress ; Glutamate dyshomeostasis ; Tissue resident cell activation ; Increased Pro-inflammatory mediators
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:55 PM
  • EAGMST approved
  • 1.13
  • Review Report
Source: https://aopwiki.org/
Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease
Disruption, Mitochondrial electron transport chain ; Increase, Cytotoxicity ; Oxidation, Glutathione (To be considered with MIE) ; Oxidative Stress ; Binding, Thiol/seleno-proteins involved in protection against oxidative stress ; Decreased protection against oxidative stress ; Chronic kidney disease ; Binding, Thiol/seleno-proteins involved in protection against oxidative stress ; Decreased protection against oxidative stress ; Oxidative Stress ; Disruption, Mitochondrial electron transport chain ; Increase, Cytotoxicity ; Oxidation, Glutathione (To be considered with MIE) ; Chronic kidney disease
  • 2/18/2019 2:42:55 PM
  • 4/29/2023 8:03:01 PM
Source: https://aopwiki.org/
Binding of Influenza A Virus (IAV) to Sialic Acid Glycan Receptor leads to viral infection proliferation
Influenza A Virus (IAV) binds sialic acid glycan receptor ; Influenza A virus (IAV) cell entry ; Influenza A Virus production increased ; Immune mechanisms antagonized by viral proteins ; Influenza A Virus (IAV) budding ; Influenza A Virus (IAV) shedding and transmission
  • 7/31/2023 5:32:46 PM
  • 10/3/2023 1:59:19 PM
Source: https://aopwiki.org/
Binding of nicotine to nicotinic receptors leading to adverse development
Binding of nicotine to nicotinic receptors alpha4Beta2 and alpha7 (agonism) ; Activation of Voltage operated calcium channels (pre-synaptic) and direct depolarisation (post-synaptic) ; Alteration of neurotrasmitter release such as dopamine, norepinephrine, serotonin ; Apoptosis ; Nicotine exposure developmental outcome ; Binding of nicotine to nicotinic receptors alpha4Beta2 and alpha7 (agonism) ; Activation of Voltage operated calcium channels (pre-synaptic) and direct depolarisation (post-synaptic) ; Alteration of neurotrasmitter release such as dopamine, norepinephrine, serotonin ; Apoptosis ; Nicotine exposure developmental outcome
  • 4/11/2010 10:00:00 AM
Source: https://www.effectopedia.org/
Binding of nicotine to nicotinic receptors leading to adverse development
Binding of nicotine to nicotinic receptors alpha4Beta2 and alpha7 (agonism) ; Activation of Voltage operated calcium channels (pre-synaptic) and direct depolarisation (post-synaptic) ; Alteration of neurotrasmitter release such as dopamine, norepinephrine, serotonin ; Apoptosis ; Nicotine exposure developmental outcome ; Binding of nicotine to nicotinic receptors alpha4Beta2 and alpha7 (agonism) ; Activation of Voltage operated calcium channels (pre-synaptic) and direct depolarisation (post-synaptic) ; Alteration of neurotrasmitter release such as dopamine, norepinephrine, serotonin ; Apoptosis ; Nicotine exposure developmental outcome
  • 4/11/2010 10:00:00 AM
Source: https://www.effectopedia.org/
Binding of nicotine to nicotinic receptors leading to adverse development
Binding of nicotine to nicotinic receptors alpha4Beta2 and alpha7 (agonism) ; Activation of Voltage operated calcium channels (pre-synaptic) and direct depolarisation (post-synaptic) ; Alteration of neurotrasmitter release such as dopamine, norepinephrine, serotonin ; Apoptosis ; Nicotine exposure developmental outcome
  • 4/11/2010 10:00:00 AM
Source: http://www.effectopedia.org/
Binding of nicotine to nicotinic receptors leading to adverse development
Binding of nicotine to nicotinic receptors alpha4Beta2 and alpha7 (agonism) ; Activation of Voltage operated calcium channels (pre-synaptic) and direct depolarisation (post-synaptic) ; Alteration of neurotrasmitter release such as dopamine, norepinephrine, serotonin ; Apoptosis ; Nicotine exposure developmental outcome
  • 4/11/2010 10:00:00 AM
Source: http://www.effectopedia.org/
Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis
Neuroinflammation ; N/A, Neurodegeneration ; Binding to ACE2 ; Encephalitis
  • 2/23/2021 9:11:26 AM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke)
Binding to ACE2 ; SARS-CoV-2 cell entry ; Thrombosis and Disseminated Intravascular Coagulation ; blood brain barrier disruption ; Cerebrovascular disease (stroke)
  • 4/27/2021 5:41:53 PM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption
Increased, recruitment of inflammatory cells ; Binding to ACE2 ; SARS-CoV-2 cell entry ; Increase, Cell death ; Increased SARS-CoV-2 production ; Intestinal barrier, disruption ; Gastrointestinal disorders ; Interferon-I antiviral response, antagonized by SARS-CoV-2 ; Gut microbiota, alteration
  • 9/13/2021 6:52:15 AM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
Increased, secretion of proinflammatory mediators ; Increased, recruitment of inflammatory cells ; Binding to ACE2 ; SARS-CoV-2 cell entry ; Increase, the risk of acute respiratory failure ; Increase, Cell death ; Increased SARS-CoV-2 production ; Hyperinflammation ; Interferon-I antiviral response, antagonized by SARS-CoV-2
  • 9/1/2022 7:39:14 AM
  • 4/29/2023 8:03:07 PM
Source: https://aopwiki.org/
Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation
Binding to ACE2 ; SARS-CoV-2 cell entry ; Increased SARS-CoV-2 production ; Interferon-I antiviral response, antagonized by SARS-CoV-2 ; Viral infection and host-to-host transmission, proliferated
  • 10/24/2021 8:58:05 PM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality
Increased Mortality ; Increased, secretion of proinflammatory and profibrotic mediators ; Binding of S protein to ACE receptor ; Enhanced viral entry and gene expression ; Increase inflammatory immune responses ; Increase, the risk of acute respiratory failure ; Increased Mortality ; Increased, secretion of proinflammatory mediators ; Binding to ACE2 ; SARS-CoV-2 cell entry ; Increased inflammatory immune responses ; Increase, the risk of acute respiratory failure ; Toll Like Receptor (TLR) Dysregulation ; Increased SARS-CoV-2 production ; Increased viral transcription and replication ; Interferon-I antiviral response, antagonized by SARS-CoV-2
  • 3/1/2020 3:04:20 PM
  • 4/29/2023 8:03:02 PM
Source: https://aopwiki.org/
Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis
Increased, recruitment of inflammatory cells ; Binding to ACE2 ; Dysregulation, ACE2 expression and activity ; Intestinal barrier, disruption ; Gastrointestinal disorders ; Gut microbiota, alteration
  • 10/19/2021 5:52:33 PM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia
Increased, secretion of proinflammatory mediators ; Induced dysregulation of ACE2 ; Increased Angiotensin II ; Binding to ACE2 ; Impaired gustatory nerve ; dysgeusia ; Downregulation, ACE2 ; Imbalanced salty and sweet taste responses
  • 3/28/2021 1:51:50 PM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
Binding to ACE2 leading to lung fibrosis
Accumulation, Collagen ; Lung fibrosis ; ACE2 inhibition ; Increases AngII ; Increase plasma Ang II ; Accumulation, Collagen ; Increased, secretion of proinflammatory mediators ; Increased, Reactive oxygen species ; Lung fibrosis ; Induced dysregulation of ACE2 ; Increased Angiotensin II ; Increase plasma Ang II ; Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R) ; Increased activation, Nuclear factor kappa B (NF-kB) ; Dysregulation, ACE2 expression and activity
  • 3/1/2020 1:07:54 PM
  • 4/29/2023 8:03:02 PM
Source: https://aopwiki.org/
Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation
Oxidative Stress ; Binding to ACE2 ; SARS-CoV-2 cell entry ; Increased SARS-CoV-2 production ; Coagulation ; Thrombosis and Disseminated Intravascular Coagulation ; Diminished protective oxidative stress response ; Interferon-I antiviral response, antagonized by SARS-CoV-2
  • 3/25/2021 11:30:46 PM
  • 11/21/2023 2:16:40 AM
Source: https://aopwiki.org/
Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
Activation of estrogen receptor in immune cells ; Induction of GATA3 expression by STAT6:ER fusion protein ; Overproduction of IL-4 from Th2 cell ; Increase of anti-single/double-stranded DNA antibody from autoreactive B cell ; Exacerbation of systemic lupus erythematosus ; Binding to estrogen receptor (ER)-α in immune cells ; Induction of GATA3 expression ; Increase of Th2 cells producing IL-4 ; Increase of anti-DNA antibody from autoreactive B cell ; Exacerbation of systemic lupus erythematosus (SLE)
  • 12/29/2019 10:57:40 PM
  • 4/29/2023 8:03:02 PM
Source: https://aopwiki.org/
Binding to the extracellular protein laminin leading to decreased cognitive function
Cognitive Function, Decreased ; Binding, extracellular matrix protein laminin ; Disrupted binding, laminin-beta1-integrin receptors with laminin ; Decreased, neural progenitor cell adhesion to laminin ; Disturbed, radial glia cell alignment and migration ; Decreased, radial glia cell density ; Disturbed, cortical architecture
  • 2/21/2023 5:07:43 PM
  • 4/29/2023 8:03:07 PM
Source: https://aopwiki.org/
Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
Binding at picrotoxin site, iGABAR chloride channel ; Reduction, Ionotropic GABA receptor chloride channel conductance ; Occurrence, A paroxysmal depolarizing shift ; Reduction, Neuronal synaptic inhibition ; Generation, Amplified excitatory postsynaptic potential (EPSP) ; Occurrence, Epileptic seizure ; Binding at picrotoxin site, iGABAR chloride channel ; Reduction, Ionotropic GABA receptor chloride channel conductance ; Reduction, Neuronal synaptic inhibition ; Generation, Amplified excitatory postsynaptic potential (EPSP) ; Occurrence, A paroxysmal depolarizing shift ; Occurrence, Epileptic seizure
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:55 PM
  • OECD endorsed (WNT and WPHA)
  • 1.15
  • Review Report
  • i-Library
Source: https://aopwiki.org/
Binding to Thyroid Peroxidase (TPO) mediated Learning impairment
Binding to Thyroid Peroxidase (TPO) ; Decreased levels of TPO ; Decrease levels of serum T4 and T3 ; Altered TR mediated proteints ; Synaptic malformation and altered function ; Learning impairment ; Binding to Thyroid Peroxidase (TPO) ; Decreased levels of TPO ; Decrease levels of serum T4 and T3 ; Altered TR mediated proteints ; Synaptic malformation and altered function ; Learning impairment
  • 10/15/2008 11:30:00 AM
Source: https://www.effectopedia.org/
Binding to Thyroid Peroxidase (TPO) mediated Learning impairment
Binding to Thyroid Peroxidase (TPO) ; Decreased levels of TPO ; Decrease levels of serum T4 and T3 ; Altered TR mediated proteints ; Synaptic malformation and altered function ; Learning impairment
  • 10/15/2008 11:30:00 AM
Source: http://www.effectopedia.org/
Binding to voltage gate sodium channels during development leads to cognitive impairment
Hippocampal anatomy, Altered ; Impairment, Learning and memory ; Altered, Action Potential ; Binding to voltage-gated sodium channel ; Disruption of sodium channel gating kinetics ; Disruption, action potential ; Altered neurotransmission in development ; Altered function of the brain
  • 3/15/2022 1:50:56 PM
  • 11/10/2023 8:34:53 AM
Source: https://aopwiki.org/
Bisphenol A analogs induce cellular dysfunction in human trophoblast cells in a thyroid hormone receptor-dependent manner: in silico and in vitro analyses
  • 2/7/2023 5:04:28 PM
  • 4/29/2023 8:03:07 PM
Source: https://aopwiki.org/
Bulky DNA adducts leading to mutations
Inadequate DNA repair ; Increase, Mutations ; Bulky DNA adducts, increase
  • 5/17/2021 1:08:02 PM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
Neuroinflammation ; Parkinsonian motor deficits ; Oxidative Stress ; Overactivation, NMDARs ; Increased, Intracellular Calcium overload ; Decrease, Oxidative phosphorylation ; Unfolded Protein Response ; Mitochondrial Injury ; Proteasomal dysfunction ; Accumulation of misfolded proteins ; Increase, Cell membrane depolarization ; Increase, Cytochrome c release ; Mitochondrial dysfunction ; Increase, Cell death ; Endoplasmic reticulum stress ; Activation of metabotropic glutamate receptor ; Inositol triphosphate receptor activation ; Inhibition GABAA receptor ; Activation of calpain signalling ; Opening, voltage-gated calcium channels ; Activation, caspases
  • 7/25/2022 7:00:16 AM
  • 9/14/2023 1:02:53 PM
Source: https://aopwiki.org/
Calcium-mediated neuronal ROS production and energy imbalance
Inhibition, Ca++ ATPase ; Increase, Ca++ (intracellular) ; Disruption, Mitochondrial electron transport chain ; Decrease, Mitochondrial ATP production ; Increase, Reactive oxygen species production ; Decreased, Nitric Oxide ; Decreased, Long-term potentiation (LTP) ; Increased, Oxidative damage ; Inhibition, Ca++ ATPase ; Increase, Ca++ (intracellular) ; Disruption, Mitochondrial electron transport chain ; Decrease, Mitochondrial ATP production ; Increase, Reactive oxygen species production ; Decreased, Nitric Oxide ; Decreased, Long-term potentiation (LTP) ; Increased, Oxidative damage
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:55 PM
Source: https://aopwiki.org/
Ceramide synthase inhibition leading to neural tube defects
Histone deacetylase inhibition ; Neural tube defects ; Inhibition of Ceramide Synthase ; Reduced complex sphingolipids ; Affected folate transporter ; decreased folate uptake ; Increased sphingolipid-1-phosphate
  • 5/2/2022 11:15:38 AM
  • 4/29/2023 8:03:06 PM
Source: https://aopwiki.org/
Chemical binding to tubulin in oocytes leading to aneuploid offspring
Binding, Tubulin ; Disruption, Microtubule dynamics ; Disorganization, Spindle ; Altered, Meiotic chromosome dynamics ; Altered, Chromosome number ; Increase, Aneuploid offspring ; Binding, Tubulin ; Disruption, Microtubule dynamics ; Disorganization, Meiotic Spindle ; Altered, Meiotic chromosome dynamics ; Altered, Chromosome number ; Increase, Aneuploid offspring
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
Source: https://aopwiki.org/
Chitin synthase 1 inhibition leading to mortality
Increase, Mortality ; Inhibition, Chitin synthase 1 ; Decrease, Cuticular chitin content ; Increase, Premature molting
  • 10/22/2020 8:11:08 PM
  • 4/29/2023 8:03:03 PM
  • EAGMST under review
  • Review Report
Source: https://aopwiki.org/
Chitinase inhibition leading to mortality
Increase, Mortality ; Increase, Premature molting ; Inhibition, Chitinase ; Decrease, Digestion of old cuticle
  • 10/21/2020 6:01:42 AM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
Chitobiase inhibition leading to mortality
Increase, Mortality ; Increase, Premature molting ; Decrease, Digestion of old cuticle ; Inhibition, Chitobiase
  • 10/21/2020 6:07:06 AM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
Cholestatic Liver Injury induced by Inhibition of the Bile Salt Export Pump (ABCB11)
Inhibition, Bile Salt Export Pump (ABCB11) ; Activation of specific nuclear receptors, Transcriptional change ; Bile accumulation, Pathological condition ; Release, Cytokine ; Increase, Inflammation ; Production, Reactive oxygen species ; Peptide Oxidation ; Cholestasis, Pathology ; Inhibition, Bile Salt Export Pump (ABCB11) ; Activation of specific nuclear receptors, Transcriptional change ; Bile accumulation, Pathological condition ; Release, Cytokine ; Increase, Inflammation ; Production, Reactive oxygen species ; Peptide Oxidation ; Cholestasis, Pathology
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:55 PM
  • AOP under development
  • 1.19
Source: https://aopwiki.org/
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
Binding of antagonist, NMDA receptors ; Inhibition, NMDARs ; Decreased, Calcium influx ; Reduced levels of BDNF ; N/A, Cell injury/death ; Impairment, Learning and memory ; Aberrant, Dendritic morphology ; Decrease of synaptogenesis ; Decrease of neuronal network function ; Reduced, Presynaptic release of glutamate ; Binding of antagonist, NMDA receptors ; Inhibition, NMDARs ; Decreased, Calcium influx ; Reduced levels of BDNF ; Cell injury/death ; Impairment, Learning and memory ; Aberrant, Dendritic morphology ; Decrease of synaptogenesis ; Decrease of neuronal network function ; Reduced, Presynaptic release of glutamate
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:55 PM
  • OECD endorsed (WNT and WPHA)
  • 1.22
  • Review Report
  • i-Library
Source: https://aopwiki.org/
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
NMDARs, Binding of antagonist ; NMDARs, Inhibition ; Calcium influx, Decreased ; Release of BDNF, Reduced ; Presynaptic release of glutamate, Reduced ; Cell death, N/A ; Dendritic morphology, Aberrant ; Synaptogenesis, Decreased ; Neuronal network function, Decreased ; Learning and memory, Impairment
  • 10/15/2016 9:00:00 AM
Source: http://www.effectopedia.org/
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
NMDARs, Binding of antagonist ; NMDARs, Inhibition ; Calcium influx, Decreased ; Release of BDNF, Reduced ; Presynaptic release of glutamate, Reduced ; Cell death, N/A ; Dendritic morphology, Aberrant ; Synaptogenesis, Decreased ; Neuronal network function, Decreased ; Learning and memory, Impairment ; NMDARs, Binding of antagonist ; NMDARs, Inhibition ; Calcium influx, Decreased ; Release of BDNF, Reduced ; Presynaptic release of glutamate, Reduced ; Cell death, N/A ; Dendritic morphology, Aberrant ; Synaptogenesis, Decreased ; Neuronal network function, Decreased ; Learning and memory, Impairment
  • 10/15/2016 9:00:00 AM
Source: https://www.effectopedia.org/
Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
N/A, Neuroinflammation ; Binding of antagonist, NMDA receptors ; Inhibition, NMDARs ; Decreased, Calcium influx ; Reduced levels of BDNF ; N/A, Cell injury/death ; N/A, Neurodegeneration ; Impairment, Learning and memory ; Neuroinflammation ; Binding of antagonist, NMDA receptors ; Inhibition, NMDARs ; Decreased, Calcium influx ; Reduced levels of BDNF ; Cell injury/death ; N/A, Neurodegeneration ; Impairment, Learning and memory
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:55 PM
  • OECD endorsed (WNT and WPHA)
  • 1.13
  • Review Report
  • i-Library
Source: https://aopwiki.org/
Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)
Increase, Adenomas/carcinomas (hepatocellular) ; Increase, Preneoplastic foci (hepatocytes) ; Increase, Cytotoxicity (hepatocytes) ; Increase, Regenerative cell proliferation (hepatocytes) ; Increase, hepatocellular adenomas and carcinomas ; Increase, Preneoplastic foci (hepatocytes) ; Increase, Cytotoxicity (hepatocytes) ; Increase, Regenerative cell proliferation (hepatocytes)
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Chronic cytotoxicity of the serous membrane leading to pleural/peritoneal mesotheliomas in the rat.
Increased, Oxidative Stress ; Increased, secretion of local growth factors ; persistent, cytotoxicity (pleura or peritoneum) ; Increased, inflammation ; Increased, Cell Proliferation (mesothelium) ; Increased, mesotheliomas ; Increased, Oxidative Stress ; Increased, secretion of local growth factors ; persistent, cytotoxicity (pleura or peritoneum) ; Increased, inflammation ; Increased, Cell Proliferation (mesothelium) ; Increased, mesotheliomas
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:58 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Co-activation of IP3R and RyR leads to economic burden through reduced IQ and non-cholinergic mechanisms
Neuroinflammation ; Hippocampal Physiology, Altered ; Cell injury/death ; Impairment, Learning and memory ; Increased, glutamate ; Increase, Cell death ; Inositol triphosphate receptor activation ; Activation, Microglia ; decreased, Bcl-2 expression ; increased, Bax expression ; decreased, Intellectual Quotient ; increased, Economic Burden ; Ryanodine receptor activation
  • 3/31/2023 2:13:27 PM
  • 9/8/2023 2:38:27 PM
Source: https://aopwiki.org/
combined unhealthy lifestyle factors leading to metabolic syndrome
  • 6/24/2021 11:05:26 AM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
Increase, Biliary excretion TH glucuronide ; Thyroxine (T4) in serum, Decreased ; Increased, Free serum thyroxine (T4) ; Increased, Clearance of thyroxine from serum ; Altered, Amphibian metamorphosis ; Increased, Hepatic thyroid hormone uptake/transport ; Displacement, Serum thyroxine (T4) from carrier protein ; Binding, Thyroid binding globulin in serum
  • 12/9/2020 8:22:16 PM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis
Increase, Biliary excretion TH glucuronide ; Thyroxine (T4) in serum, Decreased ; Binding, Transthyretin in serum ; Increased, Free serum thyroxine (T4) ; Increased, Clearance of thyroxine from serum ; Altered, Amphibian metamorphosis ; Increased, Hepatic thyroid hormone uptake/transport ; Displacement, Serum thyroxine (T4) from carrier protein
  • 12/9/2020 7:43:30 PM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat
Increase, Mitogenic cell proliferation (hepatocytes) ; Increase, Adenomas/carcinomas (hepatocellular) ; Activation, Constitutive androstane receptor ; Altered gene expression specific to CAR activation, Hepatocytes ; Increase, Preneoplastic foci (hepatocytes) ; Increase, cell proliferation (hepatocytes) ; Increase, hepatocellular adenomas and carcinomas ; Activation, Constitutive androstane receptor ; Altered gene expression specific to CAR activation, Hepatocytes ; Increase, Preneoplastic foci (hepatocytes)
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.18
Source: https://aopwiki.org/
Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
N/A, Covalent binding to protein, possibly lysine residue ; Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways ; Increase, Allergic Respiratory Hypersensitivity Response ; Activation, Dendritic Cells ; Activation/Proliferation, T-cells ; N/A, Covalent binding to protein, possibly lysine residue ; Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways ; Activation, Dendritic Cells ; Activation/Proliferation, T-cells ; Increase, Allergic Respiratory Hypersensitivity Response ; Covalent Binding, Protein ; Increased, secretion of proinflammatory mediators
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:55 PM
  • AOP under development
  • 1.20
Source: https://aopwiki.org/
Covalent Protein binding leading to Skin Sensitisation
Covalent Binding, Protein ; Activation, Keratinocytes ; Activation, Dendritic Cells ; Activation/Proliferation, T-cells ; sensitisation, skin ; Activation, Dendritic Cells ; Activation/Proliferation, T-cells ; Covalent Binding, Protein ; Activation, Keratinocytes ; sensitisation, skin
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • OECD endorsed (WNT and WPHA)
  • 1.1
  • i-Library
Source: https://aopwiki.org/
Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
Increased Mortality ; Decline, Population ; Increased, blood uric acid concentration ; Occurrence, renal proximal tubular necrosis ; Increased, blood potassium concentration ; Occurrence, tophi (urate) deposition ; Occurrence, cardiac arrhythmia ; Increased, Oxidative Stress ; Inhibition, Cyclooxygenase 1 activity ; Decreased, Prostaglandin F2alpha concentration, plasma ; Occurrence, renal ischemia ; Increased Mortality ; Decrease, Population growth rate ; Decline, Population ; Increased, blood uric acid concentration ; Occurrence, renal proximal tubular necrosis ; Increased, blood potassium concentration ; Occurrence, tophi (urate) deposition ; Occurrence, cardiac arrhythmia ; Increased, Oxidative Stress ; Inhibition, Cyclooxygenase 1 activity ; Decreased, Prostaglandin F2alpha concentration, plasma ; Occurrence, renal ischemia
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:59 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Cyclooxygenase inhibition leading reproductive failure
Inhibition, Cyclooxygenase activity ; Reduction, Prostaglandin E2 concentration ; Reduction, Ca and HCO3 transport to shell gland ; Reduction, Eggshell thickness ; N/A, Gap ; N/A, Reproductive failure ; Inhibition, Cyclooxygenase activity ; Reduction, Prostaglandin E2 concentration ; Reduction, Ca and HCO3 transport to shell gland ; Reduction, Eggshell thickness ; N/A, Gap ; N/A, Reproductive failure
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:55 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Cyclooxygenase inhibition leading to reproductive dysfunction
Decrease, Population trajectory ; Inhibition, Cyclooxygenase activity ; Decrease, Ovulation ; Reduced, Prostaglandins, ovary ; Reduced, Reproductive Success ; Declining, Population trajectory ; Decrease, Population growth rate ; Inhibition, Cyclooxygenase activity ; Decrease, Ovulation ; Reduced, Prostaglandins, ovary ; Reduced, Reproductive Success
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
Decrease, Population trajectory ; Inhibition, Cyclooxygenase activity ; Reduced, Reproductive Success ; Reduced, Prostaglandin F2alpha concentration, plasma ; Reduced, Prostaglandin F2alpha synthesis, ovary ; Reduced, Spawning behavior ; Reduced, Ability to attract spawning mates ; Decrease, Population growth rate ; Inhibition, Cyclooxygenase activity ; Reduced, Reproductive Success ; Reduced, Prostaglandin F2alpha concentration, plasma ; Reduced, Prostaglandin F2alpha synthesis, ovary ; Reduced, Spawning behavior ; Reduced, Ability to attract spawning mates
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
Decrease, Population trajectory ; Inhibition, Cyclooxygenase activity ; Reduced, Reproductive Success ; Reduced, Prostaglandin F2alpha concentration, plasma ; Reduced, Ability to attract spawning mates ; Reduced, Pheromone release ; Decreased, Prostaglandin F2alpha synthesis, ovary ; Decline, Population trajectory ; Decrease, Population growth rate ; Inhibition, Cyclooxygenase activity ; Reduced, Reproductive Success ; Reduced, Prostaglandin F2alpha concentration, plasma ; Reduced, Ability to attract spawning mates ; Reduced, Pheromone release ; Decreased, Prostaglandin F2alpha synthesis, ovary
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition
Decrease, Population trajectory ; Inhibition, Cyclooxygenase activity ; Reduced, Reproductive Success ; Decline, Population trajectory ; Reduced, Prostaglandin E2 concentration, hypothalamus ; Reduced, Gonadotropin releasing hormone, hypothalamus ; Reduced, Luteinizing hormone (LH), plasma ; Reduced, Maturation inducing steroid, plasma ; Reduced, Maturation inducing steroid receptor signalling, oocyte ; Reduced, Meiotic prophase I/metaphase I transition, oocyte ; Increased, cyclic adenosine monophosphate ; Decrease, Population growth rate ; Inhibition, Cyclooxygenase activity ; Reduced, Reproductive Success ; Reduced, Prostaglandin E2 concentration, hypothalamus ; Reduced, Gonadotropin releasing hormone, hypothalamus ; Reduced, Luteinizing hormone (LH), plasma ; Reduced, Maturation inducing steroid, plasma ; Reduced, Maturation inducing steroid receptor signalling, oocyte ; Reduced, Meiotic prophase I/metaphase I transition, oocyte ; Increased, cyclic adenosine monophosphate
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
Decrease, Population trajectory ; Inhibition, Cyclooxygenase activity ; Reduced, Reproductive Success ; Declining, Population trajectory ; Reduced, Prostaglandin E2 concentration, hypothalamus ; Reduced, Gonadotropin releasing hormone, hypothalamus ; Reduced, Luteinizing hormone (LH), plasma ; Reduced, Maturation inducing steroid, plasma ; Reduced, Maturation inducing steroid receptor signalling, oocyte ; Upregulated, Spindle assembly checkpoint protein Mad2-oocyte ; Increased, Chromosome misseggregation ; Decrease, Population growth rate ; Inhibition, Cyclooxygenase activity ; Reduced, Reproductive Success ; Reduced, Prostaglandin E2 concentration, hypothalamus ; Reduced, Gonadotropin releasing hormone, hypothalamus ; Reduced, Luteinizing hormone (LH), plasma ; Reduced, Maturation inducing steroid, plasma ; Reduced, Maturation inducing steroid receptor signalling, oocyte ; Upregulated, Spindle assembly checkpoint protein Mad2-oocyte ; Increased, Chromosome misseggregation
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
CYP26 inhibition leading to disturbed dorsal lateral hinge point bending which causes neural tube closure defects
  • 1/7/2022 9:43:44 AM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
CYP2E1 activation and formation of protein adducts leading to neurodegeneration
CYP2E1 Activation ; Protein Adduct Formation ; Oxidative Stress in Brain ; Lipid Peroxidation ; Unfolded Protein Response ; General Apoptosis ; Neurodegeneration ; CYP2E1 Activation ; Protein Adduct Formation ; Oxidative Stress in Brain ; Lipid Peroxidation ; Unfolded Protein Response ; General Apoptosis ; Neurodegeneration
  • 3/26/2018 1:02:49 PM
  • 4/29/2023 8:03:00 PM
Source: https://aopwiki.org/
Cyp2E1 Activation Leading to Liver Cancer
Activation of Cyp2E1 ; Oxidative Stress ; Hepatocytotoxicity ; Induction, persistant proliferation/sustained proliferation ; Liver Cancer ; Oxidative Stress ; Activation of Cyp2E1 ; Hepatocytotoxicity ; Induction, persistent proliferation/sustained proliferation ; Liver Cancer
  • 5/30/2017 5:25:04 PM
  • 4/29/2023 8:03:00 PM
  • OECD endorsed (WNT and WPHA)
  • 1.24
  • Review Report
  • i-Library
Source: https://aopwiki.org/
Cytochrome oxidase inhibition leading to olfactory nasal lesions
Increase, Site of Contact Nasal Tumors ; Increase, Cell death ; Inhibition, cytochrome oxidase
  • 1/28/2021 2:43:15 PM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
Increase, Cytotoxicity (club cells) ; Increase, Necrosis (terminal bronchiolar cells) ; Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells) ; Increase, Hyperplasia (terminal bronchiolar cells) ; Increase, Adenomas/carcinomas (bronchioloalveolar) ; Increase, Cytotoxicity (club cells) ; Increase, Necrosis (terminal bronchiolar cells) ; Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells) ; Increase, Hyperplasia (terminal bronchiolar cells) ; Increase, Adenomas/carcinomas (bronchioloalveolar)
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
Increase, Regenerative cell proliferation (tubular epithelial cells) ; Increase, Adenomas/carcinomas (renal tubular) ; Increase, Cytotoxicity (tubular epithelial cells) ; Increase, Hyperplasia (tubular epithelial cells) ; Increase, Regenerative cell proliferation (tubular epithelial cells) ; Increase, Adenomas/carcinomas (renal tubular) ; Increase, Cytotoxicity (tubular epithelial cells) ; Increase, Hyperplasia (tubular epithelial cells)
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
Death/Failure, Colony ; Abnormal, Roll change within caste ; impaired, Larval development ; Decreased, Glucose oxidase enzyme activity ; Decreased, Hydrogen peroxide production ; Reduced, Antiseptic incorporated in food ; Reduced, Food storage ; Death/Failure, Colony ; Abnormal, Roll change within caste ; impaired, Larval development ; Decreased, Glucose oxidase enzyme activity ; Decreased, Hydrogen peroxide production ; Reduced, Antiseptic incorporated in food ; Reduced, Food storage
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)
Decreased, Androgen receptor activity ; Decreased, Testosterone binding to androgen receptor (hypothalamus) ; Increase, Hyperplasia (Leydig cells) ; Increased, Luteinizing hormone (LH) ; Increase, Leydig cell tumors ; Decreased, Androgen receptor activity ; Decreased, Testosterone binding to androgen receptor (hypothalamus) ; Increase, Hyperplasia (Leydig cells) ; Increased, Luteinizing hormone (LH) ; Increase, Leydig cell tumors
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Decrease, cholesterol synthesis leads to orofacial clefting
Apoptosis ; Decrease, Cell proliferation ; Decrease, GLI1/2 translocation to nucleus ; Decrease, GLI1/2 target gene expression ; Decrease, palatal shelf outgrowth ; Orofacial clefting ; Decrease, Sonic Hedgehog second messenger production
  • 6/28/2023 12:18:39 PM
  • 8/31/2023 1:40:10 PM
Source: https://aopwiki.org/
Decrease, GLI1/2 target gene expression leads to orofacial clefting
Apoptosis ; Decrease, Cell proliferation ; Decrease, GLI1/2 target gene expression ; Decrease, palatal shelf outgrowth ; Orofacial clefting ; Decrease, Sonic Hedgehog second messenger production
  • 3/31/2023 7:30:59 PM
  • 10/16/2023 3:17:26 PM
Source: https://aopwiki.org/
Decreased fibrinolysis and activated bradykinin system leading to hyperinflammation
Increased, secretion of proinflammatory mediators ; Increased, recruitment of inflammatory cells ; Fibrinolysis, decreased ; Bradykinin system, hyperactivated ; Hyperinflammation
  • 4/20/2021 6:35:18 AM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
Reduction, Testosterone synthesis in Leydig cells ; Decreased, Transcription of genes by AR ; Decrease, dihydrotestosterone (DHT) level ; Decrease, androgen receptors (AR) activation ; decrease, male anogenital distance ; reduction, testosterone levels ; Reduction, Testosterone synthesis in Leydig cells ; Altered, Transcription of genes by the androgen receptor ; Decrease, dihydrotestosterone (DHT) level ; Decrease, androgen receptor activation ; anogenital distance (AGD), decreased ; Decrease, testosterone levels
  • 8/30/2019 8:36:36 AM
  • 4/29/2023 8:03:02 PM
Source: https://aopwiki.org/
Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation
Decrease, Population trajectory ; Decreased, Triiodothyronine (T3) in serum ; Reduced, Swimming performance ; Reduced, Young of year survival ; Reduced, Anterior swim bladder inflation ; Reduced, Hearing ; Inhibition, Deiodinase 1 ; Increased Mortality ; Decrease, Population growth rate ; Decreased, Triiodothyronine (T3) ; Reduced, Swimming performance ; Reduced, Young of year survival ; Reduced, Anterior swim bladder inflation ; Inhibition, Deiodinase 1
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:58 PM
  • EAGMST under review
  • 1.35
  • Review Report
Source: https://aopwiki.org/
Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation
Decrease, Population trajectory ; Decreased, Triiodothyronine (T3) in serum ; Reduced, Posterior swim bladder inflation ; Reduced, Swimming performance ; Reduced, Young of year survival ; Reduced, Anterior swim bladder inflation ; Reduced, Hearing ; Inhibition, Deiodinase 1 ; Increased Mortality ; Decrease, Population growth rate ; Decreased, Triiodothyronine (T3) ; Reduced, Posterior swim bladder inflation ; Reduced, Swimming performance ; Reduced, Young of year survival ; Reduced, Anterior swim bladder inflation ; Inhibition, Deiodinase 1
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:58 PM
  • EAGMST under review
  • 1.35
  • Review Report
Source: https://aopwiki.org/
Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation
Decrease, Population trajectory ; Inhibition, Deiodinase 2 ; Decreased, Triiodothyronine (T3) in serum ; Reduced, Swimming performance ; Reduced, Young of year survival ; Reduced, Anterior swim bladder inflation ; Reduced, Hearing ; Increased Mortality ; Decrease, Population growth rate ; Inhibition, Deiodinase 2 ; Decreased, Triiodothyronine (T3) ; Reduced, Swimming performance ; Reduced, Young of year survival ; Reduced, Anterior swim bladder inflation
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:58 PM
  • EAGMST under review
  • 1.35
  • Review Report
Source: https://aopwiki.org/
Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation
Decrease, Population trajectory ; Inhibition, Deiodinase 2 ; Decreased, Triiodothyronine (T3) in serum ; Reduced, Posterior swim bladder inflation ; Reduced, Swimming performance ; Reduced, Young of year survival ; Reduced, Anterior swim bladder inflation ; Reduced, Hearing ; Increased Mortality ; Decrease, Population growth rate ; Inhibition, Deiodinase 2 ; Decreased, Triiodothyronine (T3) ; Reduced, Posterior swim bladder inflation ; Reduced, Swimming performance ; Reduced, Young of year survival ; Reduced, Anterior swim bladder inflation
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:58 PM
  • EAGMST under review
  • 1.35
  • Review Report
Source: https://aopwiki.org/
Demethylation of PPAR promotor leading to vascular disrupting effects
peroxisome proliferator activated receptor promoter demethylation ; Increase, Oxidative Stress ; increased,Vascular endothelial dysfunction ; Angiogenesis dysfunction ; Increase, Vascular disrupting effects ; Activation of PPAR ; Abnormal expression of NO ; Activation of MMP-2 MMP-9 ; Activation of angiopoietin like protein 4 ; Activation of Angiogenic cytokines
  • 8/20/2023 5:42:30 PM
  • 8/28/2023 11:21:56 AM
Source: https://aopwiki.org/
Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia
Suppression, Immune system ; Inadequate DNA repair ; Increased Pro-inflammatory mediators ; Increase, Cell Proliferation ; Increase, Mutations in Critical Genes ; Increase, DNA damage ; Deposition of Energy ; Increase in reactive oxygen and nitrogen species (RONS) ; Acute Myeloid Leukemia
  • 12/2/2021 3:13:33 PM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
Deposition of Energy Leading to Learning and Memory Impairment
Impairment, Learning and memory ; Oxidative Stress ; Tissue resident cell activation ; Deposition of Energy ; Increase, DNA strand breaks ; Altered Signaling Pathways ; Increase, Pro-Inflammatory Mediators ; Increase, Neural Remodeling
  • 1/25/2023 2:03:29 PM
  • 6/8/2023 4:37:11 PM
Source: https://aopwiki.org/
Deposition of energy leading to lung cancer
Increase, Mutations ; N/A, Inadequate DNA repair ; Increase, Cell Proliferation ; Deposition of Ionizing Energy ; Increase DNA Double Strand Breaks ; Inadequate DNA repair ; Increase mutations ; Increase Chromosomal Aberrations ; Increase cell proliferation ; Increase, lung cancer ; Increase, DNA strand breaks ; Increase, Chromosomal aberrations ; Direct Deposition of Energy ; Inadequate DNA repair ; Increase, Mutations ; Increase, Cell Proliferation ; Deposition of Energy ; Increase, DNA strand breaks ; Increase, Chromosomal aberrations ; Increase, lung cancer
  • 12/18/2018 9:25:49 PM
  • 10/24/2023 3:02:02 PM
  • EAGMST under review
  • Review Report
Source: https://aopwiki.org/
Deposition of energy leading to occurrence of bone loss
Oxidative Stress ; Deposition of Energy ; Increase, Cell death ; Altered Signaling Pathways ; Altered Bone Cell Homeostasis ; Increase, Bone Remodeling ; Occurrence, bone loss
  • 1/11/2023 8:12:52 PM
  • 5/7/2023 5:38:54 PM
Source: https://aopwiki.org/
Deposition of energy leading to occurrence of cataracts
Inadequate DNA repair ; Increase, Mutations ; Oxidative Stress ; Increase, Cell Proliferation ; Deposition of Energy ; Increase, DNA strand breaks ; Increase, Chromosomal aberrations ; Increase, Oxidative damage to DNA ; Increased Modified Proteins ; Occurrence of Cataracts
  • 12/19/2022 2:56:03 PM
  • 5/7/2023 5:56:28 PM
Source: https://aopwiki.org/
Deposition of energy leading to population decline via DNA oxidation and follicular atresia
Decrease, Fecundity ; Increase, DNA hypomethylation ; Increase, Gene expression ; Increase, S-adenosylmethionine depletion ; Decrease, Population growth rate ; Reduction, Cumulative fecundity and spawning ; Increase, Reactive oxygen species production ; Decrease, Oogenesis ; Increase, Follicular atresia ; Decrease, Fecundity ; Decrease, Adenosine triphosphate pool ; Deposition of Energy ; Increase, DNA hypomethylation ; Increase, Gene expression ; Increase, Oxidative damage to DNA ; Increase, S-adenosylmethionine depletion ; Increased, Lipid peroxidation ; Decrease, Lipid storage ; Decrease, Fatty acid β-oxidation
  • 5/30/2019 12:08:59 PM
  • 4/29/2023 8:03:02 PM
Source: https://aopwiki.org/
Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis
Decrease, Population growth rate ; Reduction, Cumulative fecundity and spawning ; Increase, Reactive oxygen species production ; Decrease, Oogenesis ; Decrease, Fecundity ; Decrease, Oxidative phosphorylation ; Decrease, Adenosine triphosphate pool ; Increase, Oocyte apoptosis ; Deposition of Energy ; Increase, Oxidative damage to DNA ; Decrease, Mitochondrial membrane potential
  • 11/18/2019 9:01:38 AM
  • 4/29/2023 8:03:02 PM
Source: https://aopwiki.org/
Deposition of energy leading to population decline via DNA strand breaks and follicular atresia
Decrease, Population trajectory ; Increase, Reactive oxygen species production ; Peptide Oxidation ; Decrease, Ovulation ; Decrease, Fertility ; Increase, DNA damage ; Increase, Reactive oxygen species ; Increase, Apoptosis ; Decrease, Oogenesis ; Increase, Follicular atresia ; Decrease, Fecundity ; Decrease, Population growth rate ; Reduction, Cumulative fecundity and spawning ; Increase, Reactive oxygen species production ; Decrease, Ovulation ; Increase, DNA damage ; Increase, Apoptosis ; Decrease, Oogenesis ; Increase, Follicular atresia ; Decrease, Fecundity ; Increase, Oocyte apoptosis ; Deposition of Energy ; Increase, DNA strand breaks ; Increase, Oxidative DNA damage
  • 4/15/2017 8:00:03 PM
  • 4/29/2023 8:03:00 PM
Source: https://aopwiki.org/
Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis
Decrease, Mitochondrial ATP production ; Increase, Reactive oxygen species production ; Decrease, Ovulation ; Decrease, Fertility ; Decrease, Oogenesis ; Increase, Lipid peroxidation ; Increase, Uncoupling of oxidative phosphorylation ; Decrease, Fecundity ; Decrease, Population growth rate ; Reduction, Cumulative fecundity and spawning ; Decrease, Mitochondrial ATP production ; Increase, Reactive oxygen species production ; Decrease, Ovulation ; Increase, Apoptosis ; Decrease, Oogenesis ; Increase, Follicular atresia ; Decrease, Fecundity ; Decrease, Coupling of oxidative phosphorylation ; Increase, Oocyte apoptosis ; Increase, Ovarian follicle breakdown ; Deposition of Energy ; Increase, DNA strand breaks ; Increase, Oxidative DNA damage ; Increased, Lipid peroxidation ; Increase, Ovarian somatic cell apoptosis
  • 6/29/2017 12:00:09 PM
  • 4/29/2023 8:03:00 PM
  • AOP under development
Source: https://aopwiki.org/
Deposition of energy leads to vascular remodeling
Oxidative Stress ; Increased Pro-inflammatory mediators ; Deposition of Energy ; Increase, DNA strand breaks ; Altered Signaling Pathways ; Altered, Nitric Oxide Levels ; Increase, Endothelial Dysfunction ; Vascular remodeling ; Occurrence, Vascular Remodeling
  • 9/28/2022 3:20:48 PM
  • 5/3/2023 1:41:15 PM
Source: https://aopwiki.org/
Deposition of ionising energy leading to population decline via programmed cell death
Decrease, Population growth rate ; Increase, DNA damage ; Decrease, Leaf development ; Deposition of Energy ; Decrease, Reproduction ; Increase, Programmed cell death
  • 4/11/2021 12:57:58 PM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
Deposition of ionising energy leading to population decline via mitochondrial dysfunction
Decrease, Population growth rate ; Decrease, Mitochondrial ATP production ; Increase, Reactive oxygen species production ; Increased, Reactive oxygen species ; Decrease, Oxidative phosphorylation ; Decrease, Leaf development ; Deposition of Energy ; Decrease, Mitochondrial membrane potential ; Decrease, Reproduction
  • 4/11/2021 12:39:27 PM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
Deposition of ionising energy leads to population decline via impaired oogenesis and spermatogenesis
  • 7/14/2022 5:24:39 AM
  • 4/29/2023 8:03:06 PM
Source: https://aopwiki.org/
Deposition of ionising energy leads to population decline via pollen abnormal
Altered, Meiotic chromosome dynamics ; Increase, DNA damage ; Decreased, Population trajectory ; Deposition of Energy ; Decrease, Reproduction ; Increase, Pollen abnormal
  • 1/21/2022 12:24:51 PM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
Deposition of ionizing energy leading to population decline via inhibition of photosynthesis
Decrease, Population growth rate ; Increase, Reactive oxygen species production ; Increased, Reactive oxygen species ; Decrease, ATP production ; Decrease, Photosynthesis ; Decrease, Leaf development ; Deposition of Energy ; Increase, D1 protein deactivation ; Decrease, Photosystem II efficiency ; Decrease, Reproduction
  • 4/11/2021 11:13:32 AM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
Deposition of ionizing energy leads to population decline via impaired meiosis
Deposition of Ionizing Energy ; impaired, Fertility ; Altered, Meiotic chromosome dynamics ; Increased, Oxidative Stress ; Increased, Reactive oxygen species ; Increase, DNA damage ; Cell cycle, disrupted ; Decrease, Oogenesis ; Increase, Oocyte apoptosis ; Increase, Reactive oxygen species ; Decrease of egg production and cummulative fecundity ; Decreased spermatogenesis ; Decrease, Reproduction ; Decreased, Population size
  • 5/11/2021 9:06:20 AM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
Disruption of VEGFR Signaling Leading to Developmental Defects
Inhibition, VegfR2 ; Reduction, Angiogenesis ; Impairment, Endothelial network ; Insufficiency, Vascular ; Increased, Developmental Defects ; Inhibition, VegfR2 ; Reduction, Angiogenesis ; Impairment, Endothelial network ; Insufficiency, Vascular ; Increased, Developmental Defects
  • 11/29/2016 11:41:16 PM
  • 8/28/2023 12:42:24 PM
  • EAGMST under review
  • 1.6
  • Review Report
Source: https://aopwiki.org/
DNA adduct formation leading to kidney failure
  • 10/20/2022 9:11:26 AM
  • 4/29/2023 8:03:07 PM
Source: https://aopwiki.org/
DNA Adducts Leading to Liver Hemangiosarcoma
  • 7/14/2017 5:38:40 PM
  • 4/29/2023 8:03:00 PM
Source: https://aopwiki.org/
DNA Intercalation Mediated Cardiomyopathy
Intercalation with Nuclear and mt DNA ; Heart Failure ; Respiratory Failure ; Inhibition of Topoisomerase II ; Altered Expression of ETC Proteins ; Deregulation and Increase of mt Calcium Loading ; Reduced Calcium Loading Capacity of Mitochondria ; Calcium-Induced MPT ; Inhibited DNA Replication ; Altered Sychronization of Calcium in Myocytes ; Calcium-Induced Cell Death in Myocytes ; Altered Calicium Signaling ; Tumor Cell Death and Regression ; Congestive Heart Failure ; Increased Sensitivity to Calcium Loading/ROS in Myocytes ; Dialated CardioMyopathy ; Accumulating Risk for Cardiopathy
  • 4/11/2010 10:00:00 AM
Source: http://www.effectopedia.org/
DNA Intercalation Mediated Cardiomyopathy
Intercalation with Nuclear and mt DNA ; Heart Failure ; Respiratory Failure ; Inhibition of Topoisomerase II ; Altered Expression of ETC Proteins ; Deregulation and Increase of mt Calcium Loading ; Reduced Calcium Loading Capacity of Mitochondria ; Calcium-Induced MPT ; Inhibited DNA Replication ; Altered Sychronization of Calcium in Myocytes ; Calcium-Induced Cell Death in Myocytes ; Altered Calicium Signaling ; Tumor Cell Death and Regression ; Congestive Heart Failure ; Increased Sensitivity to Calcium Loading/ROS in Myocytes ; Dialated CardioMyopathy ; Accumulating Risk for Cardiopathy ; Intercalation with Nuclear and mt DNA ; Heart Failure ; Respiratory Failure ; Inhibition of Topoisomerase II ; Altered Expression of ETC Proteins ; Deregulation and Increase of mt Calcium Loading ; Reduced Calcium Loading Capacity of Mitochondria ; Calcium-Induced MPT ; Inhibited DNA Replication ; Altered Sychronization of Calcium in Myocytes ; Calcium-Induced Cell Death in Myocytes ; Altered Calicium Signaling ; Tumor Cell Death and Regression ; Congestive Heart Failure ; Increased Sensitivity to Calcium Loading/ROS in Myocytes ; Dialated CardioMyopathy ; Accumulating Risk for Cardiopathy
  • 4/11/2010 10:00:00 AM
Source: https://www.effectopedia.org/
DNA methyltransferase inhibition leading to population decline (1)
Decrease, Population trajectory ; Decrease, Oogenesis ; Decrease, Fecundity ; Increase, DNA methyltransferase inhibition ; Increase, Oocyte apoptosis ; Decrease, Global DNA methylation ; Increase, Caspase transcription ; Decrease, Population growth rate ; Decrease, Oogenesis ; Decrease, Fecundity ; Increase, Oocyte apoptosis ; Increase, DNA methyltransferase inhibition ; Decrease, Global DNA methylation ; Increase, Caspase transcription
  • 4/26/2020 10:07:35 AM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
DNA methyltransferase inhibition leading to population decline (2)
Decrease, Population trajectory ; Decrease, Oogenesis ; Decrease, Fecundity ; Increase, DNA methyltransferase inhibition ; Increase, Ovarian follicle breakdown ; Decrease, Global DNA methylation ; Increase, Caspase transcription ; Increase, Ovarian somatic cell apoptosis ; Decrease, Population growth rate ; Decrease, Oogenesis ; Decrease, Fecundity ; Increase, Ovarian follicle breakdown ; Increase, DNA methyltransferase inhibition ; Decrease, Global DNA methylation ; Increase, Caspase transcription ; Increase, Ovarian somatic cell apoptosis
  • 4/26/2020 10:08:36 AM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
DNA methyltransferase inhibition leading to population decline (3)
Decrease, Population trajectory ; Decrease, Oogenesis ; Decrease, Fecundity ; Increase, DNA methyltransferase inhibition ; Increase, Oocyte apoptosis ; Increase, DNA double-strand break ; Increase, Caspase transcription ; Decrease, Population growth rate ; Increase, DNA double-strand breaks ; Decrease, Oogenesis ; Decrease, Fecundity ; Increase, Oocyte apoptosis ; Increase, DNA methyltransferase inhibition ; Increase, DNA double-strand break ; Increase, Caspase transcription
  • 4/26/2020 10:09:06 AM
  • 11/16/2023 9:13:40 PM
Source: https://aopwiki.org/
DNA methyltransferase inhibition leading to population decline (4)
Decrease, Population trajectory ; Decrease, Oogenesis ; Decrease, Fecundity ; Increase, DNA methyltransferase inhibition ; Increase, Ovarian follicle breakdown ; Increase, DNA double-strand break ; Increase, Caspase transcription ; Increase, Ovarian somatic cell apoptosis ; Decrease, Population growth rate ; Increase, DNA double-strand breaks ; Decrease, Oogenesis ; Decrease, Fecundity ; Increase, Ovarian follicle breakdown ; Increase, DNA methyltransferase inhibition ; Increase, DNA double-strand break ; Increase, Caspase transcription ; Increase, Ovarian somatic cell apoptosis
  • 4/26/2020 10:09:30 AM
  • 11/13/2023 3:36:52 PM
Source: https://aopwiki.org/
DNA methyltransferase inhibition leading to transgenerational effects (1)
Decrease, Population trajectory ; Increase, DNA methyltransferase inhibition ; Decrease, Global DNA methylation ; Decrease, Heritable DNA methylation (F3) ; Increase, Caspase transcription (F3) ; Increase, Oocyte apoptosis (F3) ; Decrease, Oogenesis (F3) ; Decrease, Fecundity (F3) ; Decrease, Population growth rate ; Increase, DNA methyltransferase inhibition ; Decrease, Global DNA methylation ; Decrease, Heritable DNA methylation (F3) ; Increase, Caspase transcription (F3) ; Increase, Oocyte apoptosis (F3) ; Decrease, Oogenesis (F3) ; Decrease, Fecundity (F3)
  • 4/26/2020 10:09:53 AM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
DNA methyltransferase inhibition leading to transgenerational effects (2)
Decrease, Population trajectory ; Increase, DNA methyltransferase inhibition ; Decrease, Global DNA methylation ; Decrease, Heritable DNA methylation (F3) ; Increase, Caspase transcription (F3) ; Decrease, Oogenesis (F3) ; Decrease, Fecundity (F3) ; Increase, Ovarian somatic cell apoptosis (F3) ; Increase, Ovarian follicle breakdown (F3) ; Decrease, Population growth rate ; Increase, DNA methyltransferase inhibition ; Decrease, Global DNA methylation ; Decrease, Heritable DNA methylation (F3) ; Increase, Caspase transcription (F3) ; Decrease, Oogenesis (F3) ; Decrease, Fecundity (F3) ; Increase, Ovarian somatic cell apoptosis (F3) ; Increase, Ovarian follicle breakdown (F3)
  • 4/26/2020 10:10:16 AM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
Doda decarboxylase leading to mortality
Increase, Incomplete ecdysis ; Increase, Mortality ; Decrease, Tyrosine ; Decrease, dopa decarboxylase ; Increase, Defects in tanning of new cuticle ; Increase, impairment of cuticle sclerotization ; Increase, pigmentation ; Increase, delay in oviposition ; Decrease, hatching of egg
  • 8/29/2022 12:47:04 AM
  • 5/25/2023 7:26:45 AM
Source: https://aopwiki.org/
Dual oxidase (DUOX) inhibition leading to altered amphibian metamorphosis
Thyroid hormone synthesis, Decreased ; Decreased, Thyroxine (T4) in serum ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Inhibition, Dual oxidase ; Thyroxine (T4) in serum, Decreased ; Thyroid hormone synthesis, Decreased ; Decreased, Thyroxine (T4) in serum ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Inhibition, Dual oxidase
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:59 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
Inflammation, Liver ; N/A, Mitochondrial dysfunction 1 ; Cell injury/death ; Increased Mortality ; Oxidative Stress ; Increased Pro-inflammatory mediators ; Release, Cytokine ; Propagation, Oxidative stress ; Increased, Kidney Failure ; Occurrence, Kidney toxicity ; Increased, Oxidative Stress ; Increased, secretion of proinflammatory mediators ; Increased, recruitment of inflammatory cells ; Heart failure ; Th17 cell migration and inflammation induction ; Increase, the risk of acute respiratory failure ; Increase, Tissue/organ damage ; Increase, Cell death ; Prolonged TLR9 activation ; systemic inflammatory response syndrome ; Multi Organ Failure involving Acute Respiratory Distress Syndrome ; Toll Like Receptor (TLR) Dysregulation ; Thrombosis and Disseminated Intravascular Coagulation ; Increased activation, Nuclear factor kappa B (NF-kB) ; Diminished protective oxidative stress response ; Hyperinflammation ; NLRP3 inflammasome activity, increased ; increased MyD88 activation ; increased release of danger/damage associated molecular patterns ; increased platelet surface TLR9 expression ; formation of neutrophil extracellular traps (NETs) ; Platelet-neutrophil interactions, Increased
  • 3/19/2021 1:45:21 PM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
Dysregulated underperforming Toll Like Receptors (TLRs) leading to high pathogen load
Toll Like Receptor (TLR) Dysregulation
  • 3/19/2021 9:05:13 PM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
Early-life estrogen receptor activity leading to endometrial carcinoma in the mouse.
prepubertal increase, Estrogen receptor (ER) activity ; Activation, estrogen receptor alpha ; Promotion, SIX-1 postive basal-type progenitor cells ; Proliferation/Clonal Expansion, aberrant basal cells ; squamous metaplasia, aberrant basal cells ; Increased, Hyperplasia (glandular epithelial cells of endometrium) ; Increased, adenosquamous carcinomas of endometrium ; prepubertal increase, Estrogen receptor (ER) activity ; Activation, estrogen receptor alpha ; Promotion, SIX-1 postive basal-type progenitor cells ; Proliferation/Clonal Expansion, aberrant basal cells ; squamous metaplasia, aberrant basal cells ; Increased, Hyperplasia (glandular epithelial cells of endometrium) ; Increased, adenosquamous carcinomas of endometrium
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:58 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Early-life stromal estrogen receptor activation by endocrine disrupting chemicals in the mammary gland leading to enhanced cancer risk
  • 5/9/2019 2:47:16 PM
  • 4/29/2023 8:03:02 PM
Source: https://aopwiki.org/
Ecdysone receptor agonism leading to incomplete ecdysis associated mortality
Increase, Ecdysone receptor agonism ; Increase, Nuclear receptor E75b gene expression ; Increase, Fushi tarazu factor-1 gene expression ; Decrease, Circulating ecdysis triggering hormone ; Decrease, Circulating crustacean cardioactive peptide ; Decrease, Ecdysis motoneuron bursts ; Decrease, Excitatory postsynaptic potential ; Decrease, Abdominal muscle contraction ; Increase, Incomplete ecdysis ; Increased Mortality ; Increase, Mortality ; Increase, Ecdysone receptor agonism ; Increase, Nuclear receptor E75b gene expression ; Increase, Fushi tarazu factor-1 gene expression ; Decrease, Circulating ecdysis triggering hormone ; Decrease, Circulating crustacean cardioactive peptide ; Decrease, Ecdysis motoneuron bursts ; Decrease, Excitatory postsynaptic potential ; Decrease, Abdominal muscle contraction ; Increase, Incomplete ecdysis ; Increase, Mortality
  • 11/29/2016 11:41:15 PM
  • 9/3/2023 5:16:04 PM
Source: https://aopwiki.org/
EGFR Activation Leading to Decreased Lung Function
Activation, EGFR ; Occurrence, Transdifferentiation of ciliated epithelial cells ; Occurrence, Metaplasia of goblet cells ; Occurrence, Hyperplasia of goblet cells ; Increase, Proliferation of goblet cells ; Activation, SP1 ; Decrease, Apoptosis of ciliated epithelial cells ; Increase, Mucin production ; Chronic, Mucus hypersecretion ; Decrease, Lung function ; Activation, EGFR ; Occurrence, Transdifferentiation of ciliated epithelial cells ; Occurrence, Metaplasia of goblet cells ; Occurrence, Hyperplasia of goblet cells ; Increase, Proliferation of goblet cells ; Activation, Sp1 ; Decrease, Apoptosis of ciliated epithelial cells ; Increase, Mucin production ; Chronic, Mucus hypersecretion ; Decrease, Lung function ; Increase, goblet cell number
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:58 PM
  • AOP under development
  • 1.51
Source: https://aopwiki.org/
Elevated ATP demand for detoxification and repair mechanisms leading to impaired growth and development
  • 8/4/2018 12:50:00 AM
  • 4/29/2023 8:03:01 PM
Source: https://aopwiki.org/
Elevated ATP demand for detoxification and repair mechanisms leading to impaired locomotor activity
  • 8/4/2018 12:55:30 AM
  • 4/29/2023 8:03:01 PM
Source: https://aopwiki.org/
Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
Reduction, Plasma 17beta-estradiol concentrations ; Reduction, 17beta-estradiol synthesis by ovarian granulosa cells ; Activation, AHR ; dimerization, AHR/ARNT ; Reduction, Vitellogenin synthesis in liver ; Reduction, Cumulative fecundity and spawning ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Decrease, Population trajectory ; Increase, DNA methyltransferase expression ; Increase, hypermethylation of the promotor region of gonadotropin releasing hormone receptor ; Decrease, expression of gonadotropin releasing hormone receptor ; Reduction, Plasma 17beta-estradiol concentrations ; Reduction, 17beta-estradiol synthesis by ovarian granulosa cells ; Decrease, Population growth rate ; Activation, AhR ; dimerization, AHR/ARNT ; Reduction, Vitellogenin synthesis in liver ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Reduction, Cumulative fecundity and spawning ; Increase, DNA methyltransferase expression ; Increase, hypermethylation of the promotor region of gonadotropin releasing hormone receptor ; Decrease, expression of gonadotropin releasing hormone receptor
  • 10/30/2019 8:09:12 PM
  • 4/29/2023 8:03:02 PM
Source: https://aopwiki.org/
Endocytic lysosomal uptake leading to liver fibrosis
N/A, Mitochondrial dysfunction 1 ; N/A, Cell injury/death ; Release, Cytokine ; Peptide Oxidation ; Activation, Stellate cells ; Accumulation, Collagen ; N/A, Liver fibrosis ; Disruption, Lysosome ; Infiltration, Inflammatory cells ; Inflammation, Liver ; Increased Pro-inflammatory mediators ; Endocytotic lysosomal uptake ; Leukocyte recruitment/activation ; N/A, Mitochondrial dysfunction 1 ; Cell injury/death ; Increased Pro-inflammatory mediators ; Activation, Stellate cells ; Accumulation, Collagen ; N/A, Liver fibrosis ; Endocytotic lysosomal uptake ; Disruption, Lysosome ; Leukocyte recruitment/activation
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:58 PM
  • EAGMST under review
  • 1.47
  • Review Report
Source: https://aopwiki.org/
Endothelial cell dysfunction leading to thromboinflammation
Release, Cytokine ; Binding to ACE2 ; Platelet-neutrophil interactions, Increased ; Endothelial cell dysfunction ; Platelet activation, Increased ; Neutrophil activation, Increased ; Thromboinflammation, Increased
  • 8/4/2021 3:05:37 PM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
Decreased, Reproductive Success ; Decrease, Growth ; Deposition of Energy ; Increase in reactive oxygen and nitrogen species (RONS) ; increase oxidation of the di-copper moiety of the hemocyanin active site ; Decreased, oxygen binding capacity by hemocyanin ; Cognitive, sensed as hypoxic/low oxygen environment ; Increase, hemocyanin mRNA ; Increase, pulmonate breathing
  • 11/15/2022 9:21:55 PM
  • 4/29/2023 8:03:07 PM
Source: https://aopwiki.org/
Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
Increased, induction of UDPGT's in liver ; Increased, T4/T3 catabolism ; Decreased, serum T4/T3 ; Increased, Thyroid-stimulating hormone (TSH) ; Increased, Hypertrophy and proliferation (follicular cell) ; Increased, Hyperplasia (follicular cells) ; Increased Apoptosis, Adenomas/carcinomas (follicular cell) ; Induction, Upregulation of glucuronyltransferase activity ; Thyroxine (T4) in serum, Decreased ; Increase, Hypertrophy and proliferation (follicular cell) ; Increase, Hyperplasia (follicular cells) ; Increase, Adenomas/carcinomas (follicular cell) ; Increased, Clearance of thyroxine from serum ; Increased, induction of UDPGT's in liver ; Increased, T4/T3 catabolism ; Decreased, serum T4/T3 ; Increased, Thyroid-stimulating hormone (TSH) ; Increased, Hypertrophy and proliferation (follicular cell) ; Increased, Hyperplasia (follicular cells) ; Increased Apoptosis, Adenomas/carcinomas (follicular cell)
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:58 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Epigenetic modification of PPARG leading to adipogenesis
peroxisome proliferator activated receptor promoter demethylation ; Activation of specific nuclear receptors, PPAR-gamma activation ; chronic high fat diet ; activation of CCAAT/enhancer-binding protein alpha ; increased adipogenesis ; decreased dopamine ; decreased reward ; decreased DNA methylation of tyrosine hydroxylase ; decreased methylation of dopamine transporter promoter ; obesity ; peroxisome proliferator activated receptor promoter demethylation ; chronic high fat diet ; Activation of specific nuclear receptors, PPAR-gamma activation ; activation of CCAAT/enhancer-binding protein alpha ; increased adipogenesis ; decreased dopamine ; decreased reward ; decreased DNA methylation of tyrosine hydroxylase ; decreased methylation of dopamine transporter promoter ; obesity
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
Increase, Inflammation ; Increase, Papillomas/carcinomas (squamous cells) ; Increase, Cytotoxicity (epithelial cells) ; Increase, Regenerative cell proliferation (forestomach epithelial cells) ; Increase, Hyperplasia (forestomach epithelial cells) ; Increase, Inflammation ; Increase, Papillomas/carcinomas (squamous cells) ; Increase, Cytotoxicity (epithelial cells) ; Increase, Regenerative cell proliferation (forestomach epithelial cells) ; Increase, Hyperplasia (forestomach epithelial cells)
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
ER agonism leading to reduced survival due to renal failure
Agonism, Estrogen receptor ; Increase, Plasma vitellogenin concentrations ; Increased, Vitellogenin synthesis ; Increased, renal vitellogenin deposition ; Increased, glomerular rupture and renal hemorrhaging ; Increased, nephropathy ; Agonism, Estrogen receptor ; Increase, Plasma vitellogenin concentrations ; Increased, Vitellogenin synthesis ; Increased, renal vitellogenin deposition ; Increased, glomerular rupture and renal hemorrhaging ; Increased, nephropathy
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
ER agonism leading to skewed sex ratios due to altered sexual differentiation in males
Agonism, Estrogen receptor ; skewed, sex ratio ; Agonism, Estrogen receptor ; skewed, sex ratio
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
ER mediated breast cancer AOP
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:59 PM
Source: https://aopwiki.org/
ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
Increase in inflammation ; Increased, recruitment of inflammatory cells ; Insulin resistance ; Increased adipocyte size ; Increased adipocyte numbers ; Metabolically unhealthy Obesity ; Estrogen receptor alpha inactivation ; Increased fat mass ; increased lipid accumulation ; Increased pro-inflammatory cytokine expression
  • 4/5/2023 9:11:25 AM
  • 7/6/2023 9:57:33 AM
Source: https://aopwiki.org/
ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
Decreased, Mitochondrial fatty acid beta-oxidation ; Increased, Oxidative Stress ; Increased, Reactive oxygen species ; Mitochondrial dysfunction ; Insulin resistance ; Estrogen receptor alpha inactivation ; Impaired insulin signaling ; Metabolic syndrome
  • 5/25/2023 12:44:03 PM
  • 5/26/2023 7:22:55 AM
Source: https://aopwiki.org/
Estrogen Binding Mediated Population Reduction
Binding to ER ; ER Transcription Factors ; Upreregulated Gene Transcription in the liver tissue ; Gene expression for Vtg production ; Alteration of Anal fin papillae ; Alteration of Gonadal morphology ; Reduced Growth ; Reduced eggs per female ; Reduced Fertility ; Mixed sex gonads ; Sex reversal ; Delayed adult mail mortality ; Altered sex ratios ; Population reduction ; Binding to ER ; ER Transcription Factors ; Upreregulated Gene Transcription in the liver tissue ; Gene expression for Vtg production ; Alteration of Anal fin papillae ; Alteration of Gonadal morphology ; Reduced Growth ; Reduced eggs per female ; Reduced Fertility ; Mixed sex gonads ; Sex reversal ; Delayed adult mail mortality ; Altered sex ratios ; Population reduction
  • 10/15/2008 11:30:00 AM
Source: https://www.effectopedia.org/
Estrogen Binding Mediated Population Reduction
Binding to ER ; ER Transcription Factors ; Upreregulated Gene Transcription in the liver tissue ; Gene expression for Vtg production ; Alteration of Anal fin papillae ; Alteration of Gonadal morphology ; Reduced Growth ; Reduced eggs per female ; Reduced Fertility ; Mixed sex gonads ; Sex reversal ; Delayed adult mail mortality ; Altered sex ratios ; Population reduction
  • 10/15/2008 11:30:00 AM
Source: http://www.effectopedia.org/
Estrogen Receptor Activation and Female Precocious Puberty
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:58 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Estrogen receptor activation leading to breast cancer
N/A, Mitochondrial dysfunction 1 ; Increased, Oxidative Stress ; Activation, Estrogen receptor ; Increase, Cell Proliferation (Epithelial Cells) ; Decreased, Apoptosis (Epithelial Cells) ; Increased, ER binding to DNA (classical pathway) ; Increased, ER binding to T.F. to DNA (non-classical pathway) ; Increased, Proliferation (Endothelial cells) ; Increased, Migration (Endothelial Cells) ; Increased, Non-genomic signaling ; Increased, Ductal Hyperplasia ; Increase, DNA damage ; modulation, Extracellular Matrix Composition ; Increased, Invasion ; Activation, Fibroblasts ; Activation, Macrophages ; Increased, Angiogenesis ; Altered, Gene Expression ; Altered, Protein Production ; Increased, Motility ; Increased, Second Messenger Production ; N/A, Breast Cancer ; N/A, Mitochondrial dysfunction 1 ; Increased, Oxidative Stress ; Activation, Estrogen receptor ; Increase, Cell Proliferation (Epithelial Cells) ; Decreased, Apoptosis (Epithelial Cells) ; Increased, ER binding to DNA (classical pathway) ; Increased, ER binding to T.F. to DNA (non-classical pathway) ; Increased, Proliferation (Endothelial cells) ; Increased, Migration (Endothelial Cells) ; Increased, Non-genomic signaling ; Increased, Ductal Hyperplasia ; Increase, DNA damage ; modulation, Extracellular Matrix Composition ; Increased, Invasion ; Activation, Fibroblasts ; Activation, Macrophages ; Increased, Angiogenesis ; Altered, Gene Expression ; Altered, Protein Production ; Increased, Motility ; Increased, Second Messenger Production ; N/A, Breast Cancer
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:59 PM
Source: https://aopwiki.org/
Estrogen receptor agonism leading to reproductive dysfunction
Reduction, Cumulative fecundity and spawning ; Decrease, Population trajectory ; Agonism, Estrogen receptor ; Increase, Plasma vitellogenin concentrations ; Increase, Vitellogenin synthesis in liver ; Increase, Renal pathology due to VTG deposition ; Altered, Reproductive behaviour ; Altered, Larval development ; Impaired development of, Reproductive organs ; Decrease, Population growth rate ; Reduction, Cumulative fecundity and spawning ; Agonism, Estrogen receptor ; Increase, Plasma vitellogenin concentrations ; Increase, Vitellogenin synthesis in liver ; Increase, Renal pathology due to VTG deposition ; Altered, Reproductive behaviour ; Altered, Larval development ; Impaired development of, Reproductive organs
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:55 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
Activation, estrogen receptor alpha ; Agonism, Estrogen Receptor alpha ; Increased, Kisspeptin signalling ; Decreased, Gonadotropins ; Decreased, Androgen and Progestin ; Decreased, Maturation Inducing Steroid Surge by Granulosa cells ; Impaired, Oocyte maturation and ovulation ; Increased, Oocyte Atresia ; Impaired, Reproduction
  • 4/5/2022 4:44:11 AM
  • 4/29/2023 8:03:06 PM
Source: https://aopwiki.org/
Estrogen receptor antagonism leading to reproductive dysfunction
Reduction, Vitellogenin synthesis in liver ; Reduction, Cumulative fecundity and spawning ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Decrease, Population trajectory ; Antagonism, Estrogen receptor ; Decrease, Population growth rate ; Reduction, Vitellogenin synthesis in liver ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Reduction, Cumulative fecundity and spawning ; Antagonism, Estrogen receptor
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:55 PM
  • EAGMST under review
  • 1.12
Source: https://aopwiki.org/
Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
Decreased, Sodium conductance 1 ; Reduced, swimming speed ; Reduced, feeding 1 ; Increased, predation ; Reduced, survival ; Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel ; Decreased, Sodium conductance 1 ; Reduced, swimming speed ; Reduced, feeding 1 ; Increased, predation ; Reduced, survival ; Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Example6 Neurotoxicity
Interaction (VSGCs) ; chloride-permeable ion channels ; voltage-gated calcium channels ; ligand-gated chloride channels ; Seizures ; Death ; Loss of consciousness ; Signaling disruption ; Convolutions ; Tremors ; Paralysis ; Neuronal membrane potential disruption ; Disruption of homeostasis of neuronal networks ; Movement Impariment ; Behavioral Changes ; Population reduction
  • 10/15/2008 11:30:00 AM
Source: http://www.effectopedia.org/
Example6 Neurotoxicity
Interaction (VSGCs) ; chloride-permeable ion channels ; voltage-gated calcium channels ; ligand-gated chloride channels ; Seizures ; Death ; Loss of consciousness ; Signaling disruption ; Convolutions ; Tremors ; Paralysis ; Neuronal membrane potential disruption ; Disruption of homeostasis of neuronal networks ; Movement Impariment ; Behavioral Changes ; Population reduction ; Interaction (VSGCs) ; chloride-permeable ion channels ; voltage-gated calcium channels ; ligand-gated chloride channels ; Seizures ; Death ; Loss of consciousness ; Signaling disruption ; Convolutions ; Tremors ; Paralysis ; Neuronal membrane potential disruption ; Disruption of homeostasis of neuronal networks ; Movement Impariment ; Behavioral Changes ; Population reduction
  • 10/15/2008 11:30:00 AM
Source: https://www.effectopedia.org/
Excessive iron accumulation leading to neurological disorders
Decrease of neuronal network function ; Oxidative Stress in Brain ; Increased intracelluar Iron accumulation ; Neurological disorder
  • 6/21/2023 1:43:46 PM
  • 6/21/2023 1:58:00 PM
Source: https://aopwiki.org/
Excessive reactive oxygen species production leading to mortality (1)
Increase, Mortality ; Increase, Reactive oxygen species production ; Increase, Protein oxidation ; Decrease, Osmoregulation ; Increase, Body fluid overload ; Increase, Mortality ; Increase, Reactive oxygen species production ; Increase, Protein oxidation ; Increase, Abnormal osmoregulation ; Increase, Body fluid overload
  • 4/19/2020 8:48:12 AM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
Excessive reactive oxygen species production leading to mortality (2)
Increase, Mortality ; Increase, Reactive oxygen species production ; Decrease, Oxidative phosphorylation ; Decrease, ATP production ; Decrease, Mitochondrial membrane potential ; Increase, Mortality ; Increase, Reactive oxygen species production ; Decrease, Oxidative phosphorylation ; Decrease, Adenosine triphosphate pool ; Decrease, Mitochondrial membrane potential
  • 4/19/2020 8:48:39 AM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
Excessive reactive oxygen species production leading to mortality (3)
Increase, Mortality ; Increase, Reactive oxygen species production ; Increase, Lipid peroxidation ; Decrease, ATP production ; Decrease, Neutral lipids ; Increase, Mortality ; Increase, Reactive oxygen species production ; Decrease, Adenosine triphosphate pool ; Increased, Lipid peroxidation ; Decrease, Neutral lipids
  • 4/19/2020 8:49:00 AM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
Excessive reactive oxygen species production leading to mortality (4)
Increase, Mortality ; Increase, Reactive oxygen species production ; Increase, Apoptosis ; Increase, Oxidative DNA damage ; Increase, DNA double-strand break ; Increase, Mortality ; Increase, Reactive oxygen species production ; Increase, DNA double-strand breaks ; Increase, Apoptosis ; Increase, Oxidative DNA damage ; Increase, DNA double-strand break
  • 4/19/2020 8:49:22 AM
  • 11/16/2023 8:55:27 PM
Source: https://aopwiki.org/
Formation of DNA photoproducts leading to growth inhibition (1)
Increase, Mortality ; Increase, Apoptosis ; Increase, DNA double-strand break ; Increase, Formation of DNA photoproducts ; Increase, Mortality ; Increase, DNA double-strand breaks ; Increase, Apoptosis ; Increase, DNA double-strand break ; Increase, Formation of DNA photoproducts
  • 4/19/2020 8:50:03 AM
  • 11/16/2023 8:58:48 PM
Source: https://aopwiki.org/
Formation of DNA photoproducts leading to growth inhibition (2)
  • 4/19/2020 8:52:14 AM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
Formation of DNA photoproducts leading to growth inhibition (3)
  • 4/19/2020 8:52:38 AM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
Frustrated phagocytosis leads to malignant mesothelioma
Increase, Cell Proliferation ; Increased, mesotheliomas ; Increased, secretion of proinflammatory mediators ; Increased, recruitment of inflammatory cells ; Increased, Reactive oxygen species ; Frustrated phagocytosis ; Increased, DNA damage and mutation ; Genomic instability
  • 7/5/2021 10:19:06 AM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
Frustrated phagocytosis-induced lung cancer
Release, Cytokine ; Increase, Cell Proliferation ; Increased, Reactive oxygen species ; Increased, recruitment of inflammatory cells ; Frustrated phagoytosis ; Increased, DNA damage and mutation ; Lung cancer ; Release, Cytokine ; Increase, Cell Proliferation ; Increased, recruitment of inflammatory cells ; Increased, Reactive oxygen species ; Frustrated phagocytosis ; Increased, DNA damage and mutation ; Lung cancer
  • 7/3/2019 3:26:45 PM
  • 4/29/2023 8:03:02 PM
Source: https://aopwiki.org/
G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
Activation, AKT ; Activation, mTORC1 ; Activation, PI3K ; Activation, PPARα ; Up Regulation, SCD-1 ; Down Regulation, CPT1A ; Up Regulation, SREBF2 ; N/A, Steatohepatisis ; protein-coupled estrogen receptor 1 (GPER) activation ; Abnormal lipid metabolism
  • 6/17/2021 7:15:27 AM
  • 5/26/2023 7:09:55 AM
Source: https://aopwiki.org/
Gastric ulcer formation
Inhibition, PTGS-1 (Prostaglandin-endoperoxide synthase 1) ; Activation, PTGS-1 (Prostaglandin-endoperoxide synthase 1) ; Activation, PTGS-2 (Prostaglandin-endoperoxide synthase 2) ; Inhibition, PTGS-2 (Prostaglandin-endoperoxide synthase 2) ; Increase, bicarbonate ; Increase, mucous ; Increase, mucosal blood flow ; Increase, platelet aggregation ; Increase, angiogenesis ; Decrease, leukocyte adherence ; Increase, leukocyte adherence ; Activate, leukocyte ; Activate, mucosal defense ; Increase, surfactant ; Decrease, surfactant ; Activate, phospholipase ; Increase, ammonium (NH4+) ; Inhibit, gastric ulcer formation ; Activated, gastric ulcer formation ; Inhibition, PTGS-1 (Prostaglandin-endoperoxide synthase 1) ; Activation, PTGS-1 (Prostaglandin-endoperoxide synthase 1) ; Activation, PTGS-2 (Prostaglandin-endoperoxide synthase 2) ; Inhibition, PTGS-2 (Prostaglandin-endoperoxide synthase 2) ; Increase, bicarbonate ; Increase, mucous ; Increase, mucosal blood flow ; Increase, platelet aggregation ; Increase, angiogenesis ; Decrease, leukocyte adherence ; Increase, leukocyte adherence ; Activate, leukocyte ; Activate, mucosal defense ; Increase, surfactant ; Decrease, surfactant ; Activate, phospholipase ; Increase, ammonium (NH4+) ; Inhibit, gastric ulcer formation ; Activated, gastric ulcer formation
  • 4/17/2017 2:11:46 PM
  • 4/29/2023 8:03:00 PM
Source: https://aopwiki.org/
Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
impaired, Fertility ; Reduction, Testosterone synthesis in Leydig cells ; Reduction, testosterone level ; Glucocorticoid Receptor Agonist, Activation ; Repressed expression of steroidogenic enzymes ; Increased apoptosis, decreased number of adult Leydig Cells ; Decreased Sperm Number, Reduced Fertility ; Accelerated Epididymal Sperm Transit, Reduced Fertility ; Abnormal Sperm Maturation, Reduced Fertility ; Decreased sperm quantity or quality in the adult, Decreased fertility ; impaired, Fertility ; Reduction, Testosterone synthesis in Leydig cells ; Reduction, fetal/adult testosterone ; Glucocorticoid Receptor Agonist, Activation ; Repressed expression of steroidogenic enzymes ; Increased apoptosis, decreased fetal/adult Leydig Cells ; Decreased sperm quantity or quality in the adult, Decreased fertility
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Glucocorticoid Receptor activation leading to hepatic steatosis
Decreased, Mitochondrial Fatty Acid Beta Oxidation ; Activation, Glucocorticoid Receptor ; Decreased, PPAR-alpha activation ; Increased, Liver Steatosis ; Activation, Glucocorticoid Receptor ; Accumulation, Triglyceride ; Decreased, PPAR-alpha activation ; Increased, Liver Steatosis ; Decreased, Mitochondrial Fatty Acid Beta Oxidation ; Decrease, Acyl-CoA dehydrogenases
  • 2/22/2020 1:39:30 PM
  • 4/29/2023 8:03:02 PM
Source: https://aopwiki.org/
Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
Activation, Glucocorticoid Receptor ; Inhibition, Nuclear factor kappa B (NF-kB) ; Suppression, Inflammatory cytokines ; Decreased, Lymphocytes ; Induction, IKB inhibitory protein ; Suppression, Immune system ; Increased, Disease susceptibility ; Activation, Glucocorticoid Receptor ; Inhibition, Nuclear factor kappa B (NF-kB) ; Suppression, Inflammatory cytokines ; Decreased, Lymphocytes ; Induction, IKB inhibitory protein ; Suppression, Immune system ; Increased, Disease susceptibility
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:55 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
Activation, Glucocorticoid Receptor ; Decrease, Population trajectory ; Reduced, Swimming performance ; Increase, Cripto-1 expression ; Inhibition, Activin signaling ; Inhibition, Fin regeneration ; Activation, Glucocorticoid Receptor ; Decrease, Population growth rate ; Reduced, Swimming performance ; Increase, Cripto-1 expression ; Inhibition, Activin signaling ; Inhibition, Fin regeneration
  • 4/20/2020 8:16:51 PM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
Glutamate-gated chloride channel activation leading to acute mortality
Increased Mortality ; Activation, Glutamate-gated chloride channel ; Increased, Chloride conductance ; hyperpolarisation, neuron ; N/A, Ataxia, paralysis, or hyperactivity ; Decreased, population 1 ; Increased Mortality ; Activation, Glutamate-gated chloride channel ; Increased, Chloride conductance ; hyperpolarisation, neuron ; N/A, Ataxia, paralysis, or hyperactivity ; Decreased, population 1
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
Increased Mortality ; Increased, Chloride conductance ; Increased, Inhibitory postsynaptic potential ; Increased, Neuronal synaptic inhibition ; Inhibition, Feeding ; Activation, Glutamate-gated chloride channels ; Induction, pharyngeal muscle paralysis ; Increased Mortality ; Increased, Chloride conductance ; Increased, Inhibitory postsynaptic potential ; Increased, Neuronal synaptic inhibition ; Inhibition, Feeding ; Activation, Glutamate-gated chloride channels ; Induction, pharyngeal muscle paralysis
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:58 PM
Source: https://aopwiki.org/
Glutathione conjugation leading to reproductive dysfunction via oxidative stress
Depletion, GSH ; impaired, Fertility ; Increased, Reactive oxygen species ; Increased, Lipid peroxidation ; Conjugation, GSH
  • 4/4/2023 5:20:47 PM
  • 9/14/2023 1:47:17 PM
Source: https://aopwiki.org/
GnRH pulse disruption leading to mammary adenomas and carcinomas in the SD rat.
Decreased, GnRH pulsatility/release in hypothalamus ; Decreased, LH Surge from anterior pituitary ; interruption, Ovulation ; prolonged, estrus ; Increased, circulating estrogen levels ; Increased, prolactin exposure ; Hyperplasia, Mammary gland ; Increased, latency period ; Increased, Adenomas/carcinomas (mammary) ; Decreased, GnRH pulsatility/release in hypothalamus ; Decreased, LH Surge from anterior pituitary ; interruption, Ovulation ; prolonged, estrus ; Increased, circulating estrogen levels ; Increased, prolactin exposure ; Hyperplasia, Mammary gland ; Increased, latency period ; Increased, Adenomas/carcinomas (mammary)
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:58 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
GnRH pulse disruption leading to pituitary adenomas and carcinomas in the SD rat.
Decreased, GnRH pulsatility/release in hypothalamus ; Decreased, LH Surge from anterior pituitary ; interruption, Ovulation ; prolonged, estrus ; Increased, circulating estrogen levels ; Increased, lactotroph hyperplasia and hypertrophy ; Increased, adenomas (pituitary) ; Decreased, GnRH pulsatility/release in hypothalamus ; Decreased, LH Surge from anterior pituitary ; interruption, Ovulation ; prolonged, estrus ; Increased, circulating estrogen levels ; Increased, lactotroph hyperplasia and hypertrophy ; Increased, adenomas (pituitary)
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:58 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
GSK3beta inactivation leading to increased mortality via defects in developing inner ear
Reduced, Hearing ; GSK3beta inactivation ; Increased Mortality ; Decrease, Population growth rate ; Decline, Population trajectory ; Increase, Cell death ; Repression of Gbx2 expression ; foxi1 expression, increased ; six1b expression, increased ; eya1 expression, inhibited ; altered, inner ear development
  • 7/14/2021 5:47:28 PM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
Handbook development AOP
  • 2/16/2017 4:26:17 PM
  • 4/29/2023 8:02:59 PM
Source: https://aopwiki.org/
Helicobacter pylori to gastric ulcer
Decrease, surfactant ; Activate, phospholipase ; Increase, ammonium (NH4+) ; Activated, gastric ulcer formation ; Reduced, mucosal defense ; Helicobacter pylori infection ; Decrease, surfactant ; Activate, phospholipase ; Increase, ammonium (NH4+) ; Activated, gastric ulcer formation ; Reduced, mucosal defense ; Helicobacter pylori infection
  • 6/2/2017 3:06:41 PM
  • 4/29/2023 8:03:00 PM
  • AOP under development
Source: https://aopwiki.org/
Hepatic nuclear receptor activation leading to altered amphibian metamorphosis
Thyroxine (T4) in serum, Decreased ; Induction, Upregulation of glucuronyltransferase activity ; Increase, Biliary excretion TH glucuronide ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Activation, Hepatic nuclear receptor(s) ; Increased, Hepatic thyroid hormone uptake/transport ; Induction, Upregulation of glucuronyltransferase activity ; Increase, Biliary excretion TH glucuronide ; Thyroxine (T4) in serum, Decreased ; Increased, Clearance of thyroxine from serum ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Activation, Hepatic nuclear receptor(s) ; Increased, Hepatic thyroid hormone uptake/transport
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:59 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
hERG channel blockade leading to sudden cardiac death
Increased Mortality ; Occurrence, cardiac arrhythmia ; Binding to hERG channel ; hERG channel biogenesis interference ; Direct hERG channel blockage ; Induction of hERG trafficking defects ; Inhibition of Ikr ; Prolongation of Action Potential Duration ; Prolongation of QT interval ; Torsades de Pointes ; Sudden cardiac death ; hERG channel blockade ; Inhibition of rapid delayed rectifying potassium current ; Increased,Cardiac Dysregulation
  • 12/13/2021 9:40:00 AM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
Histamine (H2) receptor antagonism leading to reduced survival
Impairment, Learning and memory ; Increased, predation ; Antagonism, Histamine Receptor (H2) ; Decrease, histaminergic neuron excitation ; N/A, sedation ; Decreased, locomotion ; impaired, Learning and memory ; Decreased, survival ; Impairment, Learning and memory ; Increased, predation ; Antagonism, Histamine Receptor (H2) ; Decrease, histaminergic neuron excitation ; N/A, sedation ; Decreased, locomotion ; Decreased, survival
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Histone deacetylase inhibition leading to testicular atrophy
Apoptosis ; Histone deacetylase inhibition ; Histone acetylation, increase ; p21 (CDKN1A) expression, increase ; cell cycle, disrupted ; testicular atrophy ; spermatocyte depletion ; Apoptosis ; Histone deacetylase inhibition ; Histone acetylation, increase ; Cell cycle, disrupted ; Spermatocyte depletion ; Testicular atrophy
  • 3/10/2017 11:45:47 AM
  • 4/29/2023 8:02:59 PM
  • OECD endorsed (WNT and WPHA)
  • 1.52
  • Review Report
  • i-Library
Source: https://aopwiki.org/
Histone deacetylase inhibition leads to impeded craniofacial development
Histone deacetylase inhibition ; Neural crest cell migration, reduced ; Collagen production, reduced ; Facial cartilage structures are reduced in size and morphologically distorted ; Histone deacetylase inhibition ; Neural crest cell migration, reduced ; Collagen production, reduced ; Facial cartilage structures are reduced in size and morphologically distorted
  • 12/20/2018 8:45:23 AM
  • 4/29/2023 8:03:01 PM
Source: https://aopwiki.org/
Histone deacetylase inhibition leads to neural tube defects
Altered, Gene Expression ; Histone deacetylase inhibition ; Histone acetylation, increase ; Altered differentiation ; Neural tube defects ; Altered, Gene Expression ; Histone deacetylase inhibition ; Histone acetylation, increase ; Altered differentiation ; Neural tube defects
  • 12/20/2018 1:24:47 PM
  • 4/29/2023 8:03:01 PM
Source: https://aopwiki.org/
HMG-CoA reductase inhibition leading to decreased fertility
Inhibition, HMG-CoA reductase ; Decreased, mevalonate ; Decreased, cholesterol ; Decreased, Testosterone ; malformed, Male reproductive tract ; Decrease, Fertility ; Inhibition, HMG-CoA reductase ; Decreased, mevalonate ; Decreased, cholesterol ; Decreased, Testosterone ; malformed, Male reproductive tract ; Decrease, Fertility
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
HNF4alpha suppression leading to hepatic steatosis
Suppression, HNF4alpha ; Suppression, HNF4alpha
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme ; Increased, Plasma tyrosine ; Increase, Cytotoxicity (corneal cells) ; Increase, Inflammation (corneal cells) ; Increase, Regenerative cell proliferation (corneal cells) ; Increase, Papillomas/carcinomas (squamous cells) ; Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme ; Increased, Plasma tyrosine ; Increase, Cytotoxicity (corneal cells) ; Increase, Inflammation (corneal cells) ; Increase, Regenerative cell proliferation (corneal cells) ; Increase, Papillomas/carcinomas (squamous cells)
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease
Increased, Reactive oxygen species ; Chronic kidney disease ; Increased Angiotensin II ; Increased Ang II type 1 receptor (AT1R) ; Hyperactivation of ACE/Ang-II/AT1R axis ; Increased Sodium-sensitive hypertension
  • 3/31/2021 7:30:51 AM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
Suppression, Estrogen receptor (ER) activity ; Increased, secretion of GnRH from hypothalamus ; Increased, secretion of LH from anterior pituitary ; Hyperplasia, ovarian stromal cells ; Hyperplasia, ovarian epithelium ; Promotion, ovarian adenomas ; Promotion, ovarian granular cell tumors ; Increased, circulating estrogen levels ; Increased, Steroidogenic acute regulatory protein (StAR) ; Increased, estrogens ; Promotion, Ovarian Cancer
  • 2/26/2022 4:35:43 AM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
IKK complex inhibition leading to liver injury
N/A, Cell injury/death ; Inhibition, Nuclear factor kappa B (NF-kB) ; Necrotic Tissue ; Liver Injury ; Inhibition, IKK complex ; Activation, Caspase 8 pathway ; Activation, Tissue resident cells (Kuppfer cells) ; Increased, proinflammatory mediators (TNFalpha) ; Increase, proinflammatory mediators (TNFalpha) ; Cell injury/death ; Inhibition, Nuclear factor kappa B (NF-kB) ; Necrotic Tissue ; Liver Injury ; Inhibition, IKK complex ; Activation, Caspase 8 pathway ; Activation, Tissue resident cells (Kuppfer cells) ; Increase, proinflammatory mediators (TNFalpha)
  • 1/7/2019 1:00:15 PM
  • 4/29/2023 8:03:01 PM
Source: https://aopwiki.org/
Imbalance in redox homeostasis leading to structural damage to tissues
  • 6/29/2021 8:44:25 AM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
Immune mediated hepatitis
Increase in inflammation ; benzoquinone imine and acylglucuronide metabolites ; Mitochondrial dysfunction ; Activation of ER stress ; Apoptotic cell death ; Immune cell activation ; IFNγ signaling ; Immune mediated hepatitis
  • 11/2/2020 11:16:30 AM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
Inhibition, Nuclear factor kappa B (NF-kB) ; Increase, Increased susceptibility to infection ; Blocking of IL-1R ; Decreased IL-1 production ; Impaired IL-1 signaling ; Suppressed AP-1 ; Suppressed NF-kB ; Suppressed DC activation ; Impaired antigen presentation ; Impaired T cell activation ; Suppression, Suppression of T-cell dependent antibody response (TDAR) ; Suppressed MyD88 ; Impaired Ab production ; Inhibition of IL-1 binding to IL-1 receptor ; Suppression of T cell activation ; Inhibition, Nuclear factor kappa B (NF-kB) ; Impairment, T-cell dependent antibody response ; Impaired IL-1R1 signaling in T cell ; Suppression of T cell activation ; Impairment of TDAR
  • 12/21/2018 1:02:52 AM
  • 8/28/2023 12:41:37 PM
  • EAGMST under review
  • Review Report
Source: https://aopwiki.org/
Increased (ectopic) concentration of all-trans retinoic acid (ATRA) if fetal testis leading to reduced sperm count, males
Reduce, Sperm count ; Increased (ectopic) all-trans retinoic acid concentration ; Premature initiation of meiosis in fetal male germ cells ; Decrease (loss of) fetal male germ cells
  • 5/29/2021 4:26:47 PM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
Increased DNA damage leading to increased risk of breast cancer
Increase, Mutations ; Increase, Cell Proliferation (Epithelial Cells) ; Increased, Ductal Hyperplasia ; Increase, DNA damage ; N/A, Breast Cancer ; Tissue resident cell activation ; Increased Pro-inflammatory mediators ; Leukocyte recruitment/activation ; Increase mutations ; Increase in reactive oxygen and nitrogen species (RONS) ; Increase in inflammation ; Increase, Mutations ; Tissue resident cell activation ; Increased Pro-inflammatory mediators ; Leukocyte recruitment/activation ; Increase, Cell Proliferation (Epithelial Cells) ; Increased, Ductal Hyperplasia ; Increase, DNA damage ; N/A, Breast Cancer ; Increase in reactive oxygen and nitrogen species (RONS)
  • 5/3/2019 2:20:11 PM
  • 4/29/2023 8:03:02 PM
Source: https://aopwiki.org/
Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
Increase, Dopaminergic activity ; Decreased, Prolactin ; Increased, Estrogen receptor (ER) activity ; Decreased, Progesterone from corpus luteum ; Increase, Hyperplasia (glandular epithelial cells of endometrium) ; Increase, Endometrial adenocarcinomas ; Increase, Dopaminergic activity ; Decreased, Prolactin ; Increased, Estrogen receptor (ER) activity ; Decreased, Progesterone from corpus luteum ; Increase, Hyperplasia (glandular epithelial cells of endometrium) ; Increase, Endometrial adenocarcinomas
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Increased LCN2/iron complex leading to neurological disorders
Neuronal dysfunction ; Increased LCN2/iron complex binds to SLC22A17 receptor in neuron ; Increased intracelluar Iron accumulation ; Neurological disorder
  • 6/12/2023 9:11:18 AM
  • 6/16/2023 9:48:27 AM
Source: https://aopwiki.org/
Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure
Abnormal, Foraging activity and behavior ; Death/Failure, Colony ; Decrease, Number of worker bees ; Increase, Energetic demands and therefore metabolic stress ; Increased, Appetite and hunger ; Abnormal, Foraging activity and behavior ; Death/Failure, Colony ; Decrease, Number of worker bees ; Increase, Energetic demands and therefore metabolic stress ; Increased, Appetite and hunger
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Increased reactive oxygen and nitrogen species (RONS) leading to increased risk of breast cancer
Increase, Mutations ; Increase, Cell Proliferation (Epithelial Cells) ; Increased, Ductal Hyperplasia ; Increase, DNA damage ; N/A, Breast Cancer ; Tissue resident cell activation ; Increased Pro-inflammatory mediators ; Leukocyte recruitment/activation ; Increase in reactive oxygen and nitrogen species (RONS) ; Increase, Mutations ; Tissue resident cell activation ; Increased Pro-inflammatory mediators ; Leukocyte recruitment/activation ; Increase, Cell Proliferation (Epithelial Cells) ; Increased, Ductal Hyperplasia ; Increase, DNA damage ; N/A, Breast Cancer ; Increase in reactive oxygen and nitrogen species (RONS)
  • 5/7/2019 6:03:51 PM
  • 4/29/2023 8:03:02 PM
Source: https://aopwiki.org/
Increased reactive oxygen species production leading to decreased cognitive function
Increase, Reactive oxygen species production ; Cognitive Function, Decreased ; Increased, Oxidative Stress ; Diminished protective oxidative stress response ; Hypomyelination ; Altered, white brain matter ; Decreased, oligodendrocyte differentiation
  • 2/22/2023 1:06:00 PM
  • 4/29/2023 8:03:07 PM
Source: https://aopwiki.org/
Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
Increase, TNF ; Decrease, GLUT4 ; Decrease, Glucose uptake ; Abnormal, Glucose homeostasis ; Gestational diabetes mellitus
  • 11/19/2021 1:27:15 AM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
Increases in cellular reactive oxygen species and chronic reactive oxygen species leading to human treatment-resistant gastric cancer
Increased, Reactive oxygen species ; Oxidative Stress ; Wnt ligand stimulation ; Frizzled activation ; GSK3beta inactivation ; β-catenin activation ; Snail, Zeb, Twist activation ; Epithelial-mesenchymal transition ; Treatment-resistant gastric cancer ; Chronic reactive oxygen species ; Sustained tissue damage / macrophage activation/ porcupine-induced Wnt secretion ; Proliferation/ beta-catenin activation ; Increase, Oxidative damage to DNA ; Chronic reactive oxygen species ; Porcupine-induced Wnt secretion and Wnt signaling activation ; beta-catenin activation ; Epithelial-mesenchymal transition ; Treatment-resistant gastric cancer ; Increases in cellular reactive oxygen species
  • 5/29/2019 2:10:22 AM
  • 7/6/2023 5:40:56 AM
Source: https://aopwiki.org/
Inhibition of 11β-hydroxylase leading to decresed population trajectory
impaired, Fertility ; Decreased, 11-ketotestosterone ; 11β-hydroxylase inhibition ; Decreased plasma 11-KT level ; Decreased size and sperm volume ; impaired, Fertility ; Decrease, Population growth rate ; Decreased, plasma 11-ketotestosterone level ; 11β-hydroxylase inhibition ; Decreased spermatogenesis ; impaired fertility ; Cortisol and 11β-(OH) testosterone decreased ; Decreased plasma Cortisol level ; decreased oocyte maturation
  • 7/12/2020 2:16:17 PM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory
Decrease, Fertility ; Decreased, 11-ketotestosterone ; Impaired, Spermatogenesis ; Decreased plasma 11-KT level ; Inhibition of 11β-HSD ; impaired, Fertility ; Decrease, Population growth rate ; Decrease, Fertility ; Decreased, plasma 11-ketotestosterone level ; Impaired, Spermatogenesis ; Inhibition of 11β-HSD ; impaired fertility
  • 7/3/2020 4:44:29 PM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
Inhibition, Cytochrome P450 enzyme (CYP17A1) activity ; Reduction, 17-OH-pregnenolone conversion in DHEA ; Reduction, 17-OH-progesterone conversion in androstenedione ; Decrease, testosterone synthesis/level ; Decrease, dihydrotestosterone (DHT) level ; Decrease, androgen receptors (AR) activation ; Impaired inguinoscrotal testicular descent phase ; Malformation, cryptorchidism - maldescended testis ; Inhibition, Cytochrome P450 enzyme (CYP17A1) activity ; Reduction, 17-OH-pregnenolone conversion in DHEA ; Reduction, 17-OH-progesterone conversion in androstenedione ; Decrease, testosterone synthesis/level ; Decrease, dihydrotestosterone (DHT) level ; Decrease, androgen receptor activation ; Impaired inguinoscrotal testicular descent phase ; Malformation, cryptorchidism - maldescended testis
  • 4/10/2019 8:22:51 AM
  • 4/29/2023 8:03:01 PM
Source: https://aopwiki.org/
Inhibition of 5α-reductase leading to impaired fecundity in female fish
Reduction, Plasma 17beta-estradiol concentrations ; Reduction, Cumulative fecundity and spawning ; Reduction, Plasma vitellogenin concentrations ; Decrease, Population trajectory ; Decrease, dihydrotestosterone (DHT) level ; 5α-reductase, inhibition ; Reduction, egg production and spawning ; Reduction, Plasma 17beta-estradiol concentrations ; Decrease, Population growth rate ; Reduction, Plasma vitellogenin concentrations ; Reduction, Cumulative fecundity and spawning ; Decrease, dihydrotestosterone (DHT) level ; Inhibition, 5α-reductase
  • 4/18/2019 9:45:58 PM
  • 4/29/2023 8:03:01 PM
Source: https://aopwiki.org/
Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)
Increase, Hyperplasia (Leydig cells) ; Increase, Leydig cell tumors ; Inhibition, 5α-reductase activity ; Increased, Leutinizing hormone (LH) ; Decrease, Bioactivation of testosterone ; Increase, Hyperplasia (Leydig cells) ; Increase, Leydig cell tumors ; Inhibition, 5α-reductase activity ; Increased, Leutinizing hormone (LH) ; Decrease, Bioactivation of testosterone
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Inhibition of ALDH1A (RALDH) leading to impaired fertility via disrupted meiotic initiation of fetal oogonia of the ovary
impaired, Fertility ; irregularities, ovarian cycle ; Decreased fertility, Reduced number of oocytes ovulated ; Inhibition of ALDH1A (RALDH) ; Decreased, all-trans retinoic acid (atRA) concentration ; Disrupted meiotic initiation of fetal oogonia of the ovary ; Reduced size of the ovarian follicle pool
  • 5/24/2021 3:29:40 PM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis
N/A, Liver fibrosis ; Increased, extracellular matrix deposition ; Increased, Reactive oxygen species ; Induced dysregulation of ACE2 ; Increase plasma Ang II ; Induced, Angiotensin (Ang) II accumulation ; Increased Ang II type 1 receptor (AT1R)
  • 3/30/2021 5:45:49 PM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
Inhibition of ATP synthase
Inhibition of ATP synthase ; Death ; Reduced ATP formation ; Inhibition of ATP-dependent cellular functions ; Reduced ATP-depndent functions ; Heart Failure ; Respiratory Failure ; Increased metabolism ; Reduced mitochondrial oxygen consumption ; Increased mitochondrial reactive oxygen species formation ; Necrosis ; Apoptosis ; Hyperpolarized mitochondrial membrane potential ; Population reduction ; Inhibition of ATP synthase ; Death ; Reduced ATP formation ; Inhibition of ATP-dependent cellular functions ; Reduced ATP-depndent functions ; Heart Failure ; Respiratory Failure ; Increased metabolism ; Reduced mitochondrial oxygen consumption ; Increased mitochondrial reactive oxygen species formation ; Necrosis ; Apoptosis ; Hyperpolarized mitochondrial membrane potential ; Population reduction
  • 4/11/2010 10:00:00 AM
Source: https://www.effectopedia.org/
Inhibition of ATP synthase
Inhibition of ATP synthase ; Death ; Reduced ATP formation ; Inhibition of ATP-dependent cellular functions ; Reduced ATP-depndent functions ; Heart Failure ; Respiratory Failure ; Increased metabolism ; Reduced mitochondrial oxygen consumption ; Increased mitochondrial reactive oxygen species formation ; Necrosis ; Apoptosis ; Hyperpolarized mitochondrial membrane potential ; Population reduction
  • 4/11/2010 10:00:00 AM
Source: http://www.effectopedia.org/
Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
Binding, Immunophilins ; Inhibition, Calcineurin Activity ; Interference, nuclear localization of NFAT ; Reduction, NFAT/AP-1 complex formation ; Suppression, IL-2 and IL-4 production ; Suppression, Suppression of production of cytotoxic T-cells ; Suppression, Suppression of T-cell dependent antibody production ; Impairment, T-cell dependent antibody response ; Relief, Relief of atopic dermatitis ; Increase, Increased susceptibility to infection ; Inhibition, Calcineurin Activity ; Interference, nuclear localization of NFAT ; Reduction, NFAT/AP-1 complex formation ; Suppression, IL-2 and IL-4 production ; Impairment, T-cell dependent antibody response
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:58 PM
  • OECD endorsed (WNT and WPHA)
  • 1.38
  • Review Report
  • i-Library
Source: https://aopwiki.org/
Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome
Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) ; Inhibition, NADH-ubiquinone oxidoreductase (complex I) ; Decrease, Oxidative phosphorylation ; Decreased Na/K ATPase activity ; Decreased proximal tubular vectorial transport ; Chemical induced Fanconi syndrome ; Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) ; Inhibition, NADH-ubiquinone oxidoreductase (complex I) ; Decrease, Oxidative phosphorylation ; Decreased Na/K ATPase activity ; Decreased proximal tubular vectorial transport ; Chemical induced Fanconi syndrome
  • 12/20/2018 2:40:37 PM
  • 4/29/2023 8:03:01 PM
Source: https://aopwiki.org/
Inhibition of complexes I-IV
Inhibition of complex I ; Inhibition of complex II ; Inhibition of complex III ; Inhibition of complex IV ; Death ; Reduced ATP formation ; Inhibition of ATP-dependent cellular functions ; Reduced ATP-depndent functions ; Heart Failure ; Respiratory Failure ; Increased metabolism ; Inhibition of the electron transport chain ; Reduced mitochondrial oxygen consumption ; Reduced mitochondrial membrane potential ; Increased mitochondrial reactive oxygen species formation ; Necrosis ; Apoptosis ; Population reduction ; Inhibition of complex I ; Inhibition of complex II ; Inhibition of complex III ; Inhibition of complex IV ; Death ; Reduced ATP formation ; Inhibition of ATP-dependent cellular functions ; Reduced ATP-depndent functions ; Heart Failure ; Respiratory Failure ; Increased metabolism ; Inhibition of the electron transport chain ; Reduced mitochondrial oxygen consumption ; Reduced mitochondrial membrane potential ; Increased mitochondrial reactive oxygen species formation ; Necrosis ; Apoptosis ; Population reduction
  • 4/11/2010 10:00:00 AM
Source: https://www.effectopedia.org/
Inhibition of complexes I-IV
Inhibition of complex I ; Inhibition of complex II ; Inhibition of complex III ; Inhibition of complex IV ; Death ; Reduced ATP formation ; Inhibition of ATP-dependent cellular functions ; Reduced ATP-depndent functions ; Heart Failure ; Respiratory Failure ; Increased metabolism ; Inhibition of the electron transport chain ; Reduced mitochondrial oxygen consumption ; Reduced mitochondrial membrane potential ; Increased mitochondrial reactive oxygen species formation ; Necrosis ; Apoptosis ; Population reduction
  • 4/11/2010 10:00:00 AM
Source: http://www.effectopedia.org/
Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity
Decreased, Population trajectory ; Decreased, Reproductive Success ; CYP7B activity, inhibition ; 7α-hydroxypregnenolone synthesis in the brain, decreased ; Dopamine release in the brain, decreased ; Locomotor activity, decreased ; Decrease, Population growth rate ; Decreased, Reproductive Success ; CYP7B activity, inhibition ; 7α-hydroxypregnenolone synthesis in the brain, decreased ; Dopamine release in the brain, decreased ; Locomotor activity, decreased ; Decreased, Population trajectory
  • 5/2/2017 2:41:02 PM
  • 4/29/2023 8:03:00 PM
Source: https://aopwiki.org/
Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
Decreased, Population trajectory ; Decreased, Reproductive Success ; CYP7B activity, inhibition ; 7α-hydroxypregnenolone synthesis in the brain, decreased ; Dopamine release in the brain, decreased ; Sexual behavior, decreased ; Decrease, Population growth rate ; Decreased, Reproductive Success ; CYP7B activity, inhibition ; 7α-hydroxypregnenolone synthesis in the brain, decreased ; Dopamine release in the brain, decreased ; Decreased, Population trajectory ; Sexual behavior, decreased
  • 5/3/2017 3:40:04 PM
  • 4/29/2023 8:03:00 PM
Source: https://aopwiki.org/
Inhibition of Cystathionine Beta synthase leading to impaired the early development of anterior-posterior axis
Inhibition of cystathionine beta-synthase ; Inhibition of Methylenetetrahydrofolate reductase ; Inhibition of Methionine synthase ; Inhibition of betaine-homocysteine methyltransferase ; Increased Homocysteine level ; Increased plasma Homocysteine level ; Increased brain Homocysteine level ; Induce Neuronal dysfunctions ; Increased, Plasma HCY level ; Induced, dysfunction of microcirculation ; Impaired,anterior-posterior axis development ; Inhibition of cystathionine beta-synthase ; Increased Homocysteine level ; Increased, Plasma HCY level ; Induced, dysfunction of microcirculation ; Impaired,anterior-posterior axis development
  • 6/14/2019 12:41:37 PM
  • 4/29/2023 8:03:02 PM
Source: https://aopwiki.org/
Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
Activation, PPARα ; Activation, LXR ; peroxisome proliferator activated receptor promoter demethylation ; Activation, FAS ; Activation, SCD-1 ; Inhibition, Mitochondrial fatty acid beta-oxidation ; Inhibition, PPAR alpha ; Increased, Liver Steatosis ; Activation, NRF2 ; Activation, SHP ; Increased, Reactive oxygen species ; Increase, insulin ; Activation, insulin receptor ; Activation, mTORC2 ; Activation, AKT ; Activation, mTORC1 ; Activation, SREBP-1 ; Activation, L-FABP ; Increase, cytosolic fatty acid ; Increased, lipogenesis ; Activation, FXR ; Activation, HSD17B4 ; Inhibition, LXR ; Inhibition, LRH-1 ; Activation, aPKC ; Activation, PI3K ; Inhibition, Steatosis ; Increase, Fatty acid beta-oxidation ; Decrease, cytosolic fatty acid ; Activation, LRH-1 ; Inhibition, Fatty Acid Beta Oxidation ; N/A, Steatohepatisis ; Increased, Oncotic Necrosis ; Increased, Liver Steatosis ; Increased, Reactive oxygen species ; Inhibition, Fatty Acid Beta Oxidation ; Increase, cytosolic fatty acid ; Increased, Oncotic Necrosis ; N/A, Steatohepatisis
  • 4/12/2017 5:28:27 PM
  • 4/29/2023 8:02:59 PM
Source: https://aopwiki.org/
Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos)
Increased Mortality ; Decrease, Population growth rate ; Altered, Visual function ; Decrease, Cell proliferation ; Decreased, Eye size ; Inhibition of Fyna ; Inhibition of Plxna2 ; Overexpression of rasl11b
  • 5/28/2021 9:20:57 AM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
Inhibition of histone deacetylases class I
Inhibition of histone deacetylases (HDACs) class I ; De-repression of the Wnt/beta-catenin signalling pathway ; Accumulation of beta-catenin ; Activation of Wnt target genes ; Valproic acid exposure developmental outcome ; Inhibition of histone deacetylases (HDACs) class I ; De-repression of the Wnt/beta-catenin signalling pathway ; Accumulation of beta-catenin ; Activation of Wnt target genes ; Valproic acid exposure developmental outcome
  • 4/11/2010 10:00:00 AM
Source: https://www.effectopedia.org/
Inhibition of histone deacetylases class I
Inhibition of histone deacetylases (HDACs) class I ; De-repression of the Wnt/beta-catenin signalling pathway ; Accumulation of beta-catenin ; Activation of Wnt target genes ; Valproic acid exposure developmental outcome
  • 4/11/2010 10:00:00 AM
Source: http://www.effectopedia.org/
Inhibition of iNOS, hepatotoxicity, and regenerative proliferation leading to liver tumors
Production, Critical Metabolites (CGA 330050 and CGA 265307) ; Induction, Liver “Dysfunctional” Changes by CGA 330050 ; Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307 ; Induction, Sustained Hepatotoxicity ; Induction, Sustained Cell Proliferation ; Formation, Liver tumor ; Production, Critical Metabolites (CGA 330050 and CGA 265307) ; Induction, Liver “Dysfunctional” Changes by CGA 330050 ; Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307 ; Induction, Sustained Hepatotoxicity ; Induction, Sustained Cell Proliferation ; Formation, Liver tumor
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:55 PM
Source: https://aopwiki.org/
Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)
Decreased, Uptake of inorganic iodide ; Increase, Hypertrophy and proliferation (follicular cell) ; Increase, Hyperplasia (follicular cells) ; Increase, Thyroid-stimulating hormone (TSH) ; Decrease, Serum thyroid hormone (T4/T3) ; Increase, Adenomas/carcinomas (follicular cell) ; Thyroxine (T4) in serum, Decreased ; Thyroid hormone synthesis, Decreased ; Inhibition, Na+/I- symporter (NIS) ; Decreased, Uptake of inorganic iodide ; Increase, Hypertrophy and proliferation (follicular cell) ; Increase, Hyperplasia (follicular cells) ; Increase, Thyroid-stimulating hormone (TSH) ; Decrease, Serum thyroid hormone (T4/T3) ; Increase, Adenomas/carcinomas (follicular cell) ; Increased, Thyroid-stimulating hormone (TSH)
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
Inhibition of JAK3 ; Blockade of STAT5 phosphorylation ; Suppression of STAT5 binding to cytokine gene promoters ; Suppression of IL-2 production ; Impairment of T-cell dependent antibody response ; Inhibition of JAK3 ; Blockade of STAT5 phosphorylation ; Suppression of STAT5 binding to cytokine gene promoters ; Suppression of IL-4 production ; Impairment of T-cell dependent antibody response
  • 1/5/2020 10:55:25 PM
  • 4/29/2023 8:03:02 PM
Source: https://aopwiki.org/
Inhibition of JAK3 leading to impairment of TDAR
  • 9/14/2019 12:03:50 AM
Source: https://aopwiki.org/
Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
Decreased, survival ; Reduced, Swimming performance ; Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts ; Inhibition of lysyl oxidase ; Reduction of collagen crosslinking ; Weak collagen matrix ; Notochord distortion or malformations ; Growth, reduction ; Decreased, survival ; Reduced, Swimming performance ; Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts ; Inhibition of lysyl oxidase ; Reduction of collagen crosslinking ; Weak collagen matrix ; Notochord distortion or malformations ; Growth, reduction
  • 8/3/2017 1:52:03 PM
  • 4/29/2023 8:03:00 PM
Source: https://aopwiki.org/
Inhibition of mitochondrial DNA polymerase gamma leading to kidney toxicity
Increase, Cytotoxicity (renal tubular cell) ; Occurrence, Kidney toxicity ; Inhibition of mitochondrial DNA polymerase gamma (Pol gamma) ; Depletion, mtDNA ; Dysfunction, Mitochondria ; Increase, Cytotoxicity (renal tubular cell) ; Occurrence, Kidney toxicity ; Inhibition of mitochondrial DNA polymerase gamma (Pol gamma) ; Depletion, mtDNA ; Dysfunction, Mitochondria
  • 10/25/2017 11:15:19 AM
  • 4/29/2023 8:03:00 PM
Source: https://aopwiki.org/
Inhibition of mitochondrial electron transport chain (ETC) complexes leading to kidney toxicity
N/A, Mitochondrial dysfunction 1 ; Oxidative Stress ; Increase, Cytotoxicity (renal tubular cell) ; Occurrence, Kidney toxicity ; Increased, Oxidative Stress ; Inhibition, Mitochondrial Electron Transport Chain Complexes ; Increase, Mitochondrial Dysfunction ; Increase, Oxidative Stress
  • 1/31/2022 8:24:10 PM
  • 6/26/2023 2:28:10 PM
Source: https://aopwiki.org/
Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
Thyroxine (T4) in neuronal tissue, Decreased ; Thyroxine (T4) in serum, Decreased ; Reduced levels of BDNF ; Impairment, Learning and memory ; Decrease of synaptogenesis ; Decrease of neuronal network function ; Thyroid hormone synthesis, Decreased ; Inhibition, Na+/I- symporter (NIS) ; Decrease of Thyroidal iodide ; Decrease of GABAergic interneurons ; Thyroxine (T4) in serum, Decreased ; Thyroxine (T4) in neuronal tissue, Decreased ; Reduced levels of BDNF ; Impairment, Learning and memory ; Decrease of synaptogenesis ; Decrease of neuronal network function ; Thyroid hormone synthesis, Decreased ; Inhibition, Na+/I- symporter (NIS) ; Decrease of Thyroidal iodide ; Decrease of GABAergic interneurons
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • OECD endorsed (WNT and WPHA)
  • 1.28
  • Review Report
  • i-Library
Source: https://aopwiki.org/
Inhibition of N-linked glycosylation leads to liver injury
Increased, Liver Steatosis ; Apoptosis ; Unfolded Protein Response ; Liver Injury ; Inhibition of N-linked glycosylation ; Accumulation of misfolded proteins ; Activation of hepatic stellate cells ; Increased, Liver Steatosis ; Apoptosis ; Unfolded Protein Response ; Liver Injury ; Inhibition of N-linked glycosylation ; Accumulation of misfolded proteins ; Activation of hepatic stellate cells
  • 3/6/2019 12:18:36 PM
  • 4/29/2023 8:03:01 PM
Source: https://aopwiki.org/
Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
Peptide Oxidation ; Increase, Adenomas/carcinomas (hepatocellular) ; Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme ; Increase, Cytotoxicity ; Increased, Induction of pyruvate dehydrogenase (PDH) ; Increase, Oxidative metabolism ; Peptide Oxidation ; Increase, hepatocellular adenomas and carcinomas ; Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme ; Increase, Cytotoxicity ; Increased, Induction of pyruvate dehydrogenase (PDH) ; Increase, Oxidative metabolism
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
Neural crest cell migration, reduced ; Disruption, Progenitor cells of second heart field ; Inhibition of ALDH1A (RALDH) ; Decreased, all-trans retinoic acid (atRA) concentration ; transposition of the great arteries
  • 1/27/2022 4:16:35 PM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
Inhibition of retinaldehyde dehydrogenase leads to population decline
Decrease, Population trajectory ; Decline, Population ; Retinaldehyde dehydrogenase inhibition ; Decreased optical elements of the eye ; Decreased retinoic acid (RA) synthesis ; Decreased plasma RA level ; Increased visual impairment ; Decrease, Population growth rate ; Retinaldehyde dehydrogenase inhibition ; Altered, Photoreceptor patterning ; Decreased retinoic acid (RA) synthesis ; Decreased plasma RA level ; Altered, Visual function
  • 5/22/2019 8:45:03 AM
  • 4/29/2023 8:03:02 PM
Source: https://aopwiki.org/
Inhibition of the enzyme 5-alpha reductase type 2
Inhibition of the enzyme 5-alpha reductase type 2 ; Decrease in dihydrotestosterone conversion from testosterone ; Decrease in transcription of androgen-dependent genes ; Alteration of proliferation and differentiation of several androgen dependent tissues ; Developmental toxicity by inhibition of the 5-alpha reductase enzyme ; Inhibition of the enzyme 5-alpha reductase type 2 ; Decrease in dihydrotestosterone conversion from testosterone ; Decrease in transcription of androgen-dependent genes ; Alteration of proliferation and differentiation of several androgen dependent tissues ; Developmental toxicity by inhibition of the 5-alpha reductase enzyme
  • 4/11/2010 10:00:00 AM
Source: https://www.effectopedia.org/
Inhibition of the enzyme 5-alpha reductase type 2
Inhibition of the enzyme 5-alpha reductase type 2 ; Decrease in dihydrotestosterone conversion from testosterone ; Decrease in transcription of androgen-dependent genes ; Alteration of proliferation and differentiation of several androgen dependent tissues ; Developmental toxicity by inhibition of the 5-alpha reductase enzyme
  • 4/11/2010 10:00:00 AM
Source: http://www.effectopedia.org/
Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) ; Inhibition, NADH-ubiquinone oxidoreductase (complex I) ; N/A, Mitochondrial dysfunction 1 ; impaired, Proteostasis ; N/A, Neuroinflammation ; Degeneration of dopaminergic neurons of the nigrostriatal pathway ; Parkinsonian motor deficits ; Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) ; Inhibition, NADH-ubiquinone oxidoreductase (complex I) ; N/A, Mitochondrial dysfunction 1 ; Impaired, Proteostasis ; Neuroinflammation ; Degeneration of dopaminergic neurons of the nigrostriatal pathway ; Parkinsonian motor deficits
  • 11/29/2016 11:41:15 PM
  • 4/29/2023 8:02:54 PM
  • OECD endorsed (WNT and WPHA)
  • 1.33
  • Review Report
  • i-Library
Source: https://aopwiki.org/
Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse)
Thyroperoxidase, Inhibition ; Increase, Hypertrophy and proliferation (follicular cell) ; Increase, Hyperplasia (follicular cells) ; Increase, Thyroid-stimulating hormone (TSH) ; Decrease, Serum thyroid hormone (T4/T3) ; Increase, Adenomas/carcinomas (follicular cell) ; Decrease, Incorporation of active iodide into iodotyrosines ; Thyroxine (T4) in serum, Decreased ; Thyroperoxidase, Inhibition ; Thyroid hormone synthesis, Decreased ; Increase, Hypertrophy and proliferation (follicular cell) ; Increase, Hyperplasia (follicular cells) ; Increase, Thyroid-stimulating hormone (TSH) ; Decrease, Serum thyroid hormone (T4/T3) ; Increase, Adenomas/carcinomas (follicular cell) ; Decrease, Incorporation of active iodide into iodotyrosines ; Increased, Thyroid-stimulating hormone (TSH)
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Inhibition of thyroid peroxidase leading to impaired fertility in fish
Reduction, Plasma 17beta-estradiol concentrations ; Reduction, Cumulative fecundity and spawning ; Reduction, Plasma vitellogenin concentrations ; Thyroperoxidase, Inhibition ; Thyroid hormone synthesis, Decreased ; reduction in ovarian granulosa cells, Aromatase (Cyp19a1) ; Reduction, Plasma 17beta-estradiol concentrations ; Reduction, Vitellogenin synthesis in liver ; Reduction, Plasma vitellogenin concentrations ; Reduction, Cumulative fecundity and spawning ; Thyroperoxidase, Inhibition ; Thyroid hormone synthesis, Decreased
  • 9/19/2018 12:33:14 AM
  • 6/7/2023 9:33:54 AM
Source: https://aopwiki.org/
Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
Thyroxine (T4) in neuronal tissue, Decreased ; Thyroxine (T4) in serum, Decreased ; Hippocampal anatomy, Altered ; Hippocampal Physiology, Altered ; Hippocampal gene expression, Altered ; Thyroperoxidase, Inhibition ; Thyroid hormone synthesis, Decreased ; Cognitive Function, Decreased ; Thyroxine (T4) in serum, Decreased ; Thyroxine (T4) in neuronal tissue, Decreased ; Hippocampal gene expression, Altered ; Hippocampal anatomy, Altered ; Hippocampal Physiology, Altered ; Thyroperoxidase, Inhibition ; Thyroid hormone synthesis, Decreased ; Cognitive Function, Decreased
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • OECD endorsed (WNT and WPHA)
  • 1.10
  • Review Report
  • i-Library
Source: https://aopwiki.org/
Inhibition of tyrosinase leads to decreased population in fish
Decrease, Population trajectory ; Inhibition of tyrosinase ; Reduction of L-Dopaquinone ; Reduction in melanin level ; Reduction of melanosome level ; Reduction fo Pigmentation pattern ; Decrease, Population growth rate ; Inhibition of tyrosinase ; Reduction of L-Dopaquinone ; Reduction in melanin level ; Reduction of melanosome level ; Reduction fo Pigmentation pattern
  • 5/3/2019 12:02:43 PM
  • 4/29/2023 8:03:01 PM
Source: https://aopwiki.org/
Inhibition of voltage-gated sodium channels leading to decreased cognition
Cognitive Function, Decreased ; Binding to voltage-gated sodium channel ; Disruption of sodium channel gating kinetics ; Hypomyelination ; Altered, white brain matter ; Decreased, oligodendrocyte differentiation
  • 2/22/2023 1:31:03 PM
  • 4/29/2023 8:03:07 PM
Source: https://aopwiki.org/
Interaction with lung resident cell membrane components leads to lung cancer
Increase, Cytotoxicity (epithelial cells) ; Increase, Cell Proliferation ; Substance interaction with the lung resident cell membrane components ; Increased, secretion of proinflammatory mediators ; Increased, recruitment of inflammatory cells ; Increased, Reactive oxygen species ; Increased, DNA damage and mutation ; Lung cancer ; Secondary genotoxicity
  • 5/25/2022 9:09:25 AM
  • 4/29/2023 8:03:06 PM
Source: https://aopwiki.org/
Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
Thyroxine (T4) in neuronal tissue, Decreased ; Thyroxine (T4) in serum, Decreased ; Hippocampal anatomy, Altered ; Hippocampal Physiology, Altered ; Hippocampal gene expression, Altered ; Cognitive Function, Decreased ; Binding, Transthyretin in serum ; Displacement, Serum thyroxine (T4) from transthyretin ; Increased, Free serum thyroxine (T4) ; Increased, Uptake of thyroxine into tissue ; Increased, Clearance of thyroxine from tissues ; Thyroxine (T4) in serum, Decreased ; Thyroxine (T4) in neuronal tissue, Decreased ; Hippocampal gene expression, Altered ; Hippocampal anatomy, Altered ; Hippocampal Physiology, Altered ; Cognitive Function, Decreased ; Binding, Transthyretin in serum ; Displacement, Serum thyroxine (T4) from transthyretin ; Increased, Free serum thyroxine (T4) ; Increased, Uptake of thyroxine into tissue ; Increased, Clearance of thyroxine from serum
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:58 PM
  • AOP under development
  • 1.41
Source: https://aopwiki.org/
Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
Increase, Cytotoxicity ; Decrease, Intracellular pH ; Increase, Tissue Degeneration, Necrosis & Atrophy ; Increase, Cell Proliferation ; Increase, Respiratory or Squamous Metaplasia ; Increase, Mutations in Critical Genes ; Increase, Site of Contact Nasal Tumors ; Increase, Cytotoxicity ; Decrease, Intracellular pH ; Increase, Tissue Degeneration, Necrosis & Atrophy ; Increase, Cell Proliferation ; Increase, Respiratory or Squamous Metaplasia ; Increase, Mutations in Critical Genes ; Increase, Site of Contact Nasal Tumors
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:58 PM
  • EAGMST under review
  • 2.7
Source: https://aopwiki.org/
Iodotyrosine deiodinase (IYD) inhibition leading to altered amphibian metamorphosis
Thyroid hormone synthesis, Decreased ; Decrease of Thyroidal iodide ; Decreased, Thyroxine (T4) in serum ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Inhibition, Iodotyrosine deiodinase (IYD) ; Thyroxine (T4) in serum, Decreased ; Thyroid hormone synthesis, Decreased ; Decrease of Thyroidal iodide ; Decreased, Thyroxine (T4) in serum ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Inhibition, Iodotyrosine deiodinase (IYD)
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:59 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
Decrease, Population growth rate ; Increased, Oxidative Stress ; Increase, DNA damage ; Increase, Apoptosis ; Decrease, Fecundity ; Deposition of Energy ; Increase in reactive oxygen and nitrogen species (RONS) ; Decreased spermatogenesis ; Decrease, Reproduction
  • 3/28/2022 11:05:35 AM
  • 4/29/2023 8:03:06 PM
Source: https://aopwiki.org/
Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation
Increase, DNA damage ; Increase, Apoptosis ; Deposition of Energy ; Altered differentiation ; Activation of Tumor Protein 53 ; premature cell differentiation ; microcephaly ; Increase risk, microcephaly ; Premature cell differentiation
  • 3/9/2022 12:33:35 PM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality
Increased Mortality ; Increased, Chloride conductance ; Activation, ionotropic GABA Receptor chloride channel ; Increased, Inhibitory postsynaptic potential ; Induction, Somatic muscle paralysis ; Increased, Neuronal synaptic inhibition ; Inhibition, Feeding ; Increased Mortality ; Increased, Chloride conductance ; Activation, ionotropic GABA Receptor chloride channel ; Increased, Inhibitory postsynaptic potential ; Induction, Somatic muscle paralysis ; Increased, Neuronal synaptic inhibition ; Inhibition, Feeding
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:58 PM
Source: https://aopwiki.org/
Janus kinase (JAK)/Signal transducer and activator of transcription (STAT) and Transforming growth factor (TGF)-beta pathways activation leading to reproductive failure
Reproductive failure ; Activation, JAK/STAT pathway ; Activation, TGF-beta pathway ; Reproductive failure ; Activation, JAK/STAT pathway ; Activation, TGF-beta pathway
  • 2/15/2017 8:44:35 AM
  • 4/29/2023 8:02:59 PM
Source: https://aopwiki.org/
Juvenile hormone receptor agonism leading to male offspring induction associated population decline
Decline, Population ; Activation, Juvenile hormone receptor ; Induction, Doublesex1 gene ; Induction, Male reproductive tract ; Increased, Male offspring ; Alteration, Food-web structures ; Decline, Population ; Activation, Juvenile hormone receptor ; Induction, Doublesex1 gene ; Induction, Male reproductive tract ; Increased, Male offspring ; Alteration, Food-web structures
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:59 PM
Source: https://aopwiki.org/
Kidney dysfunction by decreased thyroid hormone
Thyroid hormone synthesis, Decreased ; Decreased, Thyroxine (T4) in serum ; Decreased, Glomerular filtration ; Decreased, Renal plasma flow ; Decreased, Sodium reabsorption ; Increased, Serum creatinine ; Occurrence, Cystic dilatation (renal tubule) ; Occurrence, Cytoplasmic vacuolization (podocyte) ; Occurrence, Cytoplasmic vacuolization (Renal tubule) ; Decreased, Renal ability to dilute urine ; Occurrence, Kidney toxicity ; Thyroxine (T4) in serum, Decreased ; Thyroid hormone synthesis, Decreased ; Decreased, Thyroxine (T4) in serum ; Decreased, Glomerular filtration ; Decreased, Renal plasma flow ; Decreased, Sodium reabsorption ; Increased, Serum creatinine ; Occurrence, Cystic dilatation (renal tubule) ; Occurrence, Cytoplasmic vacuolization (podocyte) ; Occurrence, Cytoplasmic vacuolization (Renal tubule) ; Decreased, Renal ability to dilute urine ; Occurrence, Kidney toxicity
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.40
Source: https://aopwiki.org/
Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
Increase in inflammation ; Inhibition, Nuclear factor kappa B (NF-kB) ; Increased, Kidney Failure ; Occurrence, Kidney toxicity ; Occurrence, renal proximal tubular necrosis ; Increased, Oxidative Stress ; Increase, Apoptosis ; Decrease, Mitochondrial membrane potential ; Activation of ER stress ; Altered gene expression, NRF2 dependent antioxidant pathway ; Inhibition, Mitochondrial Electron Transport Chain Complexes ; Increase, Mitochondrial Dysfunction
  • 4/8/2022 11:56:32 AM
  • 4/29/2023 8:03:06 PM
Source: https://aopwiki.org/
Kidney toxicity induced by activation of 5HT2C
Activation, 5HT2c ; N/A, Unknown ; Increased, Kidney Failure ; Activation, 5HT2c ; N/A, Unknown ; Increased, Kidney Failure
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:55 PM
Source: https://aopwiki.org/
Knickkopf leading to mortality
Increase, Incomplete ecdysis ; Increase, Mortality ; Increase, developmental abnormalities ; Decrease, 20-hydroxyecdysone ; Decrease, knickkopf gene ; Decrease, Chitin laminar organization ; Decrease, Prevent chitin degradation by chitinases ; Weak, Procuticle protection ; Decrease, New cuticle secretion
  • 8/29/2022 1:06:53 AM
  • 5/25/2023 7:27:15 AM
Source: https://aopwiki.org/
Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis
Increase, Reactive oxygen species production ; Accumulation, Collagen ; Increased, secretion of local growth factors ; Expression of Collagen ; Collagen Deposition ; Induction, Cell damage sensing ; Incudtion, Sustained inflammatory cytokine release ; Increase, Differentiation of fibroblasts ; Induction, Epithelial Mesenchymal Transition ; Pulmonary fibrosis ; Activation, Latent Transforming Growth Factor Beta 1 ; Activation, Transforming Growth Factor beta pathway ; Accumulation, Collagen ; Pulmonary fibrosis ; Induction, Epithelial Mesenchymal Transition ; Activation, Latent Transforming Growth Factor Beta 1 ; Increase, Differentiation of fibroblasts ; Activation, Transforming Growth Factor beta pathway
  • 7/26/2017 10:54:43 PM
  • 4/29/2023 8:03:00 PM
Source: https://aopwiki.org/
L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
Blockade, L-Type Calcium Channels ; Decrease, Calcium currents ; Decrease, Calcium binding to Troponin C ; Decrease, Cardiac contractility ; Decrease, Cardiac ejection fraction ; Decrease, Blood pressure ; Heart failure ; Disruption, Intracellular calcium mobilization ; Disruption, Sarcomere assembly ; Blockade, L-Type Calcium Channels ; Decrease, Calcium currents ; Decrease, Calcium binding to Troponin C ; Decrease, Cardiac contractility ; Decrease, Cardiac ejection fraction ; Disruption, Intracellular calcium mobilization ; Disruption, Sarcomere assembly ; Heart failure
  • 5/10/2018 12:37:07 PM
  • 4/29/2023 8:03:00 PM
Source: https://aopwiki.org/
L-type calcium channel blockade leading to hypotension
  • 2/11/2019 1:12:06 PM
  • 4/29/2023 8:03:01 PM
Source: https://aopwiki.org/
L-type calcium channel blockade leading to the disruption of cardiac electrophysiology
  • 5/10/2018 12:46:24 PM
  • 4/29/2023 8:03:00 PM
Source: https://aopwiki.org/
Lung surfactant function inhibition leading to decreased lung function
Substance - lung surfactant interaction ; Disruption of lung surfactant function ; Alveolar collapse ; Alveolar reopening ; Loss of barrier function ; Blood extravasation into the lungs ; Reduced lung volume ; Impaired oxygenation of the blood ; Acute inhalation toxicity ; Decrease, Lung function ; Loss of alveolar capillary membrane integrity ; Substance - lung surfactant interaction ; Inhibition of lung surfactant function ; Alveolar collapse ; Alveolar reopening ; Loss of barrier function ; Blood extravasation into the lungs ; Reduced tidal volume ; Impaired oxygenation of the blood ; Acute inhalation toxicity ; Impaired lung function
  • 6/19/2019 10:49:33 AM
  • 4/29/2023 8:03:02 PM
Source: https://aopwiki.org/
Luteinizing hormone receptor antagonism leading to reproductive dysfunction
Decline, Population trajectory ; Antagonism,LH receptor ; Reduction, Progesterone synthesis ; Reduction, Plasma progesterone concentration ; Reduction, progesterone uptake, decresed maturation ; Impaired ovulation ; Decrease of egg production and cummulative fecundity ; Antagonism,LH receptor ; Reduction, Progesterone synthesis ; Reduction, Plasma progesterone concentration ; Reduction, progesterone uptake, decresed maturation ; Impaired ovulation ; Decrease of egg production and cummulative fecundity ; Decline, Population trajectory
  • 10/3/2019 2:43:37 PM
  • 4/29/2023 8:03:02 PM
Source: https://aopwiki.org/
LXR activation leading to hepatic steatosis
Activation, LXR ; peroxisome proliferator activated receptor promoter demethylation ; Up Regulation, CD36 ; Increase, FA Influx ; Activation, ChREBP ; Activation, SREBP-1c ; Activation, FAS ; Activation, SCD-1 ; Synthesis, De Novo FA ; Accumulation, Triglyceride ; Damaging, Mitochondria ; N/A, Liver Steatosis ; Activation, LXR ; peroxisome proliferator activated receptor promoter demethylation ; Up Regulation, CD36 ; Increase, FA Influx ; Activation, ChREBP ; Activation, SREBP-1c ; Activation, FAS ; Activation, SCD-1 ; Synthesis, De Novo FA ; Accumulation, Triglyceride ; Damaging, Mitochondria ; N/A, Liver Steatosis
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:55 PM
Source: https://aopwiki.org/
Mental stress to agitation
Activation, Glucocorticoid Receptor ; Decreased, serotonin transporter activity ; Increased, extracellular serotonin ; Decreased, intracellular serotonin ; Decreased, packaged serotonin ; Decreased, synaptic release ; Inactivated, 5-HTR (serotonin receptors) ; Reduce expression, BDNF (Brain-derived neurotrophic factor) ; Decreased, neuroplasticity ; Increase, cortisone ; Reduced, BDNF (Brain-derived neurotrophic factor) ; Increased, agitation ; Decreased, extracellular serotonin ; Increased, glucocorticoid receptor activity ; Decreased, serotonin transporter activity ; Increased, extracellular serotonin ; Decreased, extracellular serotonin ; Decreased, intracellular serotonin ; Decreased, packaged serotonin ; Decreased, synaptic release ; Inactivated, 5-HTR (serotonin receptors) ; Reduce expression, BDNF (Brain-derived neurotrophic factor) ; Decreased, neuroplasticity ; Reduced, BDNF (Brain-derived neurotrophic factor) ; Increased, agitation ; Increased, glucocorticoid receptor activity
  • 5/30/2017 7:12:23 PM
  • 4/29/2023 8:03:00 PM
  • AOP under development
Source: https://aopwiki.org/
Metabolic Syndrome leading to Toll Like Receptor dysregulation
  • 6/24/2021 11:53:55 AM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
Microtubule interacting drugs lead to peripheral neuropathy
Binding of microtubule stabilizing agents (MSA) to microtubules ; Disturbance in microtubule dynamic instability ; Impaired axonial transport ; Sensory axonal peripheral neuropathy ; Binding of microtubule stabilizing agents (MSA) to microtubules ; Disturbance in microtubule dynamic instability ; Impaired axonial transport ; Sensory axonal peripheral neuropathy
  • 1/29/2019 1:39:38 PM
  • 4/29/2023 8:03:01 PM
Source: https://aopwiki.org/
Mitochondrial ATP synthase antagonism leading to growth inhibition (1)
Decrease, Population trajectory ; Decrease, Fecundity ; Increase, DNA methyltransferase inhibition ; Increase, DNA hypomethylation ; Increase, Gene expression ; Decrease, Population growth rate ; Decrease, Fecundity ; Increase, Mitochondrial ATP synthase antagonism ; Decrease, Adenosine triphosphate pool ; Decrease, Growth ; Increase, DNA methyltransferase inhibition ; Increase, DNA hypomethylation ; Increase, Gene expression ; Decrease, Cell proliferation
  • 4/22/2019 8:44:30 AM
  • 4/29/2023 8:03:01 PM
Source: https://aopwiki.org/
Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
Decrease, Population trajectory ; Decrease, Fecundity ; Increase, DNA methyltransferase inhibition ; Increase, DNA hypomethylation ; Increase, Gene expression ; Decrease, Transgenerational DNA methylation ; Decrease, Population growth rate ; Decrease, Fecundity ; Increase, Mitochondrial ATP synthase antagonism ; Decrease, Adenosine triphosphate pool ; Decrease, Growth ; Increase, DNA methyltransferase inhibition ; Increase, DNA hypomethylation ; Increase, Gene expression ; Decrease, Transgenerational DNA methylation ; Increase, Cell death
  • 4/22/2019 8:45:23 AM
  • 4/29/2023 8:03:01 PM
Source: https://aopwiki.org/
Mitochondrial complex III antagonism leading to growth inhibition (1)
Increase, Mortality ; Decrease, Mitochondrial ATP production ; Decrease, Oxidative phosphorylation ; Mitochondrial Complex III inhibition ; Increase, Necrosis ; Increase, Mortality ; Decrease, Mitochondrial ATP production ; Decrease, Oxidative phosphorylation ; Decrease, Adenosine triphosphate pool ; Increase, Necrosis ; Decrease, Growth ; Increase, Mitochondrial complex III antagonism ; Decrease, Cell proliferation
  • 3/19/2019 12:35:17 PM
  • 4/29/2023 8:03:01 PM
Source: https://aopwiki.org/
Mitochondrial complex III antagonism leading to growth inhibition (2)
Increase, Mortality ; Increase, Reactive oxygen species ; Increase, Apoptosis ; Mitochondrial Complex III inhibition ; Increase, Oxidative DNA damage ; Increase, Mortality ; Increase, Apoptosis ; Decrease, Adenosine triphosphate pool ; Decrease, Growth ; Increase, Reactive oxygen species ; Increase, Mitochondrial complex III antagonism ; Increase, Oxidative DNA damage ; Increase, Cell death
  • 3/19/2019 12:35:59 PM
  • 4/29/2023 8:03:01 PM
Source: https://aopwiki.org/
Mitochondrial complex inhibition leading to liver injury
Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) ; Inhibition, NADH-ubiquinone oxidoreductase (complex I) ; N/A, Mitochondrial dysfunction 1 ; impaired, Proteostasis ; N/A, Cell injury/death ; Mitochondrial Complex I inhibition ; Mitochondrial Complex III inhibition ; Mitochondrial Complex IV inhibition ; Mitochondrial Complex V inhibition ; Decrease in mitochondrial oxidative phosphorylation ; Increased reactive oxygen species (in the mitochondria) ; Mitochondrial Injury ; Necrotic Tissue ; Liver Injury ; Binding of inhibitor to mitochondrial complex III ; Binding of inhibitor to mitochondrial complex IV ; Binding of inhibitor to mitochondrial complex V ; Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I) ; Inhibition, NADH-ubiquinone oxidoreductase (complex I) ; N/A, Mitochondrial dysfunction 1 ; Impaired, Proteostasis ; Cell injury/death ; Increase, Mitochondrial complex III antagonism ; Mitochondrial Complex IV inhibition ; Mitochondrial Complex V inhibition ; Binding of inhibitor to mitochondrial complex III ; Binding of inhibitor to mitochondrial complex IV ; Binding of inhibitor to mitochondrial complex V ; Decrease in mitochondrial oxidative phosphorylation ; Increased reactive oxygen species (in the mitochondria) ; Mitochondrial Injury ; Necrotic Tissue ; Liver Injury
  • 12/19/2018 2:14:24 PM
  • 4/29/2023 8:03:01 PM
Source: https://aopwiki.org/
Mitochondrial complexes inhibition leading to heart failure via decreased ATP production
N/A, Mitochondrial dysfunction 1 ; Increase, Mortality ; Decrease, Mitochondrial ATP production ; Decrease, Cardiac contractility ; Heart failure ; Inhibition, Mitochondrial Electron Transport Chain Complexes
  • 1/5/2023 11:31:36 AM
  • 4/29/2023 8:03:07 PM
Source: https://aopwiki.org/
Mitochondrial complexes inhibition leading to heart failure via increased myocardial oxidative stress
N/A, Mitochondrial dysfunction 1 ; Increase, Mortality ; Cell injury/death ; Oxidative Stress ; Decrease, Cardiac contractility ; Heart failure ; Inhibition, Mitochondrial Electron Transport Chain Complexes ; Increase, Cardiac remodelling
  • 1/5/2023 9:27:28 AM
  • 4/29/2023 8:03:07 PM
Source: https://aopwiki.org/
Mitochondrial dysfunction to metabolic diseases
  • 2/13/2021 11:36:45 AM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis
Decreased testosterone by the fetal Leydig cells, Increased corticosterone ; Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists ; Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells ; Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells ; Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells ; Decreased sperm quantity / quality in the adult, Decreased fertility ; Decreased testosterone by the fetal Leydig cells, Increased corticosterone ; Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists ; Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells ; Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells ; Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells ; Decreased sperm quantity / quality in the adult, Decreased fertility
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome
Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells ; Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells ; Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells ; Decreased sperm quantity / quality in the adult, Decreased fertility ; Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome ; Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells ; Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells ; Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells ; Decreased sperm quantity / quality in the adult, Decreased fertility ; Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell
Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol ; Decreased Cholesterol, Decreased Uptake of Lipoproteins ; Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane ; Decreased Cholesterol, Decreased Testosterone Production by Adult Leydig Cells ; Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis ; Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol ; Decreased Cholesterol, Decreased Uptake of Lipoproteins ; Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane ; Decreased Cholesterol, Decreased Testosterone Production by Adult Leydig Cells ; Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis
Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells ; Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells ; Decreased sperm quantity / quality in the adult, Decreased fertility ; Decreased testosterone by the fetal Leydig cells, Increased estradiol ; Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists ; decreased testosterone by fetal Leydig cells, Dysgenesis of fetal Leydig cells ; Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells ; Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells ; Decreased sperm quantity / quality in the adult, Decreased fertility ; Decreased testosterone by the fetal Leydig cells, Increased estradiol ; Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists ; decreased testosterone by fetal Leydig cells, Dysgenesis of fetal Leydig cells
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation
Decreased sperm quantity or quality in the adult, Decreased fertility ; Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid ; Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells ; Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells ; Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells ; Decreased sperm quantity or quality in the adult, Decreased fertility ; Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid ; Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells ; Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells ; Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells ; Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis ; Decreased testosterone by the fetal Leydig cells, Dysgensis of fetal Leydig cells ; Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells ; Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis ; Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells ; Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis ; Decreased testosterone by the fetal Leydig cells, Dysgensis of fetal Leydig cells ; Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells ; Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell
Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell ; Decreased steroidogenesis, Decreased Activity of Steroidogenic Enzymes in Adult Leydig cells ; Decreased steroidogenesis, Increased Apoptosis of Adult Leydig Cells ; Decreased steroidogenesis, Alterations in the Leydig Cell Cytoskeleton ; Decreased sperm quantity or quality in the adult, Decreased fertility ; Decreased sperm quantity or quality in the adult, Decreased fertility ; Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell ; Decreased steroidogenesis, Decreased Activity of Steroidogenic Enzymes in Adult Leydig cells ; Decreased steroidogenesis, Increased Apoptosis of Adult Leydig Cells ; Decreased steroidogenesis, Alterations in the Leydig Cell Cytoskeleton
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Molecular events lead to epilepsy
Increased, intracellular sodium (Na+) ; Increased, intracellular chloride (Cl-) ; Activated, presynaptic neuron 1 ; Increased, glutamate ; Activated, NMDA receptor ; Activated, voltage-gated sodium channel ; Inhibit, voltage-gated sodium channel ; Treat, carbamazepine ; Activated, membrane depolarization ; Inactive, membrane depolarization ; Increased, RDX dose ; Repress, GABA-A receptor ; Activate, GABA-A receptor ; Activate, presynaptic neuron 2 ; Increase, GABA ; Increase, seizure ; Increased, hippocampal hyperdepolarization ; Increased, epilepsy ; Increased, intracellular sodium (Na+) ; Increased, intracellular chloride (Cl-) ; Activated, presynaptic neuron 1 ; Increased, glutamate ; Activated, NMDA receptor ; Activated, voltage-gated sodium channel ; Binding to voltage-gated sodium channel ; Treat, carbamazepine ; Activated, membrane depolarization ; Inactive, membrane depolarization ; Increased, RDX dose ; Repress, GABA-A receptor ; Activate, GABA-A receptor ; Activate, presynaptic neuron 2 ; Increase, GABA ; Increase, seizure ; Increased, hippocampal hyperdepolarization ; Increased, epilepsy
  • 4/14/2017 6:58:30 PM
  • 4/29/2023 8:03:00 PM
Source: https://aopwiki.org/
Mu Opioid Receptor Agonism leading to Analgesia via Ca Channel Inhibition
Mu Opioid Receptor Agonism ; Release of G Proteins ; Analgesia ; Inhibition of N-type Ca ion channels ; Inhibition of neurotransmitter vesicle release ; Mu Opioid Receptor Agonism ; Release of G Proteins ; Analgesia ; Inhibition of N-type Ca ion channels ; Inhibition of neurotransmitter vesicle release
  • 6/23/2017 10:33:09 AM
  • 4/29/2023 8:03:00 PM
  • AOP under development
Source: https://aopwiki.org/
Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening
hyperpolarisation, neuron ; Mu Opioid Receptor Agonism ; Release of G Proteins ; Opening of G protein gated inward rectifying K channels ; Analgesia ; hyperpolarisation, neuron ; Mu Opioid Receptor Agonism ; Release of G Proteins ; Opening of G protein gated inward rectifying K channels ; Analgesia
  • 6/8/2017 3:54:18 PM
  • 4/29/2023 8:03:00 PM
  • AOP under development
Source: https://aopwiki.org/
Na+ /K+ -ATPase inhibition leading to hypertension
Hypertension ; Decreased Na/K ATPase activity
  • 11/16/2023 6:30:20 PM
  • 11/16/2023 6:53:42 PM
Source: https://aopwiki.org/
NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
Damaging, Mitochondria ; Apoptosis ; Activation, NADPH Oxidase ; ROS formation ; Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK ; Activation, HIF-1 ; Increased, DNA Damage-Repair ; Reproductive failure ; Damaging, Mitochondria ; Apoptosis ; Activation, NADPH Oxidase ; ROS formation ; Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK ; Activation, HIF-1 ; Increased, DNA Damage-Repair ; Reproductive failure
  • 2/15/2017 8:09:24 AM
  • 4/29/2023 8:02:59 PM
Source: https://aopwiki.org/
Narcosis leading to respiratory failure
Accumulation, Biological membranes ; Disruption, Membrane integrity ; Accumulation, Biological membranes ; Disruption, Membrane integrity
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:55 PM
  • AOP under development
  • 1.2
Source: https://aopwiki.org/
Network of SSRIs (selective serotonin reuptake inhibitors)
Activation, Glucocorticoid Receptor ; Inhibit, serotonin transporter activity ; Decreased, serotonin transporter activity ; Decreased, extracellular sodium (Na+) ; Decreased, extracellular chloride (Cl-) ; Increased, extracellular serotonin ; Increased, intracellular sodium (Na+) ; Increased, intracellular chloride (Cl-) ; Decreased, intracellular serotonin ; Decreased, packaged serotonin ; Decreased, synaptic release ; Increased, 5-HT3 (5-hydroxytryptamine) ; Inactivated, 5-HTR (serotonin receptors) ; Reduce expression, BDNF (Brain-derived neurotrophic factor) ; Decreased, neuroplasticity ; Increase, cortisone ; Reduced, BDNF (Brain-derived neurotrophic factor) ; Activation, 5-HT2A (Serotonin 2A) ; Activate, PLC (Phospholipase C) ; Increase, inositol triphosphate ; Increase, intracellular calcium ; Activate, calmodulin ; Increase, myosin light chain phosphorylation ; Increase, vascular smooth muscle contraction ; Increased, seizure ; Increased, agitation ; Increased, depression ; Increase, hypertension ; Decreased, extracellular serotonin ; Activation, Glucocorticoid Receptor ; Inhibit, serotonin transporter activity ; Decreased, serotonin transporter activity ; Decreased, extracellular sodium (Na+) ; Decreased, extracellular chloride (Cl-) ; Increased, extracellular serotonin ; Decreased, extracellular serotonin ; Increased, intracellular sodium (Na+) ; Increased, intracellular chloride (Cl-) ; Decreased, intracellular serotonin ; Decreased, packaged serotonin ; Decreased, synaptic release ; Increased, 5-HT3 (5-hydroxytryptamine) ; Inactivated, 5-HTR (serotonin receptors) ; Reduce expression, BDNF (Brain-derived neurotrophic factor) ; Decreased, neuroplasticity ; Increase, cortisone ; Reduced, BDNF (Brain-derived neurotrophic factor) ; Activation, 5-HT2A (Serotonin 2A) ; Activate, PLC (Phospholipase C) ; Increase, inositol triphosphate ; Increase, intracellular calcium ; Activate, calmodulin ; Increase, myosin light chain phosphorylation ; Increase, vascular smooth muscle contraction ; Increased, seizure ; Increased, agitation ; Increased, depression ; Increase, hypertension
  • 4/13/2017 6:11:48 PM
  • 4/29/2023 8:03:00 PM
Source: https://aopwiki.org/
NFE2/Nrf2 repression to steatosis
NFE2/Nrf2 repression ; Reduced, FXR activity ; Reduced, SHP activity ; Activated, LXR ; Reduced, PPARalpha ; Reduced, HSD17B4 activity ; Reduced, fatty acid beta oxidation ; Increased, steatosis ; NFE2/Nrf2 repression ; Reduced, FXR activity ; Reduced, SHP activity ; Activated, LXR ; Reduced, PPARalpha ; Reduced, HSD17B4 activity ; Reduced, fatty acid beta oxidation ; Increased, steatosis
  • 6/2/2017 8:26:43 PM
  • 4/29/2023 8:03:00 PM
  • AOP under development
Source: https://aopwiki.org/
NFE2L2/FXR activation leading to hepatic steatosis
Activation, PPARα ; Inhibition, Mitochondrial fatty acid beta-oxidation ; Increased, De Novo FA synthesis ; Increased, Liver Steatosis ; Activation, NRF2 ; Activation, NR1H4 ; Activation, SHP ; Decreased, DHB4/HSD17B4 ; Activation, LXR alpha ; Inhibition, SREBP1c ; Activation, MTTP ; Increased, ApoB100 ; Increased, Triglyceride ; FA synthesis ; Activation, PPARα ; Increased, Liver Steatosis ; Inhibition, Mitochondrial fatty acid beta-oxidation ; Increased, De Novo FA synthesis ; Activation, NRF2 ; Activation, NR1H4 ; Activation, SHP ; Decreased, DHB4/HSD17B4 ; Activation, LXR alpha ; Inhibition, SREBP1c ; Activation, MTTP ; Increased, ApoB100 ; Increased, Triglyceride
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1
N/A, Mitochondrial dysfunction 1 ; Impairment, Learning and memory ; Activation, Nicotinic acetylcholine receptor ; Abnormal, Foraging activity and behavior ; Weakened, Colony ; Altered, Ca2+-calmodulin activated signal transduction ; Death/Failure, Colony ; N/A, Mitochondrial dysfunction 1 ; Impairment, Learning and memory ; Activation, Nicotinic acetylcholine receptor ; Abnormal, Foraging activity and behavior ; Weakened, Colony ; Altered, Ca2+-calmodulin activated signal transduction ; Death/Failure, Colony
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
N/A, Mitochondrial dysfunction 1 ; Impairment, Learning and memory ; Activation, Nicotinic acetylcholine receptor ; Abnormal, Foraging activity and behavior ; Weakened, Colony ; Altered, Ca2+-calmodulin activated signal transduction ; Death/Failure, Colony ; Abnormal, Role change within caste ; N/A, Mitochondrial dysfunction 1 ; Impairment, Learning and memory ; Activation, Nicotinic acetylcholine receptor ; Abnormal, Foraging activity and behavior ; Weakened, Colony ; Altered, Ca2+-calmodulin activated signal transduction ; Death/Failure, Colony ; Abnormal, Role change within caste
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste
Impairment, Learning and memory ; Activation, Nicotinic acetylcholine receptor ; Abnormal, Foraging activity and behavior ; Weakened, Colony ; Altered, Ca2+-calmodulin activated signal transduction ; Death/Failure, Colony ; Desensitization, Nicotinic acetylcholine receptor ; Impairment, Learning and memory ; Activation, Nicotinic acetylcholine receptor ; Abnormal, Foraging activity and behavior ; Weakened, Colony ; Altered, Ca2+-calmodulin activated signal transduction ; Death/Failure, Colony ; Desensitization, Nicotinic acetylcholine receptor
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
N/A, Mitochondrial dysfunction 1 ; Impairment, Learning and memory ; Decrease of neuronal network function ; Activation, Nicotinic acetylcholine receptor ; Death/Failure, Colony ; Abnormal, Roll change within caste ; Reduced, Brood care ; impaired, Larval development ; N/A, Mitochondrial dysfunction 1 ; Impairment, Learning and memory ; Decrease of neuronal network function ; Activation, Nicotinic acetylcholine receptor ; Death/Failure, Colony ; Abnormal, Roll change within caste ; Reduced, Brood care ; impaired, Larval development
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
Impairment, Learning and memory ; Decrease of neuronal network function ; Activation, Nicotinic acetylcholine receptor ; Death/Failure, Colony ; Abnormal, Roll change within caste ; Reduced, Brood care ; impaired, Larval development ; Desensitization, Nicotinic acetylcholine receptor ; Impairment, Learning and memory ; Decrease of neuronal network function ; Activation, Nicotinic acetylcholine receptor ; Death/Failure, Colony ; Abnormal, Roll change within caste ; Reduced, Brood care ; impaired, Larval development ; Desensitization, Nicotinic acetylcholine receptor
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
N/A, Mitochondrial dysfunction 1 ; Activation, Nicotinic acetylcholine receptor ; Death/Failure, Colony ; impaired, Hive thermoregulation ; Accumulation, Damaged mitochondrial DNA ; Accelerated, Aging ; Overwhelmed, Mitochondrial DNA repair mechanisms ; Decrease, Number of worker bees ; N/A, Mitochondrial dysfunction 1 ; Activation, Nicotinic acetylcholine receptor ; Death/Failure, Colony ; impaired, Hive thermoregulation ; Accumulation, Damaged mitochondrial DNA ; Accelerated, Aging ; Overwhelmed, Mitochondrial DNA repair mechanisms ; Decrease, Number of worker bees
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure
N/A, Mitochondrial dysfunction 1 ; Activation, Nicotinic acetylcholine receptor ; Weakened, Colony ; Death/Failure, Colony ; impaired, Hive thermoregulation ; N/A, Mitochondrial dysfunction 1 ; Activation, Nicotinic acetylcholine receptor ; Weakened, Colony ; Death/Failure, Colony ; impaired, Hive thermoregulation
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Nicotinic acetylcholine receptor activation contributes to mitochondrial dysfunction and leads to colony loss/failure
N/A, Mitochondrial dysfunction 1 ; Activation, Nicotinic acetylcholine receptor ; Weakened, Colony ; Death/Failure, Colony ; N/A, Mitochondrial dysfunction 1 ; Activation, Nicotinic acetylcholine receptor ; Weakened, Colony ; Death/Failure, Colony
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:59 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure
Impairment, Learning and memory ; Activation, Nicotinic acetylcholine receptor ; Abnormal, Foraging activity and behavior ; Weakened, Colony ; Altered, Ca2+-calmodulin activated signal transduction ; Death/Failure, Colony ; Abnormal, Role change within caste ; Desensitization, Nicotinic acetylcholine receptor ; Impairment, Learning and memory ; Activation, Nicotinic acetylcholine receptor ; Abnormal, Foraging activity and behavior ; Weakened, Colony ; Altered, Ca2+-calmodulin activated signal transduction ; Death/Failure, Colony ; Abnormal, Role change within caste ; Desensitization, Nicotinic acetylcholine receptor
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Nosema infection causes abnormal role change that leads to colony loss/failure
Weakened, Colony ; Death/Failure, Colony ; Abnormal, Role change within caste ; Weakened, Colony ; Death/Failure, Colony ; Abnormal, Role change within caste
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:59 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Nosema infection increases energetic demands leading to colony loss/failure
Abnormal, Foraging activity and behavior ; Weakened, Colony ; Death/Failure, Colony ; Increased, Energetic demands and therefore metabolic stress ; Abnormal, Foraging activity and behavior ; Weakened, Colony ; Death/Failure, Colony ; Increased, Energetic demands and therefore metabolic stress
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:59 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
Activation, PXR/SXR ; Up Regulation, CD36 ; Accumulation, Fatty acid ; Decreased, Mitochondrial fatty acid beta-oxidation ; Increased, FA Influx ; Increased, Triglyceride formation ; Up Regulation, SCD-1 ; Increased, Liver Steatosis ; Inhibition, FoxA2 ; Down Regulation, CPT1A ; Down Regulation, HMGCS2 ; Increased, Hepatic Triglycerides ; Accumulation, Hepatic FA ; Decreased, Ketogenesis ; Activation, PXR/SXR ; Up Regulation, CD36 ; Accumulation, Fatty acid ; Decreased, Mitochondrial fatty acid beta-oxidation ; Increased, Liver Steatosis ; Increased, FA Influx ; Up Regulation, SCD-1 ; Increased, Triglyceride formation ; Inhibition, FoxA2 ; Down Regulation, CPT1A ; Down Regulation, HMGCS2 ; Decreased, Ketogenesis
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
NR1I3 (CAR) suppression leading to hepatic steatosis
Activation, LXR ; peroxisome proliferator activated receptor promoter demethylation ; Up Regulation, CD36 ; Activation, ChREBP ; Accumulation, Fatty acid ; Inhibition, Mitochondrial fatty acid beta-oxidation ; Increased, FA Influx ; Suppression, Constitutive androstane receptor, NR1l3 ; Inhibition, PPAR alpha ; Activation, SREBF1 ; Increased, De Novo FA synthesis ; Increased, Fatty acid uptake ; Increased, Triglyceride formation ; Up Regulation, SCD-1 ; Up Regulation, FAS ; Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1) ; Increased, Liver Steatosis ; Activation, LXR ; peroxisome proliferator activated receptor promoter demethylation ; Up Regulation, CD36 ; Activation, ChREBP ; Accumulation, Fatty acid ; Increased, Liver Steatosis ; Inhibition, Mitochondrial fatty acid beta-oxidation ; Increased, FA Influx ; Up Regulation, SCD-1 ; Suppression, Constitutive androstane receptor, NR1l3 ; Inhibition, PPAR alpha ; Activation, SREBF1 ; Increased, De Novo FA synthesis ; Increased, Triglyceride formation ; Up Regulation, FAS ; Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1)
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction
Increase, Apoptosis ; NFE2/Nrf2 repression ; Increase, Mitochondrial Dysfunction ; Increase, Oxidative Stress ; increased,Vascular endothelial dysfunction ; Angiogenesis dysfunction ; Increase, Vascular disrupting effects
  • 8/20/2023 4:20:21 PM
  • 8/28/2023 9:52:26 AM
Source: https://aopwiki.org/
Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway
NFE2/Nrf2 repression ; increased,Vascular endothelial dysfunction ; Angiogenesis dysfunction ; Increase, Vascular disrupting effects ; Activation, HIF1α ; Activation Sema6A ; Activation, Dll4-Notch pathway
  • 8/20/2023 6:18:45 AM
  • 8/28/2023 10:42:37 AM
Source: https://aopwiki.org/
Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway
NFE2/Nrf2 repression ; Increase, Oxidative Stress ; Activation of inflammation pathway ; increased,Vascular endothelial dysfunction ; Angiogenesis dysfunction ; Increase, Vascular disrupting effects
  • 8/19/2023 11:52:00 PM
  • 11/7/2023 1:56:36 AM
Source: https://aopwiki.org/
NSAID induced PTGS1 inactivation to gastric ulcer
Activated, gastric ulcer formation ; Reduced, PTGS1 function ; Reduced, platelet aggregation ; Decreased, mucosal blood flow ; Reduced, mucosal defense ; Decreased, mucous ; Decreased, bicarbonate ; Activated, gastric ulcer formation ; Reduced, PTGS1 function ; Reduced, platelet aggregation ; Decreased, mucosal blood flow ; Reduced, mucosal defense ; Decreased, mucous ; Decreased, bicarbonate
  • 6/2/2017 2:20:27 PM
  • 4/29/2023 8:03:00 PM
  • AOP under development
Source: https://aopwiki.org/
NSAID induced PTGS2 inactivation to gastric ulcer
Activated, gastric ulcer formation ; Reduced, PTGS2 function ; Decreased, angiogenesis ; Increased, leukocyte adherence ; Increased, leukocyte activation ; Activated, gastric ulcer formation ; Reduced, PTGS2 function ; Decreased, angiogenesis ; Increased, leukocyte adherence ; Increased, leukocyte activation
  • 6/2/2017 2:50:59 PM
  • 4/29/2023 8:03:00 PM
  • AOP under development
Source: https://aopwiki.org/
Organic anion transporter (OAT1) inhibition leading to renal failure and mortality
Increased Mortality ; Decline, Population ; Inhibition, organic anion transporter 1 (OAT1) ; Increased, blood uric acid concentration ; Occurrence, renal proximal tubular necrosis ; Increased, blood potassium concentration ; Occurrence, tophi (urate) deposition ; Occurrence, cardiac arrhythmia ; Increased, Oxidative Stress ; Increased Mortality ; Decrease, Population growth rate ; Decline, Population ; Inhibition, organic anion transporter 1 (OAT1) ; Increased, blood uric acid concentration ; Occurrence, renal proximal tubular necrosis ; Increased, blood potassium concentration ; Occurrence, tophi (urate) deposition ; Occurrence, cardiac arrhythmia ; Increased, Oxidative Stress
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:58 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function
Decrease of neuronal network function ; Acetylcholinesterase (AchE) Inhibition ; Acetylcholine accumulation in synapses ; Increased Cholinergic Signaling ; Cognitive Function, Decreased
  • 6/24/2021 8:59:59 PM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
Increase, Mortality ; Increased Mortality ; Decrease, Population growth rate ; Increased, Kidney Failure ; Increased, Reactive oxygen species ; Increase, Apoptosis ; Increase, Necrosis ; Oxidation, Glutathione (To be considered with MIE) ; Increased, Lipid peroxidation
  • 8/5/2021 5:59:48 PM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
Oxidation of hemoglobin Mediated Population Reduction
Oxidation of hemoglobin (methemoglobin) ; Oxidative stress in red blood cells ; Reduced oxygen supply and hypoxia ; Respiration changes ; Headache and fatigue ; Seizures ; Death ; Population reduction ; Oxidation of hemoglobin (methemoglobin) ; Oxidative stress in red blood cells ; Reduced oxygen supply and hypoxia ; Respiration changes ; Headache and fatigue ; Seizures ; Death ; Population reduction
  • 10/15/2008 11:30:00 AM
Source: https://www.effectopedia.org/
Oxidation of hemoglobin Mediated Population Reduction
Oxidation of hemoglobin (methemoglobin) ; Oxidative stress in red blood cells ; Reduced oxygen supply and hypoxia ; Respiration changes ; Headache and fatigue ; Seizures ; Death ; Population reduction
  • 10/15/2008 11:30:00 AM
Source: http://www.effectopedia.org/
Oxidation of iron in hemoglobin leading to hematotoxicity
N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III) ; Altered regulation, Alpha hemoglobin ; Propagation, Oxidative stress ; Damaging, Red blood cells; hemolysis ; Formation, Formation of hemoglobin adducts ; Down Regulation, Gulcose-6-phosphate dehydrogenase ; Increase, RBC congestion in liver ; Increase, Liver and splenic hemosiderosis ; N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number ; N/A, Cyanosis occurs ; N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III) ; Altered regulation, Alpha hemoglobin ; Propagation, Oxidative stress ; Damaging, Red blood cells; hemolysis ; Formation, Formation of hemoglobin adducts ; Down Regulation, Gulcose-6-phosphate dehydrogenase ; Increase, RBC congestion in liver ; Increase, Liver and splenic hemosiderosis ; N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number ; N/A, Cyanosis occurs
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:55 PM
  • AOP under development
  • 1.16
Source: https://aopwiki.org/
Oxidative DNA damage leading to chromosomal aberrations and mutations
Increase, Mutations ; N/A, Inadequate DNA repair ; Increase, Oxidative damage to DNA ; Increase, DNA strand breaks ; Increase, Chromosomal aberrations ; Inadequate DNA repair ; Increase, Mutations ; Increase, DNA strand breaks ; Increase, Chromosomal aberrations ; Increase, Oxidative damage to DNA
  • 5/19/2019 8:13:15 PM
  • 4/29/2023 8:03:02 PM
Source: https://aopwiki.org/
Oxidative stress Leading to Decreased Lung Function
Oxidative Stress ; Decrease, Lung function ; Cystic Fibrosis Transmembrane Regulator Function, Decreased ; Airway Surface Liquid Height, Decreased ; Cilia Beat Frequency, Decreased ; Mucociliary Clearance, Decreased ; Mucus Viscosity, Increased ; FOXJ1 Protein, Decreased ; Motile Cilia Number/Length, Decreased
  • 7/19/2021 1:29:14 PM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction
Oxidative Stress ; Decrease, Lung function ; Cystic Fibrosis Transmembrane Regulator Function, Decreased ; Airway Surface Liquid Height, Decreased ; Cilia Beat Frequency, Decreased ; Mucociliary Clearance, Decreased
  • 9/27/2021 1:08:13 PM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1
Oxidative Stress ; Decrease, Lung function ; Cilia Beat Frequency, Decreased ; Mucociliary Clearance, Decreased ; FOXJ1 Protein, Decreased ; Motile Cilia Number/Length, Decreased
  • 9/28/2021 8:51:39 AM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
Oxidative Stress Leading to ILC2-mediated Respiratory Epithelial Remodeling
  • 7/14/2017 5:34:19 PM
  • 4/29/2023 8:03:00 PM
Source: https://aopwiki.org/
Pathway newrok: NMDA, nACh, GABA A, receptor binding leading to population reduction
Binding to the NMDA receptor ; Binding to the nACh receptor ; Binding to the GABA A receptor ; Hydrophobic binding to proteins and membranes ; Death ; Reduced membrane current ; Decreased channel open time ; Increased channel open time ; Reduction of all cell functions ; Reduced Excitatory Transmition ; Reduced Excitatory of the Hippocampus ; Facilitated Inhibitory Transmission Cortex-Thalamus ; Reversible decrease of organ functions ; Sedation ; Excitability ; Population reduction ; Binding to the NMDA receptor ; Binding to the nACh receptor ; Binding to the GABA A receptor ; Hydrophobic binding to proteins and membranes ; Death ; Reduced membrane current ; Decreased channel open time ; Increased channel open time ; Reduction of all cell functions ; Reduced Excitatory Transmition ; Reduced Excitatory of the Hippocampus ; Facilitated Inhibitory Transmission Cortex-Thalamus ; Reversible decrease of organ functions ; Sedation ; Excitability ; Population reduction
  • 10/15/2008 11:30:00 AM
Source: https://www.effectopedia.org/
Pathway newrok: NMDA, nACh, GABA A, receptor binding leading to population reduction
Binding to the NMDA receptor ; Binding to the nACh receptor ; Binding to the GABA A receptor ; Hydrophobic binding to proteins and membranes ; Death ; Reduced membrane current ; Decreased channel open time ; Increased channel open time ; Reduction of all cell functions ; Reduced Excitatory Transmition ; Reduced Excitatory of the Hippocampus ; Facilitated Inhibitory Transmission Cortex-Thalamus ; Reversible decrease of organ functions ; Sedation ; Excitability ; Population reduction
  • 10/15/2008 11:30:00 AM
Source: http://www.effectopedia.org/
Pendrin inhibition leading to altered amphibian metamorphosis
Thyroid hormone synthesis, Decreased ; Decreased, Thyroxine (T4) in serum ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Inhibition, Pendrin ; Thyroxine (T4) in serum, Decreased ; Thyroid hormone synthesis, Decreased ; Decreased, Thyroxine (T4) in serum ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Inhibition, Pendrin
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:59 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Peptide Oxidation Leading to Hypertension
Peptide Oxidation ; Oxidation, Glutathione (To be considered with MIE) ; KE1 : S-Glutathionylation, eNOS ; KE2 : Decrease, GTPCH-1 ; KE3 : Decrease, Tetrahydrobiopterin ; KE4 : Uncoupling, eNOS ; KE6 : Depletion, Nitric Oxide ; KE7 : Impaired, Vasodilation ; KE8 : Increase, Vascular Resistance ; KE5 : Decrease, AKT/eNOS activity ; Hypertension ; Peptide Oxidation ; KE1 : S-Glutathionylation, eNOS ; KE2 : Decrease, GTPCH-1 ; KE3 : Decrease, Tetrahydrobiopterin ; KE4 : Uncoupling, eNOS ; KE6 : Depletion, Nitric Oxide ; KE7 : Impaired, Vasodilation ; KE8 : Increase, Vascular Resistance ; KE5 : Decrease, AKT/eNOS activity ; Hypertension
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:58 PM
  • AOP under development
  • 1.50
Source: https://aopwiki.org/
Percellome Toxicogenomics Approach for AOP Building: Case study on Pentachlorophenol
Activation, PXR/SXR ; Activation, PXR/SXR
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:55 PM
  • AOP under development
  • 2.5
Source: https://aopwiki.org/
Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
Decreased, PPAR-alpha activation ; Decreased, PPAR-beta activation ; Decreased, PPAR-gamma activation ; Accumulation, Fatty acid ; Decreased, HSD17B10 expression ; Decreased, Mitochondrial fatty acid beta-oxidation ; Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity ; Undefined, Liver Steatosis ; Increased, Liver Steatosis ; Decreased, PPAR-alpha activation ; Decreased, PPAR-beta activation ; Decreased, PPAR-gamma activation ; Accumulation, Fatty acid ; Decreased, HSD17B10 expression ; Decreased, Mitochondrial fatty acid beta-oxidation ; Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity ; Increased, Liver Steatosis
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:55 PM
Source: https://aopwiki.org/
Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis
Increase, Inflammation ; Inactivation of PPARγ ; Activation of TGF-β signaling ; Differentiation of Myofibroblast ; Production of α-smooth muscle actin ; Expression of Collagen ; Collagen Deposition ; Lung fibrosis ; Induction, Epithelial Mesenchymal Transition ; Activation of PPARγ ; Increase, Inflammation ; Inactivation of PPARγ ; Activation of TGF-β signaling ; Collagen Deposition ; Induction, Epithelial Mesenchymal Transition ; Lung fibrosis
  • 2/15/2017 7:34:56 AM
  • 11/13/2023 5:23:25 AM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
Up Regulation, SREBF2 ; Up Regulation, Unsaturated fatty acid ; Down Regulation, GSS and GSTs gene ; Glutathione synthesis ; Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene ; Perturbation of cholesterol ; Glutathione homeostasis ; Hepatotoxicity ; Up Regulation, SREBF2 ; Up Regulation, Unsaturated fatty acid ; Down Regulation, GSS and GSTs gene ; Glutathione synthesis ; Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene ; Perturbation of cholesterol ; Glutathione homeostasis ; Hepatotoxicity
  • 2/15/2017 8:56:47 AM
  • 4/29/2023 8:02:59 PM
Source: https://aopwiki.org/
Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
Inhibition, Phospholipase A ; Damage, Lipid bilayer ; Disturbance, Lysosomal function ; Injury, Mitochondria ; Occurrence, Cytoplasmic vacuolization (hepatocyte) ; Occurrence, Ballooning degeneration (hepatocyte) ; Occurrence, Cytoplasmic vacuolization (kupffer cell) ; Induction, Microvesicular fat ; Formation, Mallory body ; Occurrence, Cytoplasmic vacuolization (Bile duct cell) ; Formation, Liver fibrosis ; Inhibition, Phospholipase A ; Damage, Lipid bilayer ; Disturbance, Lysosomal function ; Injury, Mitochondria ; Occurrence, Cytoplasmic vacuolization (hepatocyte) ; Occurrence, Ballooning degeneration (hepatocyte) ; Occurrence, Cytoplasmic vacuolization (kupffer cell) ; Induction, Microvesicular fat ; Formation, Mallory body ; Occurrence, Cytoplasmic vacuolization (Bile duct cell) ; Formation, Liver fibrosis
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.39
Source: https://aopwiki.org/
Photosystem II antagonism leading to growth inhibition via dysregulation of growth hormone
  • 1/30/2021 5:39:23 PM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
Photosystem II antagonism leading to growth inhibition via oxidative damage
  • 1/30/2021 5:36:31 PM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
Photosystem II antagonism leading to growth inhibition via suppression of photosynthesis
  • 1/30/2021 5:38:04 PM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
PLK1 Activation leading to hepatocyte apoptosis-associate liver injury via autophagy-mediated excessive COX6A1 degradation and impaired function of mitochondrial respiratory chain complex IV
  • 10/24/2023 1:42:46 AM
  • 10/24/2023 1:42:46 AM
Source: https://aopwiki.org/
PM2.5-related AOP frameworks on liver diseases
Endoplasmic reticulum stress ; Insulin resistance ; Non-alcoholic fatty liver disease ; Inhibition, Fatty acid oxidation
  • 6/28/2022 3:01:14 AM
  • 4/29/2023 8:03:06 PM
Source: https://aopwiki.org/
PM-related Adverse outcome pathway frameworks on various systems
  • 4/7/2022 1:07:05 PM
  • 4/29/2023 8:03:06 PM
Source: https://aopwiki.org/
PPARalpha activation leading to pancreatic acinar tumors in the rat and mouse
Increased, PPAR-alpha activation ; Decreased, bile flow ; Increased, cholestasis ; Alteration, lipid metabolism ; prolonged, elevation of serun CCK ; Increased, Cellular proliferation / hyperplasia of acinar cells ; Increased, Pancreatic acinar tumors ; Increased, PPAR-alpha activation ; Decreased, bile flow ; Increased, cholestasis ; Alteration, lipid metabolism ; prolonged, elevation of serun CCK ; Increased, Cellular proliferation / hyperplasia of acinar cells ; Increased, Pancreatic acinar tumors
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:58 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone
Activation, PPARα ; Decreased, cholesterol ; Decreased, 11-ketotestosterone ; Impaired, Spermatogenesis ; impaired, Fertility ; Decrease, Population growth rate ; Activation, PPARα ; Decreased, cholesterol ; Decreased, plasma 11-ketotestosterone level ; Impaired, Spermatogenesis ; Viable offspring, decreased ; Decreased, Viable Offspring
  • 4/9/2020 2:47:50 PM
  • 9/28/2023 8:35:32 PM
Source: https://aopwiki.org/
PPARG activation leading to intrahepatic cholestasis
Altered gene expression, NRF2 dependent antioxidant pathway
  • 8/14/2021 9:23:58 AM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
PPARgamma activation leading to sarcomas in rats, mice, and hamsters
Activation of specific nuclear receptors, PPAR-gamma activation ; Increased, adipogenesis ; Increased, secretion of local growth factors ; Increased, proliferation of mesenchymal cells ; Increased, IGF-1 (mouse) ; Increased, Firbrosarcoma ; Increased, liposarcoma ; Increased, hemagiosarcoma ; Activation of specific nuclear receptors, PPAR-gamma activation ; Increased, adipogenesis ; Increased, secretion of local growth factors ; Increased, proliferation of mesenchymal cells ; Increased, IGF-1 (mouse) ; Increased, Firbrosarcoma ; Increased, liposarcoma ; Increased, hemagiosarcoma
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:58 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
PPARα activation in utero leading to impaired fertility in males
impaired, Fertility ; Activation, PPARα ; Decrease, Steroidogenic acute regulatory protein (STAR) ; Reduction, Cholesterol transport in mitochondria ; Reduction, Testosterone synthesis in Leydig cells ; Reduction, testosterone level ; Decrease, Translocator protein (TSPO) ; Malformation, Male reproductive tract ; impaired, Fertility ; Activation, PPARα ; Decrease, Steroidogenic acute regulatory protein (STAR) ; Reduction, Cholesterol transport in mitochondria ; Reduction, Testosterone synthesis in Leydig cells ; Reduction, fetal/adult testosterone ; Decrease, Translocator protein (TSPO) ; Malformation, Male reproductive tract
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:55 PM
  • EAGMST under review
  • 1.21
Source: https://aopwiki.org/
PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
Activation, PPARα ; modulation, Genes/proteins that regulate hepatocyte fate ; Increase, Mitogenic cell proliferation (hepatocytes) ; Increase, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci ; Increase, Adenomas/carcinomas (hepatocellular) ; Activation, PPARα ; Increase, Phenotypic enzyme activity ; Increase, cell proliferation (hepatocytes) ; Increase, Clonal Expansion of Altered Hepatic Foci ; Increase, hepatocellular adenomas and carcinomas
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:55 PM
  • AOP under development
  • 1.17
Source: https://aopwiki.org/
PPARα activation leading to impaired fertility in adult male rodents
impaired, Fertility ; Activation, PPARα ; Reduction, Cholesterol transport in mitochondria ; Reduction, Testosterone synthesis in Leydig cells ; Reduction, testosterone level ; Increase, Luteinizing hormone (LH) ; Hyperplasia, Leydig cell ; Increase proliferation, Leydig cell ; impaired, Fertility ; Activation, PPARα ; Reduction, Cholesterol transport in mitochondria ; Reduction, Testosterone synthesis in Leydig cells ; Reduction, fetal/adult testosterone ; Increase, Luteinizing hormone (LH) ; Hyperplasia, Leydig cell ; Increase proliferation, Leydig cell
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • AOP under development
  • 1.21
Source: https://aopwiki.org/
presynaptic neuron 1 activation to epilepsy
Increased, intracellular sodium (Na+) ; Increased, seizure ; Activated, presynaptic neuron 1 ; Increased, glutamate ; Activated, NMDA receptor ; Activated, voltage-gated sodium channel ; Inhibit, voltage-gated sodium channel ; Treat, carbamazepine ; Activated, membrane depolarization ; Increased, hippocampal hyperdepolarization ; Increased, epilepsy ; Increased, intracellular sodium (Na+) ; Increased, seizure ; Activated, presynaptic neuron 1 ; Increased, glutamate ; Activated, NMDA receptor ; Activated, voltage-gated sodium channel ; Binding to voltage-gated sodium channel ; Treat, carbamazepine ; Activated, membrane depolarization ; Increased, hippocampal hyperdepolarization ; Increased, epilepsy
  • 6/2/2017 3:27:37 PM
  • 4/29/2023 8:03:00 PM
  • AOP under development
Source: https://aopwiki.org/
presynaptic neuron 2 repression to epilepsy
Increased, seizure ; Activated, membrane depolarization ; Increased, RDX dose ; Increased, hippocampal hyperdepolarization ; Increased, epilepsy ; Reduced, presynaptic neuron 2 activity ; Decreased, GABA ; Reduced, GABA-A receptor activation ; Decreased, intracellular chloride ; Increased, seizure ; Activated, membrane depolarization ; Increased, RDX dose ; Increased, hippocampal hyperdepolarization ; Increased, epilepsy ; Reduced, presynaptic neuron 2 activity ; Decreased, GABA ; Reduced, GABA-A receptor activation ; Decreased, intracellular chloride
  • 6/2/2017 4:07:00 PM
  • 4/29/2023 8:03:00 PM
  • AOP under development
Source: https://aopwiki.org/
Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation
Reduction, Plasma 17beta-estradiol concentrations ; Reduction, 17beta-estradiol synthesis by ovarian granulosa cells ; Reduction, Vitellogenin synthesis in liver ; Reduction, Cumulative fecundity and spawning ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Decrease, Population trajectory ; Inhibition, Prolyl hydroxylases ; Increased, HIF-1 heterodimer ; Decreased, Aromatase (Cyp19a1) mRNA ; Reduction, Plasma 17beta-estradiol concentrations ; Reduction, 17beta-estradiol synthesis by ovarian granulosa cells ; Decrease, Population growth rate ; Reduction, Vitellogenin synthesis in liver ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Reduction, Cumulative fecundity and spawning ; Inhibition, Prolyl hydroxylases ; Increased, HIF-1 heterodimer ; Decreased, Aromatase (Cyp19a1) mRNA
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Protein Alkylation leading to Liver Fibrosis
N/A, Cell injury/death ; Alkylation, Protein ; Increased, Activation and Recruitment of Hepatic macrophages (Kupffer Cells) ; Up Regulation, TGFbeta1 expression ; Activation, Stellate cells ; Accumulation, Collagen ; N/A, Liver fibrosis ; Tissue resident cell activation ; Increased Pro-inflammatory mediators ; Cell injury/death ; Tissue resident cell activation ; Increased Pro-inflammatory mediators ; Alkylation, Protein ; Activation, Stellate cells ; Accumulation, Collagen ; N/A, Liver fibrosis
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:55 PM
  • OECD endorsed (WNT and WPHA)
  • 1.14
  • Review Report
  • i-Library
Source: https://aopwiki.org/
Queen egg-laying decrease leads to colony loss/failure
Weakened, Colony ; Death/Failure, Colony ; Weakened, Colony ; Death/Failure, Colony
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:59 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Reactive Oxygen (ROS) formation leads to cancer via Peroxisome proliferation-activated receptor (PPAR) pathway
Decreased, PPAR-gamma activation ; Increase, Cancer ; Alteration, lipid metabolism ; Increased, Reactive oxygen species ; General Apoptosis
  • 10/18/2023 12:50:57 PM
  • 10/30/2023 1:02:00 PM
Source: https://aopwiki.org/
Reactive Oxygen Species (ROS) formation leads to cancer via inflammation pathway
Oxidative Stress ; Increase, Inflammation ; Increase, Cancer ; Increased, Reactive oxygen species ; General Apoptosis
  • 7/31/2023 1:02:24 PM
  • 10/11/2023 6:22:04 PM
Source: https://aopwiki.org/
Reactive oxygen species and subsequent oxidative stress lead to increased incidence of digestive morbidity and mortality in the general population
  • 6/13/2022 10:28:11 AM
  • 4/29/2023 8:03:06 PM
Source: https://aopwiki.org/
reactive oxygen species generation leading to increased cardiovascular morbidity and mortality
  • 2/3/2022 5:20:48 AM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
Reactive oxygen speicies overproduction leading to increased digestive morbidity and mortality in generation population
  • 9/4/2022 12:00:58 PM
  • 4/29/2023 8:03:07 PM
Source: https://aopwiki.org/
Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
Increase, Cytotoxicity (renal tubular cell) ; Occurrence, Kidney toxicity ; Disturbance, Lysosomal function ; Disruption, Lysosome ; Binding of substrate, endocytic receptor ; Increase, Cytotoxicity (renal tubular cell) ; Occurrence, Kidney toxicity ; Disturbance, Lysosomal function ; Disruption, Lysosome ; Binding of substrate, endocytic receptor
  • 10/25/2017 12:13:54 PM
  • 4/29/2023 8:03:00 PM
Source: https://aopwiki.org/
Reduced availability of GnRH leading to uterine adenocarcinoma via increased estrogen availability at target organ level
Decreased, LH Surge
  • 8/25/2023 10:22:47 AM
  • 8/25/2023 10:28:25 AM
Source: https://aopwiki.org/
Reduced environmental pH leading to thinner shells in Mytilus edulis
  • 3/16/2020 6:15:26 AM
  • 4/29/2023 8:03:02 PM
Source: https://aopwiki.org/
Reduction in photophosphorylation leading to growth inhibition in aquatic plants
Decrease, Mitochondrial ATP production ; Increase, Uncoupling of photophosphorylation ; Decrease, Chloroplast ATP production ; Decrease, Chlorophyll synthesis ; Decrease, Light harvest capacity ; Decrease, Photosynthesis ; Decrease, Glycolysis ; Decrease, Oxidative phosphorylation ; Decrease, Leaf cell mitosis ; Decrease, Leaf development ; Increase, Growth inhibition ; Decrease, Mitochondrial ATP production ; Increase, Uncoupling of photophosphorylation ; Decrease, ATP production ; Decrease, Chlorophyll synthesis ; Decrease, Light harvest capacity ; Decrease, Photosynthesis ; Decrease, Glycolysis ; Decrease, Oxidative phosphorylation ; Decrease, Leaf cell mitosis ; Decrease, Leaf development ; Increase, Growth inhibition ; Decrease, Growth
  • 10/10/2017 11:43:35 AM
  • 4/29/2023 8:03:00 PM
Source: https://aopwiki.org/
Renal protein alkylation leading to kidney toxicity
Decrease, Mitochondrial ATP production ; Alkylation, Protein ; Increase, Cytotoxicity (renal tubular cell) ; Occurrence, Kidney toxicity ; Dysfunction, Mitochondria ; Decrease, Mitochondrial ATP production ; Alkylation, Protein ; Increase, Cytotoxicity (renal tubular cell) ; Occurrence, Kidney toxicity ; Dysfunction, Mitochondria
  • 10/25/2017 1:03:32 PM
  • 4/29/2023 8:03:00 PM
Source: https://aopwiki.org/
Retinoic acid signalling leading to developmental toxicity
Binding to the retinoic acid receptor (agonism) ; Transcription of retinoic acid regulated genes ; Repression of the Wnt signalling pathway ; Developmental toxicity of retinoic acid ; Binding to the retinoic acid receptor (agonism) ; Transcription of retinoic acid regulated genes ; Repression of the Wnt signalling pathway ; Developmental toxicity of retinoic acid
  • 4/11/2010 10:00:00 AM
Source: https://www.effectopedia.org/
Retinoic acid signalling leading to developmental toxicity
Binding to the retinoic acid receptor (agonism) ; Transcription of retinoic acid regulated genes ; Repression of the Wnt signalling pathway ; Developmental toxicity of retinoic acid
  • 4/11/2010 10:00:00 AM
Source: http://www.effectopedia.org/
ROS, inflammation, and activation of nAChR lead to increased incidence of cardiovascular morbidity and mortality
  • 4/19/2022 2:46:46 PM
  • 4/29/2023 8:03:06 PM
Source: https://aopwiki.org/
S-adenosylmethionine depletion leading to population decline (1)
Increase, Mortality ; Increase, Chitin synthase inhibition ; Decrease, Cuticular chitin synthesis ; Increase, Premature molting ; Increase, Mortality ; Inhibition, Chitin synthase 1 ; Decrease, Cuticular chitin content ; Increase, Premature molting
  • 5/8/2020 11:10:27 AM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
S-adenosylmethionine depletion leading to population decline (2)
Increase, Mortality ; Decrease, Cuticular chitin synthesis ; Increase, Premature molting ; Increase, Sulfonylurea receptor binding ; Increase, Opening of voltage-dependent calcium channel ; Increase, Cell membrane depolarization ; Increase, Mortality ; Decrease, Cuticular chitin content ; Increase, Premature molting ; Increase, Sulfonylurea receptor binding ; Increase, Cell membrane depolarization ; Increase, Opening of voltage-dependent calcium channel
  • 5/8/2020 11:10:57 AM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
SARS-CoV-2 infection leading to hyperinflammation
Binding to ACE2 ; SARS-CoV-2 cell entry ; Increased SARS-CoV-2 production ; Diminished protective oxidative stress response ; Hyperinflammation ; NLRP3 inflammasome activity, increased
  • 6/25/2021 9:13:14 AM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
SARS-CoV-2 infection leading to pyroptosis
Binding to ACE2 ; SARS-CoV-2 cell entry ; Increased SARS-CoV-2 production ; Diminished protective oxidative stress response ; NLRP3 inflammasome activity, increased ; Pyroptosis
  • 6/25/2021 9:14:42 AM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia)
Binding to ACE2 ; SARS-CoV-2 cell entry ; Increased SARS-CoV-2 production ; Sustentacular cells, decrease ; olfactory sensory neurons, decrease ; Olfactory epithelium degeneration ; impaired olfactory function (anosmia)
  • 4/25/2021 3:05:39 PM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
Heart failure ; Induced, dysfunction of microcirculation ; Binding to ACE2 ; SARS-CoV-2 cell entry ; Increased inflammatory immune responses ; Endothelial cell dysfunction ; Myocardial Infarction ; Impaired mechanotransduction of pericytes ; Pericyte dysfunction ; Increased ACE2 expression
  • 10/15/2021 4:13:06 PM
  • 4/29/2023 8:03:05 PM
Source: https://aopwiki.org/
Sensitization induction of the intestinal tract by food proteins
  • 2/2/2018 1:13:59 PM
  • 4/29/2023 8:03:00 PM
Source: https://aopwiki.org/
Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via Ca Channel Inhibition
Release of G Proteins ; Inhibition of N-type Ca ion channels ; Inhibition of neurotransmitter vesicle release ; Serotonin 1A Receptor Agonism ; Anti-depressant Activity ; Release of G Proteins ; Inhibition of N-type Ca ion channels ; Inhibition of neurotransmitter vesicle release ; Serotonin 1A Receptor Agonism ; Anti-depressant Activity
  • 6/23/2017 11:21:13 AM
  • 4/29/2023 8:03:00 PM
  • AOP under development
Source: https://aopwiki.org/
Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening
hyperpolarisation, neuron ; Release of G Proteins ; Opening of G protein gated inward rectifying K channels ; Serotonin 1A Receptor Agonism ; Anti-depressant Activity ; hyperpolarisation, neuron ; Release of G Proteins ; Opening of G protein gated inward rectifying K channels ; Serotonin 1A Receptor Agonism ; Anti-depressant Activity
  • 6/23/2017 11:02:54 AM
  • 4/29/2023 8:03:00 PM
  • AOP under development
Source: https://aopwiki.org/
Serotonin transporter activation to agitation
Decreased, serotonin transporter activity ; Increased, extracellular serotonin ; Decreased, intracellular serotonin ; Decreased, packaged serotonin ; Decreased, synaptic release ; Inactivated, 5-HTR (serotonin receptors) ; Reduce expression, BDNF (Brain-derived neurotrophic factor) ; Decreased, neuroplasticity ; Increased, agitation ; Decreased, extracellular serotonin ; Increased, serotonin transporter activity ; Increased, intracellular serotonin ; Increased, packaged serotonin ; Increased, synaptic release ; Increased, extracellular serotonin ; Decreased, extracellular serotonin ; Inactivated, 5-HTR (serotonin receptors) ; Reduce expression, BDNF (Brain-derived neurotrophic factor) ; Decreased, neuroplasticity ; Increased, agitation ; Increased, serotonin transporter activity ; Increased, intracellular serotonin ; Increased, packaged serotonin ; Increased, synaptic release
  • 5/31/2017 12:08:34 AM
  • 4/29/2023 8:03:00 PM
  • AOP under development
Source: https://aopwiki.org/
Serotonin transporter activation to depression
Inhibit, serotonin transporter activity ; Decreased, serotonin transporter activity ; Increased, extracellular serotonin ; Decreased, intracellular serotonin ; Decreased, packaged serotonin ; Decreased, synaptic release ; Inactivated, 5-HTR (serotonin receptors) ; Reduce expression, BDNF (Brain-derived neurotrophic factor) ; Decreased, neuroplasticity ; Reduced, BDNF (Brain-derived neurotrophic factor) ; Increased, depression ; Decreased, extracellular serotonin ; Increased, serotonin transporter activity ; Increased, intracellular serotonin ; Increased, packaged serotonin ; Increased, synaptic release ; Increased, extracellular serotonin ; Decreased, extracellular serotonin ; Inactivated, 5-HTR (serotonin receptors) ; Reduce expression, BDNF (Brain-derived neurotrophic factor) ; Decreased, neuroplasticity ; Increased, depression ; Increased, serotonin transporter activity ; Increased, intracellular serotonin ; Increased, packaged serotonin ; Increased, synaptic release
  • 5/30/2017 7:58:08 PM
  • 4/29/2023 8:03:00 PM
  • AOP under development
Source: https://aopwiki.org/
Serotonin transporter activation to seizure
Decreased, serotonin transporter activity ; Increased, extracellular serotonin ; Decreased, intracellular serotonin ; Decreased, packaged serotonin ; Decreased, synaptic release ; Increased, 5-HT3 (5-hydroxytryptamine) ; Increased, seizure ; Decreased, extracellular serotonin ; Increased, serotonin transporter activity ; Increased, intracellular serotonin ; Increased, packaged serotonin ; Increased, synaptic release ; Decreased, 5-HT3 ; Increased, extracellular serotonin ; Decreased, extracellular serotonin ; Increased, seizure ; Increased, serotonin transporter activity ; Increased, intracellular serotonin ; Increased, packaged serotonin ; Increased, synaptic release ; Decreased, 5-HT3
  • 5/30/2017 7:45:53 PM
  • 4/29/2023 8:03:00 PM
  • AOP under development
Source: https://aopwiki.org/
Sodium channel (Nav1.1) inhibition leading to population decline
Inhibition, sodium channel ; Decreased, sodium conductance 2 ; Decreased, GABA release ; Inhibition, sodium channel ; Decreased, sodium conductance 2 ; Decreased, GABA release
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:59 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Sodium channel inhibition leading to congenital malformations
Increased, Atrioventricular block and bradycardia ; Respiratory distress/arrest ; Inhibition, sodium channel ; Decreased, Sodium conductance 1 ; N/A, hypoxia ; Increased, amputations ; Respiratory distress/arrest ; Inhibition, sodium channel ; Decreased, Sodium conductance 1 ; Increased, Atrioventricular block and bradycardia ; N/A, hypoxia ; Increased, amputations
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
sodium channel inhibition leading to increased predation
Inhibition, sodium channel ; Decreased, Sodium conductance 1 ; Reduced, swimming speed ; Increased, predation ; Inhibition, sodium channel ; Decreased, Sodium conductance 1 ; Reduced, swimming speed ; Increased, predation
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Sodium channel inhibition leading to reduced survival
Inhibition, sodium channel ; Decreased, Sodium conductance 1 ; Reduced, swimming speed ; Reduced, feeding 1 ; Increased, predation ; Reduced, survival ; Inhibition, sodium channel ; Decreased, Sodium conductance 1 ; Reduced, swimming speed ; Reduced, feeding 1 ; Increased, predation ; Reduced, survival
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
Thyroxine (T4) in neuronal tissue, Decreased ; Thyroxine (T4) in serum, Decreased ; Hippocampal anatomy, Altered ; Hippocampal Physiology, Altered ; Hippocampal gene expression, Altered ; Thyroid hormone synthesis, Decreased ; Cognitive Function, Decreased ; Inhibition, Na+/I- symporter (NIS) ; Decrease of Thyroidal iodide ; Decreased, Thyroxine (T4) in serum ; Thyroxine (T4) in serum, Decreased ; Thyroxine (T4) in neuronal tissue, Decreased ; Hippocampal gene expression, Altered ; Hippocampal anatomy, Altered ; Hippocampal Physiology, Altered ; Thyroid hormone synthesis, Decreased ; Cognitive Function, Decreased ; Inhibition, Na+/I- symporter (NIS) ; Decrease of Thyroidal iodide ; Decreased, Thyroxine (T4) in serum
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis
Thyroxine (T4) in serum, Decreased ; Thyroid hormone synthesis, Decreased ; Inhibition, Na+/I- symporter (NIS) ; Decrease of Thyroidal iodide ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Thyroxine (T4) in serum, Decreased ; Thyroid hormone synthesis, Decreased ; Inhibition, Na+/I- symporter (NIS) ; Decrease of Thyroidal iodide ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:59 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
SSRI (Selective serotonin reuptake inhibitor) to hypertension
Decreased, serotonin transporter activity ; Increased, extracellular serotonin ; Decreased, intracellular serotonin ; Decreased, packaged serotonin ; Decreased, synaptic release ; Activation, 5-HT2A (Serotonin 2A) ; Activate, PLC (Phospholipase C) ; Increase, inositol triphosphate ; Increase, intracellular calcium ; Activate, calmodulin ; Increase, myosin light chain phosphorylation ; Increase, vascular smooth muscle contraction ; Increase, hypertension ; Decreased, extracellular serotonin ; Decreased, serotonin transporter activity ; Increased, extracellular serotonin ; Decreased, extracellular serotonin ; Decreased, intracellular serotonin ; Decreased, packaged serotonin ; Decreased, synaptic release ; Activation, 5-HT2A (Serotonin 2A) ; Activate, PLC (Phospholipase C) ; Increase, inositol triphosphate ; Increase, intracellular calcium ; Activate, calmodulin ; Increase, myosin light chain phosphorylation ; Increase, vascular smooth muscle contraction ; Increase, hypertension
  • 5/31/2017 12:30:22 AM
  • 4/29/2023 8:03:00 PM
  • AOP under development
Source: https://aopwiki.org/
Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease
Stimulation, TLR7/8 in dendritic cells ; Overproduction of IL-23, matured dendritic cells ; Overproduction of IL-17 from Th17 cells ; Psoriatic skin disease ; Stimulation, TLR7/8 ; Increase, IL-23 from matured dendritic cells ; Th17 cell migration and inflammation induction ; Psoriatic skin disease ; Maturation of TNF/iNOS-Producing Dendritic Cells
  • 12/27/2019 9:09:57 AM
  • 4/29/2023 8:03:02 PM
Source: https://aopwiki.org/
Substance interaction with lung resident cell membrane components leading to atherosclerosis
Sensing of the stressor by pulmonary cells ; Increased production of pulmonary, pro-inflammatory cytokines ; Increased production of pulmonary SAA ; Formation of HDL-SAA ; Increased systemic total cholesterol pool ; Foam cell formation ; Plaque progression in arteries ; Substance interaction with the lung resident cell membrane components ; Increased, secretion of proinflammatory mediators ; Sensing of the stressor by pulmonary cells ; Transcription of genes encoding acute phase proteins, Increased ; Systemic acute phase response ; Formation of HDL-SAA ; Increased systemic total cholesterol pool ; Foam cell formation ; Atherosclerosis
  • 6/29/2017 5:37:35 AM
  • 11/23/2023 3:17:02 PM
  • AOP under development
Source: https://aopwiki.org/
Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis
Pulmonary fibrosis ; Interaction with the lung resident cell membrane components ; Increased, secretion of proinflammatory and profibrotic mediators ; Increased, recruitment of inflammatory cells ; Loss of alveolar capillary membrane integrity ; Increased, activation of T (T) helper (h) type 2 cells ; Increased, fibroblast proliferation and myofibroblast differentiation ; Increased, extracellular matrix deposition ; Accumulation, Collagen ; Substance interaction with the lung resident cell membrane components ; Increased, secretion of proinflammatory mediators ; Increased, recruitment of inflammatory cells ; Loss of alveolar capillary membrane integrity ; Increased, activation of T (T) helper (h) type 2 cells ; Increased, fibroblast proliferation and myofibroblast differentiation ; Increased, extracellular matrix deposition ; Pulmonary fibrosis
  • 11/29/2016 11:41:17 PM
  • 10/17/2023 1:04:54 PM
  • EAGMST under review
  • 1.32
  • Review Report
Source: https://aopwiki.org/
Succinate dehydrogenase inactivation leading to cancer
  • 11/16/2022 10:33:37 AM
  • 4/29/2023 8:03:07 PM
Source: https://aopwiki.org/
Succinate dehydrogenase inhibition leading to increased insulin resistance through reduction in circulating thyroxine
Thyroxine (T4) in serum, Decreased ; Thyroid hormone synthesis, Decreased ; Increase, Oxidative Stress ; Succinate dehydrogenase, inhibited ; Superoxide generation, increased ; Insulin resistance, increased
  • 6/30/2022 1:47:52 PM
  • 6/2/2023 12:12:35 PM
Source: https://aopwiki.org/
Sulfonylureareceptor binding leading to mortality
Increase, Mortality ; Decrease, Cuticular chitin content ; Increase, Premature molting ; Increase, Sulfonylurea receptor binding ; Increase, Cell membrane depolarization ; Increase, Opening of voltage-dependent calcium channel
  • 10/22/2020 8:15:52 PM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level
Increased, estrogens ; Inhibition of Sulfotransferase E1 (SULT1E1)
  • 7/28/2023 10:28:31 AM
  • 7/28/2023 11:03:07 AM
Source: https://aopwiki.org/
Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure
Suppression, Immune system ; Abnormal, Foraging activity and behavior ; Death/Failure, Colony ; Decrease, Number of worker bees ; Increased, Viral susceptibility ; Suppression, Immune system ; Abnormal, Foraging activity and behavior ; Death/Failure, Colony ; Decrease, Number of worker bees ; Increased, Viral susceptibility
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Suppression of immune system contributes to impaired development and leads to colony loss/failure
Suppression, Immune system ; Death/Failure, Colony ; impaired, Hive thermoregulation ; Decrease, Number of worker bees ; Increased, Viral susceptibility ; impaired, Development ; Suppression, Immune system ; Death/Failure, Colony ; impaired, Hive thermoregulation ; Decrease, Number of worker bees ; Increased, Viral susceptibility ; impaired, Development
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Sustained AhR Activation leading to Rodent Liver Tumours
Activation, Long term AHR receptor driven direct and indirect gene expression changes ; N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects ; Changes/Inhibition, Cellular Homeostasis and Apoptosis ; Alterations, Cellular proliferation / hyperplasia ; Formation, Hepatocellular and Bile duct tumors ; Activation, Long term AHR receptor driven direct and indirect gene expression changes ; N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects ; Changes/Inhibition, Cellular Homeostasis and Apoptosis ; Alterations, Cellular proliferation / hyperplasia ; Formation, Hepatocellular and Bile duct tumors
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • EAGMST under review
  • 1.7
Source: https://aopwiki.org/
TBX1 inhibition leading to congenital cardiac conotruncal anomalies
Inhibition, TBX1 ; Disruption, Neural crest cell migration ; Disruption, Progenitor cells of second heart field ; Impairment, Fourth pharyngeal arch development ; Abnormalities, Cardiac outflow tract formation ; Anomalies, Congenital cardiac conotruncal ; Inhibition, TBX1 ; Disruption, Neural crest cell migration ; Disruption, Progenitor cells of second heart field ; Impairment, Fourth pharyngeal arch development ; Abnormalities, Cardiac outflow tract formation ; Anomalies, Congenital cardiac conotruncal
  • 8/6/2019 7:03:26 AM
  • 4/29/2023 8:03:02 PM
Source: https://aopwiki.org/
test AOP
  • 3/3/2021 4:26:07 PM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
Increase, Reactive oxygen species production ; KE4 : Uncoupling, eNOS ; Increase, Mitochondrial Dysfunction ; Increase, Oxidative Stress ; Activation of inflammation pathway ; increased,Vascular endothelial dysfunction ; Angiogenesis dysfunction ; Increase, Vascular disrupting effects ; Activation, Dll4-Notch pathway ; Activated ANG/Tie2 pathway ; Activated BMP/TGF-beta pathway ; Activated Wnt/Frizzled pathway ; Activated AKT/ERK/PI3K pathway ; Inhibition VEGF/VEGFR pathway ; Vascular barrier disruption ; Impaired Platelet Aggregation
  • 8/21/2023 5:26:50 AM
  • 11/6/2023 3:21:00 PM
Source: https://aopwiki.org/
The AOP framwork on silica nanopariticles induced hepatoxicity
liver dysfunction
  • 7/20/2022 4:52:16 AM
  • 4/29/2023 8:03:06 PM
Source: https://aopwiki.org/
Thermal stress leading to population decline (1)
N/A, Mitochondrial dysfunction 1 ; Decrease, Population growth rate ; Decrease, Oogenesis ; Decrease, Fecundity ; Decrease, Adenosine triphosphate pool
  • 4/18/2020 9:18:10 AM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
Thermal stress leading to population decline (2)
N/A, Mitochondrial dysfunction 1 ; Decrease, Population growth rate ; Increase, Apoptosis ; Decrease, Oogenesis ; Decrease, Fecundity ; Increase, Reactive oxygen species ; Increase, Oxidative DNA damage
  • 4/18/2020 9:18:37 AM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
Thermal stress leading to population decline (3)
N/A, Mitochondrial dysfunction 1 ; Decrease, Population growth rate ; Increase, Reactive oxygen species production ; Increase, Apoptosis ; Decrease, Oogenesis ; Decrease, Fecundity ; Increase, Global DNA methylation
  • 4/18/2020 9:19:06 AM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
Thyroid hormone antagonism leading to impaired oligodendrocyte maturation during development and subsequent decreased cognition
Cognitive Function, Decreased ; Antagonism, Thyroid Receptor ; Decreased, thyroid hormone binding to thyroid hormone receptor ; Decreased, myelin basic protein expression in oligodendrocytes ; Impaired, oligodendrocyte maturation ; Hypomyelination ; Altered, white brain matter
  • 2/21/2023 3:28:10 PM
  • 4/29/2023 8:03:07 PM
Source: https://aopwiki.org/
Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain
Thyroperoxidase, Inhibition ; Thyroid hormone synthesis, Decreased ; Decrease, Serum thyroid hormone (T4/T3) ; Increase, seizure ; Altered, Thyroid hormone-dependent gene expression ; Brain thyroid hormone (T4/T3) decreased ; Abnormal, neuroblast migration ; Periventricular heterotopia formation
  • 6/22/2021 3:22:22 PM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
Hippocampal anatomy, Altered ; Hippocampal Physiology, Altered ; Hippocampal gene expression, Altered ; Cognitive Function, Decreased ; Antagonism, Thyroid Receptor ; Hippocampal gene expression, Altered ; Hippocampal anatomy, Altered ; Hippocampal Physiology, Altered ; Cognitive Function, Decreased ; Antagonism, Thyroid Receptor
  • 6/8/2019 9:12:01 PM
  • 4/29/2023 8:03:02 PM
Source: https://aopwiki.org/
Thyroperoxidase inhibition leading to altered amphibian metamorphosis
Thyroxine (T4) in serum, Decreased ; Thyroperoxidase, Inhibition ; Thyroid hormone synthesis, Decreased ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Thyroxine (T4) in serum, Decreased ; Thyroperoxidase, Inhibition ; Thyroid hormone synthesis, Decreased ; Decreased, Thyroxine (T4) in tissues ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:59 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
Thyroxine (T4) in serum, Decreased ; Increased Mortality ; Decrease, Population growth rate ; Thyroperoxidase, Inhibition ; Thyroid hormone synthesis, Decreased ; Decreased, Triiodothyronine (T3) ; Altered, Photoreceptor patterning ; Altered, Visual function
  • 12/9/2020 12:47:23 PM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
Thyroxine (T4) in serum, Decreased ; Increased Mortality ; Decrease, Population growth rate ; Thyroperoxidase, Inhibition ; Thyroid hormone synthesis, Decreased ; Decreased, Triiodothyronine (T3) ; Altered, Visual function ; Altered, retinal layer structure
  • 12/9/2020 12:45:26 PM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
Thyroperoxidase inhibition leading to altered visual function via decreased eye size
Thyroxine (T4) in serum, Decreased ; Increased Mortality ; Decrease, Population growth rate ; Thyroperoxidase, Inhibition ; Thyroid hormone synthesis, Decreased ; Decreased, Triiodothyronine (T3) ; Altered, Visual function ; Decreased, Eye size
  • 12/9/2020 12:46:57 PM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
Thyroxine (T4) in serum, Decreased ; Decrease, Population trajectory ; Thyroperoxidase, Inhibition ; Thyroid hormone synthesis, Decreased ; Decreased, Triiodothyronine (T3) in serum ; Reduced, Swimming performance ; Reduced, Young of year survival ; Reduced, Anterior swim bladder inflation ; Reduced, Hearing ; Thyroxine (T4) in serum, Decreased ; Increased Mortality ; Decrease, Population growth rate ; Thyroperoxidase, Inhibition ; Thyroid hormone synthesis, Decreased ; Decreased, Triiodothyronine (T3) ; Reduced, Swimming performance ; Reduced, Young of year survival ; Reduced, Anterior swim bladder inflation
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:58 PM
  • EAGMST under review
  • 1.35
  • Review Report
Source: https://aopwiki.org/
Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
Inactivation of PPARγ ; Activation, TGF-beta pathway ; Activation, JNK ; Induction, Epithelial Mesenchymal Transition ; Pulmonary fibrosis ; Toll-like receptor 4 activation ; Activator protein 1 activation ; Pin-1 activation ; Latent Transforming growth Factor beta expression ; Pulmonary fibrosis ; Inactivation of PPARγ ; Induction, Epithelial Mesenchymal Transition ; Activation, TGF-beta pathway ; Activation, JNK ; Toll-like receptor 4 activation ; Activator protein 1 activation ; Pin-1 activation ; Latent Transforming growth Factor beta expression
  • 6/29/2020 6:57:02 AM
  • 4/29/2023 8:03:03 PM
Source: https://aopwiki.org/
Trypsin inhibition leading to pancreatic acinar cell tumors
Trypsin inhibition ; Increased intestinal monitor peptide level ; Increased blood CCK level ; Increased exocrine secretion from pancreatic acinar cells ; Acinar cell proliferation ; Pancreatic acinar cell tumors ; Trypsin inhibition ; Increased intestinal monitor peptide level ; Increased blood CCK level ; Increased exocrine secretion from pancreatic acinar cells ; Acinar cell proliferation ; Pancreatic acinar cell tumors
  • 1/8/2020 5:45:04 AM
  • 4/29/2023 8:03:02 PM
Source: https://aopwiki.org/
Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis
Decreased, Triiodothyronine (T3) in serum ; Inhibition, Deiodinase 1 ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Decreased, Triiodothyronine (T3) ; Inhibition, Deiodinase 1 ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:59 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis
Inhibition, Deiodinase 2 ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Inhibition, Deiodinase 2 ; Increased, Thyroid-stimulating hormone (TSH) ; Decreased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Increased, Thyroxine (T4) in serum ; Altered, Thyroid hormone-dependent gene expression
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:59 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis
Altered, Amphibian metamorphosis ; Inhibition, Deiodinase 3 ; Increased, Triiodothyronine (T3) in tissues ; Altered, Amphibian metamorphosis ; Inhibition, Deiodinase 3 ; Increased, Triiodothyronine (T3) in tissues ; Altered, Thyroid hormone-dependent gene expression
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:59 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation
Increase, Mortality ; Decrease, Oogenesis ; Decrease, Oxidative phosphorylation ; Increase, Chitin synthase inhibition ; Decrease, Cuticular chitin synthesis ; Increase, Premature molting ; Decrease, Fecundity ; Increase, ATP synthase inhibition ; Decrease, ATP production ; Increase, Oocyte apoptosis ; Decrease, Oogenesis ; Decrease, Fecundity ; Decrease, Coupling of oxidative phosphorylation ; Decrease, Oxidative phosphorylation ; Increase, Mitochondrial ATP synthase antagonism ; Decrease, Adenosine triphosphate pool ; Increase, Oocyte apoptosis ; Increase, Necrosis ; Decrease, Growth ; Decrease, ATP synthase activity ; Increase, Tissue/organ damage ; Decrease, Cell proliferation
  • 5/24/2018 4:15:32 PM
  • 4/29/2023 8:03:00 PM
  • EAGMST under review
  • Review Report
Source: https://aopwiki.org/
Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death
Increase, Mortality ; Decrease, Oogenesis ; Decrease, Oxidative phosphorylation ; Decrease, Cuticular chitin synthesis ; Increase, Premature molting ; Increase, Sulfonylurea receptor binding ; Increase, Opening of voltage-dependent calcium channel ; Increase, Cell membrane depolarization ; Decrease, Fecundity ; Increase, Necrosis ; Increase, ATP synthase inhibition ; Decrease, ATP production ; Increase, Ovarian follicle breakdown ; Cell injury/death ; Decrease, Oogenesis ; Decrease, Fecundity ; Decrease, Coupling of oxidative phosphorylation ; Decrease, Oxidative phosphorylation ; Increase, Mitochondrial ATP synthase antagonism ; Decrease, Adenosine triphosphate pool ; Increase, Necrosis ; Increase, Ovarian follicle breakdown ; Decrease, Growth ; Increase, Abnormal osmoregulation ; Decrease, ATP synthase activity ; Increase, Tissue/organ damage ; Decrease, Plasma membrane ATPase activity ; Increase, Cell death
  • 5/24/2018 6:16:25 PM
  • 10/26/2023 10:33:47 AM
Source: https://aopwiki.org/
Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity
Increase, DNA damage ; Increase, Reactive oxygen species ; Increase, Apoptosis ; Increase, D1 protein blockage ; Decrease, Photosystem II activity ; Decrease, Growth ; Cell injury/death ; Increase, Reactive oxygen species production ; Increase, DNA damage ; Increase, Apoptosis ; Decrease, Coupling of oxidative phosphorylation ; Decrease, Adenosine triphosphate pool ; Increase, D1 protein antagonism ; Decrease, Photosystem II activity ; Decrease, Growth ; Increase, Reactive oxygen species ; Decreased Na/K ATPase activity ; Increase, Oxidative DNA damage ; Increase, Cell membrane depolarization ; Increase, Tissue/organ damage ; Increase, Mitochondrial complex III dysfunction ; Increase, Cell death ; Increase, Oxygen consumption
  • 5/24/2018 7:31:11 PM
  • 4/29/2023 8:03:01 PM
Source: https://aopwiki.org/
Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion
Increase, Mortality ; Decrease, Mitochondrial ATP production ; Increase, Apoptosis ; Increase, Uncoupling of oxidative phosphorylation ; Increase, Mortality ; Decrease, Mitochondrial ATP production ; Increase, Reactive oxygen species production ; Increase, Apoptosis ; Decrease, Coupling of oxidative phosphorylation ; Decrease, Growth ; Increased, Lipid peroxidation ; Increase, Tissue/organ damage ; Increase, Mitochondrial complex I dysfunction ; Decrease, Cell proliferation ; Increase, Cell death ; Increase, Oxygen consumption ; Increase, Glycolysis ; Decrease, Glucose pool
  • 6/12/2018 8:23:10 AM
  • 4/29/2023 8:03:01 PM
Source: https://aopwiki.org/
Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium
Decrease, Mitochondrial ATP production ; Increase, Fatty acid beta-oxidation ; Decrease, Photosynthesis ; Decrease, Glycolysis ; Increase, D1 protein blockage ; Decrease, Photosystem II activity ; Decrease, Growth ; Cell injury/death ; Decrease, Population growth rate ; Decrease, Mitochondrial ATP production ; Increase, Apoptosis ; Decrease, Coupling of oxidative phosphorylation ; Decrease, Photosynthesis ; Decrease, Glycolysis ; Decrease, Oxidative phosphorylation ; Decrease, Adenosine triphosphate pool ; Increase, D1 protein antagonism ; Decrease, Photosystem II activity ; Decrease, Growth ; Increase, Tissue/organ damage ; Increase, Mitochondrial complex III dysfunction ; Increase, Cytochrome c release ; Decrease, Lipid storage ; Increase, Cell death ; Increase, Cytosolic calcium
  • 5/24/2018 6:46:35 PM
  • 4/29/2023 8:03:01 PM
Source: https://aopwiki.org/
Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling
Decrease, Mitochondrial ATP production ; Decrease, Ovulation ; Decrease, Oogenesis ; Increase, Uncoupling of oxidative phosphorylation ; Decrease, Fecundity ; Cell injury/death ; Decrease, Mitochondrial ATP production ; Increase, Reactive oxygen species production ; Decrease, Ovulation ; Apoptosis ; Decrease, Oogenesis ; Decrease, Fecundity ; Decrease, Coupling of oxidative phosphorylation ; Decrease, Growth ; Increase, Oxidative DNA damage ; Increase, Protein oxidation ; Increase, Tissue/organ damage ; Increase, Mitochondrial complex I dysfunction ; Increase, Cell death ; Increase, Oxygen consumption ; Increase, Mitochondrial swelling
  • 6/12/2018 8:33:44 AM
  • 4/29/2023 8:03:01 PM
Source: https://aopwiki.org/
Unknown MIE altering cholesterol metabolism leading to decreased cognition
Cognitive Function, Decreased ; Unknown, MIE ; Hypomyelination ; Altered, white brain matter ; Altered, cholesterol metabolism ; Decreased, oligodendrocyte differentiation
  • 2/22/2023 11:43:07 AM
  • 4/29/2023 8:03:07 PM
Source: https://aopwiki.org/
unknown MIE leading to renal failure and mortality
Increased Mortality ; Occurrence, renal proximal tubular necrosis ; Increased, blood potassium concentration ; Occurrence, cardiac arrhythmia ; Increased, Oxidative Stress ; Unknown, MIE ; Increased, Reactive oxygen species ; Increased Mortality ; Occurrence, renal proximal tubular necrosis ; Increased, blood potassium concentration ; Occurrence, cardiac arrhythmia ; Increased, Oxidative Stress ; Unknown, MIE ; Increased, Reactive oxygen species
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:59 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription
Reduction, Plasma 17beta-estradiol concentrations ; Reduction, 17beta-estradiol synthesis by ovarian granulosa cells ; Reduction, Vitellogenin synthesis in liver ; Reduction, Cumulative fecundity and spawning ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Decrease, Population trajectory ; Increased, HIF-1 heterodimer ; Decreased, Aromatase (Cyp19a1) mRNA ; modulation, Unknown ; Increased, HIF-1 alpha transcription ; Reduction, Plasma 17beta-estradiol concentrations ; Reduction, 17beta-estradiol synthesis by ovarian granulosa cells ; Decrease, Population growth rate ; Reduction, Vitellogenin synthesis in liver ; Reduction, Plasma vitellogenin concentrations ; Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development ; Reduction, Cumulative fecundity and spawning ; Increased, HIF-1 heterodimer ; Decreased, Aromatase (Cyp19a1) mRNA ; modulation, Unknown ; Increased, HIF-1 alpha transcription
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals
Activation, Pregnane-X receptor, NR1l2 ; Thyroxine (T4) in neuronal tissue, Decreased ; Thyroxine (T4) in serum, Decreased ; Induction, Upregulation of glucuronyltransferase activity ; Increase, Biliary excretion TH glucuronide ; Hippocampal anatomy, Altered ; Hippocampal Physiology, Altered ; Hippocampal gene expression, Altered ; Loss, Cochlear function ; Activation, Pregnane-X receptor, NR1l2 ; Induction, Upregulation of glucuronyltransferase activity ; Increase, Biliary excretion TH glucuronide ; Thyroxine (T4) in serum, Decreased ; Thyroxine (T4) in neuronal tissue, Decreased ; Hippocampal gene expression, Altered ; Hippocampal anatomy, Altered ; Hippocampal Physiology, Altered ; Loss, Cochlear function ; Increased, Clearance of thyroxine from serum
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:55 PM
  • AOP under development
  • 1.9
Source: https://aopwiki.org/
Urinary bladder calculi leading to urothelial papillomas and carcinomas (in mouse and rat)
Increase, Urinary bladder calculi ; Increase, Cytotoxicity (urothelial cells) ; Increase, Regenerative cell proliferation (urothelial cells) ; Increase, Hyperplasia (urothelial) ; Increase, Adenomas/carcinomas (urothelial) ; Increase, Urinary bladder calculi ; Increase, Cytotoxicity (urothelial cells) ; Increase, Regenerative cell proliferation (urothelial cells) ; Increase, Hyperplasia (urothelial) ; Increase, Adenomas/carcinomas (urothelial)
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:57 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Various neuronal effects induced by elavl3, sox10, and mbp
Neuronal dysfunction ; impaired, Learning and memory ; Neuroinflammation ; Degeneration of dopaminergic neurons of the nigrostriatal pathway ; Parkinsonian motor deficits ; Increase, Mortality ; N/A, Neurodegeneration ; Acetylcholinesterase (AchE) Inhibition ; Acetylcholine accumulation in synapses ; Overactivation, NMDARs ; Decreased, Neuronal network function in adult brain ; Increased, Inhibitory postsynaptic potential ; Induction, Somatic muscle paralysis ; Increased, Neuronal synaptic inhibition ; Inhibition, Feeding ; Activation, Glutamate-gated chloride channels ; Activated, presynaptic neuron 1 ; Increase, seizure ; Increased, epilepsy ; Oxidative Stress in Brain ; Impaired axonial transport ; Sensory axonal peripheral neuropathy ; Encephalitis ; Synaptic dysfunction ; Loss of drebrin ; Neurological disorder ; Increase, CNS Neural cell death ; Decrease, elavl3 ; Decrease, sox10 ; Decrease, mbp ; Disruption, neurotransmitter release ; Decreased, Ionotropic GABA receptor chloride channel conductance
  • 10/4/2022 4:33:28 AM
  • 10/17/2023 9:06:15 AM
Source: https://aopwiki.org/
Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure
Abnormal, Foraging activity and behavior ; Weakened, Colony ; Death/Failure, Colony ; Abnormal, Foraging activity and behavior ; Weakened, Colony ; Death/Failure, Colony
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:59 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Varroa mite infestation increases virus levels leading to colony loss/failure
Weakened, Colony ; Death/Failure, Colony ; Increased, Deformed Wing Virus levels ; Weakened, Colony ; Death/Failure, Colony ; Increased, Deformed Wing Virus levels
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:59 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Vinclozoline case study
Binding to ER ; Nonspecific Protein Binding ; Binding to AR ; Binding to PR ; Binding to GR ; Binding to MR ; ER Transcription Factors ; Upreregulated Gene Transcription in the liver tissue ; Gene expression for Vtg production ; Alteration of Anal fin papillae ; Alteration of Gonadal morphology ; Reduced Growth ; Reduced eggs per female ; Reduced Fertility ; Mixed sex gonads ; Sex reversal ; Delayed adult mail mortality ; Altered sex ratios ; Population reduction
  • 10/15/2008 11:30:00 AM
Source: http://www.effectopedia.org/
Vinclozoline case study
Binding to ER ; Nonspecific Protein Binding ; Binding to AR ; Binding to PR ; Binding to GR ; Binding to MR ; ER Transcription Factors ; Upreregulated Gene Transcription in the liver tissue ; Gene expression for Vtg production ; Alteration of Anal fin papillae ; Alteration of Gonadal morphology ; Reduced Growth ; Reduced eggs per female ; Reduced Fertility ; Mixed sex gonads ; Sex reversal ; Delayed adult mail mortality ; Altered sex ratios ; Population reduction ; Binding to ER ; Nonspecific Protein Binding ; Binding to AR ; Binding to PR ; Binding to GR ; Binding to MR ; ER Transcription Factors ; Upreregulated Gene Transcription in the liver tissue ; Gene expression for Vtg production ; Alteration of Anal fin papillae ; Alteration of Gonadal morphology ; Reduced Growth ; Reduced eggs per female ; Reduced Fertility ; Mixed sex gonads ; Sex reversal ; Delayed adult mail mortality ; Altered sex ratios ; Population reduction
  • 10/15/2008 11:30:00 AM
Source: https://www.effectopedia.org/
Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation
Increased Angiotensin II ; Binding to ACE2 ; Downregulation, ACE2 ; Dysregulation, ACE2 expression and activity ; Occurrence, (Micro)vascular dysfunction
  • 3/31/2021 8:27:09 AM
  • 4/29/2023 8:03:04 PM
Source: https://aopwiki.org/
Volatile Organic Chemicals Activate TRPA1 Receptor to Induce Sensory Pulmonary Irritation
TRPA1 activation, TRPA1 Receptor ; TRPV1 activation, TRPV1 ; Activation of oxidative stress pathway ; Opening of calcium channel, Calcium influx ; Trigeminal nerve activation ; SP (Substance P) release, Local increase of SP ; Non-neuronal production of TNF, Epithelial irritation ; Immune system inflammation ; Production of nerve growth factor , Epithelial irritation ; Non-neuronal production of IL-8/CXCL1, Epithelial irritation ; Generation of novel epitopes , Antigen presentation ; Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea ; Increased Respiratory irritability and Chronic Cough, ; Sensitization, Immune system ; Increase, hypertension ; Increased CGRP, neuronal release of CGRP ; Increased neurokinin A (NKA) by neuronal cells ; Irritation of nasal mucosa inducing sneeze reflex ; TRPA1 activation, TRPA1 Receptor ; Opening of calcium channel, Calcium influx ; Trigeminal nerve activation ; SP (Substance P) release, Local increase of SP ; Increased CGRP, neuronal release of CGRP ; Increased neurokinin A (NKA) by neuronal cells ; Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea ; Irritation of nasal mucosa inducing sneeze reflex ; Increased Respiratory irritability and Chronic Cough,
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:59 PM
Source: https://aopwiki.org/
Weak acid respiratory uncoupling leading to death
Interaction with inner mitochondrial membrane & non-covalent perturbation ; Death ; Reduced ATP formation ; Inhibition of ATP-dependent cellular functions ; Reduced ATP-depndent functions ; Heart Failure ; Respiratory Failure ; Increased metabolism ; Population reduction ; Interaction with inner mitochondrial membrane & non-covalent perturbation ; Death ; Reduced ATP formation ; Inhibition of ATP-dependent cellular functions ; Reduced ATP-depndent functions ; Heart Failure ; Respiratory Failure ; Increased metabolism ; Population reduction
  • 10/15/2008 11:30:00 AM
Source: https://www.effectopedia.org/
Weak acid respiratory uncoupling leading to death
Interaction with inner mitochondrial membrane & non-covalent perturbation ; Death ; Reduced ATP formation ; Inhibition of ATP-dependent cellular functions ; Reduced ATP-depndent functions ; Heart Failure ; Respiratory Failure ; Increased metabolism ; Population reduction
  • 10/15/2008 11:30:00 AM
Source: http://www.effectopedia.org/
Weather event contributes abnormal foraging leading to colony loss/failure
Abnormal, Foraging activity and behavior ; Weakened, Colony ; Death/Failure, Colony ; Abnormal, Foraging activity and behavior ; Weakened, Colony ; Death/Failure, Colony
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:59 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Weather event contributes to colony loss/failure
Weakened, Colony ; Death/Failure, Colony ; Weakened, Colony ; Death/Failure, Colony
  • 11/29/2016 11:41:17 PM
  • 4/29/2023 8:02:59 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
Xenobiotic Inhibition of Dopamine-beta-Hydroxylase and subsequent reduced fecundity
Inhibition, Inhibition of Dopamine-beta-hydroxylase ; Decreased, Synthesis of NE ; Decreased, GnRH cfos activity ; Decreased, GnRH pulsatility/release ; Decreased, LH Surge ; Delayed, Ovulation ; Decreased, Cortical granule release/distribution upon fertilization ; Altered, Formation of cortical envelope ; Abnormal, Sperm penetration (polyspermy) ; Altered, Chromosome number (polyploid) zygote ; Decreased, Decreased fecundity ; Inhibition, Inhibition of Dopamine-beta-hydroxylase ; Decreased, Synthesis of NE ; Decreased, GnRH cfos activity ; Decreased, GnRH pulsatility/release ; Decreased, LH Surge ; Delayed, Ovulation ; Decreased, Cortical granule release/distribution upon fertilization ; Altered, Formation of cortical envelope ; Abnormal, Sperm penetration (polyspermy) ; Altered, Chromosome number (polyploid) zygote ; Decreased, Decreased fecundity
  • 11/29/2016 11:41:16 PM
  • 4/29/2023 8:02:56 PM
  • AOP under development
  • 1.29
Source: https://aopwiki.org/
α-diketone-induced bronchiolitis obliterans
Increase, Inflammation ; Induction, Epithelial Mesenchymal Transition ; Interaction of α-diketones with arginine residues ; Proteasomal dysfunction ; Airway epithelial injury ; Fibroproliferative airway lesions ; Bronchiolitis obliterans ; Increase, Inflammation ; Induction, Epithelial Mesenchymal Transition ; Interaction of α-diketones with arginine residues ; Proteasomal dysfunction ; Airway epithelial injury ; Fibroproliferative airway lesions ; Bronchiolitis obliterans
  • 1/30/2019 2:26:02 PM
  • 4/29/2023 8:03:01 PM
Source: https://aopwiki.org/
Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
Source: https://aopwiki.org/
Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
Source: https://aopwiki.org/
Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
Source: https://aopwiki.org/
Inhibition, NADH-ubiquinone oxidoreductase (complex I)
Source: https://aopwiki.org/
Inhibition, NADH-ubiquinone oxidoreductase (complex I)
Source: https://aopwiki.org/
Inhibition, NADH-ubiquinone oxidoreductase (complex I)
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
impaired, Proteostasis
Source: https://aopwiki.org/
impaired, Proteostasis
Source: https://aopwiki.org/
N/A, Neuroinflammation
Source: https://aopwiki.org/
N/A, Neuroinflammation
Source: https://aopwiki.org/
N/A, Neuroinflammation
Source: https://aopwiki.org/
N/A, Neuroinflammation
Source: https://aopwiki.org/
Degeneration of dopaminergic neurons of the nigrostriatal pathway
Source: https://aopwiki.org/
Parkinsonian motor deficits
Source: https://aopwiki.org/
Increase, Ecdysone receptor agonism
Source: https://aopwiki.org/
Increase, Nuclear receptor E75b gene expression
Source: https://aopwiki.org/
Increase, Fushi tarazu factor-1 gene expression
Source: https://aopwiki.org/
Decrease, Circulating ecdysis triggering hormone
Source: https://aopwiki.org/
Decrease, Circulating crustacean cardioactive peptide
Source: https://aopwiki.org/
Decrease, Ecdysis motoneuron bursts
Source: https://aopwiki.org/
Decrease, Excitatory postsynaptic potential
Source: https://aopwiki.org/
Decrease, Abdominal muscle contraction
Source: https://aopwiki.org/
Increase, Incomplete ecdysis
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Pathways: OAT1 inhibition
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Binding of antagonist, PPAR alpha
Source: https://aopwiki.org/
Decreased, PPARalpha transactivation of gene expression
Source: https://aopwiki.org/
Decreased, Mitochondrial Fatty Acid Beta Oxidation
Source: https://aopwiki.org/
Decreased, Mitochondrial Fatty Acid Beta Oxidation
Source: https://aopwiki.org/
Decreased, Ketogenesis (production of ketone bodies)
Source: https://aopwiki.org/
Not Increased, Circulating Ketone Bodies
Source: https://aopwiki.org/
Decreased, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids
Source: https://aopwiki.org/
Increased, Catabolism of Muscle Protein
Source: https://aopwiki.org/
stabilization, PPAR alpha co-repressor
Source: https://aopwiki.org/
Decreased, Body Weight
Source: https://aopwiki.org/
reduction in ovarian granulosa cells, Aromatase (Cyp19a1)
Source: https://aopwiki.org/
Reduction, Plasma 17beta-estradiol concentrations
Source: https://aopwiki.org/
Reduction, Plasma 17beta-estradiol concentrations
Source: https://aopwiki.org/
Reduction, Plasma 17beta-estradiol concentrations
Source: https://aopwiki.org/
Reduction, Plasma 17beta-estradiol concentrations
Source: https://aopwiki.org/
Reduction, Plasma 17beta-estradiol concentrations
Source: https://aopwiki.org/
Reduction, Plasma 17beta-estradiol concentrations
Source: https://aopwiki.org/
Reduction, Plasma 17beta-estradiol concentrations
Source: https://aopwiki.org/
Reduction, Plasma 17beta-estradiol concentrations
Source: https://aopwiki.org/
Reduction, 17beta-estradiol synthesis by ovarian granulosa cells
Source: https://aopwiki.org/
Reduction, 17beta-estradiol synthesis by ovarian granulosa cells
Source: https://aopwiki.org/
Reduction, 17beta-estradiol synthesis by ovarian granulosa cells
Source: https://aopwiki.org/
Reduction, 17beta-estradiol synthesis by ovarian granulosa cells
Source: https://aopwiki.org/
Reduction, 17beta-estradiol synthesis by ovarian granulosa cells
Source: https://aopwiki.org/
Reduction, 17beta-estradiol synthesis by ovarian granulosa cells
Source: https://aopwiki.org/
impaired, Fertility
Source: https://aopwiki.org/
impaired, Fertility
Source: https://aopwiki.org/
impaired, Fertility
Source: https://aopwiki.org/
impaired, Fertility
Source: https://aopwiki.org/
impaired, Fertility
Source: https://aopwiki.org/
irregularities, ovarian cycle
Source: https://aopwiki.org/
Activation, Pregnane-X receptor, NR1l2
Source: https://aopwiki.org/
Thyroxine (T4) in neuronal tissue, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in neuronal tissue, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in neuronal tissue, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in neuronal tissue, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in neuronal tissue, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Induction, Upregulation of glucuronyltransferase activity
Source: https://aopwiki.org/
Induction, Upregulation of glucuronyltransferase activity
Source: https://aopwiki.org/
Increase, Biliary excretion TH glucuronide
Source: https://aopwiki.org/
Increase, Biliary excretion TH glucuronide
Source: https://aopwiki.org/
Hippocampal anatomy, Altered
Source: https://aopwiki.org/
Hippocampal anatomy, Altered
Source: https://aopwiki.org/
Hippocampal anatomy, Altered
Source: https://aopwiki.org/
Hippocampal anatomy, Altered
Source: https://aopwiki.org/
Hippocampal anatomy, Altered
Source: https://aopwiki.org/
Hippocampal Physiology, Altered
Source: https://aopwiki.org/
Hippocampal Physiology, Altered
Source: https://aopwiki.org/
Hippocampal Physiology, Altered
Source: https://aopwiki.org/
Hippocampal Physiology, Altered
Source: https://aopwiki.org/
Hippocampal Physiology, Altered
Source: https://aopwiki.org/
Hippocampal gene expression, Altered
Source: https://aopwiki.org/
Hippocampal gene expression, Altered
Source: https://aopwiki.org/
Hippocampal gene expression, Altered
Source: https://aopwiki.org/
Hippocampal gene expression, Altered
Source: https://aopwiki.org/
Hippocampal gene expression, Altered
Source: https://aopwiki.org/
Loss, Cochlear function
Source: https://aopwiki.org/
Binding at picrotoxin site, iGABAR chloride channel
Source: https://aopwiki.org/
Reduction, Ionotropic GABA receptor chloride channel conductance
Source: https://aopwiki.org/
Occurrence, A paroxysmal depolarizing shift
Source: https://aopwiki.org/
Reduction, Neuronal synaptic inhibition
Source: https://aopwiki.org/
Generation, Amplified excitatory postsynaptic potential (EPSP)
Source: https://aopwiki.org/
Occurrence, Epileptic seizure
Source: https://aopwiki.org/
Occurrence, Epileptic seizure
Source: https://aopwiki.org/
Activation, PXR/SXR
Source: https://aopwiki.org/
Activation, PXR/SXR
Source: https://aopwiki.org/
Binding of antagonist, NMDA receptors
Source: https://aopwiki.org/
Binding of antagonist, NMDA receptors
Source: https://aopwiki.org/
Inhibition, NMDARs
Source: https://aopwiki.org/
Inhibition, NMDARs
Source: https://aopwiki.org/
Decreased, Calcium influx
Source: https://aopwiki.org/
Decreased, Calcium influx
Source: https://aopwiki.org/
Reduced levels of BDNF
Source: https://aopwiki.org/
Reduced levels of BDNF
Source: https://aopwiki.org/
Reduced levels of BDNF
Source: https://aopwiki.org/
N/A, Cell injury/death
Source: https://aopwiki.org/
N/A, Cell injury/death
Source: https://aopwiki.org/
N/A, Cell injury/death
Source: https://aopwiki.org/
N/A, Cell injury/death
Source: https://aopwiki.org/
N/A, Cell injury/death
Source: https://aopwiki.org/
N/A, Cell injury/death
Source: https://aopwiki.org/
N/A, Cell injury/death
Source: https://aopwiki.org/
N/A, Cell injury/death
Source: https://aopwiki.org/
N/A, Cell injury/death
Source: https://aopwiki.org/
N/A, Neurodegeneration
Source: https://aopwiki.org/
N/A, Neurodegeneration
Source: https://aopwiki.org/
N/A, Neurodegeneration
Source: https://aopwiki.org/
N/A, Neurodegeneration
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Aberrant, Dendritic morphology
Source: https://aopwiki.org/
Decrease of synaptogenesis
Source: https://aopwiki.org/
Decrease of synaptogenesis
Source: https://aopwiki.org/
Decrease of neuronal network function
Source: https://aopwiki.org/
Decrease of neuronal network function
Source: https://aopwiki.org/
Decrease of neuronal network function
Source: https://aopwiki.org/
Decrease of neuronal network function
Source: https://aopwiki.org/
Decrease of neuronal network function
Source: https://aopwiki.org/
Reduced, Presynaptic release of glutamate
Source: https://aopwiki.org/
Activation, Glucocorticoid Receptor
Source: https://aopwiki.org/
Activation, Glucocorticoid Receptor
Source: https://aopwiki.org/
Activation, Glucocorticoid Receptor
Source: https://aopwiki.org/
Activation, Glucocorticoid Receptor
Source: https://aopwiki.org/
Activation, Glucocorticoid Receptor
Source: https://aopwiki.org/
Inhibition, Nuclear factor kappa B (NF-kB)
Source: https://aopwiki.org/
Inhibition, Nuclear factor kappa B (NF-kB)
Source: https://aopwiki.org/
Inhibition, Nuclear factor kappa B (NF-kB)
Source: https://aopwiki.org/
Suppression, Inflammatory cytokines
Source: https://aopwiki.org/
Decreased, Lymphocytes
Source: https://aopwiki.org/
Induction, IKB inhibitory protein
Source: https://aopwiki.org/
Suppression, Immune system
Source: https://aopwiki.org/
Suppression, Immune system
Source: https://aopwiki.org/
Suppression, Immune system
Source: https://aopwiki.org/
Increased, Disease susceptibility
Source: https://aopwiki.org/
Alkylation, DNA
Source: https://aopwiki.org/
Alkylation, DNA
Source: https://aopwiki.org/
Alkylation, DNA
Source: https://aopwiki.org/
Increase, Mutations
Source: https://aopwiki.org/
Increase, Mutations
Source: https://aopwiki.org/
Increase, Mutations
Source: https://aopwiki.org/
Increase, Mutations
Source: https://aopwiki.org/
Increase, Mutations
Source: https://aopwiki.org/
Increase, Mutations
Source: https://aopwiki.org/
N/A, Inadequate DNA repair
Source: https://aopwiki.org/
N/A, Inadequate DNA repair
Source: https://aopwiki.org/
N/A, Inadequate DNA repair
Source: https://aopwiki.org/
N/A, Inadequate DNA repair
Source: https://aopwiki.org/
N/A, Inadequate DNA repair
Source: https://aopwiki.org/
Increase, Heritable mutations in offspring
Source: https://aopwiki.org/
Acetylcholinesterase (AchE) Inhibition
Source: https://aopwiki.org/
Acetylcholinesterase (AchE) Inhibition
Source: https://aopwiki.org/
Acetylcholinesterase (AchE) Inhibition
Source: https://aopwiki.org/
Acetylcholine accumulation in synapses
Source: https://aopwiki.org/
Acetylcholine accumulation in synapses
Source: https://aopwiki.org/
Acetylcholine accumulation in synapses
Source: https://aopwiki.org/
Increased, Atrioventricular block and bradycardia
Source: https://aopwiki.org/
Increased, Atrioventricular block and bradycardia
Source: https://aopwiki.org/
Respiratory distress/arrest
Source: https://aopwiki.org/
Respiratory distress/arrest
Source: https://aopwiki.org/
Increased Cholinergic Signaling
Source: https://aopwiki.org/
Increased Cholinergic Signaling
Source: https://aopwiki.org/
Decreased, Population trajectory
Source: https://aopwiki.org/
Decreased, Population trajectory
Source: https://aopwiki.org/
Decreased, Population trajectory
Source: https://aopwiki.org/
Decreased, Population trajectory
Source: https://aopwiki.org/
Binding, SH-/selen-proteins
Source: https://aopwiki.org/
N/A, Interferences with SH-/selen-proteins
Source: https://aopwiki.org/
Depletion, GSH
Source: https://aopwiki.org/
Depletion, GSH
Source: https://aopwiki.org/
N/A, Oxidative stress
Source: https://aopwiki.org/
Neuronal dysfunction
Source: https://aopwiki.org/
Neuronal dysfunction
Source: https://aopwiki.org/
Neuronal dysfunction
Source: https://aopwiki.org/
Activation, PPARα
Source: https://aopwiki.org/
Activation, PPARα
Source: https://aopwiki.org/
Activation, PPARα
Source: https://aopwiki.org/
Activation, PPARα
Source: https://aopwiki.org/
Activation, PPARα
Source: https://aopwiki.org/
Activation, PPARα
Source: https://aopwiki.org/
Decrease, Steroidogenic acute regulatory protein (STAR)
Source: https://aopwiki.org/
Reduction, Cholesterol transport in mitochondria
Source: https://aopwiki.org/
Reduction, Cholesterol transport in mitochondria
Source: https://aopwiki.org/
Reduction, Testosterone synthesis in Leydig cells
Source: https://aopwiki.org/
Reduction, Testosterone synthesis in Leydig cells
Source: https://aopwiki.org/
Reduction, Testosterone synthesis in Leydig cells
Source: https://aopwiki.org/
Reduction, Testosterone synthesis in Leydig cells
Source: https://aopwiki.org/
Reduction, testosterone level
Source: https://aopwiki.org/
Reduction, testosterone level
Source: https://aopwiki.org/
Reduction, testosterone level
Source: https://aopwiki.org/
Decrease, Translocator protein (TSPO)
Source: https://aopwiki.org/
Malformation, Male reproductive tract
Source: https://aopwiki.org/
N/A, Androgen receptor, Antagonism
Source: https://aopwiki.org/
Alteration, Wnt pathway
Source: https://aopwiki.org/
Feminisation or incomplete development, Primary and accessory male sex organs
Source: https://aopwiki.org/
Decreased, Transcription of genes by AR
Source: https://aopwiki.org/
Decreased, Transcription of genes by AR
Source: https://aopwiki.org/
Decreased, Transcription of genes by AR
Source: https://aopwiki.org/
Decreased, Transcription of genes by AR
Source: https://aopwiki.org/
N/A, Impairment of reproductive capacity
Source: https://aopwiki.org/
Activation, AHR
Source: https://aopwiki.org/
Activation, AHR
Source: https://aopwiki.org/
Activation, AHR
Source: https://aopwiki.org/
Activation, AHR
Source: https://aopwiki.org/
Activation, AHR
Source: https://aopwiki.org/
dimerization, AHR/ARNT
Source: https://aopwiki.org/
dimerization, AHR/ARNT
Source: https://aopwiki.org/
dimerization, AHR/ARNT
Source: https://aopwiki.org/
Increase, COX-2 expression
Source: https://aopwiki.org/
Altered, Cardiovascular development/function
Source: https://aopwiki.org/
Altered, Cardiovascular development/function
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Agonism, Androgen receptor
Source: https://aopwiki.org/
Reduction, Testosterone synthesis by ovarian theca cells
Source: https://aopwiki.org/
Reduction, Vitellogenin synthesis in liver
Source: https://aopwiki.org/
Reduction, Vitellogenin synthesis in liver
Source: https://aopwiki.org/
Reduction, Vitellogenin synthesis in liver
Source: https://aopwiki.org/
Reduction, Vitellogenin synthesis in liver
Source: https://aopwiki.org/
Reduction, Vitellogenin synthesis in liver
Source: https://aopwiki.org/
Reduction, Vitellogenin synthesis in liver
Source: https://aopwiki.org/
Reduction, Cumulative fecundity and spawning
Source: https://aopwiki.org/
Reduction, Cumulative fecundity and spawning
Source: https://aopwiki.org/
Reduction, Cumulative fecundity and spawning
Source: https://aopwiki.org/
Reduction, Cumulative fecundity and spawning
Source: https://aopwiki.org/
Reduction, Cumulative fecundity and spawning
Source: https://aopwiki.org/
Reduction, Cumulative fecundity and spawning
Source: https://aopwiki.org/
Reduction, Cumulative fecundity and spawning
Source: https://aopwiki.org/
Reduction, Cumulative fecundity and spawning
Source: https://aopwiki.org/
Reduction, Cumulative fecundity and spawning
Source: https://aopwiki.org/
Reduction, Plasma vitellogenin concentrations
Source: https://aopwiki.org/
Reduction, Plasma vitellogenin concentrations
Source: https://aopwiki.org/
Reduction, Plasma vitellogenin concentrations
Source: https://aopwiki.org/
Reduction, Plasma vitellogenin concentrations
Source: https://aopwiki.org/
Reduction, Plasma vitellogenin concentrations
Source: https://aopwiki.org/
Reduction, Plasma vitellogenin concentrations
Source: https://aopwiki.org/
Reduction, Plasma vitellogenin concentrations
Source: https://aopwiki.org/
Reduction, Plasma vitellogenin concentrations
Source: https://aopwiki.org/
Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
Source: https://aopwiki.org/
Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
Source: https://aopwiki.org/
Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
Source: https://aopwiki.org/
Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
Source: https://aopwiki.org/
Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
Source: https://aopwiki.org/
Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
Source: https://aopwiki.org/
Reduction, Gonadotropins, circulating concentrations
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Decrease, Population trajectory
Source: https://aopwiki.org/
Inhibition, Aromatase
Source: https://aopwiki.org/
Inhibition, Aromatase
Source: https://aopwiki.org/
Inhibition, Ca++ ATPase
Source: https://aopwiki.org/
Increase, Ca++ (intracellular)
Source: https://aopwiki.org/
Disruption, Mitochondrial electron transport chain
Source: https://aopwiki.org/
Disruption, Mitochondrial electron transport chain
Source: https://aopwiki.org/
Decrease, Mitochondrial ATP production
Source: https://aopwiki.org/
Decrease, Mitochondrial ATP production
Source: https://aopwiki.org/
Decrease, Mitochondrial ATP production
Source: https://aopwiki.org/
Decrease, Mitochondrial ATP production
Source: https://aopwiki.org/
Decrease, Mitochondrial ATP production
Source: https://aopwiki.org/
Decrease, Mitochondrial ATP production
Source: https://aopwiki.org/
Decrease, Mitochondrial ATP production
Source: https://aopwiki.org/
Decrease, Mitochondrial ATP production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Decreased, Nitric Oxide
Source: https://aopwiki.org/
Decreased, Long-term potentiation (LTP)
Source: https://aopwiki.org/
Increased, Oxidative damage
Source: https://aopwiki.org/
Inhibition, Bile Salt Export Pump (ABCB11)
Source: https://aopwiki.org/
Activation of specific nuclear receptors, Transcriptional change
Source: https://aopwiki.org/
Bile accumulation, Pathological condition
Source: https://aopwiki.org/
Release, Cytokine
Source: https://aopwiki.org/
Release, Cytokine
Source: https://aopwiki.org/
Release, Cytokine
Source: https://aopwiki.org/
Increase, Inflammation
Source: https://aopwiki.org/
Increase, Inflammation
Source: https://aopwiki.org/
Increase, Inflammation
Source: https://aopwiki.org/
Increase, Inflammation
Source: https://aopwiki.org/
Production, Reactive oxygen species
Source: https://aopwiki.org/
Peptide Oxidation
Source: https://aopwiki.org/
Peptide Oxidation
Source: https://aopwiki.org/
Peptide Oxidation
Source: https://aopwiki.org/
Peptide Oxidation
Pathways: Hypertension
Source: https://aopwiki.org/
Peptide Oxidation
Source: https://aopwiki.org/
Peptide Oxidation
Source: https://aopwiki.org/
Cholestasis, Pathology
Source: https://aopwiki.org/
Inhibition, Cyclooxygenase activity
Source: https://aopwiki.org/
Inhibition, Cyclooxygenase activity
Source: https://aopwiki.org/
Inhibition, Cyclooxygenase activity
Source: https://aopwiki.org/
Inhibition, Cyclooxygenase activity
Source: https://aopwiki.org/
Inhibition, Cyclooxygenase activity
Source: https://aopwiki.org/
Inhibition, Cyclooxygenase activity
Source: https://aopwiki.org/
Reduction, Prostaglandin E2 concentration
Source: https://aopwiki.org/
Reduction, Ca and HCO3 transport to shell gland
Source: https://aopwiki.org/
Reduction, Eggshell thickness
Source: https://aopwiki.org/
N/A, Gap
Source: https://aopwiki.org/
N/A, Reproductive failure
Source: https://aopwiki.org/
Agonism, Estrogen receptor
Source: https://aopwiki.org/
Agonism, Estrogen receptor
Source: https://aopwiki.org/
Agonism, Estrogen receptor
Source: https://aopwiki.org/
Increase, Plasma vitellogenin concentrations
Source: https://aopwiki.org/
Increase, Plasma vitellogenin concentrations
Source: https://aopwiki.org/
Increase, Vitellogenin synthesis in liver
Source: https://aopwiki.org/
Increase, Renal pathology due to VTG deposition
Source: https://aopwiki.org/
Altered, Reproductive behaviour
Source: https://aopwiki.org/
Altered, Larval development
Source: https://aopwiki.org/
Impaired development of, Reproductive organs
Source: https://aopwiki.org/
Antagonism, Estrogen receptor
Source: https://aopwiki.org/
N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III)
Source: https://aopwiki.org/
Altered regulation, Alpha hemoglobin
Source: https://aopwiki.org/
Propagation, Oxidative stress
Source: https://aopwiki.org/
Damaging, Red blood cells; hemolysis
Source: https://aopwiki.org/
Formation, Formation of hemoglobin adducts
Source: https://aopwiki.org/
Down Regulation, Gulcose-6-phosphate dehydrogenase
Source: https://aopwiki.org/
Increase, RBC congestion in liver
Source: https://aopwiki.org/
Increase, Liver and splenic hemosiderosis
Source: https://aopwiki.org/
N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number
Source: https://aopwiki.org/
N/A, Cyanosis occurs
Source: https://aopwiki.org/
Production, Critical Metabolites (CGA 330050 and CGA 265307)
Source: https://aopwiki.org/
Induction, Liver “Dysfunctional” Changes by CGA 330050
Source: https://aopwiki.org/
Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307
Source: https://aopwiki.org/
Induction, Sustained Hepatotoxicity
Source: https://aopwiki.org/
Induction, Sustained Cell Proliferation
Source: https://aopwiki.org/
Formation, Liver tumor
Source: https://aopwiki.org/
Activation, 5HT2c
Source: https://aopwiki.org/
N/A, Unknown
Source: https://aopwiki.org/
Increased, Kidney Failure
Source: https://aopwiki.org/
Activation, LXR
Source: https://aopwiki.org/
Activation, LXR
Source: https://aopwiki.org/
Activation, LXR
Source: https://aopwiki.org/
peroxisome proliferator activated receptor promoter demethylation
Source: https://aopwiki.org/
peroxisome proliferator activated receptor promoter demethylation
Source: https://aopwiki.org/
peroxisome proliferator activated receptor promoter demethylation
Source: https://aopwiki.org/
peroxisome proliferator activated receptor promoter demethylation
Source: https://aopwiki.org/
Up Regulation, CD36
Source: https://aopwiki.org/
Up Regulation, CD36
Source: https://aopwiki.org/
Up Regulation, CD36
Source: https://aopwiki.org/
Up Regulation, CD36
Source: https://aopwiki.org/
Increase, FA Influx
Source: https://aopwiki.org/
Activation, ChREBP
Source: https://aopwiki.org/
Activation, ChREBP
Source: https://aopwiki.org/
Activation, SREBP-1c
Source: https://aopwiki.org/
Activation, FAS
Source: https://aopwiki.org/
Activation, FAS
Source: https://aopwiki.org/
Activation, SCD-1
Source: https://aopwiki.org/
Activation, SCD-1
Source: https://aopwiki.org/
Synthesis, De Novo FA
Source: https://aopwiki.org/
Accumulation, Triglyceride
Source: https://aopwiki.org/
Accumulation, Triglyceride
Source: https://aopwiki.org/
Damaging, Mitochondria
Source: https://aopwiki.org/
Damaging, Mitochondria
Source: https://aopwiki.org/
N/A, Liver Steatosis
Source: https://aopwiki.org/
Accumulation, Biological membranes
Source: https://aopwiki.org/
Disruption, Membrane integrity
Source: https://aopwiki.org/
Decreased, PPAR-alpha activation
Source: https://aopwiki.org/
Decreased, PPAR-alpha activation
Source: https://aopwiki.org/
Decreased, PPAR-beta activation
Source: https://aopwiki.org/
Decreased, PPAR-gamma activation
Source: https://aopwiki.org/
Accumulation, Fatty acid
Source: https://aopwiki.org/
Accumulation, Fatty acid
Source: https://aopwiki.org/
Accumulation, Fatty acid
Source: https://aopwiki.org/
Accumulation, Fatty acid
Source: https://aopwiki.org/
Decreased, HSD17B10 expression
Source: https://aopwiki.org/
Decreased, Mitochondrial fatty acid beta-oxidation
Source: https://aopwiki.org/
Decreased, Mitochondrial fatty acid beta-oxidation
Source: https://aopwiki.org/
Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity
Source: https://aopwiki.org/
Undefined, Liver Steatosis
Source: https://aopwiki.org/
modulation, Genes/proteins that regulate hepatocyte fate
Source: https://aopwiki.org/
Increase, Mitogenic cell proliferation (hepatocytes)
Source: https://aopwiki.org/
Increase, Mitogenic cell proliferation (hepatocytes)
Source: https://aopwiki.org/
Increase, Mitogenic cell proliferation (hepatocytes)
Pathways: AR- HCC
Source: https://aopwiki.org/
Increase, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci
Source: https://aopwiki.org/
Increase, Adenomas/carcinomas (hepatocellular)
Source: https://aopwiki.org/
Increase, Adenomas/carcinomas (hepatocellular)
Source: https://aopwiki.org/
Increase, Adenomas/carcinomas (hepatocellular)
Source: https://aopwiki.org/
Increase, Adenomas/carcinomas (hepatocellular)
Pathways: AR- HCC
Source: https://aopwiki.org/
Increase, Adenomas/carcinomas (hepatocellular)
Source: https://aopwiki.org/
Alkylation, Protein
Source: https://aopwiki.org/
Alkylation, Protein
Source: https://aopwiki.org/
Increased, Activation and Recruitment of Hepatic macrophages (Kupffer Cells)
Source: https://aopwiki.org/
Up Regulation, TGFbeta1 expression
Source: https://aopwiki.org/
Activation, Stellate cells
Source: https://aopwiki.org/
Activation, Stellate cells
Source: https://aopwiki.org/
Accumulation, Collagen
Source: https://aopwiki.org/
Accumulation, Collagen
Source: https://aopwiki.org/
Accumulation, Collagen
Source: https://aopwiki.org/
Accumulation, Collagen
Source: https://aopwiki.org/
N/A, Liver fibrosis
Source: https://aopwiki.org/
N/A, Liver fibrosis
Source: https://aopwiki.org/
N/A, Covalent binding to protein, possibly lysine residue
Source: https://aopwiki.org/
Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways
Source: https://aopwiki.org/
Increase, Allergic Respiratory Hypersensitivity Response
Source: https://aopwiki.org/
Covalent Binding, Protein
Source: https://aopwiki.org/
Activation, Keratinocytes
Source: https://aopwiki.org/
Activation, Dendritic Cells
Source: https://aopwiki.org/
Activation, Dendritic Cells
Source: https://aopwiki.org/
Activation/Proliferation, T-cells
Source: https://aopwiki.org/
Activation/Proliferation, T-cells
Source: https://aopwiki.org/
sensitisation, skin
Source: https://aopwiki.org/
Activation, Long term AHR receptor driven direct and indirect gene expression changes
Source: https://aopwiki.org/
N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects
Source: https://aopwiki.org/
Changes/Inhibition, Cellular Homeostasis and Apoptosis
Source: https://aopwiki.org/
Alterations, Cellular proliferation / hyperplasia
Source: https://aopwiki.org/
Formation, Hepatocellular and Bile duct tumors
Source: https://aopwiki.org/
Thyroperoxidase, Inhibition
Source: https://aopwiki.org/
Thyroperoxidase, Inhibition
Source: https://aopwiki.org/
Thyroperoxidase, Inhibition
Source: https://aopwiki.org/
Thyroperoxidase, Inhibition
Source: https://aopwiki.org/
Thyroperoxidase, Inhibition
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Cognitive Function, Decreased
Source: https://aopwiki.org/
Cognitive Function, Decreased
Source: https://aopwiki.org/
Cognitive Function, Decreased
Source: https://aopwiki.org/
Cognitive Function, Decreased
Source: https://aopwiki.org/
Inhibition, VegfR2
Source: https://aopwiki.org/
Reduction, Angiogenesis
Source: https://aopwiki.org/
Impairment, Endothelial network
Source: https://aopwiki.org/
Impairment, Endothelial network
Source: https://aopwiki.org/
Insufficiency, Vascular
Source: https://aopwiki.org/
Increased, Developmental Defects
Source: https://aopwiki.org/
Formation, Pro-mutagenic DNA Adducts
Source: https://aopwiki.org/
Increased, Induced Mutations in Critical Genes
Source: https://aopwiki.org/
Metabolism of AFB1, Production of Reactive Electrophiles
Source: https://aopwiki.org/
Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF)
Source: https://aopwiki.org/
Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts
Source: https://aopwiki.org/
Tumorigenesis, Hepatocellular carcinoma
Source: https://aopwiki.org/
Binding of agonist, Ionotropic glutamate receptors
Source: https://aopwiki.org/
Overactivation, NMDARs
Source: https://aopwiki.org/
Overactivation, NMDARs
Source: https://aopwiki.org/
Increased, Intracellular Calcium overload
Source: https://aopwiki.org/
Increased, Intracellular Calcium overload
Source: https://aopwiki.org/
Decreased, Neuronal network function in adult brain
Source: https://aopwiki.org/
Increase, Luteinizing hormone (LH)
Source: https://aopwiki.org/
Hyperplasia, Leydig cell
Source: https://aopwiki.org/
Increase proliferation, Leydig cell
Source: https://aopwiki.org/
skewed, sex ratio
Source: https://aopwiki.org/
Increased, Vitellogenin synthesis
Source: https://aopwiki.org/
Increased, renal vitellogenin deposition
Source: https://aopwiki.org/
Increased, glomerular rupture and renal hemorrhaging
Source: https://aopwiki.org/
Increased, nephropathy
Source: https://aopwiki.org/
Inhibition, Na+/I- symporter (NIS)
Source: https://aopwiki.org/
Inhibition, Na+/I- symporter (NIS)
Source: https://aopwiki.org/
Inhibition, Na+/I- symporter (NIS)
Source: https://aopwiki.org/
Decrease of Thyroidal iodide
Source: https://aopwiki.org/
Decrease of Thyroidal iodide
Source: https://aopwiki.org/
Decrease of Thyroidal iodide
Source: https://aopwiki.org/
Decrease of Thyroidal iodide
Source: https://aopwiki.org/
Decrease of GABAergic interneurons
Source: https://aopwiki.org/
Suppression, VLDL secretion
Source: https://aopwiki.org/
Inhibition, Mitochondrial fatty acid beta-oxidation
Source: https://aopwiki.org/
Inhibition, Mitochondrial fatty acid beta-oxidation
Source: https://aopwiki.org/
Inhibition, Mitochondrial fatty acid beta-oxidation
Source: https://aopwiki.org/
Inhibition, Mitochondrial fatty acid beta-oxidation
Source: https://aopwiki.org/
Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway)
Source: https://aopwiki.org/
Increased, SCD-1
Source: https://aopwiki.org/
Increased, FA Influx
Source: https://aopwiki.org/
Increased, FA Influx
Source: https://aopwiki.org/
Increased, FA Influx
Source: https://aopwiki.org/
Up Regulation, LDLR (low density lipoprotein receptor)
Source: https://aopwiki.org/
Increased, LDL uptake
Source: https://aopwiki.org/
Up Regulation, CYP1A1
Source: https://aopwiki.org/
Accumulation, Liver lipid
Source: https://aopwiki.org/
Suppression, Constitutive androstane receptor, NR1l3
Source: https://aopwiki.org/
Inhibition, PPAR alpha
Source: https://aopwiki.org/
Inhibition, PPAR alpha
Source: https://aopwiki.org/
Activation, SREBF1
Source: https://aopwiki.org/
Activation, SREBF1
Source: https://aopwiki.org/
Increased, De Novo FA synthesis
Source: https://aopwiki.org/
Increased, De Novo FA synthesis
Source: https://aopwiki.org/
Increased, Fatty acid uptake
Source: https://aopwiki.org/
Increased, Triglyceride formation
Source: https://aopwiki.org/
Increased, Triglyceride formation
Source: https://aopwiki.org/
Up Regulation, SCD-1
Source: https://aopwiki.org/
Up Regulation, SCD-1
Source: https://aopwiki.org/
Up Regulation, SCD-1
Source: https://aopwiki.org/
Up Regulation, FAS
Source: https://aopwiki.org/
Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1)
Source: https://aopwiki.org/
Increased, Liver Steatosis
Source: https://aopwiki.org/
Increased, Liver Steatosis
Source: https://aopwiki.org/
Increased, Liver Steatosis
Source: https://aopwiki.org/
Increased, Liver Steatosis
Source: https://aopwiki.org/
Increased, Liver Steatosis
Source: https://aopwiki.org/
Increased, Liver Steatosis
Source: https://aopwiki.org/
Increased, Liver Steatosis
Source: https://aopwiki.org/
Increased, Liver Steatosis
Source: https://aopwiki.org/
Suppression, HNF4alpha
Source: https://aopwiki.org/
Inhibition, FoxA2
Source: https://aopwiki.org/
Down Regulation, CPT1A
Source: https://aopwiki.org/
Down Regulation, HMGCS2
Source: https://aopwiki.org/
Increased, Hepatic Triglycerides
Source: https://aopwiki.org/
Accumulation, Hepatic FA
Source: https://aopwiki.org/
Decreased, Ketogenesis
Source: https://aopwiki.org/
Activation, NRF2
Source: https://aopwiki.org/
Activation, NRF2
Source: https://aopwiki.org/
Activation, NR1H4
Source: https://aopwiki.org/
Activation, SHP
Source: https://aopwiki.org/
Activation, SHP
Source: https://aopwiki.org/
Decreased, DHB4/HSD17B4
Source: https://aopwiki.org/
Activation, LXR alpha
Source: https://aopwiki.org/
Inhibition, SREBP1c
Source: https://aopwiki.org/
Activation, MTTP
Source: https://aopwiki.org/
Increased, ApoB100
Source: https://aopwiki.org/
Increased, Triglyceride
Source: https://aopwiki.org/
FA synthesis
Source: https://aopwiki.org/
systemic inflammation leading to hepatic steatosis
Source: https://aopwiki.org/
Activation, AKT2
Source: https://aopwiki.org/
Activtation, SREBP-1c
Source: https://aopwiki.org/
Decrease, Ovulation
Source: https://aopwiki.org/
Decrease, Ovulation
Source: https://aopwiki.org/
Decrease, Ovulation
Source: https://aopwiki.org/
Decrease, Ovulation
Source: https://aopwiki.org/
Reduced, Prostaglandins, ovary
Source: https://aopwiki.org/
Reduced, Reproductive Success
Source: https://aopwiki.org/
Reduced, Reproductive Success
Source: https://aopwiki.org/
Reduced, Reproductive Success
Source: https://aopwiki.org/
Reduced, Reproductive Success
Source: https://aopwiki.org/
Reduced, Reproductive Success
Source: https://aopwiki.org/
Declining, Population trajectory
Source: https://aopwiki.org/
Declining, Population trajectory
Source: https://aopwiki.org/
Glucocorticoid Receptor Agonist, Activation
Source: https://aopwiki.org/
Repressed expression of steroidogenic enzymes
Source: https://aopwiki.org/
Increased apoptosis, decreased number of adult Leydig Cells
Source: https://aopwiki.org/
Decreased Sperm Number, Reduced Fertility
Source: https://aopwiki.org/
Accelerated Epididymal Sperm Transit, Reduced Fertility
Source: https://aopwiki.org/
Abnormal Sperm Maturation, Reduced Fertility
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Increased corticosterone
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells
Source: https://aopwiki.org/
Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells
Source: https://aopwiki.org/
Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells
Source: https://aopwiki.org/
Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells
Source: https://aopwiki.org/
Decreased sperm quantity / quality in the adult, Decreased fertility
Source: https://aopwiki.org/
Decreased sperm quantity / quality in the adult, Decreased fertility
Source: https://aopwiki.org/
Decreased sperm quantity / quality in the adult, Decreased fertility
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Increased estradiol
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists
Source: https://aopwiki.org/
decreased testosterone by fetal Leydig cells, Dysgenesis of fetal Leydig cells
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome
Source: https://aopwiki.org/
Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol
Source: https://aopwiki.org/
Decreased Cholesterol, Decreased Uptake of Lipoproteins
Source: https://aopwiki.org/
Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane
Source: https://aopwiki.org/
Decreased Cholesterol, Decreased Testosterone Production by Adult Leydig Cells
Source: https://aopwiki.org/
Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis
Source: https://aopwiki.org/
Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell
Source: https://aopwiki.org/
Decreased steroidogenesis, Decreased Activity of Steroidogenic Enzymes in Adult Leydig cells
Source: https://aopwiki.org/
Decreased steroidogenesis, Increased Apoptosis of Adult Leydig Cells
Source: https://aopwiki.org/
Decreased steroidogenesis, Alterations in the Leydig Cell Cytoskeleton
Source: https://aopwiki.org/
Decreased sperm quantity or quality in the adult, Decreased fertility
Source: https://aopwiki.org/
Decreased sperm quantity or quality in the adult, Decreased fertility
Source: https://aopwiki.org/
Decreased sperm quantity or quality in the adult, Decreased fertility
Source: https://aopwiki.org/
Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid
Source: https://aopwiki.org/
Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells
Source: https://aopwiki.org/
Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells
Source: https://aopwiki.org/
Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells
Source: https://aopwiki.org/
Inhibition, Inhibition of Dopamine-beta-hydroxylase
Pathways: DBH inhibition
Source: https://aopwiki.org/
Decreased, Synthesis of NE
Pathways: DBH inhibition
Source: https://aopwiki.org/
Decreased, GnRH cfos activity
Pathways: DBH inhibition
Source: https://aopwiki.org/
Decreased, GnRH cfos activity
Source: https://aopwiki.org/
Decreased, GnRH pulsatility/release
Pathways: DBH inhibition
Source: https://aopwiki.org/
Decreased, GnRH pulsatility/release
Source: https://aopwiki.org/
Decreased, LH Surge
Pathways: DBH inhibition
Source: https://aopwiki.org/
Decreased, LH Surge
Source: https://aopwiki.org/
Delayed, Ovulation
Pathways: DBH inhibition
Source: https://aopwiki.org/
Delayed, Ovulation
Source: https://aopwiki.org/
Decreased, Cortical granule release/distribution upon fertilization
Pathways: DBH inhibition
Source: https://aopwiki.org/
Decreased, Cortical granule release/distribution upon fertilization
Source: https://aopwiki.org/
Altered, Formation of cortical envelope
Pathways: DBH inhibition
Source: https://aopwiki.org/
Altered, Formation of cortical envelope
Source: https://aopwiki.org/
Abnormal, Sperm penetration (polyspermy)
Pathways: DBH inhibition
Source: https://aopwiki.org/
Abnormal, Sperm penetration (polyspermy)
Source: https://aopwiki.org/
Altered, Chromosome number (polyploid) zygote
Pathways: DBH inhibition
Source: https://aopwiki.org/
Altered, Chromosome number (polyploid) zygote
Source: https://aopwiki.org/
Decreased, Decreased fecundity
Pathways: DBH inhibition
Source: https://aopwiki.org/
Decreased, Decreased fecundity
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Dysgensis of fetal Leydig cells
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells
Source: https://aopwiki.org/
Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis
Source: https://aopwiki.org/
Activation, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Activation, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Activation, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Activation, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Activation, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Activation, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Activation, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Activation, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Activation, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Abnormal, Foraging activity and behavior
Source: https://aopwiki.org/
Abnormal, Foraging activity and behavior
Source: https://aopwiki.org/
Abnormal, Foraging activity and behavior
Source: https://aopwiki.org/
Abnormal, Foraging activity and behavior
Source: https://aopwiki.org/
Abnormal, Foraging activity and behavior
Source: https://aopwiki.org/
Abnormal, Foraging activity and behavior
Source: https://aopwiki.org/
Abnormal, Foraging activity and behavior
Source: https://aopwiki.org/
Abnormal, Foraging activity and behavior
Source: https://aopwiki.org/
Abnormal, Foraging activity and behavior
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Altered, Ca2+-calmodulin activated signal transduction
Source: https://aopwiki.org/
Altered, Ca2+-calmodulin activated signal transduction
Source: https://aopwiki.org/
Altered, Ca2+-calmodulin activated signal transduction
Source: https://aopwiki.org/
Altered, Ca2+-calmodulin activated signal transduction
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Abnormal, Roll change within caste
Source: https://aopwiki.org/
Abnormal, Roll change within caste
Source: https://aopwiki.org/
Abnormal, Roll change within caste
Source: https://aopwiki.org/
Abnormal, Roll change within caste
Source: https://aopwiki.org/
Reduced, Brood care
Source: https://aopwiki.org/
Reduced, Brood care
Source: https://aopwiki.org/
Reduced, Brood care
Source: https://aopwiki.org/
impaired, Larval development
Source: https://aopwiki.org/
impaired, Larval development
Source: https://aopwiki.org/
impaired, Larval development
Source: https://aopwiki.org/
impaired, Larval development
Source: https://aopwiki.org/
impaired, Hive thermoregulation
Source: https://aopwiki.org/
impaired, Hive thermoregulation
Source: https://aopwiki.org/
impaired, Hive thermoregulation
Source: https://aopwiki.org/
Accumulation, Damaged mitochondrial DNA
Source: https://aopwiki.org/
Accelerated, Aging
Source: https://aopwiki.org/
Overwhelmed, Mitochondrial DNA repair mechanisms
Source: https://aopwiki.org/
Decrease, Number of worker bees
Source: https://aopwiki.org/
Decrease, Number of worker bees
Source: https://aopwiki.org/
Decrease, Number of worker bees
Source: https://aopwiki.org/
Decrease, Number of worker bees
Source: https://aopwiki.org/
Increase, Energetic demands and therefore metabolic stress
Source: https://aopwiki.org/
Increased, Appetite and hunger
Source: https://aopwiki.org/
Increased, Viral susceptibility
Source: https://aopwiki.org/
Increased, Viral susceptibility
Source: https://aopwiki.org/
impaired, Development
Source: https://aopwiki.org/
Decreased, Glucose oxidase enzyme activity
Source: https://aopwiki.org/
Decreased, Hydrogen peroxide production
Source: https://aopwiki.org/
Reduced, Antiseptic incorporated in food
Source: https://aopwiki.org/
Reduced, Food storage
Source: https://aopwiki.org/
Abnormal, Role change within caste
Source: https://aopwiki.org/
Abnormal, Role change within caste
Source: https://aopwiki.org/
Abnormal, Role change within caste
Source: https://aopwiki.org/
Desensitization, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Desensitization, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Desensitization, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Desensitization, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Inhibition, sodium channel
Source: https://aopwiki.org/
Inhibition, sodium channel
Source: https://aopwiki.org/
Inhibition, sodium channel
Source: https://aopwiki.org/
Inhibition, sodium channel
Source: https://aopwiki.org/
Decreased, Sodium conductance 1
Source: https://aopwiki.org/
Decreased, Sodium conductance 1
Source: https://aopwiki.org/
Decreased, Sodium conductance 1
Source: https://aopwiki.org/
Decreased, Sodium conductance 1
Source: https://aopwiki.org/
Reduced, swimming speed
Source: https://aopwiki.org/
Reduced, swimming speed
Source: https://aopwiki.org/
Reduced, swimming speed
Source: https://aopwiki.org/
Reduced, feeding 1
Source: https://aopwiki.org/
Reduced, feeding 1
Source: https://aopwiki.org/
Increased, predation
Source: https://aopwiki.org/
Increased, predation
Source: https://aopwiki.org/
Increased, predation
Source: https://aopwiki.org/
Increased, predation
Source: https://aopwiki.org/
Increased, predation
Source: https://aopwiki.org/
Reduced, survival
Source: https://aopwiki.org/
Reduced, survival
Source: https://aopwiki.org/
N/A, hypoxia
Source: https://aopwiki.org/
Increased, amputations
Source: https://aopwiki.org/
Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel
Source: https://aopwiki.org/
modulation, sodium channel
Source: https://aopwiki.org/
prolonged, Depolarization of neuronal membrane
Source: https://aopwiki.org/
Overactivation, Neuronotransmitter release
Source: https://aopwiki.org/
Overactivation, muscle contraction
Source: https://aopwiki.org/
Increased, Ataxia, paralysis, or hyperactivity
Source: https://aopwiki.org/
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
Source: https://aopwiki.org/
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
Source: https://aopwiki.org/
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
Source: https://aopwiki.org/
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
Source: https://aopwiki.org/
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
Source: https://aopwiki.org/
Increased, muscular waves in foot
Source: https://aopwiki.org/
Increased, water retention in foot
Source: https://aopwiki.org/
Increased, valve movement
Source: https://aopwiki.org/
Increased, valve movement
Source: https://aopwiki.org/
Increased, valve movement
Source: https://aopwiki.org/
Increased, valve movement
Source: https://aopwiki.org/
Depletion, energy reserves
Source: https://aopwiki.org/
Increased, foot detachment
Source: https://aopwiki.org/
Increased, locomotion
Source: https://aopwiki.org/
Increased, serotonin (5-HT)
Source: https://aopwiki.org/
Increased, serotonin (5-HT)
Source: https://aopwiki.org/
Increased, serotonin (5-HT)
Source: https://aopwiki.org/
Increased, serotonin (5-HT)
Source: https://aopwiki.org/
Increased, serotonin (5-HT)
Source: https://aopwiki.org/
Increase, predation
Source: https://aopwiki.org/
Decline, Population
Source: https://aopwiki.org/
Decline, Population
Pathways: OAT1 inhibition
Source: https://aopwiki.org/
Decline, Population
Source: https://aopwiki.org/
Decline, Population
Source: https://aopwiki.org/
Decline, Population
Source: https://aopwiki.org/
Decline, Population
Source: https://aopwiki.org/
Decreased, anxiety
Source: https://aopwiki.org/
Decreased, sheltering
Source: https://aopwiki.org/
Antagonism, Histamine Receptor (H2)
Source: https://aopwiki.org/
Decrease, histaminergic neuron excitation
Source: https://aopwiki.org/
N/A, sedation
Source: https://aopwiki.org/
Decreased, locomotion
Source: https://aopwiki.org/
impaired, Learning and memory
Source: https://aopwiki.org/
impaired, Learning and memory
Source: https://aopwiki.org/
Decreased, survival
Source: https://aopwiki.org/
Decreased, survival
Source: https://aopwiki.org/
Reduced, Prostaglandin F2alpha concentration, plasma
Source: https://aopwiki.org/
Reduced, Prostaglandin F2alpha concentration, plasma
Source: https://aopwiki.org/
Reduced, Prostaglandin F2alpha synthesis, ovary
Source: https://aopwiki.org/
Reduced, Spawning behavior
Source: https://aopwiki.org/
Reduced, Ability to attract spawning mates
Source: https://aopwiki.org/
Reduced, Ability to attract spawning mates
Source: https://aopwiki.org/
Reduced, Pheromone release
Source: https://aopwiki.org/
Decreased, Prostaglandin F2alpha synthesis, ovary
Source: https://aopwiki.org/
Decline, Population trajectory
Source: https://aopwiki.org/
Decline, Population trajectory
Source: https://aopwiki.org/
Decline, Population trajectory
Source: https://aopwiki.org/
Reduced, Prostaglandin E2 concentration, hypothalamus
Source: https://aopwiki.org/
Reduced, Prostaglandin E2 concentration, hypothalamus
Source: https://aopwiki.org/
Reduced, Gonadotropin releasing hormone, hypothalamus
Source: https://aopwiki.org/
Reduced, Gonadotropin releasing hormone, hypothalamus
Source: https://aopwiki.org/
Reduced, Luteinizing hormone (LH), plasma
Source: https://aopwiki.org/
Reduced, Luteinizing hormone (LH), plasma
Source: https://aopwiki.org/
Reduced, Maturation inducing steroid, plasma
Source: https://aopwiki.org/
Reduced, Maturation inducing steroid, plasma
Source: https://aopwiki.org/
Reduced, Maturation inducing steroid receptor signalling, oocyte
Source: https://aopwiki.org/
Reduced, Maturation inducing steroid receptor signalling, oocyte
Source: https://aopwiki.org/
Reduced, Meiotic prophase I/metaphase I transition, oocyte
Source: https://aopwiki.org/
Increased, cyclic adenosine monophosphate
Source: https://aopwiki.org/
Upregulated, Spindle assembly checkpoint protein Mad2-oocyte
Source: https://aopwiki.org/
Increased, Chromosome misseggregation
Source: https://aopwiki.org/
impaired, ion channels
Source: https://aopwiki.org/
Altered, Action Potential
Source: https://aopwiki.org/
Increased, cardiac arrthymia
Source: https://aopwiki.org/
Increased, Binding of chemicals to 2u (serum)
Source: https://aopwiki.org/
Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium)
Source: https://aopwiki.org/
Increase, Cytotoxicity (renal tubular cell)
Source: https://aopwiki.org/
Increase, Cytotoxicity (renal tubular cell)
Source: https://aopwiki.org/
Increase, Cytotoxicity (renal tubular cell)
Source: https://aopwiki.org/
Increase, Cytotoxicity (renal tubular cell)
Source: https://aopwiki.org/
Increase, Regenerative cell proliferation (tubular epithelial cells)
Source: https://aopwiki.org/
Increase, Regenerative cell proliferation (tubular epithelial cells)
Source: https://aopwiki.org/
Increase, Hyperplasia (renal tubular cells)
Source: https://aopwiki.org/
Increase, Adenomas/carcinomas (renal tubular)
Source: https://aopwiki.org/
Increase, Adenomas/carcinomas (renal tubular)
Source: https://aopwiki.org/
Binding, Tubulin
Source: https://aopwiki.org/
Disruption, Microtubule dynamics
Source: https://aopwiki.org/
Disorganization, Spindle
Source: https://aopwiki.org/
Altered, Meiotic chromosome dynamics
Source: https://aopwiki.org/
Altered, Chromosome number
Source: https://aopwiki.org/
Increase, Aneuploid offspring
Source: https://aopwiki.org/
Activation, Constitutive androstane receptor
Source: https://aopwiki.org/
Altered gene expression specific to CAR activation, Hepatocytes
Source: https://aopwiki.org/
Increase, Preneoplastic foci (hepatocytes)
Source: https://aopwiki.org/
Increase, Preneoplastic foci (hepatocytes)
Pathways: AR- HCC
Source: https://aopwiki.org/
Increase, Preneoplastic foci (hepatocytes)
Source: https://aopwiki.org/
Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme
Source: https://aopwiki.org/
Increase, Cytotoxicity
Source: https://aopwiki.org/
Increase, Cytotoxicity
Source: https://aopwiki.org/
Increase, Cytotoxicity
Source: https://aopwiki.org/
Increased, Induction of pyruvate dehydrogenase (PDH)
Source: https://aopwiki.org/
Increase, Oxidative metabolism
Source: https://aopwiki.org/
Increase, Cytotoxicity (club cells)
Source: https://aopwiki.org/
Increase, Necrosis (terminal bronchiolar cells)
Source: https://aopwiki.org/
Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells)
Source: https://aopwiki.org/
Increase, Hyperplasia (terminal bronchiolar cells)
Source: https://aopwiki.org/
Increase, Adenomas/carcinomas (bronchioloalveolar)
Source: https://aopwiki.org/
Decreased, Uptake of inorganic iodide
Source: https://aopwiki.org/
Increase, Hypertrophy and proliferation (follicular cell)
Source: https://aopwiki.org/
Increase, Hypertrophy and proliferation (follicular cell)
Source: https://aopwiki.org/
Increase, Hyperplasia (follicular cells)
Source: https://aopwiki.org/
Increase, Hyperplasia (follicular cells)
Source: https://aopwiki.org/
Increase, Thyroid-stimulating hormone (TSH)
Source: https://aopwiki.org/
Increase, Thyroid-stimulating hormone (TSH)
Source: https://aopwiki.org/
Decrease, Serum thyroid hormone (T4/T3)
Source: https://aopwiki.org/
Decrease, Serum thyroid hormone (T4/T3)
Source: https://aopwiki.org/
Increase, Adenomas/carcinomas (follicular cell)
Source: https://aopwiki.org/
Increase, Adenomas/carcinomas (follicular cell)
Source: https://aopwiki.org/
Decreased, Androgen receptor activity
Source: https://aopwiki.org/
Decreased, Testosterone binding to androgen receptor (hypothalamus)
Source: https://aopwiki.org/
Increase, Hyperplasia (Leydig cells)
Source: https://aopwiki.org/
Increase, Hyperplasia (Leydig cells)
Source: https://aopwiki.org/
Increased, Luteinizing hormone (LH)
Source: https://aopwiki.org/
Increase, Leydig cell tumors
Source: https://aopwiki.org/
Increase, Leydig cell tumors
Source: https://aopwiki.org/
Increase, Dopaminergic activity
Source: https://aopwiki.org/
Decreased, Prolactin
Source: https://aopwiki.org/
Increased, Estrogen receptor (ER) activity
Source: https://aopwiki.org/
Decreased, Progesterone from corpus luteum
Source: https://aopwiki.org/
Increase, Hyperplasia (glandular epithelial cells of endometrium)
Source: https://aopwiki.org/
Increase, Endometrial adenocarcinomas
Source: https://aopwiki.org/
Activation, Glutamate-gated chloride channel
Source: https://aopwiki.org/
Increased, Chloride conductance
Source: https://aopwiki.org/
Increased, Chloride conductance
Source: https://aopwiki.org/
Increased, Chloride conductance
Source: https://aopwiki.org/
hyperpolarisation, neuron
Source: https://aopwiki.org/
hyperpolarisation, neuron
Source: https://aopwiki.org/
hyperpolarisation, neuron
Source: https://aopwiki.org/
N/A, Ataxia, paralysis, or hyperactivity
Source: https://aopwiki.org/
Decreased, population 1
Source: https://aopwiki.org/
Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme
Source: https://aopwiki.org/
Increased, Plasma tyrosine
Source: https://aopwiki.org/
Increase, Cytotoxicity (corneal cells)
Source: https://aopwiki.org/
Increase, Inflammation (corneal cells)
Source: https://aopwiki.org/
Increase, Regenerative cell proliferation (corneal cells)
Source: https://aopwiki.org/
Increase, Papillomas/carcinomas (squamous cells)
Source: https://aopwiki.org/
Increase, Papillomas/carcinomas (squamous cells)
Source: https://aopwiki.org/
Increase, Cytotoxicity (epithelial cells)
Source: https://aopwiki.org/
Increase, Regenerative cell proliferation (forestomach epithelial cells)
Source: https://aopwiki.org/
Increase, Hyperplasia (forestomach epithelial cells)
Source: https://aopwiki.org/
Increase, Cytotoxicity (tubular epithelial cells)
Source: https://aopwiki.org/
Increase, Hyperplasia (tubular epithelial cells)
Source: https://aopwiki.org/
Activation, Androgen receptor
Pathways: AR- HCC
Source: https://aopwiki.org/
Increase, Cytotoxicity (hepatocytes)
Source: https://aopwiki.org/
Increase, Regenerative cell proliferation (hepatocytes)
Source: https://aopwiki.org/
Decrease, Incorporation of active iodide into iodotyrosines
Source: https://aopwiki.org/
Inhibition, 5α-reductase activity
Source: https://aopwiki.org/
Increased, Leutinizing hormone (LH)
Source: https://aopwiki.org/
Decrease, Bioactivation of testosterone
Source: https://aopwiki.org/
Increase, Urinary bladder calculi
Source: https://aopwiki.org/
Increase, Cytotoxicity (urothelial cells)
Source: https://aopwiki.org/
Increase, Regenerative cell proliferation (urothelial cells)
Source: https://aopwiki.org/
Increase, Regenerative cell proliferation (urothelial cells)
Source: https://aopwiki.org/
Increase, Hyperplasia (urothelial)
Source: https://aopwiki.org/
Increase, Hyperplasia (urothelial)
Source: https://aopwiki.org/
Increase, Adenomas/carcinomas (urothelial)
Source: https://aopwiki.org/
Inhibition, Prolyl hydroxylases
Source: https://aopwiki.org/
Increased, HIF-1 heterodimer
Source: https://aopwiki.org/
Increased, HIF-1 heterodimer
Source: https://aopwiki.org/
Decreased, Aromatase (Cyp19a1) mRNA
Source: https://aopwiki.org/
Decreased, Aromatase (Cyp19a1) mRNA
Source: https://aopwiki.org/
modulation, Unknown
Source: https://aopwiki.org/
Increased, HIF-1 alpha transcription
Source: https://aopwiki.org/
Inhibition, HMG-CoA reductase
Source: https://aopwiki.org/
Decreased, mevalonate
Source: https://aopwiki.org/
Decreased, cholesterol
Source: https://aopwiki.org/
Decreased, cholesterol
Source: https://aopwiki.org/
Decreased, Testosterone
Source: https://aopwiki.org/
malformed, Male reproductive tract
Source: https://aopwiki.org/
Decrease, Fertility
Source: https://aopwiki.org/
Decrease, Fertility
Source: https://aopwiki.org/
Decrease, Fertility
Source: https://aopwiki.org/
Decrease, Fertility
Source: https://aopwiki.org/
Inhibition, Antgonism of NE receptor
Source: https://aopwiki.org/
Decreased, Binding of NE to NE receptors on GnRH neurons
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in serum
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in serum
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in serum
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in serum
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in serum
Source: https://aopwiki.org/
Decreased, Glomerular filtration
Source: https://aopwiki.org/
Decreased, Renal plasma flow
Source: https://aopwiki.org/
Decreased, Sodium reabsorption
Source: https://aopwiki.org/
Increased, Serum creatinine
Source: https://aopwiki.org/
Occurrence, Cystic dilatation (renal tubule)
Source: https://aopwiki.org/
Occurrence, Cytoplasmic vacuolization (podocyte)
Source: https://aopwiki.org/
Occurrence, Cytoplasmic vacuolization (Renal tubule)
Source: https://aopwiki.org/
Decreased, Renal ability to dilute urine
Source: https://aopwiki.org/
Occurrence, Kidney toxicity
Source: https://aopwiki.org/
Occurrence, Kidney toxicity
Source: https://aopwiki.org/
Occurrence, Kidney toxicity
Source: https://aopwiki.org/
Occurrence, Kidney toxicity
Source: https://aopwiki.org/
Inhibition, Phospholipase A
Source: https://aopwiki.org/
Damage, Lipid bilayer
Source: https://aopwiki.org/
Disturbance, Lysosomal function
Source: https://aopwiki.org/
Disturbance, Lysosomal function
Source: https://aopwiki.org/
Injury, Mitochondria
Source: https://aopwiki.org/
Occurrence, Cytoplasmic vacuolization (hepatocyte)
Source: https://aopwiki.org/
Occurrence, Ballooning degeneration (hepatocyte)
Source: https://aopwiki.org/
Occurrence, Cytoplasmic vacuolization (kupffer cell)
Source: https://aopwiki.org/
Induction, Microvesicular fat
Source: https://aopwiki.org/
Formation, Mallory body
Source: https://aopwiki.org/
Occurrence, Cytoplasmic vacuolization (Bile duct cell)
Source: https://aopwiki.org/
Formation, Liver fibrosis
Source: https://aopwiki.org/
Oxidation, Uroporphyrinogen
Source: https://aopwiki.org/
Inhibition, UROD
Source: https://aopwiki.org/
Accumulation, Highly carboxylated porphyrins
Source: https://aopwiki.org/
Induction, CYP1A2/CYP1A5
Source: https://aopwiki.org/
Uroporphyria
Source: https://aopwiki.org/
Decrease, Intracellular pH
Source: https://aopwiki.org/
Increase, Tissue Degeneration, Necrosis & Atrophy
Source: https://aopwiki.org/
Increase, Cell Proliferation
Source: https://aopwiki.org/
Increase, Cell Proliferation
Source: https://aopwiki.org/
Increase, Cell Proliferation
Source: https://aopwiki.org/
Increase, Respiratory or Squamous Metaplasia
Source: https://aopwiki.org/
Increase, Mutations in Critical Genes
Source: https://aopwiki.org/
Increase, Site of Contact Nasal Tumors
Source: https://aopwiki.org/
Inhibition, organic anion transporter 1 (OAT1)
Pathways: OAT1 inhibition
Source: https://aopwiki.org/
Increased, blood uric acid concentration
Pathways: OAT1 inhibition
Source: https://aopwiki.org/
Increased, blood uric acid concentration
Source: https://aopwiki.org/
Occurrence, renal proximal tubular necrosis
Pathways: OAT1 inhibition
Source: https://aopwiki.org/
Occurrence, renal proximal tubular necrosis
Source: https://aopwiki.org/
Occurrence, renal proximal tubular necrosis
Source: https://aopwiki.org/
Increased, blood potassium concentration
Pathways: OAT1 inhibition
Source: https://aopwiki.org/
Increased, blood potassium concentration
Source: https://aopwiki.org/
Increased, blood potassium concentration
Source: https://aopwiki.org/
Occurrence, tophi (urate) deposition
Pathways: OAT1 inhibition
Source: https://aopwiki.org/
Occurrence, tophi (urate) deposition
Source: https://aopwiki.org/
Occurrence, cardiac arrhythmia
Pathways: OAT1 inhibition
Source: https://aopwiki.org/
Occurrence, cardiac arrhythmia
Source: https://aopwiki.org/
Occurrence, cardiac arrhythmia
Source: https://aopwiki.org/
Increased, Oxidative Stress
Pathways: OAT1 inhibition
Source: https://aopwiki.org/
Increased, Oxidative Stress
Source: https://aopwiki.org/
Increased, Oxidative Stress
Source: https://aopwiki.org/
Increased, Oxidative Stress
Source: https://aopwiki.org/
Increased, Oxidative Stress
Source: https://aopwiki.org/
Increase, Cancer
Source: https://aopwiki.org/
Disruption, Lysosome
Source: https://aopwiki.org/
Disruption, Lysosome
Source: https://aopwiki.org/
Infiltration, Inflammatory cells
Source: https://aopwiki.org/
Inflammation, Liver
Source: https://aopwiki.org/
Inflammation, Liver
Source: https://aopwiki.org/
Activation, EGFR
Source: https://aopwiki.org/
Occurrence, Transdifferentiation of ciliated epithelial cells
Source: https://aopwiki.org/
Occurrence, Metaplasia of goblet cells
Source: https://aopwiki.org/
Occurrence, Hyperplasia of goblet cells
Source: https://aopwiki.org/
Increase, Proliferation of goblet cells
Source: https://aopwiki.org/
Activation, SP1
Source: https://aopwiki.org/
Decrease, Apoptosis of ciliated epithelial cells
Source: https://aopwiki.org/
Increase, Mucin production
Source: https://aopwiki.org/
Chronic, Mucus hypersecretion
Source: https://aopwiki.org/
Decrease, Lung function
Source: https://aopwiki.org/
Oxidation, Glutathione (To be considered with MIE)
Pathways: Hypertension
Source: https://aopwiki.org/
Oxidation, Glutathione (To be considered with MIE)
Source: https://aopwiki.org/
KE1 : S-Glutathionylation, eNOS
Pathways: Hypertension
Source: https://aopwiki.org/
KE2 : Decrease, GTPCH-1
Pathways: Hypertension
Source: https://aopwiki.org/
KE3 : Decrease, Tetrahydrobiopterin
Pathways: Hypertension
Source: https://aopwiki.org/
KE4 : Uncoupling, eNOS
Pathways: Hypertension
Source: https://aopwiki.org/
KE6 : Depletion, Nitric Oxide
Pathways: Hypertension
Source: https://aopwiki.org/
KE7 : Impaired, Vasodilation
Pathways: Hypertension
Source: https://aopwiki.org/
KE8 : Increase, Vascular Resistance
Pathways: Hypertension
Source: https://aopwiki.org/
KE5 : Decrease, AKT/eNOS activity
Pathways: Hypertension
Source: https://aopwiki.org/
Hypertension
Pathways: Hypertension
Source: https://aopwiki.org/
reduced dimerization, ARNT/HIF1-alpha
Source: https://aopwiki.org/
Increase, Pericardial edema
Source: https://aopwiki.org/
reduced production, VEGF
Source: https://aopwiki.org/
Increase, Early Life Stage Mortality
Source: https://aopwiki.org/
Increase, Early Life Stage Mortality
Source: https://aopwiki.org/
Binding, Transthyretin in serum
Source: https://aopwiki.org/
Displacement, Serum thyroxine (T4) from transthyretin
Source: https://aopwiki.org/
Increased, Free serum thyroxine (T4)
Source: https://aopwiki.org/
Increased, Uptake of thyroxine into tissue
Source: https://aopwiki.org/
Increased, Clearance of thyroxine from tissues
Source: https://aopwiki.org/
Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol
Source: https://aopwiki.org/
reduction in ovarian granulosa cells synthesis of estradiol, Reduced steroidogenic production of estradiol in granulosa cells
Source: https://aopwiki.org/
Reduced Estradiol in Circulation, Reduced steroidogenic production of estradiol in granulosa cells leading to decreased estradiol in circulation
Source: https://aopwiki.org/
Decreased positive estrogenic feedback on hypothalamus, Reduced estradiol in circulation decreases estrogen concentration at hypothalamus
Source: https://aopwiki.org/
Decreased Kisspeptin release from neurons in AVPV, Decreased hypothalamic estrogen reduces kisspeptinergic neuron response
Source: https://aopwiki.org/
Decreased GnRH Release, Decreased Kisspeptin stimulation of GnRH neurons
Source: https://aopwiki.org/
Decreased LH release from Anterior Pituitary, Decreased GnRH stimulation of Anterior Pituitary Gonadotrophs
Source: https://aopwiki.org/
Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation
Source: https://aopwiki.org/
Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation
Source: https://aopwiki.org/
Decreased fertility, Reduced number of oocytes ovulated
Source: https://aopwiki.org/
Decreased fertility, Reduced number of oocytes ovulated
Source: https://aopwiki.org/
Binding, Immunophilins
Source: https://aopwiki.org/
Inhibition, Calcineurin Activity
Source: https://aopwiki.org/
Interference, nuclear localization of NFAT
Source: https://aopwiki.org/
Reduction, NFAT/AP-1 complex formation
Source: https://aopwiki.org/
Suppression, IL-2 and IL-4 production
Source: https://aopwiki.org/
Suppression, Suppression of production of cytotoxic T-cells
Source: https://aopwiki.org/
Suppression, Suppression of T-cell dependent antibody production
Source: https://aopwiki.org/
Impairment, T-cell dependent antibody response
Source: https://aopwiki.org/
Relief, Relief of atopic dermatitis
Source: https://aopwiki.org/
Increase, Increased susceptibility to infection
Source: https://aopwiki.org/
Increase, Increased susceptibility to infection
Source: https://aopwiki.org/
Inhibition, Deiodinase 2
Source: https://aopwiki.org/
Inhibition, Deiodinase 2
Source: https://aopwiki.org/
Inhibition, Deiodinase 2
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in serum
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in serum
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in serum
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in serum
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in serum
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in serum
Source: https://aopwiki.org/
Reduced, Posterior swim bladder inflation
Source: https://aopwiki.org/
Reduced, Posterior swim bladder inflation
Source: https://aopwiki.org/
Reduced, Swimming performance
Source: https://aopwiki.org/
Reduced, Swimming performance
Source: https://aopwiki.org/
Reduced, Swimming performance
Source: https://aopwiki.org/
Reduced, Swimming performance
Source: https://aopwiki.org/
Reduced, Swimming performance
Source: https://aopwiki.org/
Reduced, Swimming performance
Source: https://aopwiki.org/
Reduced, Swimming performance
Source: https://aopwiki.org/
Reduced, Young of year survival
Source: https://aopwiki.org/
Reduced, Young of year survival
Source: https://aopwiki.org/
Reduced, Young of year survival
Source: https://aopwiki.org/
Reduced, Young of year survival
Source: https://aopwiki.org/
Reduced, Young of year survival
Source: https://aopwiki.org/
Reduced, Anterior swim bladder inflation
Source: https://aopwiki.org/
Reduced, Anterior swim bladder inflation
Source: https://aopwiki.org/
Reduced, Anterior swim bladder inflation
Source: https://aopwiki.org/
Reduced, Anterior swim bladder inflation
Source: https://aopwiki.org/
Reduced, Anterior swim bladder inflation
Source: https://aopwiki.org/
Reduced, Hearing
Source: https://aopwiki.org/
Reduced, Hearing
Source: https://aopwiki.org/
Reduced, Hearing
Source: https://aopwiki.org/
Reduced, Hearing
Source: https://aopwiki.org/
Reduced, Hearing
Source: https://aopwiki.org/
Reduced, Hearing
Source: https://aopwiki.org/
Inhibition, Deiodinase 1
Source: https://aopwiki.org/
Inhibition, Deiodinase 1
Source: https://aopwiki.org/
Inhibition, Deiodinase 1
Source: https://aopwiki.org/
Activation, ionotropic GABA Receptor chloride channel
Source: https://aopwiki.org/
Increased, Inhibitory postsynaptic potential
Source: https://aopwiki.org/
Increased, Inhibitory postsynaptic potential
Source: https://aopwiki.org/
Induction, Somatic muscle paralysis
Source: https://aopwiki.org/
Increased, Neuronal synaptic inhibition
Source: https://aopwiki.org/
Increased, Neuronal synaptic inhibition
Source: https://aopwiki.org/
Inhibition, Feeding
Source: https://aopwiki.org/
Inhibition, Feeding
Source: https://aopwiki.org/
Activation, Glutamate-gated chloride channels
Source: https://aopwiki.org/
Induction, pharyngeal muscle paralysis
Source: https://aopwiki.org/
Increased, induction of UDPGT's in liver
Source: https://aopwiki.org/
Increased, T4/T3 catabolism
Source: https://aopwiki.org/
Decreased, serum T4/T3
Source: https://aopwiki.org/
Increased, Thyroid-stimulating hormone (TSH)
Source: https://aopwiki.org/
Increased, Hypertrophy and proliferation (follicular cell)
Source: https://aopwiki.org/
Increased, Hyperplasia (follicular cells)
Source: https://aopwiki.org/
Increased Apoptosis, Adenomas/carcinomas (follicular cell)
Source: https://aopwiki.org/
Activation of specific nuclear receptors, PPAR-gamma activation
Source: https://aopwiki.org/
Activation of specific nuclear receptors, PPAR-gamma activation
Source: https://aopwiki.org/
Increased, adipogenesis
Source: https://aopwiki.org/
Increased, secretion of local growth factors
Source: https://aopwiki.org/
Increased, secretion of local growth factors
Source: https://aopwiki.org/
Increased, secretion of local growth factors
Source: https://aopwiki.org/
Increased, proliferation of mesenchymal cells
Source: https://aopwiki.org/
Increased, IGF-1 (mouse)
Source: https://aopwiki.org/
Increased, Firbrosarcoma
Source: https://aopwiki.org/
Increased, liposarcoma
Source: https://aopwiki.org/
Increased, hemagiosarcoma
Source: https://aopwiki.org/
Activation, beta-2 adrenergic receptor
Source: https://aopwiki.org/
Increased activity, beta-2 adrenergic receptor
Source: https://aopwiki.org/
relaxation, smooth muscle
Source: https://aopwiki.org/
Proliferation/Clonal Expansion, smooth muscle
Source: https://aopwiki.org/
Hypertrophy/hyperplasia, smooth muscle
Source: https://aopwiki.org/
Promotion, mesovarian leiomyomas
Source: https://aopwiki.org/
Decreased, Ovarian E2
Source: https://aopwiki.org/
Suppression, Estrogen receptor (ER) activity
Source: https://aopwiki.org/
Increased, secretion of GnRH from hypothalamus
Source: https://aopwiki.org/
Increased, secrection of FSH from anterior pituitary
Source: https://aopwiki.org/
Increased, secretion of LH from anterior pituitary
Source: https://aopwiki.org/
Hyperplasia, ovarian stromal cells
Source: https://aopwiki.org/
Hyperplasia, ovarian epithelium
Source: https://aopwiki.org/
Decrease, E2 blood concentrations at hypothalamus
Source: https://aopwiki.org/
Promotion, ovarian adenomas
Source: https://aopwiki.org/
Promotion, ovarian granular cell tumors
Source: https://aopwiki.org/
Increased, PPAR-alpha activation
Source: https://aopwiki.org/
Decreased, bile flow
Source: https://aopwiki.org/
Increased, cholestasis
Source: https://aopwiki.org/
Alteration, lipid metabolism
Source: https://aopwiki.org/
prolonged, elevation of serun CCK
Source: https://aopwiki.org/
Increased, Cellular proliferation / hyperplasia of acinar cells
Source: https://aopwiki.org/
Increased, Pancreatic acinar tumors
Source: https://aopwiki.org/
prepubertal increase, Estrogen receptor (ER) activity
Source: https://aopwiki.org/
Activation, estrogen receptor alpha
Source: https://aopwiki.org/
Promotion, SIX-1 postive basal-type progenitor cells
Source: https://aopwiki.org/
Proliferation/Clonal Expansion, aberrant basal cells
Source: https://aopwiki.org/
squamous metaplasia, aberrant basal cells
Source: https://aopwiki.org/
Increased, Hyperplasia (glandular epithelial cells of endometrium)
Source: https://aopwiki.org/
Increased, adenosquamous carcinomas of endometrium
Source: https://aopwiki.org/
Decreased, GnRH pulsatility/release in hypothalamus
Source: https://aopwiki.org/
Decreased, GnRH pulsatility/release in hypothalamus
Source: https://aopwiki.org/
Decreased, LH Surge from anterior pituitary
Source: https://aopwiki.org/
Decreased, LH Surge from anterior pituitary
Source: https://aopwiki.org/
interruption, Ovulation
Source: https://aopwiki.org/
interruption, Ovulation
Source: https://aopwiki.org/
prolonged, estrus
Source: https://aopwiki.org/
prolonged, estrus
Source: https://aopwiki.org/
Increased, circulating estrogen levels
Source: https://aopwiki.org/
Increased, circulating estrogen levels
Source: https://aopwiki.org/
Increased, prolactin exposure
Source: https://aopwiki.org/
Hyperplasia, Mammary gland
Source: https://aopwiki.org/
Increased, latency period
Source: https://aopwiki.org/
Increased, latency period
Source: https://aopwiki.org/
Increased, Adenomas/carcinomas (mammary)
Source: https://aopwiki.org/
Increased, Adenomas/carcinomas (mammary)
Source: https://aopwiki.org/
Increased, lactotroph hyperplasia and hypertrophy
Source: https://aopwiki.org/
Increased, adenomas (pituitary)
Source: https://aopwiki.org/
Decreased, Dopaminergic activity
Source: https://aopwiki.org/
Increased, prolactin secretion
Source: https://aopwiki.org/
Increased, hyperplasia (mammary gland)
Source: https://aopwiki.org/
persistent, cytotoxicity (pleura or peritoneum)
Source: https://aopwiki.org/
Increased, inflammation
Source: https://aopwiki.org/
Increased, Cell Proliferation (mesothelium)
Source: https://aopwiki.org/
Increased, mesotheliomas
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in tissues
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in tissues
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in tissues
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in tissues
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in tissues
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in tissues
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in tissues
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in tissues
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in tissues
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in tissues
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in tissues
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in tissues
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in tissues
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in tissues
Source: https://aopwiki.org/
Altered, Amphibian metamorphosis
Source: https://aopwiki.org/
Altered, Amphibian metamorphosis
Source: https://aopwiki.org/
Altered, Amphibian metamorphosis
Source: https://aopwiki.org/
Altered, Amphibian metamorphosis
Source: https://aopwiki.org/
Altered, Amphibian metamorphosis
Source: https://aopwiki.org/
Altered, Amphibian metamorphosis
Source: https://aopwiki.org/
Altered, Amphibian metamorphosis
Source: https://aopwiki.org/
Altered, Amphibian metamorphosis
Source: https://aopwiki.org/
Altered, Amphibian metamorphosis
Source: https://aopwiki.org/
Inhibition, Cyclooxygenase 1 activity
Source: https://aopwiki.org/
Decreased, Prostaglandin F2alpha concentration, plasma
Source: https://aopwiki.org/
Occurrence, renal ischemia
Source: https://aopwiki.org/
Increased, Deformed Wing Virus levels
Source: https://aopwiki.org/
Increased, Energetic demands and therefore metabolic stress
Source: https://aopwiki.org/
Unknown, MIE
Source: https://aopwiki.org/
Increased, Reactive oxygen species
Source: https://aopwiki.org/
Increased, Reactive oxygen species
Source: https://aopwiki.org/
Increased, Reactive oxygen species
Source: https://aopwiki.org/
Increased, Reactive oxygen species
Source: https://aopwiki.org/
Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone
Source: https://aopwiki.org/
Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP
Source: https://aopwiki.org/
Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin
Source: https://aopwiki.org/
Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failure of secondary hemostasis
Source: https://aopwiki.org/
Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage)
Source: https://aopwiki.org/
Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin)
Source: https://aopwiki.org/
Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal
Source: https://aopwiki.org/
Hemostasis, Depletion from blood of fully functional carboxylated clotting factors
Source: https://aopwiki.org/
Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction
Source: https://aopwiki.org/
Osteoporosis and vascular calcification, Bone deterioration
Source: https://aopwiki.org/
Impaired recruitment , Population trajectory
Source: https://aopwiki.org/
Inhibition, Iodotyrosine deiodinase (IYD)
Source: https://aopwiki.org/
Inhibition, Deiodinase 3
Source: https://aopwiki.org/
Increased, Triiodothyronine (T3) in tissues
Source: https://aopwiki.org/
Inhibition, Pendrin
Source: https://aopwiki.org/
Inhibition, Dual oxidase
Source: https://aopwiki.org/
Activation, Hepatic nuclear receptor(s)
Source: https://aopwiki.org/
Increased, Hepatic thyroid hormone uptake/transport
Source: https://aopwiki.org/
Increased, oocyte maturation
Source: https://aopwiki.org/
induced spawning
Source: https://aopwiki.org/
Increased, Reproductive Success
Source: https://aopwiki.org/
Increased, Reproductive Success
Source: https://aopwiki.org/
Increase, cilia movement
Source: https://aopwiki.org/
Increase, cilia movement
Source: https://aopwiki.org/
Increase, cilia movement
Source: https://aopwiki.org/
Increased, Population
Source: https://aopwiki.org/
Increased, Population
Source: https://aopwiki.org/
TRPA1 activation, TRPA1 Receptor
Source: https://aopwiki.org/
TRPV1 activation, TRPV1
Source: https://aopwiki.org/
Activation of oxidative stress pathway
Source: https://aopwiki.org/
Opening of calcium channel, Calcium influx
Source: https://aopwiki.org/
Trigeminal nerve activation
Source: https://aopwiki.org/
SP (Substance P) release, Local increase of SP
Source: https://aopwiki.org/
Non-neuronal production of TNF, Epithelial irritation
Source: https://aopwiki.org/
Immune system inflammation
Source: https://aopwiki.org/
Production of nerve growth factor , Epithelial irritation
Source: https://aopwiki.org/
Non-neuronal production of IL-8/CXCL1, Epithelial irritation
Source: https://aopwiki.org/
Generation of novel epitopes , Antigen presentation
Source: https://aopwiki.org/
Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea
Source: https://aopwiki.org/
Increased Respiratory irritability and Chronic Cough,
Source: https://aopwiki.org/
Sensitization, Immune system
Source: https://aopwiki.org/
Decreased, sodium conductance 2
Source: https://aopwiki.org/
Decreased, GABA release
Source: https://aopwiki.org/
Activation, Estrogen receptor
Source: https://aopwiki.org/
Increase, Cell Proliferation (Epithelial Cells)
Source: https://aopwiki.org/
Increase, Cell Proliferation (Epithelial Cells)
Source: https://aopwiki.org/
Increase, Cell Proliferation (Epithelial Cells)
Source: https://aopwiki.org/
Decreased, Apoptosis (Epithelial Cells)
Source: https://aopwiki.org/
Increased, ER binding to DNA (classical pathway)
Source: https://aopwiki.org/
Increased, ER binding to T.F. to DNA (non-classical pathway)
Source: https://aopwiki.org/
Increased, Proliferation (Endothelial cells)
Source: https://aopwiki.org/
Increased, Migration (Endothelial Cells)
Source: https://aopwiki.org/
Increased, Non-genomic signaling
Source: https://aopwiki.org/
Increased, Ductal Hyperplasia
Source: https://aopwiki.org/
Increased, Ductal Hyperplasia
Source: https://aopwiki.org/
Increased, Ductal Hyperplasia
Source: https://aopwiki.org/
Increase, DNA damage
Source: https://aopwiki.org/
Increase, DNA damage
Source: https://aopwiki.org/
Increase, DNA damage
Source: https://aopwiki.org/
Increase, DNA damage
Source: https://aopwiki.org/
Increase, DNA damage
Source: https://aopwiki.org/
modulation, Extracellular Matrix Composition
Source: https://aopwiki.org/
Increased, Invasion
Source: https://aopwiki.org/
Activation, Fibroblasts
Source: https://aopwiki.org/
Activation, Macrophages
Source: https://aopwiki.org/
Increased, Angiogenesis
Source: https://aopwiki.org/
Altered, Gene Expression
Source: https://aopwiki.org/
Altered, Gene Expression
Source: https://aopwiki.org/
Altered, Protein Production
Source: https://aopwiki.org/
Increased, Motility
Source: https://aopwiki.org/
Increased, Second Messenger Production
Source: https://aopwiki.org/
N/A, Breast Cancer
Source: https://aopwiki.org/
N/A, Breast Cancer
Source: https://aopwiki.org/
N/A, Breast Cancer
Source: https://aopwiki.org/
Activation, Juvenile hormone receptor
Source: https://aopwiki.org/
Induction, Doublesex1 gene
Source: https://aopwiki.org/
Induction, Male reproductive tract
Source: https://aopwiki.org/
Increased, Male offspring
Source: https://aopwiki.org/
Alteration, Food-web structures
Source: https://aopwiki.org/
Binding to (interferes with) topoisomerase II enzyme
Source: https://aopwiki.org/
MLL chromosomal translocation
Source: https://aopwiki.org/
Infant leukaemia
Source: https://aopwiki.org/
increased mantel display
Source: https://aopwiki.org/
increased mantel display
Source: https://aopwiki.org/
Induced parturition
Source: https://aopwiki.org/
Induced parturition
Source: https://aopwiki.org/
Decreased, Reproductive Success
Source: https://aopwiki.org/
Decreased, Reproductive Success
Source: https://aopwiki.org/
Decreased, Reproductive Success
Source: https://aopwiki.org/
Decompartmentalization
Source: https://aopwiki.org/
Direct mitochondrial inhibition
Source: https://aopwiki.org/
narcosis
Source: https://aopwiki.org/
Mitochondrial impairment
Source: https://aopwiki.org/
Mitochondrial impairment
Source: https://aopwiki.org/
Apoptosis
Source: https://aopwiki.org/
Apoptosis
Source: https://aopwiki.org/
Apoptosis
Source: https://aopwiki.org/
Apoptosis
Source: https://aopwiki.org/
Necrosis
Source: https://aopwiki.org/
Inactivation of PPARγ
Source: https://aopwiki.org/
Inactivation of PPARγ
Source: https://aopwiki.org/
Activation of TGF-β signaling
Source: https://aopwiki.org/
Differentiation of Myofibroblast
Source: https://aopwiki.org/
Production of α-smooth muscle actin
Source: https://aopwiki.org/
Expression of Collagen
Source: https://aopwiki.org/
Expression of Collagen
Source: https://aopwiki.org/
Collagen Deposition
Source: https://aopwiki.org/
Collagen Deposition
Source: https://aopwiki.org/
Lung fibrosis
Source: https://aopwiki.org/
Lung fibrosis
Source: https://aopwiki.org/
Activation, NADPH Oxidase
Source: https://aopwiki.org/
ROS formation
Source: https://aopwiki.org/
Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK
Source: https://aopwiki.org/
Activation, HIF-1
Source: https://aopwiki.org/
Increased, DNA Damage-Repair
Source: https://aopwiki.org/
Reproductive failure
Source: https://aopwiki.org/
Reproductive failure
Source: https://aopwiki.org/
Reproductive failure
Source: https://aopwiki.org/
Activation, JAK/STAT pathway
Source: https://aopwiki.org/
Activation, TGF-beta pathway
Source: https://aopwiki.org/
Activation, TGF-beta pathway
Source: https://aopwiki.org/
Up Regulation, SREBF2
Source: https://aopwiki.org/
Up Regulation, Unsaturated fatty acid
Source: https://aopwiki.org/
Down Regulation, GSS and GSTs gene
Source: https://aopwiki.org/
Glutathione synthesis
Source: https://aopwiki.org/
Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene
Source: https://aopwiki.org/
Perturbation of cholesterol
Source: https://aopwiki.org/
Glutathione homeostasis
Source: https://aopwiki.org/
Hepatotoxicity
Source: https://aopwiki.org/
Activation, JNK
Source: https://aopwiki.org/
Activation, JNK
Source: https://aopwiki.org/
Activation, FOXO
Source: https://aopwiki.org/
Inhibition, Wnt pathway
Source: https://aopwiki.org/
Defect of Embryogenesis
Source: https://aopwiki.org/
Increase, insulin
Source: https://aopwiki.org/
Activation, insulin receptor
Source: https://aopwiki.org/
Activation, mTORC2
Source: https://aopwiki.org/
Activation, AKT
Source: https://aopwiki.org/
Activation, AKT
Source: https://aopwiki.org/
Activation, mTORC1
Source: https://aopwiki.org/
Activation, mTORC1
Source: https://aopwiki.org/
Activation, SREBP-1
Source: https://aopwiki.org/
Activation, L-FABP
Source: https://aopwiki.org/
Increase, cytosolic fatty acid
Source: https://aopwiki.org/
Increased, lipogenesis
Source: https://aopwiki.org/
Activation, FXR
Source: https://aopwiki.org/
Activation, HSD17B4
Source: https://aopwiki.org/
Inhibition, LXR
Source: https://aopwiki.org/
Inhibition, LRH-1
Source: https://aopwiki.org/
Activation, aPKC
Source: https://aopwiki.org/
Activation, PI3K
Source: https://aopwiki.org/
Activation, PI3K
Source: https://aopwiki.org/
Inhibition, Steatosis
Source: https://aopwiki.org/
Increase, Fatty acid beta-oxidation
Source: https://aopwiki.org/
Increase, Fatty acid beta-oxidation
Source: https://aopwiki.org/
Decrease, cytosolic fatty acid
Source: https://aopwiki.org/
Activation, LRH-1
Source: https://aopwiki.org/
Inhibit, serotonin transporter activity
Source: https://aopwiki.org/
Inhibit, serotonin transporter activity
Source: https://aopwiki.org/
Decreased, serotonin transporter activity
Source: https://aopwiki.org/
Decreased, serotonin transporter activity
Source: https://aopwiki.org/
Decreased, serotonin transporter activity
Source: https://aopwiki.org/
Decreased, serotonin transporter activity
Source: https://aopwiki.org/
Decreased, serotonin transporter activity
Source: https://aopwiki.org/
Decreased, serotonin transporter activity
Source: https://aopwiki.org/
Decreased, extracellular sodium (Na+)
Source: https://aopwiki.org/
Decreased, extracellular chloride (Cl-)
Source: https://aopwiki.org/
Increased, extracellular serotonin
Source: https://aopwiki.org/
Increased, extracellular serotonin
Source: https://aopwiki.org/
Increased, extracellular serotonin
Source: https://aopwiki.org/
Increased, extracellular serotonin
Source: https://aopwiki.org/
Increased, extracellular serotonin
Source: https://aopwiki.org/
Increased, extracellular serotonin
Source: https://aopwiki.org/
Increased, intracellular sodium (Na+)
Source: https://aopwiki.org/
Increased, intracellular sodium (Na+)
Source: https://aopwiki.org/
Increased, intracellular sodium (Na+)
Source: https://aopwiki.org/
Increased, intracellular chloride (Cl-)
Source: https://aopwiki.org/
Increased, intracellular chloride (Cl-)
Source: https://aopwiki.org/
Decreased, intracellular serotonin
Source: https://aopwiki.org/
Decreased, intracellular serotonin
Source: https://aopwiki.org/
Decreased, intracellular serotonin
Source: https://aopwiki.org/
Decreased, intracellular serotonin
Source: https://aopwiki.org/
Decreased, intracellular serotonin
Source: https://aopwiki.org/
Decreased, intracellular serotonin
Source: https://aopwiki.org/
Decreased, packaged serotonin
Source: https://aopwiki.org/
Decreased, packaged serotonin
Source: https://aopwiki.org/
Decreased, packaged serotonin
Source: https://aopwiki.org/
Decreased, packaged serotonin
Source: https://aopwiki.org/
Decreased, packaged serotonin
Source: https://aopwiki.org/
Decreased, packaged serotonin
Source: https://aopwiki.org/
Decreased, synaptic release
Source: https://aopwiki.org/
Decreased, synaptic release
Source: https://aopwiki.org/
Decreased, synaptic release
Source: https://aopwiki.org/
Decreased, synaptic release
Source: https://aopwiki.org/
Decreased, synaptic release
Source: https://aopwiki.org/
Decreased, synaptic release
Source: https://aopwiki.org/
Increased, 5-HT3 (5-hydroxytryptamine)
Source: https://aopwiki.org/
Increased, 5-HT3 (5-hydroxytryptamine)
Source: https://aopwiki.org/
Inactivated, 5-HTR (serotonin receptors)
Source: https://aopwiki.org/
Inactivated, 5-HTR (serotonin receptors)
Source: https://aopwiki.org/
Inactivated, 5-HTR (serotonin receptors)
Source: https://aopwiki.org/
Inactivated, 5-HTR (serotonin receptors)
Source: https://aopwiki.org/
Reduce expression, BDNF (Brain-derived neurotrophic factor)
Source: https://aopwiki.org/
Reduce expression, BDNF (Brain-derived neurotrophic factor)
Source: https://aopwiki.org/
Reduce expression, BDNF (Brain-derived neurotrophic factor)
Source: https://aopwiki.org/
Reduce expression, BDNF (Brain-derived neurotrophic factor)
Source: https://aopwiki.org/
Decreased, neuroplasticity
Source: https://aopwiki.org/
Decreased, neuroplasticity
Source: https://aopwiki.org/
Decreased, neuroplasticity
Source: https://aopwiki.org/
Decreased, neuroplasticity
Source: https://aopwiki.org/
Increase, cortisone
Source: https://aopwiki.org/
Increase, cortisone
Source: https://aopwiki.org/
Reduced, BDNF (Brain-derived neurotrophic factor)
Source: https://aopwiki.org/
Reduced, BDNF (Brain-derived neurotrophic factor)
Source: https://aopwiki.org/
Reduced, BDNF (Brain-derived neurotrophic factor)
Source: https://aopwiki.org/
Activation, 5-HT2A (Serotonin 2A)
Source: https://aopwiki.org/
Activation, 5-HT2A (Serotonin 2A)
Source: https://aopwiki.org/
Activate, PLC (Phospholipase C)
Source: https://aopwiki.org/
Activate, PLC (Phospholipase C)
Source: https://aopwiki.org/
Increase, inositol triphosphate
Source: https://aopwiki.org/
Increase, inositol triphosphate
Source: https://aopwiki.org/
Increase, intracellular calcium
Source: https://aopwiki.org/
Increase, intracellular calcium
Source: https://aopwiki.org/
Increase, intracellular calcium
Source: https://aopwiki.org/
Activate, calmodulin
Source: https://aopwiki.org/
Activate, calmodulin
Source: https://aopwiki.org/
Increase, myosin light chain phosphorylation
Source: https://aopwiki.org/
Increase, myosin light chain phosphorylation
Source: https://aopwiki.org/
Increase, vascular smooth muscle contraction
Source: https://aopwiki.org/
Increase, vascular smooth muscle contraction
Source: https://aopwiki.org/
Increased, seizure
Source: https://aopwiki.org/
Increased, seizure
Source: https://aopwiki.org/
Increased, seizure
Source: https://aopwiki.org/
Increased, seizure
Source: https://aopwiki.org/
Increased, agitation
Source: https://aopwiki.org/
Increased, agitation
Source: https://aopwiki.org/
Increased, agitation
Source: https://aopwiki.org/
Increased, depression
Source: https://aopwiki.org/
Increased, depression
Source: https://aopwiki.org/
Increase, hypertension
Source: https://aopwiki.org/
Increase, hypertension
Source: https://aopwiki.org/
Increase, hypertension
Source: https://aopwiki.org/
Decreased, extracellular serotonin
Source: https://aopwiki.org/
Decreased, extracellular serotonin
Source: https://aopwiki.org/
Decreased, extracellular serotonin
Source: https://aopwiki.org/
Decreased, extracellular serotonin
Source: https://aopwiki.org/
Decreased, extracellular serotonin
Source: https://aopwiki.org/
Decreased, extracellular serotonin
Source: https://aopwiki.org/
Activated, presynaptic neuron 1
Source: https://aopwiki.org/
Activated, presynaptic neuron 1
Source: https://aopwiki.org/
Increased, glutamate
Source: https://aopwiki.org/
Increased, glutamate
Source: https://aopwiki.org/
Increased, glutamate
Source: https://aopwiki.org/
Activated, NMDA receptor
Source: https://aopwiki.org/
Activated, NMDA receptor
Source: https://aopwiki.org/
Activated, voltage-gated sodium channel
Source: https://aopwiki.org/
Activated, voltage-gated sodium channel
Source: https://aopwiki.org/
Inhibit, voltage-gated sodium channel
Source: https://aopwiki.org/
Inhibit, voltage-gated sodium channel
Source: https://aopwiki.org/
Treat, carbamazepine
Source: https://aopwiki.org/
Treat, carbamazepine
Source: https://aopwiki.org/
Activated, membrane depolarization
Source: https://aopwiki.org/
Activated, membrane depolarization
Source: https://aopwiki.org/
Activated, membrane depolarization
Source: https://aopwiki.org/
Inactive, membrane depolarization
Source: https://aopwiki.org/
Increased, RDX dose
Source: https://aopwiki.org/
Increased, RDX dose
Source: https://aopwiki.org/
Repress, GABA-A receptor
Source: https://aopwiki.org/
Activate, GABA-A receptor
Source: https://aopwiki.org/
Activate, presynaptic neuron 2
Source: https://aopwiki.org/
Increase, GABA
Source: https://aopwiki.org/
Increase, seizure
Source: https://aopwiki.org/
Increased, hippocampal hyperdepolarization
Source: https://aopwiki.org/
Increased, hippocampal hyperdepolarization
Source: https://aopwiki.org/
Increased, hippocampal hyperdepolarization
Source: https://aopwiki.org/
Increased, epilepsy
Source: https://aopwiki.org/
Increased, epilepsy
Source: https://aopwiki.org/
Increased, epilepsy
Source: https://aopwiki.org/
Increase, Reactive oxygen species
Source: https://aopwiki.org/
Increase, Reactive oxygen species
Source: https://aopwiki.org/
Increase, Reactive oxygen species
Source: https://aopwiki.org/
Increase, Apoptosis
Source: https://aopwiki.org/
Increase, Apoptosis
Source: https://aopwiki.org/
Increase, Apoptosis
Source: https://aopwiki.org/
Increase, Apoptosis
Source: https://aopwiki.org/
Increase, Apoptosis
Source: https://aopwiki.org/
Increase, Apoptosis
Source: https://aopwiki.org/
Increase, Apoptosis
Source: https://aopwiki.org/
Decrease, Oogenesis
Source: https://aopwiki.org/
Decrease, Oogenesis
Source: https://aopwiki.org/
Decrease, Oogenesis
Source: https://aopwiki.org/
Decrease, Oogenesis
Source: https://aopwiki.org/
Decrease, Oogenesis
Source: https://aopwiki.org/
Decrease, Oogenesis
Source: https://aopwiki.org/
Decrease, Oogenesis
Source: https://aopwiki.org/
Decrease, Oogenesis
Source: https://aopwiki.org/
Decrease, Oogenesis
Source: https://aopwiki.org/
Inhibition, PTGS-1 (Prostaglandin-endoperoxide synthase 1)
Source: https://aopwiki.org/
Activation, PTGS-1 (Prostaglandin-endoperoxide synthase 1)
Source: https://aopwiki.org/
Activation, PTGS-2 (Prostaglandin-endoperoxide synthase 2)
Source: https://aopwiki.org/
Inhibition, PTGS-2 (Prostaglandin-endoperoxide synthase 2)
Source: https://aopwiki.org/
Increase, bicarbonate
Source: https://aopwiki.org/
Increase, mucous
Source: https://aopwiki.org/
Increase, mucosal blood flow
Source: https://aopwiki.org/
Increase, platelet aggregation
Source: https://aopwiki.org/
Increase, angiogenesis
Source: https://aopwiki.org/
Decrease, leukocyte adherence
Source: https://aopwiki.org/
Increase, leukocyte adherence
Source: https://aopwiki.org/
Activate, leukocyte
Source: https://aopwiki.org/
Activate, mucosal defense
Source: https://aopwiki.org/
Increase, surfactant
Source: https://aopwiki.org/
Decrease, surfactant
Source: https://aopwiki.org/
Decrease, surfactant
Source: https://aopwiki.org/
Activate, phospholipase
Source: https://aopwiki.org/
Activate, phospholipase
Source: https://aopwiki.org/
Increase, ammonium (NH4+)
Source: https://aopwiki.org/
Increase, ammonium (NH4+)
Source: https://aopwiki.org/
Inhibit, gastric ulcer formation
Source: https://aopwiki.org/
Activated, gastric ulcer formation
Source: https://aopwiki.org/
Activated, gastric ulcer formation
Source: https://aopwiki.org/
Activated, gastric ulcer formation
Source: https://aopwiki.org/
Activated, gastric ulcer formation
Source: https://aopwiki.org/
CYP7B activity, inhibition
Source: https://aopwiki.org/
CYP7B activity, inhibition
Source: https://aopwiki.org/
7α-hydroxypregnenolone synthesis in the brain, decreased
Source: https://aopwiki.org/
7α-hydroxypregnenolone synthesis in the brain, decreased
Source: https://aopwiki.org/
Dopamine release in the brain, decreased
Source: https://aopwiki.org/
Dopamine release in the brain, decreased
Source: https://aopwiki.org/
Locomotor activity, decreased
Source: https://aopwiki.org/
Sexual behavior, decreased
Source: https://aopwiki.org/
Activation of Cyp2E1
Source: https://aopwiki.org/
Oxidative Stress
Source: https://aopwiki.org/
Oxidative Stress
Source: https://aopwiki.org/
Oxidative Stress
Source: https://aopwiki.org/
Oxidative Stress
Source: https://aopwiki.org/
Hepatocytotoxicity
Source: https://aopwiki.org/
Induction, persistant proliferation/sustained proliferation
Source: https://aopwiki.org/
Liver Cancer
Source: https://aopwiki.org/
Increased, glucocorticoid receptor activity
Source: https://aopwiki.org/
Increased, serotonin transporter activity
Source: https://aopwiki.org/
Increased, serotonin transporter activity
Source: https://aopwiki.org/
Increased, serotonin transporter activity
Source: https://aopwiki.org/
Increased, intracellular serotonin
Source: https://aopwiki.org/
Increased, intracellular serotonin
Source: https://aopwiki.org/
Increased, intracellular serotonin
Source: https://aopwiki.org/
Increased, packaged serotonin
Source: https://aopwiki.org/
Increased, packaged serotonin
Source: https://aopwiki.org/
Increased, packaged serotonin
Source: https://aopwiki.org/
Increased, synaptic release
Source: https://aopwiki.org/
Increased, synaptic release
Source: https://aopwiki.org/
Increased, synaptic release
Source: https://aopwiki.org/
Decreased, 5-HT3
Source: https://aopwiki.org/
Reduced, PTGS1 function
Source: https://aopwiki.org/
Reduced, platelet aggregation
Source: https://aopwiki.org/
Decreased, mucosal blood flow
Source: https://aopwiki.org/
Reduced, mucosal defense
Source: https://aopwiki.org/
Reduced, mucosal defense
Source: https://aopwiki.org/
Decreased, mucous
Source: https://aopwiki.org/
Decreased, bicarbonate
Source: https://aopwiki.org/
Reduced, PTGS2 function
Source: https://aopwiki.org/
Decreased, angiogenesis
Source: https://aopwiki.org/
Increased, leukocyte adherence
Source: https://aopwiki.org/
Increased, leukocyte activation
Source: https://aopwiki.org/
Helicobacter pylori infection
Source: https://aopwiki.org/
Reduced, presynaptic neuron 2 activity
Source: https://aopwiki.org/
Decreased, GABA
Source: https://aopwiki.org/
Reduced, GABA-A receptor activation
Source: https://aopwiki.org/
Decreased, intracellular chloride
Source: https://aopwiki.org/
NFE2/Nrf2 repression
Source: https://aopwiki.org/
Reduced, FXR activity
Source: https://aopwiki.org/
Reduced, SHP activity
Source: https://aopwiki.org/
Activated, LXR
Source: https://aopwiki.org/
Reduced, PPARalpha
Source: https://aopwiki.org/
Reduced, HSD17B4 activity
Source: https://aopwiki.org/
Reduced, fatty acid beta oxidation
Source: https://aopwiki.org/
Increased, steatosis
Source: https://aopwiki.org/
Mu Opioid Receptor Agonism
Source: https://aopwiki.org/
Mu Opioid Receptor Agonism
Source: https://aopwiki.org/
Release of G Proteins
Source: https://aopwiki.org/
Release of G Proteins
Source: https://aopwiki.org/
Release of G Proteins
Source: https://aopwiki.org/
Release of G Proteins
Source: https://aopwiki.org/
Opening of G protein gated inward rectifying K channels
Source: https://aopwiki.org/
Opening of G protein gated inward rectifying K channels
Source: https://aopwiki.org/
Analgesia
Source: https://aopwiki.org/
Analgesia
Source: https://aopwiki.org/
Inhibition of N-type Ca ion channels
Source: https://aopwiki.org/
Inhibition of N-type Ca ion channels
Source: https://aopwiki.org/
Inhibition of neurotransmitter vesicle release
Source: https://aopwiki.org/
Inhibition of neurotransmitter vesicle release
Source: https://aopwiki.org/
Serotonin 1A Receptor Agonism
Source: https://aopwiki.org/
Serotonin 1A Receptor Agonism
Source: https://aopwiki.org/
Anti-depressant Activity
Source: https://aopwiki.org/
Anti-depressant Activity
Source: https://aopwiki.org/
Increased CGRP, neuronal release of CGRP
Source: https://aopwiki.org/
Increased neurokinin A (NKA) by neuronal cells
Source: https://aopwiki.org/
Irritation of nasal mucosa inducing sneeze reflex
Source: https://aopwiki.org/
Increase, Follicular atresia
Source: https://aopwiki.org/
Sensing of the stressor by pulmonary cells
Source: https://aopwiki.org/
Increased production of pulmonary, pro-inflammatory cytokines
Source: https://aopwiki.org/
Increased production of pulmonary SAA
Source: https://aopwiki.org/
Formation of HDL-SAA
Source: https://aopwiki.org/
Increased systemic total cholesterol pool
Source: https://aopwiki.org/
Foam cell formation
Source: https://aopwiki.org/
Plaque progression in arteries
Source: https://aopwiki.org/
Increase, Lipid peroxidation
Source: https://aopwiki.org/
Increase, Lipid peroxidation
Source: https://aopwiki.org/
Increase, Uncoupling of oxidative phosphorylation
Source: https://aopwiki.org/
Increase, Uncoupling of oxidative phosphorylation
Source: https://aopwiki.org/
Increase, Uncoupling of oxidative phosphorylation
Source: https://aopwiki.org/
chronic high fat diet
Source: https://aopwiki.org/
activation of CCAAT/enhancer-binding protein alpha
Source: https://aopwiki.org/
increased adipogenesis
Source: https://aopwiki.org/
decreased dopamine
Source: https://aopwiki.org/
decreased reward
Source: https://aopwiki.org/
decreased DNA methylation of tyrosine hydroxylase
Source: https://aopwiki.org/
decreased methylation of dopamine transporter promoter
Source: https://aopwiki.org/
obesity
Source: https://aopwiki.org/
Induction, Cell damage sensing
Source: https://aopwiki.org/
Incudtion, Sustained inflammatory cytokine release
Source: https://aopwiki.org/
Increase, Differentiation of fibroblasts
Source: https://aopwiki.org/
Induction, Epithelial Mesenchymal Transition
Source: https://aopwiki.org/
Induction, Epithelial Mesenchymal Transition
Source: https://aopwiki.org/
Induction, Epithelial Mesenchymal Transition
Source: https://aopwiki.org/
Induction, Epithelial Mesenchymal Transition
Source: https://aopwiki.org/
Pulmonary fibrosis
Source: https://aopwiki.org/
Pulmonary fibrosis
Source: https://aopwiki.org/
Pulmonary fibrosis
Source: https://aopwiki.org/
DNA double-strand break
Source: https://aopwiki.org/
Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts
Source: https://aopwiki.org/
Inhibition of lysyl oxidase
Source: https://aopwiki.org/
Reduction of collagen crosslinking
Source: https://aopwiki.org/
Weak collagen matrix
Source: https://aopwiki.org/
Notochord distortion or malformations
Source: https://aopwiki.org/
Growth, reduction
Source: https://aopwiki.org/
Activation, Latent Transforming Growth Factor Beta 1
Source: https://aopwiki.org/
Activation, Transforming Growth Factor beta pathway
Source: https://aopwiki.org/
Increase, Uncoupling of photophosphorylation
Source: https://aopwiki.org/
Decrease, Chloroplast ATP production
Source: https://aopwiki.org/
Decrease, Chlorophyll synthesis
Source: https://aopwiki.org/
Decrease, Light harvest capacity
Source: https://aopwiki.org/
Decrease, Photosynthesis
Source: https://aopwiki.org/
Decrease, Photosynthesis
Source: https://aopwiki.org/
Decrease, Glycolysis
Source: https://aopwiki.org/
Decrease, Glycolysis
Source: https://aopwiki.org/
Decrease, Oxidative phosphorylation
Source: https://aopwiki.org/
Decrease, Oxidative phosphorylation
Source: https://aopwiki.org/
Decrease, Oxidative phosphorylation
Source: https://aopwiki.org/
Decrease, Oxidative phosphorylation
Source: https://aopwiki.org/
Decrease, Oxidative phosphorylation
Source: https://aopwiki.org/
Decrease, Oxidative phosphorylation
Source: https://aopwiki.org/
Decrease, Leaf cell mitosis
Source: https://aopwiki.org/
Decrease, Leaf development
Source: https://aopwiki.org/
Increase, Growth inhibition
Source: https://aopwiki.org/
Inhibition of mitochondrial DNA polymerase gamma (Pol gamma)
Source: https://aopwiki.org/
Depletion, mtDNA
Source: https://aopwiki.org/
Dysfunction, Mitochondria
Source: https://aopwiki.org/
Dysfunction, Mitochondria
Source: https://aopwiki.org/
Binding of substrate, endocytic receptor
Source: https://aopwiki.org/
Binding, Thiol/seleno-proteins involved in protection against oxidative stress
Source: https://aopwiki.org/
Binding, Thiol/seleno-proteins involved in protection against oxidative stress
Source: https://aopwiki.org/
Glutamate dyshomeostasis
Source: https://aopwiki.org/
Inhibition, Fatty Acid Beta Oxidation
Source: https://aopwiki.org/
N/A, Steatohepatisis
Source: https://aopwiki.org/
Increased, Oncotic Necrosis
Source: https://aopwiki.org/
Tissue resident cell activation
Source: https://aopwiki.org/
Tissue resident cell activation
Source: https://aopwiki.org/
Tissue resident cell activation
Source: https://aopwiki.org/
Tissue resident cell activation
Source: https://aopwiki.org/
Increased Pro-inflammatory mediators
Source: https://aopwiki.org/
Increased Pro-inflammatory mediators
Source: https://aopwiki.org/
Increased Pro-inflammatory mediators
Source: https://aopwiki.org/
Increased Pro-inflammatory mediators
Source: https://aopwiki.org/
Increased Pro-inflammatory mediators
Source: https://aopwiki.org/
Interaction with the lung resident cell membrane components
Source: https://aopwiki.org/
Increased, secretion of proinflammatory and profibrotic mediators
Source: https://aopwiki.org/
Increased, secretion of proinflammatory and profibrotic mediators
Source: https://aopwiki.org/
Increased, recruitment of inflammatory cells
Source: https://aopwiki.org/
Increased, recruitment of inflammatory cells
Source: https://aopwiki.org/
Loss of alveolar capillary membrane integrity
Source: https://aopwiki.org/
Increased, activation of T (T) helper (h) type 2 cells
Source: https://aopwiki.org/
Increased, fibroblast proliferation and myofibroblast differentiation
Source: https://aopwiki.org/
Increased, extracellular matrix deposition
Source: https://aopwiki.org/
Histone deacetylase inhibition
Source: https://aopwiki.org/
Histone deacetylase inhibition
Source: https://aopwiki.org/
Histone deacetylase inhibition
Source: https://aopwiki.org/
Histone acetylation, increase
Source: https://aopwiki.org/
Histone acetylation, increase
Source: https://aopwiki.org/
p21 (CDKN1A) expression, increase
Source: https://aopwiki.org/
cell cycle, disrupted
Source: https://aopwiki.org/
testicular atrophy
Source: https://aopwiki.org/
Activation of PPARγ
Source: https://aopwiki.org/
CYP2E1 Activation
Source: https://aopwiki.org/
Protein Adduct Formation
Source: https://aopwiki.org/
Oxidative Stress in Brain
Source: https://aopwiki.org/
Lipid Peroxidation
Source: https://aopwiki.org/
Unfolded Protein Response
Source: https://aopwiki.org/
Unfolded Protein Response
Source: https://aopwiki.org/
General Apoptosis
Source: https://aopwiki.org/
Neurodegeneration
Source: https://aopwiki.org/
Neurodegeneration
Source: https://aopwiki.org/
spermatocyte depletion
Source: https://aopwiki.org/
Increase, Chitin synthase inhibition
Source: https://aopwiki.org/
Increase, Chitin synthase inhibition
Source: https://aopwiki.org/
Decrease, Cuticular chitin synthesis
Source: https://aopwiki.org/
Decrease, Cuticular chitin synthesis
Source: https://aopwiki.org/
Decrease, Cuticular chitin synthesis
Source: https://aopwiki.org/
Decrease, Cuticular chitin synthesis
Source: https://aopwiki.org/
Increase, Premature molting
Source: https://aopwiki.org/
Increase, Premature molting
Source: https://aopwiki.org/
Increase, Premature molting
Source: https://aopwiki.org/
Increase, Premature molting
Source: https://aopwiki.org/
Increase, Sulfonylurea receptor binding
Source: https://aopwiki.org/
Increase, Sulfonylurea receptor binding
Source: https://aopwiki.org/
Increase, Opening of voltage-dependent calcium channel
Source: https://aopwiki.org/
Increase, Opening of voltage-dependent calcium channel
Source: https://aopwiki.org/
Increase, Cell membrane depolarization
Source: https://aopwiki.org/
Increase, Cell membrane depolarization
Source: https://aopwiki.org/
Increase, D1 protein blockage
Source: https://aopwiki.org/
Increase, D1 protein blockage
Source: https://aopwiki.org/
Decrease, Photosystem II activity
Source: https://aopwiki.org/
Decrease, Photosystem II activity
Source: https://aopwiki.org/
Decrease, Growth
Source: https://aopwiki.org/
Decrease, Growth
Source: https://aopwiki.org/
Fatty Acid Beta Oxidation, Decreased
Source: https://aopwiki.org/
Decrease, Fecundity
Source: https://aopwiki.org/
Decrease, Fecundity
Source: https://aopwiki.org/
Decrease, Fecundity
Source: https://aopwiki.org/
Decrease, Fecundity
Source: https://aopwiki.org/
Decrease, Fecundity
Source: https://aopwiki.org/
Decrease, Fecundity
Source: https://aopwiki.org/
Decrease, Fecundity
Source: https://aopwiki.org/
Decrease, Fecundity
Source: https://aopwiki.org/
Decrease, Fecundity
Source: https://aopwiki.org/
Decrease, Fecundity
Source: https://aopwiki.org/
Decrease, Fecundity
Source: https://aopwiki.org/
Decrease, Fecundity
Source: https://aopwiki.org/
Blockade, L-Type Calcium Channels
Source: https://aopwiki.org/
Decrease, Calcium currents
Source: https://aopwiki.org/
Decrease, Calcium binding to Troponin C
Source: https://aopwiki.org/
Decrease, Cardiac contractility
Source: https://aopwiki.org/
Decrease, Cardiac ejection fraction
Source: https://aopwiki.org/
Decrease, Blood pressure
Source: https://aopwiki.org/
Heart failure
Source: https://aopwiki.org/
Disruption, Intracellular calcium mobilization
Source: https://aopwiki.org/
Disruption, Sarcomere assembly
Source: https://aopwiki.org/
Decreased protection against oxidative stress
Source: https://aopwiki.org/
Decreased protection against oxidative stress
Source: https://aopwiki.org/
Endocytotic lysosomal uptake
Source: https://aopwiki.org/
Leukocyte recruitment/activation
Source: https://aopwiki.org/
Leukocyte recruitment/activation
Source: https://aopwiki.org/
Leukocyte recruitment/activation
Source: https://aopwiki.org/
Deposition of Ionizing Energy
Source: https://aopwiki.org/
Deposition of Ionizing Energy
Source: https://aopwiki.org/
Increase DNA Double Strand Breaks
Source: https://aopwiki.org/
Inadequate DNA repair
Source: https://aopwiki.org/
Increase mutations
Source: https://aopwiki.org/
Increase mutations
Source: https://aopwiki.org/
Increase Chromosomal Aberrations
Source: https://aopwiki.org/
Increase Chromosomal Aberrations
Source: https://aopwiki.org/
Increase cell proliferation
Source: https://aopwiki.org/
Increase cell proliferation
Source: https://aopwiki.org/
Increase, lung cancer
Source: https://aopwiki.org/
Mitochondrial Complex I inhibition
Source: https://aopwiki.org/
Mitochondrial Complex III inhibition
Source: https://aopwiki.org/
Mitochondrial Complex III inhibition
Source: https://aopwiki.org/
Mitochondrial Complex III inhibition
Source: https://aopwiki.org/
Mitochondrial Complex IV inhibition
Source: https://aopwiki.org/
Mitochondrial Complex V inhibition
Source: https://aopwiki.org/
Decrease in mitochondrial oxidative phosphorylation
Source: https://aopwiki.org/
Increased reactive oxygen species (in the mitochondria)
Source: https://aopwiki.org/
Mitochondrial Injury
Source: https://aopwiki.org/
Necrotic Tissue
Source: https://aopwiki.org/
Necrotic Tissue
Source: https://aopwiki.org/
Liver Injury
Source: https://aopwiki.org/
Liver Injury
Source: https://aopwiki.org/
Liver Injury
Source: https://aopwiki.org/
Neural crest cell migration, reduced
Source: https://aopwiki.org/
Collagen production, reduced
Source: https://aopwiki.org/
Facial cartilage structures are reduced in size and morphologically distorted
Source: https://aopwiki.org/
Altered differentiation
Source: https://aopwiki.org/
Neural tube defects
Source: https://aopwiki.org/
Decreased Na/K ATPase activity
Source: https://aopwiki.org/
Decreased proximal tubular vectorial transport
Source: https://aopwiki.org/
Chemical induced Fanconi syndrome
Source: https://aopwiki.org/
Blocking of IL-1R
Source: https://aopwiki.org/
Decreased IL-1 production
Source: https://aopwiki.org/
Impaired IL-1 signaling
Source: https://aopwiki.org/
Suppressed AP-1
Source: https://aopwiki.org/
Suppressed NF-kB
Source: https://aopwiki.org/
Suppressed DC activation
Source: https://aopwiki.org/
Impaired antigen presentation
Source: https://aopwiki.org/
Impaired T cell activation
Source: https://aopwiki.org/
Suppression, Suppression of T-cell dependent antibody response (TDAR)
Source: https://aopwiki.org/
Suppressed MyD88
Source: https://aopwiki.org/
Inhibition, IKK complex
Source: https://aopwiki.org/
Activation, Caspase 8 pathway
Source: https://aopwiki.org/
Activation, Tissue resident cells (Kuppfer cells)
Source: https://aopwiki.org/
Increased, proinflammatory mediators (TNFalpha)
Source: https://aopwiki.org/
Increase, proinflammatory mediators (TNFalpha)
Source: https://aopwiki.org/
Binding of microtubule stabilizing agents (MSA) to microtubules
Source: https://aopwiki.org/
Disturbance in microtubule dynamic instability
Source: https://aopwiki.org/
Impaired axonial transport
Source: https://aopwiki.org/
Sensory axonal peripheral neuropathy
Source: https://aopwiki.org/
Interaction of α-diketones with arginine residues
Source: https://aopwiki.org/
Proteasomal dysfunction
Source: https://aopwiki.org/
Airway epithelial injury
Source: https://aopwiki.org/
Fibroproliferative airway lesions
Source: https://aopwiki.org/
Bronchiolitis obliterans
Source: https://aopwiki.org/
Systemic or topycal administration of chemicals
Source: https://aopwiki.org/
Distribution and deposition of chemicals to skin and/or eyes
Source: https://aopwiki.org/
Absorption of photon energy
Source: https://aopwiki.org/
ROS generation from photoactivated chemicals
Source: https://aopwiki.org/
Radicals of target chemicals
Source: https://aopwiki.org/
Oxidation of membrane lipids
Source: https://aopwiki.org/
Oxidation/denatuation of membrane proteins
Source: https://aopwiki.org/
Oxidation of DNA
Source: https://aopwiki.org/
Formation of DNA photo-adducts
Source: https://aopwiki.org/
Formation of protein photo-adducts
Source: https://aopwiki.org/
Inflamatory events in light-exposed tissues
Source: https://aopwiki.org/
Activation, Muscarinic Acetylcholine Receptors
Source: https://aopwiki.org/
Chronic kidney disease
Source: https://aopwiki.org/
Inhibition of N-linked glycosylation
Source: https://aopwiki.org/
Accumulation of misfolded proteins
Source: https://aopwiki.org/
Activation of hepatic stellate cells
Source: https://aopwiki.org/
Increase, Necrosis
Source: https://aopwiki.org/
Increase, Necrosis
Source: https://aopwiki.org/
Increase, Oxidative DNA damage
Source: https://aopwiki.org/
Increase, Oxidative DNA damage
Source: https://aopwiki.org/
Inhibition, Cytochrome P450 enzyme (CYP17A1) activity
Source: https://aopwiki.org/
Reduction, 17-OH-pregnenolone conversion in DHEA
Source: https://aopwiki.org/
Reduction, 17-OH-progesterone conversion in androstenedione
Source: https://aopwiki.org/
Decrease, testosterone synthesis/level
Source: https://aopwiki.org/
Decrease, dihydrotestosterone (DHT) level
Source: https://aopwiki.org/
Decrease, dihydrotestosterone (DHT) level
Source: https://aopwiki.org/
Decrease, dihydrotestosterone (DHT) level
Source: https://aopwiki.org/
Decrease, dihydrotestosterone (DHT) level
Source: https://aopwiki.org/
Decrease, androgen receptors (AR) activation
Source: https://aopwiki.org/
Decrease, androgen receptors (AR) activation
Source: https://aopwiki.org/
Decrease, androgen receptors (AR) activation
Source: https://aopwiki.org/
Decrease, androgen receptors (AR) activation
Source: https://aopwiki.org/
Decrease, androgen receptors (AR) activation
Source: https://aopwiki.org/
Impaired inguinoscrotal testicular descent phase
Source: https://aopwiki.org/
Malformation, cryptorchidism - maldescended testis
Source: https://aopwiki.org/
5α-reductase, inhibition
Source: https://aopwiki.org/
5α-reductase, inhibition
Source: https://aopwiki.org/
Reduction, egg production and spawning
Source: https://aopwiki.org/
Increase, DNA methyltransferase inhibition
Source: https://aopwiki.org/
Increase, DNA methyltransferase inhibition
Source: https://aopwiki.org/
Increase, DNA methyltransferase inhibition
Source: https://aopwiki.org/
Increase, DNA methyltransferase inhibition
Source: https://aopwiki.org/
Increase, DNA methyltransferase inhibition
Source: https://aopwiki.org/
Increase, DNA methyltransferase inhibition
Source: https://aopwiki.org/
Increase, DNA methyltransferase inhibition
Source: https://aopwiki.org/
Increase, DNA methyltransferase inhibition
Source: https://aopwiki.org/
Increase, DNA hypomethylation
Source: https://aopwiki.org/
Increase, DNA hypomethylation
Source: https://aopwiki.org/
Increase, DNA hypomethylation
Source: https://aopwiki.org/
Increase, Gene expression
Source: https://aopwiki.org/
Increase, Gene expression
Source: https://aopwiki.org/
Increase, Gene expression
Source: https://aopwiki.org/
Decrease, Transgenerational DNA methylation
Source: https://aopwiki.org/
Occurrence, Focal Seizure
Source: https://aopwiki.org/
Inhibition of tyrosinase
Source: https://aopwiki.org/
Reduction of L-Dopaquinone
Source: https://aopwiki.org/
Reduction in melanin level
Source: https://aopwiki.org/
Reduction of melanosome level
Source: https://aopwiki.org/
Reduction fo Pigmentation pattern
Source: https://aopwiki.org/
Increase in reactive oxygen and nitrogen species (RONS)
Source: https://aopwiki.org/
Increase in reactive oxygen and nitrogen species (RONS)
Source: https://aopwiki.org/
Increase in inflammation
Source: https://aopwiki.org/
Increase in inflammation
Pathways: Hepatitis
Source: https://aopwiki.org/
Increase in inflammation
Source: https://aopwiki.org/
Increase in inflammation
Source: https://aopwiki.org/
Increase, Oxidative damage to DNA
Source: https://aopwiki.org/
Increase, DNA strand breaks
Source: https://aopwiki.org/
Increase, DNA strand breaks
Source: https://aopwiki.org/
Increase, DNA strand breaks
Source: https://aopwiki.org/
Increase, Chromosomal aberrations
Source: https://aopwiki.org/
Increase, Chromosomal aberrations
Source: https://aopwiki.org/
Retinaldehyde dehydrogenase inhibition
Source: https://aopwiki.org/
Decreased optical elements of the eye
Source: https://aopwiki.org/
Decreased retinoic acid (RA) synthesis
Source: https://aopwiki.org/
Decreased plasma RA level
Source: https://aopwiki.org/
Increased visual impairment
Source: https://aopwiki.org/
Impaired Ab production
Source: https://aopwiki.org/
Wnt ligand stimulation
Source: https://aopwiki.org/
Frizzled activation
Source: https://aopwiki.org/
GSK3beta inactivation
Source: https://aopwiki.org/
GSK3beta inactivation
Source: https://aopwiki.org/
β-catenin activation
Source: https://aopwiki.org/
Snail, Zeb, Twist activation
Source: https://aopwiki.org/
Epithelial-mesenchymal transition
Source: https://aopwiki.org/
Treatment-resistant gastric cancer
Source: https://aopwiki.org/
Increase, S-adenosylmethionine depletion
Source: https://aopwiki.org/
Binding of inhibitor to mitochondrial complex III
Source: https://aopwiki.org/
Binding of inhibitor to mitochondrial complex IV
Source: https://aopwiki.org/
Binding of inhibitor to mitochondrial complex V
Source: https://aopwiki.org/
Antagonism, Thyroid Receptor
Source: https://aopwiki.org/
Inhibition of cystathionine beta-synthase
Source: https://aopwiki.org/
Inhibition of Methylenetetrahydrofolate reductase
Source: https://aopwiki.org/
Inhibition of Methionine synthase
Source: https://aopwiki.org/
Inhibition of betaine-homocysteine methyltransferase
Source: https://aopwiki.org/
Increased Homocysteine level
Source: https://aopwiki.org/
Increased plasma Homocysteine level
Source: https://aopwiki.org/
Increased brain Homocysteine level
Source: https://aopwiki.org/
Induce Neuronal dysfunctions
Source: https://aopwiki.org/
Increased, Plasma HCY level
Source: https://aopwiki.org/
Induced, dysfunction of microcirculation
Source: https://aopwiki.org/
Impaired,anterior-posterior axis development
Source: https://aopwiki.org/
Substance - lung surfactant interaction
Source: https://aopwiki.org/
Disruption of lung surfactant function
Source: https://aopwiki.org/
Alveolar collapse
Source: https://aopwiki.org/
Alveolar reopening
Source: https://aopwiki.org/
Loss of barrier function
Source: https://aopwiki.org/
Blood extravasation into the lungs
Source: https://aopwiki.org/
Reduced lung volume
Source: https://aopwiki.org/
Impaired oxygenation of the blood
Source: https://aopwiki.org/
Acute inhalation toxicity
Source: https://aopwiki.org/
Frustrated phagoytosis
Source: https://aopwiki.org/
Increased, DNA damage and mutation
Source: https://aopwiki.org/
Lung cancer
Source: https://aopwiki.org/
Inhibition, TBX1
Source: https://aopwiki.org/
Disruption, Neural crest cell migration
Source: https://aopwiki.org/
Disruption, Progenitor cells of second heart field
Source: https://aopwiki.org/
Impairment, Fourth pharyngeal arch development
Source: https://aopwiki.org/
Abnormalities, Cardiac outflow tract formation
Source: https://aopwiki.org/
Anomalies, Congenital cardiac conotruncal
Source: https://aopwiki.org/
Direct Deposition of Energy
Source: https://aopwiki.org/
decrease, transcription of genes by AR
Source: https://aopwiki.org/
decrease, transcription of genes by AR
Source: https://aopwiki.org/
decrease, male anogenital distance
Source: https://aopwiki.org/
decrease, male anogenital distance
Source: https://aopwiki.org/
decrease, male anogenital distance
Source: https://aopwiki.org/
Antagonism, Androgen receptor
Source: https://aopwiki.org/
Antagonism, Androgen receptor
Source: https://aopwiki.org/
Antagonism, Androgen receptor
Source: https://aopwiki.org/
reduction, testosterone levels
Source: https://aopwiki.org/
Antagonism,LH receptor
Source: https://aopwiki.org/
Reduction, Progesterone synthesis
Source: https://aopwiki.org/
Reduction, Plasma progesterone concentration
Source: https://aopwiki.org/
Reduction, progesterone uptake, decresed maturation
Source: https://aopwiki.org/
Impaired ovulation
Source: https://aopwiki.org/
Decrease of egg production and cummulative fecundity
Source: https://aopwiki.org/
Increase, DNA methyltransferase expression
Source: https://aopwiki.org/
Increase, hypermethylation of the promotor region of gonadotropin releasing hormone receptor
Source: https://aopwiki.org/
Decrease, expression of gonadotropin releasing hormone receptor
Source: https://aopwiki.org/
Inhibition of IL-1 binding to IL-1 receptor
Source: https://aopwiki.org/
Suppression of T cell activation
Source: https://aopwiki.org/
Dysregulation of heart rate and vascular tone
Source: https://aopwiki.org/
Increase, ATP synthase inhibition
Source: https://aopwiki.org/
Increase, ATP synthase inhibition
Source: https://aopwiki.org/
Decrease, ATP production
Source: https://aopwiki.org/
Decrease, ATP production
Source: https://aopwiki.org/
Decrease, ATP production
Source: https://aopwiki.org/
Decrease, ATP production
Source: https://aopwiki.org/
Increase, Oocyte apoptosis
Source: https://aopwiki.org/
Increase, Oocyte apoptosis
Source: https://aopwiki.org/
Increase, Oocyte apoptosis
Source: https://aopwiki.org/
Increase, Ovarian follicle breakdown
Source: https://aopwiki.org/
Increase, Ovarian follicle breakdown
Source: https://aopwiki.org/
Increase, Ovarian follicle breakdown
Source: https://aopwiki.org/
Status epilepticus
Source: https://aopwiki.org/
Chronic reactive oxygen species
Source: https://aopwiki.org/
Sustained tissue damage / macrophage activation/ porcupine-induced Wnt secretion
Source: https://aopwiki.org/
Proliferation/ beta-catenin activation
Source: https://aopwiki.org/
Impaired coordination and movement
Source: https://aopwiki.org/
Stimulation, TLR7/8 in dendritic cells
Source: https://aopwiki.org/
Overproduction of IL-23, matured dendritic cells
Source: https://aopwiki.org/
Overproduction of IL-17 from Th17 cells
Source: https://aopwiki.org/
Psoriatic skin disease
Source: https://aopwiki.org/
Activation of estrogen receptor in immune cells
Source: https://aopwiki.org/
Induction of GATA3 expression by STAT6:ER fusion protein
Source: https://aopwiki.org/
Overproduction of IL-4 from Th2 cell
Source: https://aopwiki.org/
Increase of anti-single/double-stranded DNA antibody from autoreactive B cell
Source: https://aopwiki.org/
Exacerbation of systemic lupus erythematosus
Source: https://aopwiki.org/
Inhibition of JAK3
Source: https://aopwiki.org/
Blockade of STAT5 phosphorylation
Source: https://aopwiki.org/
Suppression of STAT5 binding to cytokine gene promoters
Source: https://aopwiki.org/
Suppression of IL-2 production
Source: https://aopwiki.org/
Impairment of T-cell dependent antibody response
Source: https://aopwiki.org/
Trypsin inhibition
Source: https://aopwiki.org/
Increased intestinal monitor peptide level
Source: https://aopwiki.org/
Increased blood CCK level
Source: https://aopwiki.org/
Increased exocrine secretion from pancreatic acinar cells
Source: https://aopwiki.org/
Acinar cell proliferation
Source: https://aopwiki.org/
Pancreatic acinar cell tumors
Source: https://aopwiki.org/
ACE2 inhibition
Source: https://aopwiki.org/
Increases AngII
Source: https://aopwiki.org/
Increase plasma Ang II
Source: https://aopwiki.org/
Binding of S protein to ACE receptor
Source: https://aopwiki.org/
Enhanced viral entry and gene expression
Source: https://aopwiki.org/
Increase inflammatory immune responses
Source: https://aopwiki.org/
Increase, the risk of acute respiratory failure
Source: https://aopwiki.org/
Reduce, Sperm count
Source: https://aopwiki.org/
Decreased, 11-ketotestosterone
Source: https://aopwiki.org/
Decreased, 11-ketotestosterone
Source: https://aopwiki.org/
Decreased, 11-ketotestosterone
Source: https://aopwiki.org/
Impaired, Spermatogenesis
Source: https://aopwiki.org/
Impaired, Spermatogenesis
Source: https://aopwiki.org/
Increase, Protein oxidation
Source: https://aopwiki.org/
Decrease, Osmoregulation
Source: https://aopwiki.org/
Increase, Body fluid overload
Source: https://aopwiki.org/
Decrease, Mitochondrial membrane potential
Source: https://aopwiki.org/
Decrease, Neutral lipids
Source: https://aopwiki.org/
Increase, DNA double-strand break
Source: https://aopwiki.org/
Increase, DNA double-strand break
Source: https://aopwiki.org/
Increase, DNA double-strand break
Source: https://aopwiki.org/
Increase, DNA double-strand break
Source: https://aopwiki.org/
Increase, Formation of DNA photoproducts
Source: https://aopwiki.org/
Increase, Cripto-1 expression
Source: https://aopwiki.org/
Inhibition, Activin signaling
Source: https://aopwiki.org/
Inhibition, Fin regeneration
Source: https://aopwiki.org/
Urothelial cell injury/death
Source: https://aopwiki.org/
Urothelial Tumor
Source: https://aopwiki.org/
Decrease, Global DNA methylation
Source: https://aopwiki.org/
Decrease, Global DNA methylation
Source: https://aopwiki.org/
Decrease, Global DNA methylation
Source: https://aopwiki.org/
Decrease, Global DNA methylation
Source: https://aopwiki.org/
Increase, Caspase transcription
Source: https://aopwiki.org/
Increase, Caspase transcription
Source: https://aopwiki.org/
Increase, Caspase transcription
Source: https://aopwiki.org/
Increase, Caspase transcription
Source: https://aopwiki.org/
Increase, Ovarian somatic cell apoptosis
Source: https://aopwiki.org/
Increase, Ovarian somatic cell apoptosis
Source: https://aopwiki.org/
Decrease, Heritable DNA methylation (F3)
Source: https://aopwiki.org/
Decrease, Heritable DNA methylation (F3)
Source: https://aopwiki.org/
Increase, Caspase transcription (F3)
Source: https://aopwiki.org/
Increase, Caspase transcription (F3)
Source: https://aopwiki.org/
Increase, Oocyte apoptosis (F3)
Source: https://aopwiki.org/
Decrease, Oogenesis (F3)
Source: https://aopwiki.org/
Decrease, Oogenesis (F3)
Source: https://aopwiki.org/
Decrease, Fecundity (F3)
Source: https://aopwiki.org/
Decrease, Fecundity (F3)
Source: https://aopwiki.org/
Increase, Ovarian somatic cell apoptosis (F3)
Source: https://aopwiki.org/
Increase, Ovarian follicle breakdown (F3)
Source: https://aopwiki.org/
increase, retained nipples in males
Source: https://aopwiki.org/
Reduction, 17beta-estradiol synthesis by the undifferentiated gonad
Source: https://aopwiki.org/
Increased, Differentiation to Testis
Source: https://aopwiki.org/
Increased, Male Biased Sex Ratio
Source: https://aopwiki.org/
Toll-like receptor 4 activation
Source: https://aopwiki.org/
Activator protein 1 activation
Source: https://aopwiki.org/
Pin-1 activation
Source: https://aopwiki.org/
Latent Transforming growth Factor beta expression
Source: https://aopwiki.org/
11β-hydroxylase inhibition
Source: https://aopwiki.org/
Decreased plasma 11-KT level
Source: https://aopwiki.org/
Decreased plasma 11-KT level
Source: https://aopwiki.org/
Decreased size and sperm volume
Source: https://aopwiki.org/
Inhibition of 11β-HSD
Source: https://aopwiki.org/
Decreased, Calcium influx
Source: https://aopwiki.org/
Decreased, Calcium influx
Source: https://aopwiki.org/
Reduced levels of BDNF
Source: https://aopwiki.org/
Reduced levels of BDNF
Source: https://aopwiki.org/
Reduced levels of BDNF
Source: https://aopwiki.org/
Cell injury/death
Source: https://aopwiki.org/
Cell injury/death
Source: https://aopwiki.org/
Cell injury/death
Source: https://aopwiki.org/
Cell injury/death
Source: https://aopwiki.org/
Cell injury/death
Source: https://aopwiki.org/
Cell injury/death
Source: https://aopwiki.org/
Cell injury/death
Source: https://aopwiki.org/
Cell injury/death
Source: https://aopwiki.org/
Cell injury/death
Source: https://aopwiki.org/
Cell injury/death
Source: https://aopwiki.org/
Cell injury/death
Source: https://aopwiki.org/
Cell injury/death
Source: https://aopwiki.org/
Cell injury/death
Source: https://aopwiki.org/
Cell injury/death
Source: https://aopwiki.org/
Cell injury/death
Source: https://aopwiki.org/
Cell injury/death
Source: https://aopwiki.org/
Cell injury/death
Source: https://aopwiki.org/
N/A, Neurodegeneration
Source: https://aopwiki.org/
N/A, Neurodegeneration
Source: https://aopwiki.org/
N/A, Neurodegeneration
Source: https://aopwiki.org/
N/A, Neurodegeneration
Source: https://aopwiki.org/
N/A, Neurodegeneration
Source: https://aopwiki.org/
N/A, Neurodegeneration
Source: https://aopwiki.org/
N/A, Neurodegeneration
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Impairment, Learning and memory
Source: https://aopwiki.org/
Aberrant, Dendritic morphology
Source: https://aopwiki.org/
Decrease of synaptogenesis
Source: https://aopwiki.org/
Decrease of synaptogenesis
Source: https://aopwiki.org/
Decrease of neuronal network function
Source: https://aopwiki.org/
Decrease of neuronal network function
Source: https://aopwiki.org/
Decrease of neuronal network function
Source: https://aopwiki.org/
Decrease of neuronal network function
Source: https://aopwiki.org/
Decrease of neuronal network function
Source: https://aopwiki.org/
Decrease of neuronal network function
Source: https://aopwiki.org/
Decrease of neuronal network function
Pathways: tau-AOP
Source: https://aopwiki.org/
Decrease of neuronal network function
Source: https://aopwiki.org/
Decrease of neuronal network function
Source: https://aopwiki.org/
Reduced, Presynaptic release of glutamate
Source: https://aopwiki.org/
Activation, Glucocorticoid Receptor
Source: https://aopwiki.org/
Activation, Glucocorticoid Receptor
Source: https://aopwiki.org/
Activation, Glucocorticoid Receptor
Source: https://aopwiki.org/
Activation, Glucocorticoid Receptor
Source: https://aopwiki.org/
Inhibition, Nuclear factor kappa B (NF-kB)
Source: https://aopwiki.org/
Inhibition, Nuclear factor kappa B (NF-kB)
Source: https://aopwiki.org/
Inhibition, Nuclear factor kappa B (NF-kB)
Source: https://aopwiki.org/
Inhibition, Nuclear factor kappa B (NF-kB)
Source: https://aopwiki.org/
Suppression, Inflammatory cytokines
Source: https://aopwiki.org/
Decreased, Lymphocytes
Source: https://aopwiki.org/
Induction, IKB inhibitory protein
Source: https://aopwiki.org/
Suppression, Immune system
Source: https://aopwiki.org/
Suppression, Immune system
Source: https://aopwiki.org/
Suppression, Immune system
Source: https://aopwiki.org/
Suppression, Immune system
Source: https://aopwiki.org/
Increased, Disease susceptibility
Source: https://aopwiki.org/
Alkylation, DNA
Source: https://aopwiki.org/
Alkylation, DNA
Source: https://aopwiki.org/
Alkylation, DNA
Source: https://aopwiki.org/
Inadequate DNA repair
Source: https://aopwiki.org/
Inadequate DNA repair
Source: https://aopwiki.org/
Inadequate DNA repair
Source: https://aopwiki.org/
Inadequate DNA repair
Source: https://aopwiki.org/
Inadequate DNA repair
Source: https://aopwiki.org/
Inadequate DNA repair
Source: https://aopwiki.org/
Inadequate DNA repair
Source: https://aopwiki.org/
Inadequate DNA repair
Source: https://aopwiki.org/
Inadequate DNA repair
Source: https://aopwiki.org/
Increase, Mutations
Source: https://aopwiki.org/
Increase, Mutations
Source: https://aopwiki.org/
Increase, Mutations
Source: https://aopwiki.org/
Increase, Mutations
Source: https://aopwiki.org/
Increase, Mutations
Source: https://aopwiki.org/
Increase, Mutations
Source: https://aopwiki.org/
Increase, Mutations
Source: https://aopwiki.org/
Increase, Mutations
Source: https://aopwiki.org/
Increase, Mutations
Source: https://aopwiki.org/
Increase, Heritable mutations in offspring
Source: https://aopwiki.org/
Acetylcholinesterase (AchE) Inhibition
Source: https://aopwiki.org/
Acetylcholinesterase (AchE) Inhibition
Source: https://aopwiki.org/
Acetylcholinesterase (AchE) Inhibition
Source: https://aopwiki.org/
Acetylcholinesterase (AchE) Inhibition
Source: https://aopwiki.org/
Acetylcholinesterase (AchE) Inhibition
Source: https://aopwiki.org/
Acetylcholinesterase (AchE) Inhibition
Source: https://aopwiki.org/
Acetylcholine accumulation in synapses
Source: https://aopwiki.org/
Acetylcholine accumulation in synapses
Source: https://aopwiki.org/
Acetylcholine accumulation in synapses
Source: https://aopwiki.org/
Acetylcholine accumulation in synapses
Source: https://aopwiki.org/
Acetylcholine accumulation in synapses
Source: https://aopwiki.org/
Increased Cholinergic Signaling
Source: https://aopwiki.org/
Increased Cholinergic Signaling
Source: https://aopwiki.org/
Increased Cholinergic Signaling
Source: https://aopwiki.org/
Respiratory distress/arrest
Source: https://aopwiki.org/
Respiratory distress/arrest
Source: https://aopwiki.org/
Dysregulation of heart rate and vascular tone
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Pathways: OAT1 inhibition
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Pathways: TPOi eye size
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Increased Mortality
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Pathways: OAT1 inhibition
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Pathways: TPOi eye size
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Decrease, Population growth rate
Source: https://aopwiki.org/
Binding, Thiol/seleno-proteins involved in protection against oxidative stress
Source: https://aopwiki.org/
Binding, Thiol/seleno-proteins involved in protection against oxidative stress
Source: https://aopwiki.org/
Decreased protection against oxidative stress
Source: https://aopwiki.org/
Decreased protection against oxidative stress
Source: https://aopwiki.org/
Oxidative Stress
Source: https://aopwiki.org/
Oxidative Stress
Source: https://aopwiki.org/
Oxidative Stress
Source: https://aopwiki.org/
Oxidative Stress
Source: https://aopwiki.org/
Oxidative Stress
Source: https://aopwiki.org/
Oxidative Stress
Source: https://aopwiki.org/
Oxidative Stress
Source: https://aopwiki.org/
Oxidative Stress
Source: https://aopwiki.org/
Oxidative Stress
Pathways: tau-AOP
Source: https://aopwiki.org/
Oxidative Stress
Source: https://aopwiki.org/
Oxidative Stress
Source: https://aopwiki.org/
Oxidative Stress
Source: https://aopwiki.org/
Oxidative Stress
Source: https://aopwiki.org/
Oxidative Stress
Source: https://aopwiki.org/
Oxidative Stress
Source: https://aopwiki.org/
Oxidative Stress
Source: https://aopwiki.org/
Oxidative Stress
Source: https://aopwiki.org/
Oxidative Stress
Source: https://aopwiki.org/
Oxidative Stress
Source: https://aopwiki.org/
Glutamate dyshomeostasis
Source: https://aopwiki.org/
Tissue resident cell activation
Source: https://aopwiki.org/
Tissue resident cell activation
Source: https://aopwiki.org/
Tissue resident cell activation
Source: https://aopwiki.org/
Tissue resident cell activation
Source: https://aopwiki.org/
Tissue resident cell activation
Source: https://aopwiki.org/
Increased Pro-inflammatory mediators
Source: https://aopwiki.org/
Increased Pro-inflammatory mediators
Source: https://aopwiki.org/
Increased Pro-inflammatory mediators
Source: https://aopwiki.org/
Increased Pro-inflammatory mediators
Source: https://aopwiki.org/
Increased Pro-inflammatory mediators
Source: https://aopwiki.org/
Increased Pro-inflammatory mediators
Source: https://aopwiki.org/
Increased Pro-inflammatory mediators
Source: https://aopwiki.org/
Increased Pro-inflammatory mediators
Source: https://aopwiki.org/
Activation, PPARα
Source: https://aopwiki.org/
Activation, PPARα
Source: https://aopwiki.org/
Activation, PPARα
Source: https://aopwiki.org/
Activation, PPARα
Source: https://aopwiki.org/
Activation, PPARα
Source: https://aopwiki.org/
Activation, PPARα
Source: https://aopwiki.org/
Decrease, Steroidogenic acute regulatory protein (STAR)
Source: https://aopwiki.org/
Reduction, Cholesterol transport in mitochondria
Source: https://aopwiki.org/
Reduction, Cholesterol transport in mitochondria
Source: https://aopwiki.org/
Reduction, Testosterone synthesis in Leydig cells
Source: https://aopwiki.org/
Reduction, Testosterone synthesis in Leydig cells
Source: https://aopwiki.org/
Reduction, Testosterone synthesis in Leydig cells
Source: https://aopwiki.org/
Reduction, Testosterone synthesis in Leydig cells
Source: https://aopwiki.org/
Reduction, fetal/adult testosterone
Source: https://aopwiki.org/
Reduction, fetal/adult testosterone
Source: https://aopwiki.org/
Reduction, fetal/adult testosterone
Source: https://aopwiki.org/
Reduction, fetal/adult testosterone
Source: https://aopwiki.org/
Decrease, Translocator protein (TSPO)
Source: https://aopwiki.org/
Malformation, Male reproductive tract
Source: https://aopwiki.org/
N/A, Androgen receptor, Antagonism
Source: https://aopwiki.org/
Alteration, Wnt pathway
Source: https://aopwiki.org/
Feminisation or incomplete development, Primary and accessory male sex organs
Source: https://aopwiki.org/
Altered, Transcription of genes by the androgen receptor
Source: https://aopwiki.org/
Altered, Transcription of genes by the androgen receptor
Source: https://aopwiki.org/
Altered, Transcription of genes by the androgen receptor
Source: https://aopwiki.org/
Altered, Transcription of genes by the androgen receptor
Source: https://aopwiki.org/
Altered, Transcription of genes by the androgen receptor
Source: https://aopwiki.org/
Altered, Transcription of genes by the androgen receptor
Source: https://aopwiki.org/
N/A, Impairment of reproductive capacity
Source: https://aopwiki.org/
Activation, AhR
Source: https://aopwiki.org/
Activation, AhR
Source: https://aopwiki.org/
Activation, AhR
Source: https://aopwiki.org/
Activation, AhR
Source: https://aopwiki.org/
Activation, AhR
Source: https://aopwiki.org/
Activation, AhR
Source: https://aopwiki.org/
Activation, AhR
Source: https://aopwiki.org/
Activation, AhR
Source: https://aopwiki.org/
Activation, AhR
Source: https://aopwiki.org/
Activation, AhR
Source: https://aopwiki.org/
Activation, AhR
Source: https://aopwiki.org/
Activation, AhR
Source: https://aopwiki.org/
Activation, AhR
Source: https://aopwiki.org/
Activation, AhR
Source: https://aopwiki.org/
Activation, AhR
Source: https://aopwiki.org/
Activation, AhR
Source: https://aopwiki.org/
Activation, AhR
Source: https://aopwiki.org/
Activation, AhR
Source: https://aopwiki.org/
Activation, AhR
Source: https://aopwiki.org/
dimerization, AHR/ARNT
Source: https://aopwiki.org/
dimerization, AHR/ARNT
Source: https://aopwiki.org/
dimerization, AHR/ARNT
Source: https://aopwiki.org/
dimerization, AHR/ARNT
Source: https://aopwiki.org/
dimerization, AHR/ARNT
Source: https://aopwiki.org/
dimerization, AHR/ARNT
Source: https://aopwiki.org/
Increase, COX-2 expression
Source: https://aopwiki.org/
Altered, Cardiovascular development/function
Source: https://aopwiki.org/
Altered, Cardiovascular development/function
Source: https://aopwiki.org/
Altered, Cardiovascular development/function
Source: https://aopwiki.org/
Increase, Early Life Stage Mortality
Source: https://aopwiki.org/
Increase, Early Life Stage Mortality
Source: https://aopwiki.org/
Increase, Early Life Stage Mortality
Source: https://aopwiki.org/
Increase, Early Life Stage Mortality
Source: https://aopwiki.org/
Agonism, Androgen receptor
Source: https://aopwiki.org/
Agonism, Androgen receptor
Source: https://aopwiki.org/
Agonism, Androgen receptor
Source: https://aopwiki.org/
Reduction, Gonadotropins, circulating concentrations
Source: https://aopwiki.org/
Reduction, Testosterone synthesis by ovarian theca cells
Source: https://aopwiki.org/
Reduction, Vitellogenin synthesis in liver
Source: https://aopwiki.org/
Reduction, Vitellogenin synthesis in liver
Source: https://aopwiki.org/
Reduction, Vitellogenin synthesis in liver
Source: https://aopwiki.org/
Reduction, Vitellogenin synthesis in liver
Source: https://aopwiki.org/
Reduction, Vitellogenin synthesis in liver
Source: https://aopwiki.org/
Reduction, Vitellogenin synthesis in liver
Source: https://aopwiki.org/
Reduction, Vitellogenin synthesis in liver
Source: https://aopwiki.org/
Reduction, Plasma vitellogenin concentrations
Source: https://aopwiki.org/
Reduction, Plasma vitellogenin concentrations
Source: https://aopwiki.org/
Reduction, Plasma vitellogenin concentrations
Source: https://aopwiki.org/
Reduction, Plasma vitellogenin concentrations
Source: https://aopwiki.org/
Reduction, Plasma vitellogenin concentrations
Source: https://aopwiki.org/
Reduction, Plasma vitellogenin concentrations
Source: https://aopwiki.org/
Reduction, Plasma vitellogenin concentrations
Source: https://aopwiki.org/
Reduction, Plasma vitellogenin concentrations
Source: https://aopwiki.org/
Reduction, Plasma vitellogenin concentrations
Source: https://aopwiki.org/
Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
Source: https://aopwiki.org/
Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
Source: https://aopwiki.org/
Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
Source: https://aopwiki.org/
Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
Source: https://aopwiki.org/
Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
Source: https://aopwiki.org/
Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
Source: https://aopwiki.org/
Reduction, Vitellogenin accumulation into oocytes and oocyte growth/development
Source: https://aopwiki.org/
Reduction, Cumulative fecundity and spawning
Source: https://aopwiki.org/
Reduction, Cumulative fecundity and spawning
Source: https://aopwiki.org/
Reduction, Cumulative fecundity and spawning
Source: https://aopwiki.org/
Reduction, Cumulative fecundity and spawning
Source: https://aopwiki.org/
Reduction, Cumulative fecundity and spawning
Source: https://aopwiki.org/
Reduction, Cumulative fecundity and spawning
Source: https://aopwiki.org/
Reduction, Cumulative fecundity and spawning
Source: https://aopwiki.org/
Reduction, Cumulative fecundity and spawning
Source: https://aopwiki.org/
Reduction, Cumulative fecundity and spawning
Source: https://aopwiki.org/
Reduction, Cumulative fecundity and spawning
Source: https://aopwiki.org/
Reduction, Cumulative fecundity and spawning
Source: https://aopwiki.org/
Reduction, Cumulative fecundity and spawning
Source: https://aopwiki.org/
Reduction, Cumulative fecundity and spawning
Source: https://aopwiki.org/
Reduction, Cumulative fecundity and spawning
Source: https://aopwiki.org/
Inhibition, Aromatase
Source: https://aopwiki.org/
Inhibition, Aromatase
Source: https://aopwiki.org/
Inhibition, Ca++ ATPase
Source: https://aopwiki.org/
Increase, Ca++ (intracellular)
Source: https://aopwiki.org/
Disruption, Mitochondrial electron transport chain
Source: https://aopwiki.org/
Disruption, Mitochondrial electron transport chain
Source: https://aopwiki.org/
Decrease, Mitochondrial ATP production
Source: https://aopwiki.org/
Decrease, Mitochondrial ATP production
Source: https://aopwiki.org/
Decrease, Mitochondrial ATP production
Source: https://aopwiki.org/
Decrease, Mitochondrial ATP production
Source: https://aopwiki.org/
Decrease, Mitochondrial ATP production
Source: https://aopwiki.org/
Decrease, Mitochondrial ATP production
Source: https://aopwiki.org/
Decrease, Mitochondrial ATP production
Source: https://aopwiki.org/
Decrease, Mitochondrial ATP production
Source: https://aopwiki.org/
Decrease, Mitochondrial ATP production
Source: https://aopwiki.org/
Decrease, Mitochondrial ATP production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Increase, Reactive oxygen species production
Source: https://aopwiki.org/
Decreased, Nitric Oxide
Source: https://aopwiki.org/
Decreased, Long-term potentiation (LTP)
Source: https://aopwiki.org/
Increased, Oxidative damage
Source: https://aopwiki.org/
Inhibition, Bile Salt Export Pump (ABCB11)
Source: https://aopwiki.org/
Activation of specific nuclear receptors, Transcriptional change
Source: https://aopwiki.org/
Bile accumulation, Pathological condition
Source: https://aopwiki.org/
Release, Cytokine
Source: https://aopwiki.org/
Release, Cytokine
Source: https://aopwiki.org/
Release, Cytokine
Source: https://aopwiki.org/
Release, Cytokine
Source: https://aopwiki.org/
Increase, Inflammation
Source: https://aopwiki.org/
Increase, Inflammation
Source: https://aopwiki.org/
Increase, Inflammation
Source: https://aopwiki.org/
Increase, Inflammation
Source: https://aopwiki.org/
Increase, Inflammation
Source: https://aopwiki.org/
Increase, Inflammation
Source: https://aopwiki.org/
Increase, Inflammation
Source: https://aopwiki.org/
Production, Reactive oxygen species
Source: https://aopwiki.org/
Peptide Oxidation
Source: https://aopwiki.org/
Peptide Oxidation
Source: https://aopwiki.org/
Peptide Oxidation
Pathways: Hypertension
Source: https://aopwiki.org/
Peptide Oxidation
Source: https://aopwiki.org/
Cholestasis, Pathology
Source: https://aopwiki.org/
Inhibition, Cyclooxygenase activity
Source: https://aopwiki.org/
Inhibition, Cyclooxygenase activity
Source: https://aopwiki.org/
Inhibition, Cyclooxygenase activity
Source: https://aopwiki.org/
Inhibition, Cyclooxygenase activity
Source: https://aopwiki.org/
Inhibition, Cyclooxygenase activity
Source: https://aopwiki.org/
Inhibition, Cyclooxygenase activity
Source: https://aopwiki.org/
Reduction, Prostaglandin E2 concentration
Source: https://aopwiki.org/
Reduction, Ca and HCO3 transport to shell gland
Source: https://aopwiki.org/
Reduction, Eggshell thickness
Source: https://aopwiki.org/
N/A, Gap
Source: https://aopwiki.org/
N/A, Reproductive failure
Source: https://aopwiki.org/
Agonism, Estrogen receptor
Source: https://aopwiki.org/
Agonism, Estrogen receptor
Source: https://aopwiki.org/
Agonism, Estrogen receptor
Source: https://aopwiki.org/
Increase, Plasma vitellogenin concentrations
Source: https://aopwiki.org/
Increase, Plasma vitellogenin concentrations
Source: https://aopwiki.org/
Increase, Vitellogenin synthesis in liver
Source: https://aopwiki.org/
Increase, Renal pathology due to VTG deposition
Source: https://aopwiki.org/
Altered, Reproductive behaviour
Source: https://aopwiki.org/
Altered, Larval development
Source: https://aopwiki.org/
Impaired development of, Reproductive organs
Source: https://aopwiki.org/
Antagonism, Estrogen receptor
Source: https://aopwiki.org/
Antagonism, Estrogen receptor
Source: https://aopwiki.org/
N/A, Parent compound is converted to the reactive metabolite and forms free radicals leading to oxidation of heme iron(II) in hemoglobin to iron(III)
Source: https://aopwiki.org/
Altered regulation, Alpha hemoglobin
Source: https://aopwiki.org/
Propagation, Oxidative stress
Source: https://aopwiki.org/
Propagation, Oxidative stress
Source: https://aopwiki.org/
Damaging, Red blood cells; hemolysis
Source: https://aopwiki.org/
Formation, Formation of hemoglobin adducts
Source: https://aopwiki.org/
Down Regulation, Gulcose-6-phosphate dehydrogenase
Source: https://aopwiki.org/
Increase, RBC congestion in liver
Source: https://aopwiki.org/
Increase, Liver and splenic hemosiderosis
Source: https://aopwiki.org/
N/A, Methemoglobinemia, decreased hemoglobin, hematocrit, red blood cell number
Source: https://aopwiki.org/
N/A, Cyanosis occurs
Source: https://aopwiki.org/
Production, Critical Metabolites (CGA 330050 and CGA 265307)
Source: https://aopwiki.org/
Induction, Liver “Dysfunctional” Changes by CGA 330050
Source: https://aopwiki.org/
Inhibition, Inducible Nitric Oxide Synthase by Metabolite CGA 265307
Source: https://aopwiki.org/
Induction, Sustained Hepatotoxicity
Source: https://aopwiki.org/
Induction, Sustained Cell Proliferation
Source: https://aopwiki.org/
Formation, Liver tumor
Source: https://aopwiki.org/
Activation, 5HT2c
Source: https://aopwiki.org/
N/A, Unknown
Source: https://aopwiki.org/
Increased, Kidney Failure
Source: https://aopwiki.org/
Increased, Kidney Failure
Source: https://aopwiki.org/
Increased, Kidney Failure
Source: https://aopwiki.org/
Increased, Kidney Failure
Source: https://aopwiki.org/
Activation, LXR
Source: https://aopwiki.org/
Activation, LXR
Source: https://aopwiki.org/
peroxisome proliferator activated receptor promoter demethylation
Source: https://aopwiki.org/
peroxisome proliferator activated receptor promoter demethylation
Source: https://aopwiki.org/
peroxisome proliferator activated receptor promoter demethylation
Source: https://aopwiki.org/
peroxisome proliferator activated receptor promoter demethylation
Source: https://aopwiki.org/
Up Regulation, CD36
Source: https://aopwiki.org/
Up Regulation, CD36
Source: https://aopwiki.org/
Up Regulation, CD36
Source: https://aopwiki.org/
Up Regulation, CD36
Source: https://aopwiki.org/
Increase, FA Influx
Source: https://aopwiki.org/
Activation, ChREBP
Source: https://aopwiki.org/
Activation, ChREBP
Source: https://aopwiki.org/
Activation, SREBP-1c
Source: https://aopwiki.org/
Activation, FAS
Source: https://aopwiki.org/
Activation, SCD-1
Source: https://aopwiki.org/
Synthesis, De Novo FA
Source: https://aopwiki.org/
Accumulation, Triglyceride
Source: https://aopwiki.org/
Accumulation, Triglyceride
Source: https://aopwiki.org/
Accumulation, Triglyceride
Source: https://aopwiki.org/
Damaging, Mitochondria
Source: https://aopwiki.org/
Damaging, Mitochondria
Source: https://aopwiki.org/
Damaging, Mitochondria
Source: https://aopwiki.org/
N/A, Liver Steatosis
Source: https://aopwiki.org/
N/A, Liver Steatosis
Source: https://aopwiki.org/
Accumulation, Biological membranes
Source: https://aopwiki.org/
Disruption, Membrane integrity
Source: https://aopwiki.org/
Decreased, PPAR-alpha activation
Source: https://aopwiki.org/
Decreased, PPAR-alpha activation
Source: https://aopwiki.org/
Decreased, PPAR-beta activation
Source: https://aopwiki.org/
Decreased, PPAR-gamma activation
Source: https://aopwiki.org/
Decreased, PPAR-gamma activation
Source: https://aopwiki.org/
Accumulation, Fatty acid
Source: https://aopwiki.org/
Accumulation, Fatty acid
Source: https://aopwiki.org/
Accumulation, Fatty acid
Source: https://aopwiki.org/
Accumulation, Fatty acid
Source: https://aopwiki.org/
Decreased, HSD17B10 expression
Source: https://aopwiki.org/
Decreased, Mitochondrial fatty acid beta-oxidation
Source: https://aopwiki.org/
Decreased, Mitochondrial fatty acid beta-oxidation
Source: https://aopwiki.org/
Decreased, Mitochondrial fatty acid beta-oxidation
Source: https://aopwiki.org/
Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity
Source: https://aopwiki.org/
Increased, Liver Steatosis
Source: https://aopwiki.org/
Increased, Liver Steatosis
Source: https://aopwiki.org/
Increased, Liver Steatosis
Source: https://aopwiki.org/
Increased, Liver Steatosis
Source: https://aopwiki.org/
Increased, Liver Steatosis
Source: https://aopwiki.org/
Increased, Liver Steatosis
Source: https://aopwiki.org/
Increased, Liver Steatosis
Source: https://aopwiki.org/
Increased, Liver Steatosis
Source: https://aopwiki.org/
Increase, Phenotypic enzyme activity
Source: https://aopwiki.org/
Increase, cell proliferation (hepatocytes)
Source: https://aopwiki.org/
Increase, cell proliferation (hepatocytes)
Source: https://aopwiki.org/
Increase, cell proliferation (hepatocytes)
Pathways: AR- HCC
Source: https://aopwiki.org/
Increase, Clonal Expansion of Altered Hepatic Foci
Source: https://aopwiki.org/
Increase, hepatocellular adenomas and carcinomas
Source: https://aopwiki.org/
Increase, hepatocellular adenomas and carcinomas
Source: https://aopwiki.org/
Increase, hepatocellular adenomas and carcinomas
Source: https://aopwiki.org/
Increase, hepatocellular adenomas and carcinomas
Pathways: AR- HCC
Source: https://aopwiki.org/
Increase, hepatocellular adenomas and carcinomas
Source: https://aopwiki.org/
Alkylation, Protein
Source: https://aopwiki.org/
Alkylation, Protein
Source: https://aopwiki.org/
Activation, Stellate cells
Source: https://aopwiki.org/
Activation, Stellate cells
Source: https://aopwiki.org/
Activation, Stellate cells
Source: https://aopwiki.org/
Accumulation, Collagen
Source: https://aopwiki.org/
Accumulation, Collagen
Source: https://aopwiki.org/
Accumulation, Collagen
Source: https://aopwiki.org/
Accumulation, Collagen
Source: https://aopwiki.org/
Accumulation, Collagen
Source: https://aopwiki.org/
Accumulation, Collagen
Source: https://aopwiki.org/
N/A, Liver fibrosis
Source: https://aopwiki.org/
N/A, Liver fibrosis
Source: https://aopwiki.org/
N/A, Liver fibrosis
Source: https://aopwiki.org/
N/A, Liver fibrosis
Source: https://aopwiki.org/
N/A, Covalent binding to protein, possibly lysine residue
Source: https://aopwiki.org/
Activation, Inflammatory cytokines, chemokines, cytoprotective gene pathways
Source: https://aopwiki.org/
Activation, Dendritic Cells
Source: https://aopwiki.org/
Activation, Dendritic Cells
Source: https://aopwiki.org/
Activation/Proliferation, T-cells
Source: https://aopwiki.org/
Activation/Proliferation, T-cells
Source: https://aopwiki.org/
Increase, Allergic Respiratory Hypersensitivity Response
Source: https://aopwiki.org/
Covalent Binding, Protein
Source: https://aopwiki.org/
Covalent Binding, Protein
Source: https://aopwiki.org/
Activation, Keratinocytes
Source: https://aopwiki.org/
sensitisation, skin
Source: https://aopwiki.org/
Activation, Long term AHR receptor driven direct and indirect gene expression changes
Source: https://aopwiki.org/
N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects
Source: https://aopwiki.org/
Changes/Inhibition, Cellular Homeostasis and Apoptosis
Source: https://aopwiki.org/
Alterations, Cellular proliferation / hyperplasia
Source: https://aopwiki.org/
Alterations, Cellular proliferation / hyperplasia
Source: https://aopwiki.org/
Formation, Hepatocellular and Bile duct tumors
Source: https://aopwiki.org/
Thyroperoxidase, Inhibition
Source: https://aopwiki.org/
Thyroperoxidase, Inhibition
Source: https://aopwiki.org/
Thyroperoxidase, Inhibition
Source: https://aopwiki.org/
Thyroperoxidase, Inhibition
Source: https://aopwiki.org/
Thyroperoxidase, Inhibition
Source: https://aopwiki.org/
Thyroperoxidase, Inhibition
Source: https://aopwiki.org/
Thyroperoxidase, Inhibition
Pathways: TPOi eye size
Source: https://aopwiki.org/
Thyroperoxidase, Inhibition
Source: https://aopwiki.org/
Thyroperoxidase, Inhibition
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Pathways: TPOi eye size
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Thyroid hormone synthesis, Decreased
Source: https://aopwiki.org/
Cognitive Function, Decreased
Source: https://aopwiki.org/
Cognitive Function, Decreased
Source: https://aopwiki.org/
Cognitive Function, Decreased
Source: https://aopwiki.org/
Cognitive Function, Decreased
Source: https://aopwiki.org/
Cognitive Function, Decreased
Source: https://aopwiki.org/
Cognitive Function, Decreased
Source: https://aopwiki.org/
Cognitive Function, Decreased
Source: https://aopwiki.org/
Cognitive Function, Decreased
Source: https://aopwiki.org/
Cognitive Function, Decreased
Source: https://aopwiki.org/
Cognitive Function, Decreased
Source: https://aopwiki.org/
Cognitive Function, Decreased
Source: https://aopwiki.org/
Cognitive Function, Decreased
Source: https://aopwiki.org/
Inhibition, VegfR2
Source: https://aopwiki.org/
Reduction, Angiogenesis
Source: https://aopwiki.org/
Impairment, Endothelial network
Source: https://aopwiki.org/
Impairment, Endothelial network
Source: https://aopwiki.org/
Insufficiency, Vascular
Source: https://aopwiki.org/
Increased, Developmental Defects
Source: https://aopwiki.org/
Formation, Pro-mutagenic DNA Adducts
Source: https://aopwiki.org/
Increased, Induced Mutations in Critical Genes
Source: https://aopwiki.org/
Metabolism of AFB1, Production of Reactive Electrophiles
Source: https://aopwiki.org/
Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF)
Source: https://aopwiki.org/
Increased, Insufficient repair or mis-repair of pro-mutagenic DNA adducts
Source: https://aopwiki.org/
Tumorigenesis, Hepatocellular carcinoma
Source: https://aopwiki.org/
Binding of agonist, Ionotropic glutamate receptors
Source: https://aopwiki.org/
Binding of agonist, Ionotropic glutamate receptors
Source: https://aopwiki.org/
Overactivation, NMDARs
Source: https://aopwiki.org/
Overactivation, NMDARs
Source: https://aopwiki.org/
Overactivation, NMDARs
Source: https://aopwiki.org/
Overactivation, NMDARs
Source: https://aopwiki.org/
Overactivation, NMDARs
Source: https://aopwiki.org/
Increased, Intracellular Calcium overload
Source: https://aopwiki.org/
Increased, Intracellular Calcium overload
Source: https://aopwiki.org/
Increased, Intracellular Calcium overload
Source: https://aopwiki.org/
Increased, Intracellular Calcium overload
Source: https://aopwiki.org/
Decreased, Neuronal network function in adult brain
Source: https://aopwiki.org/
Decreased, Neuronal network function in adult brain
Source: https://aopwiki.org/
Decreased, Neuronal network function in adult brain
Source: https://aopwiki.org/
Increase, Luteinizing hormone (LH)
Source: https://aopwiki.org/
Hyperplasia, Leydig cell
Source: https://aopwiki.org/
Increase proliferation, Leydig cell
Source: https://aopwiki.org/
skewed, sex ratio
Source: https://aopwiki.org/
Increased, Vitellogenin synthesis
Source: https://aopwiki.org/
Increased, renal vitellogenin deposition
Source: https://aopwiki.org/
Increased, glomerular rupture and renal hemorrhaging
Source: https://aopwiki.org/
Increased, nephropathy
Source: https://aopwiki.org/
Inhibition, Na+/I- symporter (NIS)
Source: https://aopwiki.org/
Inhibition, Na+/I- symporter (NIS)
Source: https://aopwiki.org/
Inhibition, Na+/I- symporter (NIS)
Source: https://aopwiki.org/
Inhibition, Na+/I- symporter (NIS)
Source: https://aopwiki.org/
Decrease of Thyroidal iodide
Source: https://aopwiki.org/
Decrease of Thyroidal iodide
Source: https://aopwiki.org/
Decrease of Thyroidal iodide
Source: https://aopwiki.org/
Decrease of Thyroidal iodide
Source: https://aopwiki.org/
Decrease of GABAergic interneurons
Source: https://aopwiki.org/
Suppression, VLDL secretion
Source: https://aopwiki.org/
Inhibition, Mitochondrial fatty acid beta-oxidation
Source: https://aopwiki.org/
Inhibition, Mitochondrial fatty acid beta-oxidation
Source: https://aopwiki.org/
Inhibition, Mitochondrial fatty acid beta-oxidation
Source: https://aopwiki.org/
Decreased, PCK1 expression (control point for glycolysis/gluconeogenesis pathway)
Source: https://aopwiki.org/
Increased, FA Influx
Source: https://aopwiki.org/
Increased, FA Influx
Source: https://aopwiki.org/
Increased, FA Influx
Source: https://aopwiki.org/
Up Regulation, LDLR (low density lipoprotein receptor)
Source: https://aopwiki.org/
Increased, LDL uptake
Source: https://aopwiki.org/
Up Regulation, CYP1A1
Source: https://aopwiki.org/
Up Regulation, CYP1A1
Source: https://aopwiki.org/
Up Regulation, SCD-1
Source: https://aopwiki.org/
Up Regulation, SCD-1
Source: https://aopwiki.org/
Up Regulation, SCD-1
Source: https://aopwiki.org/
Up Regulation, SCD-1
Source: https://aopwiki.org/
Accumulation, Liver lipid
Source: https://aopwiki.org/
Suppression, Constitutive androstane receptor, NR1l3
Source: https://aopwiki.org/
Inhibition, PPAR alpha
Source: https://aopwiki.org/
Activation, SREBF1
Source: https://aopwiki.org/
Activation, SREBF1
Source: https://aopwiki.org/
Increased, De Novo FA synthesis
Source: https://aopwiki.org/
Increased, De Novo FA synthesis
Source: https://aopwiki.org/
Increased, Triglyceride formation
Source: https://aopwiki.org/
Increased, Triglyceride formation
Source: https://aopwiki.org/
Up Regulation, FAS
Source: https://aopwiki.org/
Up Regulation, Acetyl-CoA carboxylase-1 (ACC-1)
Source: https://aopwiki.org/
Suppression, HNF4alpha
Source: https://aopwiki.org/
Inhibition, FoxA2
Source: https://aopwiki.org/
Down Regulation, CPT1A
Source: https://aopwiki.org/
Down Regulation, CPT1A
Source: https://aopwiki.org/
Down Regulation, HMGCS2
Source: https://aopwiki.org/
Decreased, Ketogenesis
Source: https://aopwiki.org/
Activation, NRF2
Source: https://aopwiki.org/
Activation, NR1H4
Source: https://aopwiki.org/
Activation, SHP
Source: https://aopwiki.org/
Decreased, DHB4/HSD17B4
Source: https://aopwiki.org/
Activation, LXR alpha
Source: https://aopwiki.org/
Inhibition, SREBP1c
Source: https://aopwiki.org/
Activation, MTTP
Source: https://aopwiki.org/
Increased, ApoB100
Source: https://aopwiki.org/
Increased, Triglyceride
Source: https://aopwiki.org/
systemic inflammation leading to hepatic steatosis
Source: https://aopwiki.org/
Activation, AKT2
Source: https://aopwiki.org/
Decrease, Ovulation
Source: https://aopwiki.org/
Decrease, Ovulation
Source: https://aopwiki.org/
Decrease, Ovulation
Source: https://aopwiki.org/
Decrease, Ovulation
Source: https://aopwiki.org/
Reduced, Prostaglandins, ovary
Source: https://aopwiki.org/
Reduced, Reproductive Success
Source: https://aopwiki.org/
Reduced, Reproductive Success
Source: https://aopwiki.org/
Reduced, Reproductive Success
Source: https://aopwiki.org/
Reduced, Reproductive Success
Source: https://aopwiki.org/
Reduced, Reproductive Success
Source: https://aopwiki.org/
Glucocorticoid Receptor Agonist, Activation
Source: https://aopwiki.org/
Repressed expression of steroidogenic enzymes
Source: https://aopwiki.org/
Increased apoptosis, decreased fetal/adult Leydig Cells
Source: https://aopwiki.org/
Increased apoptosis, decreased fetal/adult Leydig Cells
Source: https://aopwiki.org/
Decreased sperm quantity or quality in the adult, Decreased fertility
Source: https://aopwiki.org/
Decreased sperm quantity or quality in the adult, Decreased fertility
Source: https://aopwiki.org/
Decreased sperm quantity or quality in the adult, Decreased fertility
Source: https://aopwiki.org/
Decreased sperm quantity or quality in the adult, Decreased fertility
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Increased corticosterone
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells
Source: https://aopwiki.org/
Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells
Source: https://aopwiki.org/
Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells
Source: https://aopwiki.org/
Decreased number and function of adult Leydig cells, Decreased COUP-TFII stem Leydig cells
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells
Source: https://aopwiki.org/
Decreased sperm quantity / quality in the adult, Decreased fertility
Source: https://aopwiki.org/
Decreased sperm quantity / quality in the adult, Decreased fertility
Source: https://aopwiki.org/
Decreased sperm quantity / quality in the adult, Decreased fertility
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Increased estradiol
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists
Source: https://aopwiki.org/
decreased testosterone by fetal Leydig cells, Dysgenesis of fetal Leydig cells
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome
Source: https://aopwiki.org/
Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol
Source: https://aopwiki.org/
Decreased Cholesterol, Decreased Uptake of Lipoproteins
Source: https://aopwiki.org/
Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane
Source: https://aopwiki.org/
Decreased Cholesterol, Decreased Testosterone Production by Adult Leydig Cells
Source: https://aopwiki.org/
Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis
Source: https://aopwiki.org/
Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell
Source: https://aopwiki.org/
Decreased steroidogenesis, Decreased Activity of Steroidogenic Enzymes in Adult Leydig cells
Source: https://aopwiki.org/
Decreased steroidogenesis, Increased Apoptosis of Adult Leydig Cells
Source: https://aopwiki.org/
Decreased steroidogenesis, Alterations in the Leydig Cell Cytoskeleton
Source: https://aopwiki.org/
Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid
Source: https://aopwiki.org/
Apoptosis of adult Leydig cells, Decreased testosterone by adult Leydig cells
Source: https://aopwiki.org/
Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells
Source: https://aopwiki.org/
Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells
Source: https://aopwiki.org/
chronic high fat diet
Source: https://aopwiki.org/
Activation of specific nuclear receptors, PPAR-gamma activation
Source: https://aopwiki.org/
Activation of specific nuclear receptors, PPAR-gamma activation
Source: https://aopwiki.org/
activation of CCAAT/enhancer-binding protein alpha
Source: https://aopwiki.org/
increased adipogenesis
Source: https://aopwiki.org/
decreased dopamine
Source: https://aopwiki.org/
decreased reward
Source: https://aopwiki.org/
decreased DNA methylation of tyrosine hydroxylase
Source: https://aopwiki.org/
decreased methylation of dopamine transporter promoter
Source: https://aopwiki.org/
obesity
Source: https://aopwiki.org/
Inhibition, Inhibition of Dopamine-beta-hydroxylase
Pathways: DBH inhibition
Source: https://aopwiki.org/
Decreased, Synthesis of NE
Pathways: DBH inhibition
Source: https://aopwiki.org/
Decreased, GnRH cfos activity
Pathways: DBH inhibition
Source: https://aopwiki.org/
Decreased, GnRH cfos activity
Source: https://aopwiki.org/
Decreased, GnRH pulsatility/release
Pathways: DBH inhibition
Source: https://aopwiki.org/
Decreased, GnRH pulsatility/release
Source: https://aopwiki.org/
Decreased, LH Surge
Pathways: DBH inhibition
Source: https://aopwiki.org/
Decreased, LH Surge
Source: https://aopwiki.org/
Decreased, LH Surge
Source: https://aopwiki.org/
Delayed, Ovulation
Pathways: DBH inhibition
Source: https://aopwiki.org/
Delayed, Ovulation
Source: https://aopwiki.org/
Decreased, Cortical granule release/distribution upon fertilization
Pathways: DBH inhibition
Source: https://aopwiki.org/
Decreased, Cortical granule release/distribution upon fertilization
Source: https://aopwiki.org/
Altered, Formation of cortical envelope
Pathways: DBH inhibition
Source: https://aopwiki.org/
Altered, Formation of cortical envelope
Source: https://aopwiki.org/
Abnormal, Sperm penetration (polyspermy)
Pathways: DBH inhibition
Source: https://aopwiki.org/
Abnormal, Sperm penetration (polyspermy)
Source: https://aopwiki.org/
Altered, Chromosome number (polyploid) zygote
Pathways: DBH inhibition
Source: https://aopwiki.org/
Altered, Chromosome number (polyploid) zygote
Source: https://aopwiki.org/
Decreased, Decreased fecundity
Pathways: DBH inhibition
Source: https://aopwiki.org/
Decreased, Decreased fecundity
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Dysgensis of fetal Leydig cells
Source: https://aopwiki.org/
Decreased testosterone by the fetal Leydig cells, Decreased COUP-TFII stem Leydig cells
Source: https://aopwiki.org/
Decreased fertility in the adult, Decreased sperm quantity and/or quality in the adult testis
Source: https://aopwiki.org/
Activation, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Activation, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Activation, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Activation, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Activation, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Activation, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Activation, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Activation, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Activation, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Abnormal, Foraging activity and behavior
Source: https://aopwiki.org/
Abnormal, Foraging activity and behavior
Source: https://aopwiki.org/
Abnormal, Foraging activity and behavior
Source: https://aopwiki.org/
Abnormal, Foraging activity and behavior
Source: https://aopwiki.org/
Abnormal, Foraging activity and behavior
Source: https://aopwiki.org/
Abnormal, Foraging activity and behavior
Source: https://aopwiki.org/
Abnormal, Foraging activity and behavior
Source: https://aopwiki.org/
Abnormal, Foraging activity and behavior
Source: https://aopwiki.org/
Abnormal, Foraging activity and behavior
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Weakened, Colony
Source: https://aopwiki.org/
Altered, Ca2+-calmodulin activated signal transduction
Source: https://aopwiki.org/
Altered, Ca2+-calmodulin activated signal transduction
Source: https://aopwiki.org/
Altered, Ca2+-calmodulin activated signal transduction
Source: https://aopwiki.org/
Altered, Ca2+-calmodulin activated signal transduction
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Death/Failure, Colony
Source: https://aopwiki.org/
Abnormal, Roll change within caste
Source: https://aopwiki.org/
Abnormal, Roll change within caste
Source: https://aopwiki.org/
Abnormal, Roll change within caste
Source: https://aopwiki.org/
Abnormal, Roll change within caste
Source: https://aopwiki.org/
Reduced, Brood care
Source: https://aopwiki.org/
Reduced, Brood care
Source: https://aopwiki.org/
Reduced, Brood care
Source: https://aopwiki.org/
impaired, Larval development
Source: https://aopwiki.org/
impaired, Larval development
Source: https://aopwiki.org/
impaired, Larval development
Source: https://aopwiki.org/
impaired, Larval development
Source: https://aopwiki.org/
impaired, Hive thermoregulation
Source: https://aopwiki.org/
impaired, Hive thermoregulation
Source: https://aopwiki.org/
impaired, Hive thermoregulation
Source: https://aopwiki.org/
Accumulation, Damaged mitochondrial DNA
Source: https://aopwiki.org/
Accelerated, Aging
Source: https://aopwiki.org/
Overwhelmed, Mitochondrial DNA repair mechanisms
Source: https://aopwiki.org/
Decrease, Number of worker bees
Source: https://aopwiki.org/
Decrease, Number of worker bees
Source: https://aopwiki.org/
Decrease, Number of worker bees
Source: https://aopwiki.org/
Decrease, Number of worker bees
Source: https://aopwiki.org/
Increase, Energetic demands and therefore metabolic stress
Source: https://aopwiki.org/
Increased, Appetite and hunger
Source: https://aopwiki.org/
Increased, Viral susceptibility
Source: https://aopwiki.org/
Increased, Viral susceptibility
Source: https://aopwiki.org/
impaired, Development
Source: https://aopwiki.org/
Decreased, Glucose oxidase enzyme activity
Source: https://aopwiki.org/
Decreased, Hydrogen peroxide production
Source: https://aopwiki.org/
Reduced, Antiseptic incorporated in food
Source: https://aopwiki.org/
Reduced, Food storage
Source: https://aopwiki.org/
Abnormal, Role change within caste
Source: https://aopwiki.org/
Abnormal, Role change within caste
Source: https://aopwiki.org/
Abnormal, Role change within caste
Source: https://aopwiki.org/
Desensitization, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Desensitization, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Desensitization, Nicotinic acetylcholine receptor
Source: https://aopwiki.org/
Inhibition, sodium channel
Source: https://aopwiki.org/
Inhibition, sodium channel
Source: https://aopwiki.org/
Inhibition, sodium channel
Source: https://aopwiki.org/
Inhibition, sodium channel
Source: https://aopwiki.org/
Decreased, Sodium conductance 1
Source: https://aopwiki.org/
Decreased, Sodium conductance 1
Source: https://aopwiki.org/
Decreased, Sodium conductance 1
Source: https://aopwiki.org/
Decreased, Sodium conductance 1
Source: https://aopwiki.org/
Reduced, swimming speed
Source: https://aopwiki.org/
Reduced, swimming speed
Source: https://aopwiki.org/
Reduced, swimming speed
Source: https://aopwiki.org/
Reduced, feeding 1
Source: https://aopwiki.org/
Reduced, feeding 1
Source: https://aopwiki.org/
Increased, predation
Source: https://aopwiki.org/
Increased, predation
Source: https://aopwiki.org/
Increased, predation
Source: https://aopwiki.org/
Increased, predation
Source: https://aopwiki.org/
Increased, predation
Source: https://aopwiki.org/
Reduced, survival
Source: https://aopwiki.org/
Reduced, survival
Source: https://aopwiki.org/
Increased, Atrioventricular block and bradycardia
Source: https://aopwiki.org/
N/A, hypoxia
Source: https://aopwiki.org/
Increased, amputations
Source: https://aopwiki.org/
Inhibition, Ether-a-go-go (ERG) voltage-gated potassium channel
Source: https://aopwiki.org/
modulation, sodium channel
Source: https://aopwiki.org/
prolonged, Depolarization of neuronal membrane
Source: https://aopwiki.org/
Overactivation, Neuronotransmitter release
Source: https://aopwiki.org/
Overactivation, muscle contraction
Source: https://aopwiki.org/
Increased, Ataxia, paralysis, or hyperactivity
Source: https://aopwiki.org/
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
Source: https://aopwiki.org/
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
Source: https://aopwiki.org/
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
Source: https://aopwiki.org/
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
Source: https://aopwiki.org/
Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT)
Source: https://aopwiki.org/
Increased, muscular waves in foot
Source: https://aopwiki.org/
Increased, water retention in foot
Source: https://aopwiki.org/
Increased, valve movement
Source: https://aopwiki.org/
Increased, valve movement
Source: https://aopwiki.org/
Increased, valve movement
Source: https://aopwiki.org/
Increased, valve movement
Source: https://aopwiki.org/
Depletion, energy reserves
Source: https://aopwiki.org/
Increased, foot detachment
Source: https://aopwiki.org/
Increased, locomotion
Source: https://aopwiki.org/
Increased, serotonin (5-HT)
Source: https://aopwiki.org/
Increased, serotonin (5-HT)
Source: https://aopwiki.org/
Increased, serotonin (5-HT)
Source: https://aopwiki.org/
Increased, serotonin (5-HT)
Source: https://aopwiki.org/
Increased, serotonin (5-HT)
Source: https://aopwiki.org/
Increase, predation
Source: https://aopwiki.org/
Decline, Population
Source: https://aopwiki.org/
Decline, Population
Pathways: OAT1 inhibition
Source: https://aopwiki.org/
Decline, Population
Source: https://aopwiki.org/
Decline, Population
Source: https://aopwiki.org/
Decline, Population
Source: https://aopwiki.org/
Decreased, anxiety
Source: https://aopwiki.org/
Decreased, sheltering
Source: https://aopwiki.org/
Antagonism, Histamine Receptor (H2)
Source: https://aopwiki.org/
Decrease, histaminergic neuron excitation
Source: https://aopwiki.org/
N/A, sedation
Source: https://aopwiki.org/
Decreased, locomotion
Source: https://aopwiki.org/
Decreased, survival
Source: https://aopwiki.org/
Decreased, survival
Source: https://aopwiki.org/
Reduced, Prostaglandin F2alpha concentration, plasma
Source: https://aopwiki.org/
Reduced, Prostaglandin F2alpha concentration, plasma
Source: https://aopwiki.org/
Reduced, Prostaglandin F2alpha synthesis, ovary
Source: https://aopwiki.org/
Reduced, Spawning behavior
Source: https://aopwiki.org/
Reduced, Ability to attract spawning mates
Source: https://aopwiki.org/
Reduced, Ability to attract spawning mates
Source: https://aopwiki.org/
Reduced, Pheromone release
Source: https://aopwiki.org/
Decreased, Prostaglandin F2alpha synthesis, ovary
Source: https://aopwiki.org/
Reduced, Prostaglandin E2 concentration, hypothalamus
Source: https://aopwiki.org/
Reduced, Prostaglandin E2 concentration, hypothalamus
Source: https://aopwiki.org/
Reduced, Gonadotropin releasing hormone, hypothalamus
Source: https://aopwiki.org/
Reduced, Gonadotropin releasing hormone, hypothalamus
Source: https://aopwiki.org/
Reduced, Luteinizing hormone (LH), plasma
Source: https://aopwiki.org/
Reduced, Luteinizing hormone (LH), plasma
Source: https://aopwiki.org/
Reduced, Maturation inducing steroid, plasma
Source: https://aopwiki.org/
Reduced, Maturation inducing steroid, plasma
Source: https://aopwiki.org/
Reduced, Maturation inducing steroid receptor signalling, oocyte
Source: https://aopwiki.org/
Reduced, Maturation inducing steroid receptor signalling, oocyte
Source: https://aopwiki.org/
Reduced, Meiotic prophase I/metaphase I transition, oocyte
Source: https://aopwiki.org/
Increased, cyclic adenosine monophosphate
Source: https://aopwiki.org/
Upregulated, Spindle assembly checkpoint protein Mad2-oocyte
Source: https://aopwiki.org/
Increased, Chromosome misseggregation
Source: https://aopwiki.org/
impaired, ion channels
Source: https://aopwiki.org/
Altered, Action Potential
Source: https://aopwiki.org/
Altered, Action Potential
Source: https://aopwiki.org/
Increased, cardiac arrthymia
Source: https://aopwiki.org/
Increased, Binding of chemicals to 2u (serum)
Source: https://aopwiki.org/
Increased, Accumulation of alpha2u microglobulin (proximal tubular epithelium)
Source: https://aopwiki.org/
Increase, Cytotoxicity (renal tubular cell)
Source: https://aopwiki.org/
Increase, Cytotoxicity (renal tubular cell)
Source: https://aopwiki.org/
Increase, Cytotoxicity (renal tubular cell)
Source: https://aopwiki.org/
Increase, Cytotoxicity (renal tubular cell)
Source: https://aopwiki.org/
Increase, Cytotoxicity (renal tubular cell)
Source: https://aopwiki.org/
Increase, Regenerative cell proliferation (tubular epithelial cells)
Source: https://aopwiki.org/
Increase, Regenerative cell proliferation (tubular epithelial cells)
Source: https://aopwiki.org/
Increase, Hyperplasia (renal tubular cells)
Source: https://aopwiki.org/
Increase, Adenomas/carcinomas (renal tubular)
Source: https://aopwiki.org/
Increase, Adenomas/carcinomas (renal tubular)
Source: https://aopwiki.org/
Binding, Tubulin
Source: https://aopwiki.org/
Disruption, Microtubule dynamics
Source: https://aopwiki.org/
Disorganization, Meiotic Spindle
Source: https://aopwiki.org/
Altered, Meiotic chromosome dynamics
Source: https://aopwiki.org/
Altered, Meiotic chromosome dynamics
Source: https://aopwiki.org/
Altered, Meiotic chromosome dynamics
Source: https://aopwiki.org/
Altered, Chromosome number
Source: https://aopwiki.org/
Increase, Aneuploid offspring
Source: https://aopwiki.org/
Activation, Constitutive androstane receptor
Source: https://aopwiki.org/
Altered gene expression specific to CAR activation, Hepatocytes
Source: https://aopwiki.org/
Increase, Preneoplastic foci (hepatocytes)
Source: https://aopwiki.org/
Increase, Preneoplastic foci (hepatocytes)
Pathways: AR- HCC
Source: https://aopwiki.org/
Increase, Preneoplastic foci (hepatocytes)
Source: https://aopwiki.org/
Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme
Source: https://aopwiki.org/
Increase, Cytotoxicity
Source: https://aopwiki.org/
Increase, Cytotoxicity
Source: https://aopwiki.org/
Increase, Cytotoxicity
Source: https://aopwiki.org/
Increased, Induction of pyruvate dehydrogenase (PDH)
Source: https://aopwiki.org/
Increase, Oxidative metabolism
Source: https://aopwiki.org/
Increase, Cytotoxicity (club cells)
Source: https://aopwiki.org/
Increase, Necrosis (terminal bronchiolar cells)
Source: https://aopwiki.org/
Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells)
Source: https://aopwiki.org/
Increase, Hyperplasia (terminal bronchiolar cells)
Source: https://aopwiki.org/
Increase, Adenomas/carcinomas (bronchioloalveolar)
Source: https://aopwiki.org/
Decreased, Uptake of inorganic iodide
Source: https://aopwiki.org/
Increase, Hypertrophy and proliferation (follicular cell)
Source: https://aopwiki.org/
Increase, Hypertrophy and proliferation (follicular cell)
Source: https://aopwiki.org/
Increase, Hypertrophy and proliferation (follicular cell)
Source: https://aopwiki.org/
Increase, Hyperplasia (follicular cells)
Source: https://aopwiki.org/
Increase, Hyperplasia (follicular cells)
Source: https://aopwiki.org/
Increase, Hyperplasia (follicular cells)
Source: https://aopwiki.org/
Increase, Thyroid-stimulating hormone (TSH)
Source: https://aopwiki.org/
Increase, Thyroid-stimulating hormone (TSH)
Source: https://aopwiki.org/
Decrease, Serum thyroid hormone (T4/T3)
Source: https://aopwiki.org/
Decrease, Serum thyroid hormone (T4/T3)
Source: https://aopwiki.org/
Decrease, Serum thyroid hormone (T4/T3)
Source: https://aopwiki.org/
Increase, Adenomas/carcinomas (follicular cell)
Source: https://aopwiki.org/
Increase, Adenomas/carcinomas (follicular cell)
Source: https://aopwiki.org/
Increase, Adenomas/carcinomas (follicular cell)
Source: https://aopwiki.org/
Decreased, Androgen receptor activity
Source: https://aopwiki.org/
Decreased, Testosterone binding to androgen receptor (hypothalamus)
Source: https://aopwiki.org/
Increase, Hyperplasia (Leydig cells)
Source: https://aopwiki.org/
Increase, Hyperplasia (Leydig cells)
Source: https://aopwiki.org/
Increased, Luteinizing hormone (LH)
Source: https://aopwiki.org/
Increase, Leydig cell tumors
Source: https://aopwiki.org/
Increase, Leydig cell tumors
Source: https://aopwiki.org/
Increase, Dopaminergic activity
Source: https://aopwiki.org/
Decreased, Prolactin
Source: https://aopwiki.org/
Increased, Estrogen receptor (ER) activity
Source: https://aopwiki.org/
Increased, Estrogen receptor (ER) activity
Source: https://aopwiki.org/
Decreased, Progesterone from corpus luteum
Source: https://aopwiki.org/
Increase, Hyperplasia (glandular epithelial cells of endometrium)
Source: https://aopwiki.org/
Increase, Hyperplasia (glandular epithelial cells of endometrium)
Source: https://aopwiki.org/
Increase, Endometrial adenocarcinomas
Source: https://aopwiki.org/
Activation, Glutamate-gated chloride channel
Source: https://aopwiki.org/
Increased, Chloride conductance
Source: https://aopwiki.org/
Increased, Chloride conductance
Source: https://aopwiki.org/
Increased, Chloride conductance
Source: https://aopwiki.org/
hyperpolarisation, neuron
Source: https://aopwiki.org/
hyperpolarisation, neuron
Source: https://aopwiki.org/
hyperpolarisation, neuron
Source: https://aopwiki.org/
N/A, Ataxia, paralysis, or hyperactivity
Source: https://aopwiki.org/
Decreased, population 1
Source: https://aopwiki.org/
Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme
Source: https://aopwiki.org/
Increased, Plasma tyrosine
Source: https://aopwiki.org/
Increase, Cytotoxicity (corneal cells)
Source: https://aopwiki.org/
Increase, Inflammation (corneal cells)
Source: https://aopwiki.org/
Increase, Regenerative cell proliferation (corneal cells)
Source: https://aopwiki.org/
Increase, Papillomas/carcinomas (squamous cells)
Source: https://aopwiki.org/
Increase, Papillomas/carcinomas (squamous cells)
Source: https://aopwiki.org/
Increase, Cytotoxicity (epithelial cells)
Source: https://aopwiki.org/
Increase, Cytotoxicity (epithelial cells)
Source: https://aopwiki.org/
Increase, Regenerative cell proliferation (forestomach epithelial cells)
Source: https://aopwiki.org/
Increase, Hyperplasia (forestomach epithelial cells)
Source: https://aopwiki.org/
Increase, Cytotoxicity (tubular epithelial cells)
Source: https://aopwiki.org/
Increase, Hyperplasia (tubular epithelial cells)
Source: https://aopwiki.org/
Activation, Androgen receptor
Pathways: AR- HCC
Source: https://aopwiki.org/
Activation, Androgen receptor
Source: https://aopwiki.org/
Increase, Cytotoxicity (hepatocytes)
Source: https://aopwiki.org/
Increase, Regenerative cell proliferation (hepatocytes)
Source: https://aopwiki.org/
Decrease, Incorporation of active iodide into iodotyrosines
Source: https://aopwiki.org/
Inhibition, 5α-reductase activity
Source: https://aopwiki.org/
Increased, Leutinizing hormone (LH)
Source: https://aopwiki.org/
Decrease, Bioactivation of testosterone
Source: https://aopwiki.org/
Increase, Urinary bladder calculi
Source: https://aopwiki.org/
Increase, Cytotoxicity (urothelial cells)
Source: https://aopwiki.org/
Increase, Regenerative cell proliferation (urothelial cells)
Source: https://aopwiki.org/
Increase, Regenerative cell proliferation (urothelial cells)
Source: https://aopwiki.org/
Increase, Hyperplasia (urothelial)
Source: https://aopwiki.org/
Increase, Hyperplasia (urothelial)
Source: https://aopwiki.org/
Increase, Adenomas/carcinomas (urothelial)
Source: https://aopwiki.org/
Inhibition, Prolyl hydroxylases
Source: https://aopwiki.org/
Increased, HIF-1 heterodimer
Source: https://aopwiki.org/
Increased, HIF-1 heterodimer
Source: https://aopwiki.org/
Decreased, Aromatase (Cyp19a1) mRNA
Source: https://aopwiki.org/
Decreased, Aromatase (Cyp19a1) mRNA
Source: https://aopwiki.org/
modulation, Unknown
Source: https://aopwiki.org/
Increased, HIF-1 alpha transcription
Source: https://aopwiki.org/
Inhibition, HMG-CoA reductase
Source: https://aopwiki.org/
Decreased, mevalonate
Source: https://aopwiki.org/
Decreased, cholesterol
Source: https://aopwiki.org/
Decreased, cholesterol
Source: https://aopwiki.org/
Decreased, Testosterone
Source: https://aopwiki.org/
malformed, Male reproductive tract
Source: https://aopwiki.org/
Decrease, Fertility
Source: https://aopwiki.org/
Decrease, Fertility
Source: https://aopwiki.org/
Inhibition, Antgonism of NE receptor
Source: https://aopwiki.org/
Decreased, Binding of NE to NE receptors on GnRH neurons
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in serum
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in serum
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in serum
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in serum
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in serum
Source: https://aopwiki.org/
Decreased, Glomerular filtration
Source: https://aopwiki.org/
Decreased, Renal plasma flow
Source: https://aopwiki.org/
Decreased, Sodium reabsorption
Source: https://aopwiki.org/
Increased, Serum creatinine
Source: https://aopwiki.org/
Occurrence, Cystic dilatation (renal tubule)
Source: https://aopwiki.org/
Occurrence, Cytoplasmic vacuolization (podocyte)
Source: https://aopwiki.org/
Occurrence, Cytoplasmic vacuolization (Renal tubule)
Source: https://aopwiki.org/
Decreased, Renal ability to dilute urine
Source: https://aopwiki.org/
Occurrence, Kidney toxicity
Source: https://aopwiki.org/
Occurrence, Kidney toxicity
Source: https://aopwiki.org/
Occurrence, Kidney toxicity
Source: https://aopwiki.org/
Occurrence, Kidney toxicity
Source: https://aopwiki.org/
Occurrence, Kidney toxicity
Source: https://aopwiki.org/
Occurrence, Kidney toxicity
Source: https://aopwiki.org/
Occurrence, Kidney toxicity
Source: https://aopwiki.org/
Inhibition, Phospholipase A
Source: https://aopwiki.org/
Damage, Lipid bilayer
Source: https://aopwiki.org/
Disturbance, Lysosomal function
Source: https://aopwiki.org/
Disturbance, Lysosomal function
Source: https://aopwiki.org/
Injury, Mitochondria
Source: https://aopwiki.org/
Occurrence, Cytoplasmic vacuolization (hepatocyte)
Source: https://aopwiki.org/
Occurrence, Ballooning degeneration (hepatocyte)
Source: https://aopwiki.org/
Occurrence, Cytoplasmic vacuolization (kupffer cell)
Source: https://aopwiki.org/
Induction, Microvesicular fat
Source: https://aopwiki.org/
Formation, Mallory body
Source: https://aopwiki.org/
Occurrence, Cytoplasmic vacuolization (Bile duct cell)
Source: https://aopwiki.org/
Formation, Liver fibrosis
Source: https://aopwiki.org/
Induction, CYP1A2/CYP1A5
Source: https://aopwiki.org/
Induction, CYP1A2/CYP1A5
Source: https://aopwiki.org/
Oxidation, Uroporphyrinogen
Source: https://aopwiki.org/
Inhibition, UROD
Source: https://aopwiki.org/
Accumulation, Highly carboxylated porphyrins
Source: https://aopwiki.org/
Uroporphyria
Source: https://aopwiki.org/
Decrease, Intracellular pH
Source: https://aopwiki.org/
Increase, Tissue Degeneration, Necrosis & Atrophy
Source: https://aopwiki.org/
Increase, Cell Proliferation
Source: https://aopwiki.org/
Increase, Cell Proliferation
Source: https://aopwiki.org/
Increase, Cell Proliferation
Source: https://aopwiki.org/
Increase, Cell Proliferation
Source: https://aopwiki.org/
Increase, Cell Proliferation
Source: https://aopwiki.org/
Increase, Cell Proliferation
Source: https://aopwiki.org/
Increase, Cell Proliferation
Source: https://aopwiki.org/
Increase, Cell Proliferation
Source: https://aopwiki.org/
Increase, Respiratory or Squamous Metaplasia
Source: https://aopwiki.org/
Increase, Mutations in Critical Genes
Source: https://aopwiki.org/
Increase, Mutations in Critical Genes
Source: https://aopwiki.org/
Increase, Site of Contact Nasal Tumors
Source: https://aopwiki.org/
Increase, Site of Contact Nasal Tumors
Source: https://aopwiki.org/
Inhibition, organic anion transporter 1 (OAT1)
Pathways: OAT1 inhibition
Source: https://aopwiki.org/
Increased, blood uric acid concentration
Pathways: OAT1 inhibition
Source: https://aopwiki.org/
Increased, blood uric acid concentration
Source: https://aopwiki.org/
Occurrence, renal proximal tubular necrosis
Pathways: OAT1 inhibition
Source: https://aopwiki.org/
Occurrence, renal proximal tubular necrosis
Source: https://aopwiki.org/
Occurrence, renal proximal tubular necrosis
Source: https://aopwiki.org/
Occurrence, renal proximal tubular necrosis
Source: https://aopwiki.org/
Increased, blood potassium concentration
Pathways: OAT1 inhibition
Source: https://aopwiki.org/
Increased, blood potassium concentration
Source: https://aopwiki.org/
Increased, blood potassium concentration
Source: https://aopwiki.org/
Occurrence, tophi (urate) deposition
Pathways: OAT1 inhibition
Source: https://aopwiki.org/
Occurrence, tophi (urate) deposition
Source: https://aopwiki.org/
Occurrence, cardiac arrhythmia
Pathways: OAT1 inhibition
Source: https://aopwiki.org/
Occurrence, cardiac arrhythmia
Source: https://aopwiki.org/
Occurrence, cardiac arrhythmia
Source: https://aopwiki.org/
Occurrence, cardiac arrhythmia
Source: https://aopwiki.org/
Increased, Oxidative Stress
Pathways: OAT1 inhibition
Source: https://aopwiki.org/
Increased, Oxidative Stress
Source: https://aopwiki.org/
Increased, Oxidative Stress
Source: https://aopwiki.org/
Increased, Oxidative Stress
Source: https://aopwiki.org/
Increased, Oxidative Stress
Source: https://aopwiki.org/
Increased, Oxidative Stress
Source: https://aopwiki.org/
Increased, Oxidative Stress
Source: https://aopwiki.org/
Increased, Oxidative Stress
Source: https://aopwiki.org/
Increased, Oxidative Stress
Source: https://aopwiki.org/
Increased, Oxidative Stress
Source: https://aopwiki.org/
Increased, Oxidative Stress
Source: https://aopwiki.org/
Increased, Oxidative Stress
Source: https://aopwiki.org/
Increased, Oxidative Stress
Source: https://aopwiki.org/
Increase, Cancer
Source: https://aopwiki.org/
Increase, Cancer
Source: https://aopwiki.org/
Increase, Cancer
Source: https://aopwiki.org/
Endocytotic lysosomal uptake
Source: https://aopwiki.org/
Disruption, Lysosome
Source: https://aopwiki.org/
Disruption, Lysosome
Source: https://aopwiki.org/
Leukocyte recruitment/activation
Source: https://aopwiki.org/
Leukocyte recruitment/activation
Source: https://aopwiki.org/
Leukocyte recruitment/activation
Source: https://aopwiki.org/
Leukocyte recruitment/activation
Source: https://aopwiki.org/
Activation, EGFR
Source: https://aopwiki.org/
Occurrence, Transdifferentiation of ciliated epithelial cells
Source: https://aopwiki.org/
Occurrence, Metaplasia of goblet cells
Source: https://aopwiki.org/
Occurrence, Hyperplasia of goblet cells
Source: https://aopwiki.org/
Increase, Proliferation of goblet cells
Source: https://aopwiki.org/
Activation, Sp1
Source: https://aopwiki.org/
Decrease, Apoptosis of ciliated epithelial cells
Source: https://aopwiki.org/
Increase, Mucin production
Source: https://aopwiki.org/
Chronic, Mucus hypersecretion
Source: https://aopwiki.org/
Decrease, Lung function
Source: https://aopwiki.org/
Decrease, Lung function
Source: https://aopwiki.org/
Decrease, Lung function
Source: https://aopwiki.org/
Decrease, Lung function
Source: https://aopwiki.org/
Decrease, Lung function
Source: https://aopwiki.org/
Decrease, Lung function
Source: https://aopwiki.org/
Decrease, Lung function
Source: https://aopwiki.org/
KE1 : S-Glutathionylation, eNOS
Pathways: Hypertension
Source: https://aopwiki.org/
KE2 : Decrease, GTPCH-1
Pathways: Hypertension
Source: https://aopwiki.org/
KE3 : Decrease, Tetrahydrobiopterin
Pathways: Hypertension
Source: https://aopwiki.org/
KE4 : Uncoupling, eNOS
Pathways: Hypertension
Source: https://aopwiki.org/
KE4 : Uncoupling, eNOS
Source: https://aopwiki.org/
KE6 : Depletion, Nitric Oxide
Pathways: Hypertension
Source: https://aopwiki.org/
KE7 : Impaired, Vasodilation
Pathways: Hypertension
Source: https://aopwiki.org/
KE8 : Increase, Vascular Resistance
Pathways: Hypertension
Source: https://aopwiki.org/
KE5 : Decrease, AKT/eNOS activity
Pathways: Hypertension
Source: https://aopwiki.org/
Hypertension
Pathways: Hypertension
Source: https://aopwiki.org/
Hypertension
Source: https://aopwiki.org/
reduced dimerization, ARNT/HIF1-alpha
Source: https://aopwiki.org/
reduced dimerization, ARNT/HIF1-alpha
Source: https://aopwiki.org/
reduced production, VEGF
Source: https://aopwiki.org/
reduced production, VEGF
Source: https://aopwiki.org/
Binding, Transthyretin in serum
Source: https://aopwiki.org/
Binding, Transthyretin in serum
Source: https://aopwiki.org/
Displacement, Serum thyroxine (T4) from transthyretin
Source: https://aopwiki.org/
Increased, Free serum thyroxine (T4)
Source: https://aopwiki.org/
Increased, Free serum thyroxine (T4)
Source: https://aopwiki.org/
Increased, Free serum thyroxine (T4)
Source: https://aopwiki.org/
Increased, Uptake of thyroxine into tissue
Source: https://aopwiki.org/
Increased, Clearance of thyroxine from serum
Source: https://aopwiki.org/
Increased, Clearance of thyroxine from serum
Source: https://aopwiki.org/
Increased, Clearance of thyroxine from serum
Source: https://aopwiki.org/
Increased, Clearance of thyroxine from serum
Source: https://aopwiki.org/
Increased, Clearance of thyroxine from serum
Source: https://aopwiki.org/
Increased, Clearance of thyroxine from serum
Source: https://aopwiki.org/
Increased, Clearance of thyroxine from serum
Source: https://aopwiki.org/
Inhibition of Aromatase Enzyme, Chemical exposure during critical window of estrous cycle between diestrus 2 and proestrus inhibits aromatase conversion of testosterone to estradiol
Source: https://aopwiki.org/
reduction in ovarian granulosa cells synthesis of estradiol, Reduced steroidogenic production of estradiol in granulosa cells
Source: https://aopwiki.org/
Reduced Estradiol in Circulation, Reduced steroidogenic production of estradiol in granulosa cells leading to decreased estradiol in circulation
Source: https://aopwiki.org/
Decreased positive estrogenic feedback on hypothalamus, Reduced estradiol in circulation decreases estrogen concentration at hypothalamus
Source: https://aopwiki.org/
Decreased Kisspeptin release from neurons in AVPV, Decreased hypothalamic estrogen reduces kisspeptinergic neuron response
Source: https://aopwiki.org/
Decreased GnRH Release, Decreased Kisspeptin stimulation of GnRH neurons
Source: https://aopwiki.org/
Decreased LH release from Anterior Pituitary, Decreased GnRH stimulation of Anterior Pituitary Gonadotrophs
Source: https://aopwiki.org/
Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation
Source: https://aopwiki.org/
Ovulation of oocytes Reduced, Delayed, or Blocked, Decrease or delay in LH surge required for ovulation
Source: https://aopwiki.org/
Decreased fertility, Reduced number of oocytes ovulated
Source: https://aopwiki.org/
Decreased fertility, Reduced number of oocytes ovulated
Source: https://aopwiki.org/
Decreased fertility, Reduced number of oocytes ovulated
Source: https://aopwiki.org/
Inhibition, Calcineurin Activity
Source: https://aopwiki.org/
Interference, nuclear localization of NFAT
Source: https://aopwiki.org/
Reduction, NFAT/AP-1 complex formation
Source: https://aopwiki.org/
Suppression, IL-2 and IL-4 production
Source: https://aopwiki.org/
Impairment, T-cell dependent antibody response
Source: https://aopwiki.org/
Impairment, T-cell dependent antibody response
Source: https://aopwiki.org/
Inhibition, Deiodinase 2
Source: https://aopwiki.org/
Inhibition, Deiodinase 2
Source: https://aopwiki.org/
Inhibition, Deiodinase 2
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3)
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3)
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3)
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3)
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3)
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3)
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3)
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3)
Pathways: TPOi eye size
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3)
Source: https://aopwiki.org/
Reduced, Posterior swim bladder inflation
Source: https://aopwiki.org/
Reduced, Posterior swim bladder inflation
Source: https://aopwiki.org/
Reduced, Swimming performance
Source: https://aopwiki.org/
Reduced, Swimming performance
Source: https://aopwiki.org/
Reduced, Swimming performance
Source: https://aopwiki.org/
Reduced, Swimming performance
Source: https://aopwiki.org/
Reduced, Swimming performance
Source: https://aopwiki.org/
Reduced, Swimming performance
Source: https://aopwiki.org/
Reduced, Swimming performance
Source: https://aopwiki.org/
Reduced, Young of year survival
Source: https://aopwiki.org/
Reduced, Young of year survival
Source: https://aopwiki.org/
Reduced, Young of year survival
Source: https://aopwiki.org/
Reduced, Young of year survival
Source: https://aopwiki.org/
Reduced, Young of year survival
Source: https://aopwiki.org/
Reduced, Anterior swim bladder inflation
Source: https://aopwiki.org/
Reduced, Anterior swim bladder inflation
Source: https://aopwiki.org/
Reduced, Anterior swim bladder inflation
Source: https://aopwiki.org/
Reduced, Anterior swim bladder inflation
Source: https://aopwiki.org/
Reduced, Anterior swim bladder inflation
Source: https://aopwiki.org/
Inhibition, Deiodinase 1
Source: https://aopwiki.org/
Inhibition, Deiodinase 1
Source: https://aopwiki.org/
Inhibition, Deiodinase 1
Source: https://aopwiki.org/
Activation, ionotropic GABA Receptor chloride channel
Source: https://aopwiki.org/
Increased, Inhibitory postsynaptic potential
Source: https://aopwiki.org/
Increased, Inhibitory postsynaptic potential
Source: https://aopwiki.org/
Increased, Inhibitory postsynaptic potential
Source: https://aopwiki.org/
Induction, Somatic muscle paralysis
Source: https://aopwiki.org/
Induction, Somatic muscle paralysis
Source: https://aopwiki.org/
Increased, Neuronal synaptic inhibition
Source: https://aopwiki.org/
Increased, Neuronal synaptic inhibition
Source: https://aopwiki.org/
Increased, Neuronal synaptic inhibition
Source: https://aopwiki.org/
Inhibition, Feeding
Source: https://aopwiki.org/
Inhibition, Feeding
Source: https://aopwiki.org/
Inhibition, Feeding
Source: https://aopwiki.org/
Activation, Glutamate-gated chloride channels
Source: https://aopwiki.org/
Activation, Glutamate-gated chloride channels
Source: https://aopwiki.org/
Induction, pharyngeal muscle paralysis
Source: https://aopwiki.org/
Increased, induction of UDPGT's in liver
Source: https://aopwiki.org/
Increased, T4/T3 catabolism
Source: https://aopwiki.org/
Decreased, serum T4/T3
Source: https://aopwiki.org/
Increased, Thyroid-stimulating hormone (TSH)
Source: https://aopwiki.org/
Increased, Thyroid-stimulating hormone (TSH)
Source: https://aopwiki.org/
Increased, Thyroid-stimulating hormone (TSH)
Source: https://aopwiki.org/
Increased, Thyroid-stimulating hormone (TSH)
Source: https://aopwiki.org/
Increased, Hypertrophy and proliferation (follicular cell)
Source: https://aopwiki.org/
Increased, Hyperplasia (follicular cells)
Source: https://aopwiki.org/
Increased Apoptosis, Adenomas/carcinomas (follicular cell)
Source: https://aopwiki.org/
Increased, adipogenesis
Source: https://aopwiki.org/
Increased, secretion of local growth factors
Source: https://aopwiki.org/
Increased, secretion of local growth factors
Source: https://aopwiki.org/
Increased, proliferation of mesenchymal cells
Source: https://aopwiki.org/
Increased, IGF-1 (mouse)
Source: https://aopwiki.org/
Increased, Firbrosarcoma
Source: https://aopwiki.org/
Increased, liposarcoma
Source: https://aopwiki.org/
Increased, hemagiosarcoma
Source: https://aopwiki.org/
Activation, beta-2 adrenergic receptor
Source: https://aopwiki.org/
Increased activity, beta-2 adrenergic receptor
Source: https://aopwiki.org/
relaxation, smooth muscle
Source: https://aopwiki.org/
Proliferation/Clonal Expansion, smooth muscle
Source: https://aopwiki.org/
Hypertrophy/hyperplasia, smooth muscle
Source: https://aopwiki.org/
Promotion, mesovarian leiomyomas
Source: https://aopwiki.org/
Decreased, Ovarian E2
Source: https://aopwiki.org/
Suppression, Estrogen receptor (ER) activity
Source: https://aopwiki.org/
Suppression, Estrogen receptor (ER) activity
Source: https://aopwiki.org/
Increased, secretion of GnRH from hypothalamus
Source: https://aopwiki.org/
Increased, secretion of GnRH from hypothalamus
Source: https://aopwiki.org/
Increased, secrection of FSH from anterior pituitary
Source: https://aopwiki.org/
Increased, secretion of LH from anterior pituitary
Source: https://aopwiki.org/
Increased, secretion of LH from anterior pituitary
Source: https://aopwiki.org/
Hyperplasia, ovarian stromal cells
Source: https://aopwiki.org/
Hyperplasia, ovarian stromal cells
Source: https://aopwiki.org/
Hyperplasia, ovarian epithelium
Source: https://aopwiki.org/
Hyperplasia, ovarian epithelium
Source: https://aopwiki.org/
Decrease, E2 blood concentrations at hypothalamus
Source: https://aopwiki.org/
Promotion, ovarian adenomas
Source: https://aopwiki.org/
Promotion, ovarian adenomas
Source: https://aopwiki.org/
Promotion, ovarian granular cell tumors
Source: https://aopwiki.org/
Promotion, ovarian granular cell tumors
Source: https://aopwiki.org/
Increased, PPAR-alpha activation
Source: https://aopwiki.org/
Decreased, bile flow
Source: https://aopwiki.org/
Increased, cholestasis
Source: https://aopwiki.org/
Alteration, lipid metabolism
Source: https://aopwiki.org/
Alteration, lipid metabolism
Source: https://aopwiki.org/
prolonged, elevation of serun CCK
Source: https://aopwiki.org/
Increased, Cellular proliferation / hyperplasia of acinar cells
Source: https://aopwiki.org/
Increased, Pancreatic acinar tumors
Source: https://aopwiki.org/
prepubertal increase, Estrogen receptor (ER) activity
Source: https://aopwiki.org/
Activation, estrogen receptor alpha
Source: https://aopwiki.org/
Activation, estrogen receptor alpha
Source: https://aopwiki.org/
Activation, estrogen receptor alpha
Source: https://aopwiki.org/
Activation, estrogen receptor alpha
Source: https://aopwiki.org/
Promotion, SIX-1 postive basal-type progenitor cells
Source: https://aopwiki.org/
Proliferation/Clonal Expansion, aberrant basal cells
Source: https://aopwiki.org/
squamous metaplasia, aberrant basal cells
Source: https://aopwiki.org/
Increased, Hyperplasia (glandular epithelial cells of endometrium)
Source: https://aopwiki.org/
Increased, adenosquamous carcinomas of endometrium
Source: https://aopwiki.org/
Decreased, GnRH pulsatility/release in hypothalamus
Source: https://aopwiki.org/
Decreased, GnRH pulsatility/release in hypothalamus
Source: https://aopwiki.org/
Decreased, LH Surge from anterior pituitary
Source: https://aopwiki.org/
Decreased, LH Surge from anterior pituitary
Source: https://aopwiki.org/
interruption, Ovulation
Source: https://aopwiki.org/
interruption, Ovulation
Source: https://aopwiki.org/
prolonged, estrus
Source: https://aopwiki.org/
prolonged, estrus
Source: https://aopwiki.org/
Increased, circulating estrogen levels
Source: https://aopwiki.org/
Increased, circulating estrogen levels
Source: https://aopwiki.org/
Increased, circulating estrogen levels
Source: https://aopwiki.org/
Increased, prolactin exposure
Source: https://aopwiki.org/
Hyperplasia, Mammary gland
Source: https://aopwiki.org/
Increased, latency period
Source: https://aopwiki.org/
Increased, latency period
Source: https://aopwiki.org/
Increased, Adenomas/carcinomas (mammary)
Source: https://aopwiki.org/
Increased, Adenomas/carcinomas (mammary)
Source: https://aopwiki.org/
Increased, lactotroph hyperplasia and hypertrophy
Source: https://aopwiki.org/
Increased, adenomas (pituitary)
Source: https://aopwiki.org/
Decreased, Dopaminergic activity
Source: https://aopwiki.org/
Increased, prolactin secretion
Source: https://aopwiki.org/
Increased, hyperplasia (mammary gland)
Source: https://aopwiki.org/
persistent, cytotoxicity (pleura or peritoneum)
Source: https://aopwiki.org/
Increased, inflammation
Source: https://aopwiki.org/
Increased, Cell Proliferation (mesothelium)
Source: https://aopwiki.org/
Increased, mesotheliomas
Source: https://aopwiki.org/
Increased, mesotheliomas
Source: https://aopwiki.org/
Substance interaction with the lung resident cell membrane components
Source: https://aopwiki.org/
Substance interaction with the lung resident cell membrane components
Source: https://aopwiki.org/
Substance interaction with the lung resident cell membrane components
Source: https://aopwiki.org/
Increased, secretion of proinflammatory mediators
Source: https://aopwiki.org/
Increased, secretion of proinflammatory mediators
Source: https://aopwiki.org/
Increased, secretion of proinflammatory mediators
Source: https://aopwiki.org/
Increased, secretion of proinflammatory mediators
Source: https://aopwiki.org/
Increased, secretion of proinflammatory mediators
Source: https://aopwiki.org/
Increased, secretion of proinflammatory mediators
Source: https://aopwiki.org/
Increased, secretion of proinflammatory mediators
Source: https://aopwiki.org/
Increased, secretion of proinflammatory mediators
Source: https://aopwiki.org/
Increased, secretion of proinflammatory mediators
Source: https://aopwiki.org/
Increased, secretion of proinflammatory mediators
Source: https://aopwiki.org/
Increased, secretion of proinflammatory mediators
Source: https://aopwiki.org/
Increased, secretion of proinflammatory mediators
Source: https://aopwiki.org/
Increased, recruitment of inflammatory cells
Source: https://aopwiki.org/
Increased, recruitment of inflammatory cells
Source: https://aopwiki.org/
Increased, recruitment of inflammatory cells
Source: https://aopwiki.org/
Increased, recruitment of inflammatory cells
Source: https://aopwiki.org/
Increased, recruitment of inflammatory cells
Source: https://aopwiki.org/
Increased, recruitment of inflammatory cells
Source: https://aopwiki.org/
Increased, recruitment of inflammatory cells
Source: https://aopwiki.org/
Increased, recruitment of inflammatory cells
Source: https://aopwiki.org/
Increased, recruitment of inflammatory cells
Source: https://aopwiki.org/
Increased, recruitment of inflammatory cells
Source: https://aopwiki.org/
Loss of alveolar capillary membrane integrity
Source: https://aopwiki.org/
Loss of alveolar capillary membrane integrity
Source: https://aopwiki.org/
Increased, activation of T (T) helper (h) type 2 cells
Source: https://aopwiki.org/
Increased, fibroblast proliferation and myofibroblast differentiation
Source: https://aopwiki.org/
Increased, extracellular matrix deposition
Source: https://aopwiki.org/
Increased, extracellular matrix deposition
Source: https://aopwiki.org/
Increased, extracellular matrix deposition
Source: https://aopwiki.org/
Increased, extracellular matrix deposition
Source: https://aopwiki.org/
Increased, extracellular matrix deposition
Source: https://aopwiki.org/
Pulmonary fibrosis
Source: https://aopwiki.org/
Pulmonary fibrosis
Source: https://aopwiki.org/
Pulmonary fibrosis
Source: https://aopwiki.org/
Pulmonary fibrosis
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in tissues
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in tissues
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in tissues
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in tissues
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in tissues
Source: https://aopwiki.org/
Decreased, Thyroxine (T4) in tissues
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in tissues
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in tissues
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in tissues
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in tissues
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in tissues
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in tissues
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in tissues
Source: https://aopwiki.org/
Decreased, Triiodothyronine (T3) in tissues
Source: https://aopwiki.org/
Altered, Amphibian metamorphosis
Source: https://aopwiki.org/
Altered, Amphibian metamorphosis
Source: https://aopwiki.org/
Altered, Amphibian metamorphosis
Source: https://aopwiki.org/
Altered, Amphibian metamorphosis
Source: https://aopwiki.org/
Altered, Amphibian metamorphosis
Source: https://aopwiki.org/
Altered, Amphibian metamorphosis
Source: https://aopwiki.org/
Altered, Amphibian metamorphosis
Source: https://aopwiki.org/
Altered, Amphibian metamorphosis
Source: https://aopwiki.org/
Altered, Amphibian metamorphosis
Source: https://aopwiki.org/
Altered, Amphibian metamorphosis
Source: https://aopwiki.org/
Altered, Amphibian metamorphosis
Source: https://aopwiki.org/
Inhibition, Cyclooxygenase 1 activity
Source: https://aopwiki.org/
Decreased, Prostaglandin F2alpha concentration, plasma
Source: https://aopwiki.org/
Occurrence, renal ischemia
Source: https://aopwiki.org/
Increased, Deformed Wing Virus levels
Source: https://aopwiki.org/
Increased, Energetic demands and therefore metabolic stress
Source: https://aopwiki.org/
Unknown, MIE
Source: https://aopwiki.org/
Unknown, MIE
Source: https://aopwiki.org/
Increased, Reactive oxygen species
Source: https://aopwiki.org/
Increased, Reactive oxygen species
Source: https://aopwiki.org/
Increased, Reactive oxygen species
Source: https://aopwiki.org/
Increased, Reactive oxygen species
Source: https://aopwiki.org/
Increased, Reactive oxygen species
Source: https://aopwiki.org/
Increased, Reactive oxygen species
Source: https://aopwiki.org/
Increased, Reactive oxygen species
Source: https://aopwiki.org/
Increased, Reactive oxygen species
Source: https://aopwiki.org/
Increased, Reactive oxygen species
Source: https://aopwiki.org/
Increased, Reactive oxygen species
Source: https://aopwiki.org/
Increased, Reactive oxygen species
Source: https://aopwiki.org/
Increased, Reactive oxygen species
Source: https://aopwiki.org/
Increased, Reactive oxygen species
Source: https://aopwiki.org/
Increased, Reactive oxygen species
Source: https://aopwiki.org/
Increased, Reactive oxygen species
Source: https://aopwiki.org/
Increased, Reactive oxygen species
Source: https://aopwiki.org/
Increased, Reactive oxygen species
Source: https://aopwiki.org/
Increased, Reactive oxygen species
Source: https://aopwiki.org/
Increased, Reactive oxygen species
Source: https://aopwiki.org/
Increased, Reactive oxygen species
Source: https://aopwiki.org/
Increased, Reactive oxygen species
Source: https://aopwiki.org/
Irreversible inhibition of hepatic VKOR by binding of AR at tyrosine 139, Failure to cycle vitamin K epoxide to vitamin K to form vitamin K hydroquinone
Source: https://aopwiki.org/
Uncoupling of oxidative phosphorylation, Reduced ability to generate ATP
Source: https://aopwiki.org/
Anticoagulant rodenticide interferes with carboxylation of Gla proteins in bone, Impairment of post-translational modification (carboxylation) of osteocalcin
Source: https://aopwiki.org/
Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failure of secondary hemostasis
Source: https://aopwiki.org/
Failure in vascular repair mechanisms, Unresolved blood loss (hemorrhage)
Source: https://aopwiki.org/
Failure in gamma-glutamyl carboxylation of clotting factors II, VII, IX and X, Under carboxylation of clotting factors (e.g., des-gamma-carboxy prothrombin)
Source: https://aopwiki.org/
Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tissue, impaired carbon dioxide and waste product removal
Source: https://aopwiki.org/
Hemostasis, Depletion from blood of fully functional carboxylated clotting factors
Source: https://aopwiki.org/
Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction
Source: https://aopwiki.org/
Osteoporosis and vascular calcification, Bone deterioration
Source: https://aopwiki.org/
Impaired recruitment , Population trajectory
Source: https://aopwiki.org/
Inhibition, Iodotyrosine deiodinase (IYD)
Source: https://aopwiki.org/
Inhibition, Deiodinase 3
Source: https://aopwiki.org/
Increased, Triiodothyronine (T3) in tissues
Source: https://aopwiki.org/
Inhibition, Pendrin
Source: https://aopwiki.org/
Inhibition, Dual oxidase
Source: https://aopwiki.org/
Activation, Hepatic nuclear receptor(s)
Source: https://aopwiki.org/
Increased, Hepatic thyroid hormone uptake/transport
Source: https://aopwiki.org/
Increased, Hepatic thyroid hormone uptake/transport
Source: https://aopwiki.org/
Increased, Hepatic thyroid hormone uptake/transport
Source: https://aopwiki.org/
Increased, Hepatic thyroid hormone uptake/transport
Source: https://aopwiki.org/
Increased, oocyte maturation
Source: https://aopwiki.org/
induced spawning
Source: https://aopwiki.org/
Increased, Reproductive Success
Source: https://aopwiki.org/
Increased, Reproductive Success
Source: https://aopwiki.org/
Increase, cilia movement
Source: https://aopwiki.org/
Increase, cilia movement
Source: https://aopwiki.org/
Increase, cilia movement
Source: https://aopwiki.org/
Increased, Population
Source: https://aopwiki.org/
Increased, Population
Source: https://aopwiki.org/
TRPA1 activation, TRPA1 Receptor
Source: https://aopwiki.org/
Opening of calcium channel, Calcium influx
Source: https://aopwiki.org/
Trigeminal nerve activation
Source: https://aopwiki.org/
SP (Substance P) release, Local increase of SP
Source: https://aopwiki.org/
Increased CGRP, neuronal release of CGRP
Source: https://aopwiki.org/
Increased neurokinin A (NKA) by neuronal cells
Source: https://aopwiki.org/
Trigeminal and/or vagal nerve excitation causes Airway Hyper-responsiveness,Cough, Dyspnea
Source: https://aopwiki.org/
Irritation of nasal mucosa inducing sneeze reflex
Source: https://aopwiki.org/
Increased Respiratory irritability and Chronic Cough,
Source: https://aopwiki.org/
Decreased, sodium conductance 2
Source: https://aopwiki.org/
Decreased, GABA release
Source: https://aopwiki.org/
Activation, Estrogen receptor
Source: https://aopwiki.org/
Increase, Cell Proliferation (Epithelial Cells)
Source: https://aopwiki.org/
Increase, Cell Proliferation (Epithelial Cells)
Source: https://aopwiki.org/
Increase, Cell Proliferation (Epithelial Cells)
Source: https://aopwiki.org/
Decreased, Apoptosis (Epithelial Cells)
Source: https://aopwiki.org/
Decreased, Apoptosis (Epithelial Cells)
Source: https://aopwiki.org/
Increased, ER binding to DNA (classical pathway)
Source: https://aopwiki.org/
Increased, ER binding to T.F. to DNA (non-classical pathway)
Source: https://aopwiki.org/
Increased, Proliferation (Endothelial cells)
Source: https://aopwiki.org/
Increased, Migration (Endothelial Cells)
Source: https://aopwiki.org/
Increased, Migration (Endothelial Cells)
Source: https://aopwiki.org/
Increased, Non-genomic signaling
Source: https://aopwiki.org/
Increased, Ductal Hyperplasia
Source: https://aopwiki.org/
Increased, Ductal Hyperplasia
Source: https://aopwiki.org/
Increased, Ductal Hyperplasia
Source: https://aopwiki.org/
Increase, DNA damage
Source: https://aopwiki.org/
Increase, DNA damage
Source: https://aopwiki.org/
Increase, DNA damage
Source: https://aopwiki.org/
Increase, DNA damage
Source: https://aopwiki.org/
Increase, DNA damage
Source: https://aopwiki.org/
Increase, DNA damage
Source: https://aopwiki.org/
Increase, DNA damage
Source: https://aopwiki.org/
Increase, DNA damage
Source: https://aopwiki.org/
Increase, DNA damage
Source: https://aopwiki.org/
Increase, DNA damage
Source: https://aopwiki.org/
Increase, DNA damage
Source: https://aopwiki.org/
Increase, DNA damage
Source: https://aopwiki.org/
Increase, DNA damage
Source: https://aopwiki.org/
modulation, Extracellular Matrix Composition
Source: https://aopwiki.org/
Increased, Invasion
Source: https://aopwiki.org/
Increased, Invasion
Source: https://aopwiki.org/
Increased, Invasion
Source: https://aopwiki.org/
Activation, Fibroblasts
Source: https://aopwiki.org/
Activation, Fibroblasts
Source: https://aopwiki.org/
Activation, Macrophages
Source: https://aopwiki.org/
Activation, Macrophages
Source: https://aopwiki.org/
Increased, Angiogenesis
Source: https://aopwiki.org/
Altered, Gene Expression
Source: https://aopwiki.org/
Altered, Gene Expression
Source: https://aopwiki.org/
Altered, Protein Production
Source: https://aopwiki.org/
Increased, Motility
Source: https://aopwiki.org/
Increased, Motility
Source: https://aopwiki.org/
Increased, Second Messenger Production
Source: https://aopwiki.org/
N/A, Breast Cancer
Source: https://aopwiki.org/
N/A, Breast Cancer
Source: https://aopwiki.org/
N/A, Breast Cancer
Source: https://aopwiki.org/
N/A, Breast Cancer
Source: https://aopwiki.org/
Activation, Juvenile hormone receptor
Source: https://aopwiki.org/
Induction, Doublesex1 gene
Source: https://aopwiki.org/
Induction, Male reproductive tract
Source: https://aopwiki.org/
Increased, Male offspring
Source: https://aopwiki.org/
Alteration, Food-web structures
Source: https://aopwiki.org/
Binding to (interferes with) topoisomerase II enzyme
Source: https://aopwiki.org/
Increase, DNA double-strand breaks
Source: https://aopwiki.org/
Increase, DNA double-strand breaks
Source: https://aopwiki.org/
Increase, DNA double-strand breaks
Source: https://aopwiki.org/
Increase, DNA double-strand breaks
Source: https://aopwiki.org/
Increase, DNA double-strand breaks
Source: https://aopwiki.org/
MLL chromosomal translocation
Source: https://aopwiki.org/
Infant leukaemia
Source: https://aopwiki.org/
increased mantel display
Source: https://aopwiki.org/
increased mantel display
Source: https://aopwiki.org/
Induced parturition
Source: https://aopwiki.org/
Induced parturition
Source: https://aopwiki.org/
Decreased, Reproductive Success
Source: https://aopwiki.org/
Decreased, Reproductive Success
Source: https://aopwiki.org/
Decreased, Reproductive Success
Source: https://aopwiki.org/
Decreased, Reproductive Success
Source: https://aopwiki.org/
Decompartmentalization
Source: https://aopwiki.org/
Direct mitochondrial inhibition
Source: https://aopwiki.org/
narcosis
Source: https://aopwiki.org/
Mitochondrial impairment
Source: https://aopwiki.org/
Mitochondrial impairment
Source: https://aopwiki.org/
Apoptosis
Source: https://aopwiki.org/
Apoptosis
Source: https://aopwiki.org/
Apoptosis
Source: https://aopwiki.org/
Apoptosis
Source: https://aopwiki.org/
Apoptosis
Source: https://aopwiki.org/
Apoptosis
Source: https://aopwiki.org/
Apoptosis
Source: https://aopwiki.org/
Apoptosis
Source: https://aopwiki.org/
Apoptosis
Source: https://aopwiki.org/
Apoptosis
Source: https://aopwiki.org/
Apoptosis
Source: https://aopwiki.org/
Apoptosis
Source: https://aopwiki.org/
Apoptosis
Source: https://aopwiki.org/
Apoptosis
Source: https://aopwiki.org/
Necrosis
Source: https://aopwiki.org/
Inactivation of PPARγ
Source: https://aopwiki.org/
Inactivation of PPARγ
Source: https://aopwiki.org/
Activation of TGF-β signaling
Source: https://aopwiki.org/
Activation of TGF-β signaling
Source: https://aopwiki.org/
Collagen Deposition
Source: https://aopwiki.org/
Induction, Epithelial Mesenchymal Transition
Source: https://aopwiki.org/
Induction, Epithelial Mesenchymal Transition
Source: https://aopwiki.org/
Induction, Epithelial Mesenchymal Transition
Source: https://aopwiki.org/
Induction, Epithelial Mesenchymal Transition
Source: https://aopwiki.org/
Induction, Epithelial Mesenchymal Transition
Source: https://aopwiki.org/
Induction, Epithelial Mesenchymal Transition
Source: https://aopwiki.org/
Induction, Epithelial Mesenchymal Transition
Source: https://aopwiki.org/
Lung fibrosis
Source: https://aopwiki.org/
Lung fibrosis
Source: https://aopwiki.org/
Lung fibrosis
Source: https://aopwiki.org/
Lung fibrosis
Source: https://aopwiki.org/
Lung fibrosis
Source: https://aopwiki.org/
Activation, NADPH Oxidase
Source: https://aopwiki.org/
ROS formation
Source: https://aopwiki.org/
ROS formation
Source: https://aopwiki.org/
Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK
Source: https://aopwiki.org/
Activation, HIF-1
Source: https://aopwiki.org/
Increased, DNA Damage-Repair
Source: https://aopwiki.org/
Reproductive failure
Source: https://aopwiki.org/
Reproductive failure
Source: https://aopwiki.org/
Reproductive failure
Source: https://aopwiki.org/
Activation, JAK/STAT pathway
Source: https://aopwiki.org/
Activation, TGF-beta pathway
Source: https://aopwiki.org/
Activation, TGF-beta pathway
Source: https://aopwiki.org/
Up Regulation, SREBF2
Source: https://aopwiki.org/
Up Regulation, SREBF2
Source: https://aopwiki.org/
Up Regulation, Unsaturated fatty acid
Source: https://aopwiki.org/
Down Regulation, GSS and GSTs gene
Source: https://aopwiki.org/
Glutathione synthesis
Source: https://aopwiki.org/
Activation, 3-hydroxy-3-methylglutaryl-CoA reductase gene
Source: https://aopwiki.org/
Perturbation of cholesterol
Source: https://aopwiki.org/
Glutathione homeostasis
Source: https://aopwiki.org/
Hepatotoxicity
Source: https://aopwiki.org/
Activation, JNK
Source: https://aopwiki.org/
Activation, JNK
Source: https://aopwiki.org/
Activation, FOXO
Source: https://aopwiki.org/
Inhibition, Wnt pathway
Source: https://aopwiki.org/
Defect of Embryogenesis
Source: https://aopwiki.org/
Histone deacetylase inhibition
Source: https://aopwiki.org/
Histone deacetylase inhibition
Source: https://aopwiki.org/
Histone deacetylase inhibition
Source: https://aopwiki.org/
Histone deacetylase inhibition
Source: https://aopwiki.org/
Histone acetylation, increase
Source: https://aopwiki.org/
Histone acetylation, increase
Source: https://aopwiki.org/
Cell cycle, disrupted
Source: https://aopwiki.org/
Cell cycle, disrupted
Source: https://aopwiki.org/
Cell cycle, disrupted
Source: https://aopwiki.org/
Spermatocyte depletion
Source: https://aopwiki.org/
Testicular atrophy
Source: https://aopwiki.org/
Inhibition, Fatty Acid Beta Oxidation
Source: https://aopwiki.org/
Increase, cytosolic fatty acid
Source: https://aopwiki.org/
Increased, Oncotic Necrosis
Source: https://aopwiki.org/
N/A, Steatohepatisis
Source: https://aopwiki.org/
N/A, Steatohepatisis
Source: https://aopwiki.org/
Inhibit, serotonin transporter activity
Source: https://aopwiki.org/
Decreased, serotonin transporter activity
Source: https://aopwiki.org/
Decreased, serotonin transporter activity
Source: https://aopwiki.org/
Decreased, serotonin transporter activity
Source: https://aopwiki.org/
Decreased, extracellular sodium (Na+)
Source: https://aopwiki.org/
Decreased, extracellular chloride (Cl-)
Source: https://aopwiki.org/
Increased, extracellular serotonin
Source: https://aopwiki.org/
Increased, extracellular serotonin
Source: https://aopwiki.org/
Increased, extracellular serotonin
Source: https://aopwiki.org/
Increased, extracellular serotonin
Source: https://aopwiki.org/
Increased, extracellular serotonin
Source: https://aopwiki.org/
Increased, extracellular serotonin
Source: https://aopwiki.org/
Decreased, extracellular serotonin
Source: https://aopwiki.org/
Decreased, extracellular serotonin
Source: https://aopwiki.org/
Decreased, extracellular serotonin
Source: https://aopwiki.org/
Decreased, extracellular serotonin
Source: https://aopwiki.org/
Decreased, extracellular serotonin
Source: https://aopwiki.org/
Decreased, extracellular serotonin
Source: https://aopwiki.org/
Increased, intracellular sodium (Na+)
Source: https://aopwiki.org/
Increased, intracellular sodium (Na+)
Source: https://aopwiki.org/
Increased, intracellular sodium (Na+)
Source: https://aopwiki.org/
Increased, intracellular chloride (Cl-)
Source: https://aopwiki.org/
Increased, intracellular chloride (Cl-)
Source: https://aopwiki.org/
Decreased, intracellular serotonin
Source: https://aopwiki.org/
Decreased, intracellular serotonin
Source: https://aopwiki.org/
Decreased, intracellular serotonin
Source: https://aopwiki.org/
Decreased, packaged serotonin
Source: https://aopwiki.org/
Decreased, packaged serotonin
Source: https://aopwiki.org/
Decreased, packaged serotonin
Source: https://aopwiki.org/
Decreased, synaptic release
Source: https://aopwiki.org/
Decreased, synaptic release
Source: https://aopwiki.org/
Decreased, synaptic release
Source: https://aopwiki.org/
Increased, 5-HT3 (5-hydroxytryptamine)
Source: https://aopwiki.org/
Inactivated, 5-HTR (serotonin receptors)
Source: https://aopwiki.org/
Inactivated, 5-HTR (serotonin receptors)
Source: https://aopwiki.org/
Inactivated, 5-HTR (serotonin receptors)
Source: https://aopwiki.org/
Inactivated, 5-HTR (serotonin receptors)
Source: https://aopwiki.org/
Reduce expression, BDNF (Brain-derived neurotrophic factor)
Source: https://aopwiki.org/
Reduce expression, BDNF (Brain-derived neurotrophic factor)
Source: https://aopwiki.org/
Reduce expression, BDNF (Brain-derived neurotrophic factor)
Source: https://aopwiki.org/
Reduce expression, BDNF (Brain-derived neurotrophic factor)
Source: https://aopwiki.org/
Decreased, neuroplasticity
Source: https://aopwiki.org/
Decreased, neuroplasticity
Source: https://aopwiki.org/
Decreased, neuroplasticity
Source: https://aopwiki.org/
Decreased, neuroplasticity
Source: https://aopwiki.org/
Increase, cortisone
Source: https://aopwiki.org/
Reduced, BDNF (Brain-derived neurotrophic factor)
Source: https://aopwiki.org/
Reduced, BDNF (Brain-derived neurotrophic factor)
Source: https://aopwiki.org/
Activation, 5-HT2A (Serotonin 2A)
Source: https://aopwiki.org/
Activation, 5-HT2A (Serotonin 2A)
Source: https://aopwiki.org/
Activate, PLC (Phospholipase C)
Source: https://aopwiki.org/
Activate, PLC (Phospholipase C)
Source: https://aopwiki.org/
Increase, inositol triphosphate
Source: https://aopwiki.org/
Increase, inositol triphosphate
Source: https://aopwiki.org/
Increase, intracellular calcium
Source: https://aopwiki.org/
Increase, intracellular calcium
Source: https://aopwiki.org/
Increase, intracellular calcium
Source: https://aopwiki.org/
Increase, intracellular calcium
Source: https://aopwiki.org/
Activate, calmodulin
Source: https://aopwiki.org/
Activate, calmodulin
Source: https://aopwiki.org/
Increase, myosin light chain phosphorylation
Source: https://aopwiki.org/
Increase, myosin light chain phosphorylation
Source: https://aopwiki.org/
Increase, vascular smooth muscle contraction
Source: https://aopwiki.org/
Increase, vascular smooth muscle contraction
Source: https://aopwiki.org/
Increased, seizure
Source: https://aopwiki.org/
Increased, seizure
Source: https://aopwiki.org/
Increased, seizure
Source: https://aopwiki.org/
Increased, seizure
Source: https://aopwiki.org/
Increased, agitation
Source: https://aopwiki.org/
Increased, agitation
Source: https://aopwiki.org/
Increased, agitation
Source: https://aopwiki.org/
Increased, depression
Source: https://aopwiki.org/
Increased, depression
Source: https://aopwiki.org/
Increase, hypertension
Source: https://aopwiki.org/
Increase, hypertension
Source: https://aopwiki.org/
Activated, presynaptic neuron 1
Source: https://aopwiki.org/
Activated, presynaptic neuron 1
Source: https://aopwiki.org/
Activated, presynaptic neuron 1
Source: https://aopwiki.org/
Increased, glutamate
Source: https://aopwiki.org/
Increased, glutamate
Source: https://aopwiki.org/
Increased, glutamate
Source: https://aopwiki.org/
Increased, glutamate
Source: https://aopwiki.org/
Activated, NMDA receptor
Source: https://aopwiki.org/
Activated, NMDA receptor
Source: https://aopwiki.org/
Activated, voltage-gated sodium channel
Source: https://aopwiki.org/
Activated, voltage-gated sodium channel
Source: https://aopwiki.org/
Binding to voltage-gated sodium channel
Source: https://aopwiki.org/
Binding to voltage-gated sodium channel
Source: https://aopwiki.org/
Binding to voltage-gated sodium channel
Source: https://aopwiki.org/
Binding to voltage-gated sodium channel
Source: https://aopwiki.org/
Treat, carbamazepine
Source: https://aopwiki.org/
Treat, carbamazepine
Source: https://aopwiki.org/
Activated, membrane depolarization
Source: https://aopwiki.org/
Activated, membrane depolarization
Source: https://aopwiki.org/
Activated, membrane depolarization
Source: https://aopwiki.org/
Inactive, membrane depolarization
Source: https://aopwiki.org/
Increased, RDX dose
Source: https://aopwiki.org/
Increased, RDX dose
Source: https://aopwiki.org/
Repress, GABA-A receptor
Source: https://aopwiki.org/
Activate, GABA-A receptor
Source: https://aopwiki.org/
Activate, presynaptic neuron 2
Source: https://aopwiki.org/
Increase, GABA
Source: https://aopwiki.org/
Increase, seizure
Source: https://aopwiki.org/
Increase, seizure
Source: https://aopwiki.org/
Increase, seizure
Source: https://aopwiki.org/
Increased, hippocampal hyperdepolarization
Source: https://aopwiki.org/
Increased, hippocampal hyperdepolarization
Source: https://aopwiki.org/
Increased, hippocampal hyperdepolarization
Source: https://aopwiki.org/
Increased, epilepsy
Source: https://aopwiki.org/
Increased, epilepsy
Source: https://aopwiki.org/
Increased, epilepsy
Source: https://aopwiki.org/
Increased, epilepsy
Source: https://aopwiki.org/
Increase, Apoptosis
Source: https://aopwiki.org/
Increase, Apoptosis
Source: https://aopwiki.org/
Increase, Apoptosis
Source: https://aopwiki.org/
Increase, Apoptosis
Source: https://aopwiki.org/
Increase, Apoptosis
Source: https://aopwiki.org/
Increase, Apoptosis
Source: https://aopwiki.org/
Increase, Apoptosis
Source: https://aopwiki.org/
Increase, Apoptosis
Source: https://aopwiki.org/
Increase, Apoptosis
Source: https://aopwiki.org/
Increase, Apoptosis
Source: https://aopwiki.org/
Increase, Apoptosis
Source: https://aopwiki.org/
Increase, Apoptosis
Source: https://aopwiki.org/
Increase, Apoptosis
Source: https://aopwiki.org/
Increase, Apoptosis
Source: https://aopwiki.org/
Increase, Apoptosis
Source: https://aopwiki.org/
Increase, Apoptosis
Source: https://aopwiki.org/
Increase, Apoptosis
Source: https://aopwiki.org/
Decrease, Oogenesis
Source: https://aopwiki.org/
Decrease, Oogenesis
Source: https://aopwiki.org/
Decrease, Oogenesis
Source: https://aopwiki.org/
Decrease, Oogenesis
Source: https://aopwiki.org/
Decrease, Oogenesis
Source: https://aopwiki.org/
Decrease, Oogenesis
Source: https://aopwiki.org/
Decrease, Oogenesis
Source: https://aopwiki.org/
Decrease, Oogenesis
Source: https://aopwiki.org/
Decrease, Oogenesis
Source: https://aopwiki.org/
Decrease, Oogenesis
Source: https://aopwiki.org/
Decrease, Oogenesis
Source: https://aopwiki.org/
Decrease, Oogenesis
Source: https://aopwiki.org/
Decrease, Oogenesis
Source: https://aopwiki.org/
Decrease, Oogenesis
Source: https://aopwiki.org/
Decrease, Oogenesis
Source: https://aopwiki.org/
Increase, Follicular atresia
Source: https://aopwiki.org/
Increase, Follicular atresia
Source: https://aopwiki.org/
Increase, Follicular atresia
Source: https://aopwiki.org/
Decrease, Fecundity
Source: https://aopwiki.org/
Decrease, Fecundity
Source: https://aopwiki.org/
Decrease, Fecundity
Source: https://aopwiki.org/
Decrease, Fecundity
Source: https://aopwiki.org/
Decrease, Fecundity
Source: https://aopwiki.org/
Decrease, Fecundity
Source: https://aopwiki.org/
Decrease, Fecundity
Source: https://aopwiki.org/
Decrease, Fecundity
Source: https://aopwiki.org/
Decrease, Fecundity
Source: https://aopwiki.org/
Decrease, Fecundity
Source: https://aopwiki.org/
Decrease, Fecundity
Source: https://aopwiki.org/
Decrease, Fecundity
Source: https://aopwiki.org/
Decrease, Fecundity
Source: https://aopwiki.org/
Decrease, Fecundity
Source: https://aopwiki.org/
Decrease, Fecundity
Source: https://aopwiki.org/
Decrease, Fecundity
Source: https://aopwiki.org/
Decrease, Fecundity
Source: https://aopwiki.org/
Inhibition, PTGS-1 (Prostaglandin-endoperoxide synthase 1)
Source: https://aopwiki.org/
Activation, PTGS-1 (Prostaglandin-endoperoxide synthase 1)
Source: https://aopwiki.org/
Activation, PTGS-2 (Prostaglandin-endoperoxide synthase 2)
Source: https://aopwiki.org/
Inhibition, PTGS-2 (Prostaglandin-endoperoxide synthase 2)
Source: https://aopwiki.org/
Increase, bicarbonate
Source: https://aopwiki.org/
Increase, mucous
Source: https://aopwiki.org/
Increase, mucosal blood flow
Source: https://aopwiki.org/
Increase, platelet aggregation
Source: https://aopwiki.org/
Increase, angiogenesis
Source: https://aopwiki.org/
Increase, angiogenesis
Source: https://aopwiki.org/
Decrease, leukocyte adherence
Source: https://aopwiki.org/
Increase, leukocyte adherence
Source: https://aopwiki.org/
Activate, leukocyte
Source: https://aopwiki.org/
Activate, mucosal defense
Source: https://aopwiki.org/
Increase, surfactant
Source: https://aopwiki.org/
Decrease, surfactant
Source: https://aopwiki.org/
Decrease, surfactant
Source: https://aopwiki.org/
Activate, phospholipase
Source: https://aopwiki.org/
Activate, phospholipase
Source: https://aopwiki.org/
Increase, ammonium (NH4+)
Source: https://aopwiki.org/
Increase, ammonium (NH4+)
Source: https://aopwiki.org/
Inhibit, gastric ulcer formation
Source: https://aopwiki.org/
Activated, gastric ulcer formation
Source: https://aopwiki.org/
Activated, gastric ulcer formation
Source: https://aopwiki.org/
Activated, gastric ulcer formation
Source: https://aopwiki.org/
Activated, gastric ulcer formation
Source: https://aopwiki.org/
CYP7B activity, inhibition
Source: https://aopwiki.org/
CYP7B activity, inhibition
Source: https://aopwiki.org/
7α-hydroxypregnenolone synthesis in the brain, decreased
Source: https://aopwiki.org/
7α-hydroxypregnenolone synthesis in the brain, decreased
Source: https://aopwiki.org/
Dopamine release in the brain, decreased
Source: https://aopwiki.org/
Dopamine release in the brain, decreased
Source: https://aopwiki.org/
Locomotor activity, decreased
Source: https://aopwiki.org/
Decreased, Population trajectory
Source: https://aopwiki.org/
Decreased, Population trajectory
Source: https://aopwiki.org/
Decreased, Population trajectory
Source: https://aopwiki.org/
Decreased, Population trajectory
Source: https://aopwiki.org/
Sexual behavior, decreased
Source: https://aopwiki.org/
Activation of Cyp2E1
Source: https://aopwiki.org/
Activation of Cyp2E1
Source: https://aopwiki.org/
Hepatocytotoxicity
Source: https://aopwiki.org/
Induction, persistent proliferation/sustained proliferation
Source: https://aopwiki.org/
Liver Cancer
Source: https://aopwiki.org/
Increased, glucocorticoid receptor activity
Source: https://aopwiki.org/
Increased, serotonin transporter activity
Source: https://aopwiki.org/
Increased, serotonin transporter activity
Source: https://aopwiki.org/
Increased, serotonin transporter activity
Source: https://aopwiki.org/
Increased, intracellular serotonin
Source: https://aopwiki.org/
Increased, intracellular serotonin
Source: https://aopwiki.org/
Increased, intracellular serotonin
Source: https://aopwiki.org/
Increased, packaged serotonin
Source: https://aopwiki.org/
Increased, packaged serotonin
Source: https://aopwiki.org/
Increased, packaged serotonin
Source: https://aopwiki.org/
Increased, synaptic release
Source: https://aopwiki.org/
Increased, synaptic release
Source: https://aopwiki.org/
Increased, synaptic release
Source: https://aopwiki.org/
Decreased, 5-HT3
Source: https://aopwiki.org/
Reduced, PTGS1 function
Source: https://aopwiki.org/
Reduced, platelet aggregation
Source: https://aopwiki.org/
Decreased, mucosal blood flow
Source: https://aopwiki.org/
Reduced, mucosal defense
Source: https://aopwiki.org/
Reduced, mucosal defense
Source: https://aopwiki.org/
Decreased, mucous
Source: https://aopwiki.org/
Decreased, bicarbonate
Source: https://aopwiki.org/
Reduced, PTGS2 function
Source: https://aopwiki.org/
Decreased, angiogenesis
Source: https://aopwiki.org/
Increased, leukocyte adherence
Source: https://aopwiki.org/
Increased, leukocyte activation
Source: https://aopwiki.org/
Helicobacter pylori infection
Source: https://aopwiki.org/
Reduced, presynaptic neuron 2 activity
Source: https://aopwiki.org/
Decreased, GABA
Source: https://aopwiki.org/
Reduced, GABA-A receptor activation
Source: https://aopwiki.org/
Decreased, intracellular chloride
Source: https://aopwiki.org/
NFE2/Nrf2 repression
Source: https://aopwiki.org/
NFE2/Nrf2 repression
Source: https://aopwiki.org/
NFE2/Nrf2 repression
Source: https://aopwiki.org/
NFE2/Nrf2 repression
Source: https://aopwiki.org/
Reduced, FXR activity
Source: https://aopwiki.org/
Reduced, SHP activity
Source: https://aopwiki.org/
Activated, LXR
Source: https://aopwiki.org/
Reduced, PPARalpha
Source: https://aopwiki.org/
Reduced, HSD17B4 activity
Source: https://aopwiki.org/
Reduced, fatty acid beta oxidation
Source: https://aopwiki.org/
Increased, steatosis
Source: https://aopwiki.org/
Mu Opioid Receptor Agonism
Source: https://aopwiki.org/
Mu Opioid Receptor Agonism
Source: https://aopwiki.org/
Release of G Proteins
Source: https://aopwiki.org/
Release of G Proteins
Source: https://aopwiki.org/
Release of G Proteins
Source: https://aopwiki.org/
Release of G Proteins
Source: https://aopwiki.org/
Opening of G protein gated inward rectifying K channels
Source: https://aopwiki.org/
Opening of G protein gated inward rectifying K channels
Source: https://aopwiki.org/
Analgesia
Source: https://aopwiki.org/
Analgesia
Source: https://aopwiki.org/
Inhibition of N-type Ca ion channels
Source: https://aopwiki.org/
Inhibition of N-type Ca ion channels
Source: https://aopwiki.org/
Inhibition of neurotransmitter vesicle release
Source: https://aopwiki.org/
Inhibition of neurotransmitter vesicle release
Source: https://aopwiki.org/
Serotonin 1A Receptor Agonism
Source: https://aopwiki.org/
Serotonin 1A Receptor Agonism
Source: https://aopwiki.org/
Anti-depressant Activity
Source: https://aopwiki.org/
Anti-depressant Activity
Source: https://aopwiki.org/
Sensing of the stressor by pulmonary cells
Source: https://aopwiki.org/
Transcription of genes encoding acute phase proteins, Increased
Source: https://aopwiki.org/
Systemic acute phase response
Source: https://aopwiki.org/
Formation of HDL-SAA
Source: https://aopwiki.org/
Increased systemic total cholesterol pool
Source: https://aopwiki.org/
Foam cell formation
Source: https://aopwiki.org/
Atherosclerosis
Source: https://aopwiki.org/
Decrease, Coupling of oxidative phosphorylation
Source: https://aopwiki.org/
Decrease, Coupling of oxidative phosphorylation
Source: https://aopwiki.org/
Decrease, Coupling of oxidative phosphorylation
Source: https://aopwiki.org/
Decrease, Coupling of oxidative phosphorylation
Source: https://aopwiki.org/
Decrease, Coupling of oxidative phosphorylation
Source: https://aopwiki.org/
Decrease, Coupling of oxidative phosphorylation
Source: https://aopwiki.org/
Decrease, Coupling of oxidative phosphorylation
Source: https://aopwiki.org/
Activation, Latent Transforming Growth Factor Beta 1
Source: https://aopwiki.org/
Increase, Differentiation of fibroblasts
Source: https://aopwiki.org/
Activation, Transforming Growth Factor beta pathway
Source: https://aopwiki.org/
Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts
Source: https://aopwiki.org/
Inhibition of lysyl oxidase
Source: https://aopwiki.org/
Reduction of collagen crosslinking
Source: https://aopwiki.org/
Weak collagen matrix
Source: https://aopwiki.org/
Notochord distortion or malformations
Source: https://aopwiki.org/
Growth, reduction
Source: https://aopwiki.org/
Increase, Uncoupling of photophosphorylation
Source: https://aopwiki.org/
Decrease, ATP production
Source: https://aopwiki.org/
Decrease, ATP production
Source: https://aopwiki.org/
Decrease, ATP production
Source: https://aopwiki.org/
Decrease, Chlorophyll synthesis
Source: https://aopwiki.org/
Decrease, Light harvest capacity
Source: https://aopwiki.org/
Decrease, Photosynthesis
Source: https://aopwiki.org/
Decrease, Photosynthesis
Source: https://aopwiki.org/
Decrease, Photosynthesis
Source: https://aopwiki.org/
Decrease, Photosynthesis
Source: https://aopwiki.org/
Decrease, Glycolysis
Source: https://aopwiki.org/
Decrease, Glycolysis
Source: https://aopwiki.org/
Decrease, Oxidative phosphorylation
Source: https://aopwiki.org/
Decrease, Oxidative phosphorylation
Source: https://aopwiki.org/
Decrease, Oxidative phosphorylation
Source: https://aopwiki.org/
Decrease, Oxidative phosphorylation
Source: https://aopwiki.org/
Decrease, Oxidative phosphorylation
Source: https://aopwiki.org/
Decrease, Oxidative phosphorylation
Source: https://aopwiki.org/
Decrease, Oxidative phosphorylation
Source: https://aopwiki.org/
Decrease, Oxidative phosphorylation
Source: https://aopwiki.org/
Decrease, Oxidative phosphorylation
Source: https://aopwiki.org/
Decrease, Oxidative phosphorylation
Source: https://aopwiki.org/
Decrease, Leaf cell mitosis
Source: https://aopwiki.org/
Decrease, Leaf development
Source: https://aopwiki.org/
Decrease, Leaf development
Source: https://aopwiki.org/
Decrease, Leaf development
Source: https://aopwiki.org/
Decrease, Leaf development
Source: https://aopwiki.org/
Decrease, Leaf development
Source: https://aopwiki.org/
Increase, Growth inhibition
Source: https://aopwiki.org/
Inhibition of mitochondrial DNA polymerase gamma (Pol gamma)
Source: https://aopwiki.org/
Depletion, mtDNA
Source: https://aopwiki.org/
Dysfunction, Mitochondria
Source: https://aopwiki.org/
Dysfunction, Mitochondria
Source: https://aopwiki.org/
Binding of substrate, endocytic receptor
Source: https://aopwiki.org/
CYP2E1 Activation
Source: https://aopwiki.org/
Protein Adduct Formation
Source: https://aopwiki.org/
Oxidative Stress in Brain
Source: https://aopwiki.org/
Oxidative Stress in Brain
Source: https://aopwiki.org/
Oxidative Stress in Brain
Source: https://aopwiki.org/
Oxidative Stress in Brain
Source: https://aopwiki.org/
Lipid Peroxidation
Source: https://aopwiki.org/
Unfolded Protein Response
Source: https://aopwiki.org/
Unfolded Protein Response
Source: https://aopwiki.org/
Unfolded Protein Response
Source: https://aopwiki.org/
General Apoptosis
Source: https://aopwiki.org/
General Apoptosis
Source: https://aopwiki.org/
General Apoptosis
Source: https://aopwiki.org/
Neurodegeneration
Source: https://aopwiki.org/
Blockade, L-Type Calcium Channels
Source: https://aopwiki.org/
Decrease, Calcium currents
Source: https://aopwiki.org/
Decrease, Calcium binding to Troponin C
Source: https://aopwiki.org/
Decrease, Cardiac contractility
Source: https://aopwiki.org/
Decrease, Cardiac contractility
Source: https://aopwiki.org/
Decrease, Cardiac contractility
Source: https://aopwiki.org/
Decrease, Cardiac ejection fraction
Source: https://aopwiki.org/
Disruption, Intracellular calcium mobilization
Source: https://aopwiki.org/
Disruption, Sarcomere assembly
Source: https://aopwiki.org/
Heart failure
Source: https://aopwiki.org/
Heart failure
Source: https://aopwiki.org/
Heart failure
Source: https://aopwiki.org/
Heart failure
Source: https://aopwiki.org/
Heart failure
Source: https://aopwiki.org/
Heart failure
Source: https://aopwiki.org/
Increase, Mitochondrial ATP synthase antagonism
Source: https://aopwiki.org/
Increase, Mitochondrial ATP synthase antagonism
Source: https://aopwiki.org/
Increase, Mitochondrial ATP synthase antagonism
Source: https://aopwiki.org/
Increase, Mitochondrial ATP synthase antagonism
Source: https://aopwiki.org/
Decrease, Adenosine triphosphate pool
Source: https://aopwiki.org/
Decrease, Adenosine triphosphate pool
Source: https://aopwiki.org/
Decrease, Adenosine triphosphate pool
Source: https://aopwiki.org/
Decrease, Adenosine triphosphate pool
Source: https://aopwiki.org/
Decrease, Adenosine triphosphate pool
Source: https://aopwiki.org/
Decrease, Adenosine triphosphate pool
Source: https://aopwiki.org/
Decrease, Adenosine triphosphate pool
Source: https://aopwiki.org/
Decrease, Adenosine triphosphate pool
Source: https://aopwiki.org/
Decrease, Adenosine triphosphate pool
Source: https://aopwiki.org/
Decrease, Adenosine triphosphate pool
Source: https://aopwiki.org/
Decrease, Adenosine triphosphate pool
Source: https://aopwiki.org/
Decrease, Adenosine triphosphate pool
Source: https://aopwiki.org/
Decrease, Adenosine triphosphate pool
Source: https://aopwiki.org/
Increase, Oocyte apoptosis
Source: https://aopwiki.org/
Increase, Oocyte apoptosis
Source: https://aopwiki.org/
Increase, Oocyte apoptosis
Source: https://aopwiki.org/
Increase, Oocyte apoptosis
Source: https://aopwiki.org/
Increase, Oocyte apoptosis
Source: https://aopwiki.org/
Increase, Oocyte apoptosis
Source: https://aopwiki.org/
Increase, Oocyte apoptosis
Source: https://aopwiki.org/
Increase, Necrosis
Source: https://aopwiki.org/
Increase, Necrosis
Source: https://aopwiki.org/
Increase, Necrosis
Source: https://aopwiki.org/
Increase, Necrosis
Source: https://aopwiki.org/
Increase, Ovarian follicle breakdown
Source: https://aopwiki.org/
Increase, Ovarian follicle breakdown
Source: https://aopwiki.org/
Increase, Ovarian follicle breakdown
Source: https://aopwiki.org/
Increase, Ovarian follicle breakdown
Source: https://aopwiki.org/
Increase, D1 protein antagonism
Source: https://aopwiki.org/
Increase, D1 protein antagonism
Source: https://aopwiki.org/
Decrease, Photosystem II activity
Source: https://aopwiki.org/
Decrease, Photosystem II activity
Source: https://aopwiki.org/
Decrease, Growth
Source: https://aopwiki.org/
Decrease, Growth
Source: https://aopwiki.org/
Decrease, Growth
Source: https://aopwiki.org/
Decrease, Growth
Source: https://aopwiki.org/
Decrease, Growth
Source: https://aopwiki.org/
Decrease, Growth
Source: https://aopwiki.org/
Decrease, Growth
Source: https://aopwiki.org/
Decrease, Growth
Source: https://aopwiki.org/
Decrease, Growth
Source: https://aopwiki.org/
Decrease, Growth
Source: https://aopwiki.org/
Decrease, Growth
Source: https://aopwiki.org/
Decrease, Growth
Source: https://aopwiki.org/
Increase, Reactive oxygen species
Source: https://aopwiki.org/
Increase, Reactive oxygen species
Source: https://aopwiki.org/
Increase, Reactive oxygen species
Source: https://aopwiki.org/
Increase, Reactive oxygen species
Source: https://aopwiki.org/
Increase, Reactive oxygen species
Source: https://aopwiki.org/
Increase, Reactive oxygen species
Source: https://aopwiki.org/
Deposition of Energy
Source: https://aopwiki.org/
Deposition of Energy
Source: https://aopwiki.org/
Deposition of Energy
Source: https://aopwiki.org/
Deposition of Energy
Source: https://aopwiki.org/
Deposition of Energy
Source: https://aopwiki.org/
Deposition of Energy
Source: https://aopwiki.org/
Deposition of Energy
Source: https://aopwiki.org/
Deposition of Energy
Source: https://aopwiki.org/
Deposition of Energy
Source: https://aopwiki.org/
Deposition of Energy
Source: https://aopwiki.org/
Deposition of Energy
Source: https://aopwiki.org/
Deposition of Energy
Source: https://aopwiki.org/
Deposition of Energy
Source: https://aopwiki.org/
Deposition of Energy
Source: https://aopwiki.org/
Deposition of Energy
Source: https://aopwiki.org/
Deposition of Energy
Source: https://aopwiki.org/
Deposition of Energy
Source: https://aopwiki.org/
Increase, DNA strand breaks
Source: https://aopwiki.org/
Increase, DNA strand breaks
Source: https://aopwiki.org/
Increase, DNA strand breaks
Source: https://aopwiki.org/
Increase, DNA strand breaks
Source: https://aopwiki.org/
Increase, DNA strand breaks
Source: https://aopwiki.org/
Increase, DNA strand breaks
Source: https://aopwiki.org/
Increase, DNA strand breaks
Source: https://aopwiki.org/
Increase, DNA strand breaks
Source: https://aopwiki.org/
Increase, Chromosomal aberrations
Source: https://aopwiki.org/
Increase, Chromosomal aberrations
Source: https://aopwiki.org/
Increase, Chromosomal aberrations
Source: https://aopwiki.org/
Increase, lung cancer
Source: https://aopwiki.org/
Increase, Mitochondrial complex III antagonism
Source: https://aopwiki.org/
Increase, Mitochondrial complex III antagonism
Source: https://aopwiki.org/
Increase, Mitochondrial complex III antagonism
Source: https://aopwiki.org/
Mitochondrial Complex IV inhibition
Source: https://aopwiki.org/
Mitochondrial Complex V inhibition
Source: https://aopwiki.org/
Binding of inhibitor to mitochondrial complex III
Source: https://aopwiki.org/
Binding of inhibitor to mitochondrial complex IV
Source: https://aopwiki.org/
Binding of inhibitor to mitochondrial complex V
Source: https://aopwiki.org/
Decrease in mitochondrial oxidative phosphorylation
Source: https://aopwiki.org/
Increased reactive oxygen species (in the mitochondria)
Source: https://aopwiki.org/
Mitochondrial Injury
Source: https://aopwiki.org/
Mitochondrial Injury
Source: https://aopwiki.org/
Necrotic Tissue
Source: https://aopwiki.org/
Necrotic Tissue
Source: https://aopwiki.org/
Liver Injury
Source: https://aopwiki.org/
Liver Injury
Source: https://aopwiki.org/
Liver Injury
Source: https://aopwiki.org/
Neural crest cell migration, reduced
Source: https://aopwiki.org/
Neural crest cell migration, reduced
Source: https://aopwiki.org/
Collagen production, reduced
Source: https://aopwiki.org/
Facial cartilage structures are reduced in size and morphologically distorted
Source: https://aopwiki.org/
Facial cartilage structures are reduced in size and morphologically distorted
Source: https://aopwiki.org/
Altered differentiation
Source: https://aopwiki.org/
Altered differentiation
Source: https://aopwiki.org/
Neural tube defects
Source: https://aopwiki.org/
Neural tube defects
Source: https://aopwiki.org/
Decreased Na/K ATPase activity
Source: https://aopwiki.org/
Decreased Na/K ATPase activity
Source: https://aopwiki.org/
Decreased Na/K ATPase activity
Source: https://aopwiki.org/
Decreased proximal tubular vectorial transport
Source: https://aopwiki.org/
Chemical induced Fanconi syndrome
Source: https://aopwiki.org/
Impaired IL-1R1 signaling in T cell
Source: https://aopwiki.org/
Suppression of T cell activation
Source: https://aopwiki.org/
Impairment of TDAR
Source: https://aopwiki.org/
Inhibition, IKK complex
Source: https://aopwiki.org/
Activation, Caspase 8 pathway
Source: https://aopwiki.org/
Activation, Tissue resident cells (Kuppfer cells)
Source: https://aopwiki.org/
Increase, proinflammatory mediators (TNFalpha)
Source: https://aopwiki.org/
Binding of microtubule stabilizing agents (MSA) to microtubules
Source: https://aopwiki.org/
Disturbance in microtubule dynamic instability
Source: https://aopwiki.org/
Impaired axonial transport
Source: https://aopwiki.org/
Impaired axonial transport
Pathways: tau-AOP
Source: https://aopwiki.org/
Impaired axonial transport
Source: https://aopwiki.org/
Sensory axonal peripheral neuropathy
Source: https://aopwiki.org/
Sensory axonal peripheral neuropathy
Source: https://aopwiki.org/
Sensory axonal peripheral neuropathy
Source: https://aopwiki.org/
Interaction of α-diketones with arginine residues
Source: https://aopwiki.org/
Proteasomal dysfunction
Source: https://aopwiki.org/
Proteasomal dysfunction
Source: https://aopwiki.org/
Airway epithelial injury
Source: https://aopwiki.org/
Airway epithelial injury
Source: https://aopwiki.org/
Fibroproliferative airway lesions
Source: https://aopwiki.org/
Bronchiolitis obliterans
Source: https://aopwiki.org/
Activation, Muscarinic Acetylcholine Receptors
Source: https://aopwiki.org/
Occurrence, Focal Seizure
Source: https://aopwiki.org/
Status epilepticus
Source: https://aopwiki.org/
ROS generation from photoactivated chemicals
Source: https://aopwiki.org/
ROS generation from photoactivated chemicals
Source: https://aopwiki.org/
Oxidation of membrane lipids
Source: https://aopwiki.org/
Oxidation/denatuation of membrane proteins
Source: https://aopwiki.org/
Inflamatory events in light-exposed tissues
Source: https://aopwiki.org/
Inflamatory events in light-exposed tissues
Source: https://aopwiki.org/
Oxidation, Glutathione (To be considered with MIE)
Source: https://aopwiki.org/
Oxidation, Glutathione (To be considered with MIE)
Source: https://aopwiki.org/
Chronic kidney disease
Source: https://aopwiki.org/
Chronic kidney disease
Source: https://aopwiki.org/
Inhibition of N-linked glycosylation
Source: https://aopwiki.org/
Accumulation of misfolded proteins
Source: https://aopwiki.org/
Accumulation of misfolded proteins
Source: https://aopwiki.org/
Activation of hepatic stellate cells
Source: https://aopwiki.org/
Increase, Oxidative DNA damage
Source: https://aopwiki.org/
Increase, Oxidative DNA damage
Source: https://aopwiki.org/
Increase, Oxidative DNA damage
Source: https://aopwiki.org/
Increase, Oxidative DNA damage
Source: https://aopwiki.org/
Increase, Oxidative DNA damage
Source: https://aopwiki.org/
Increase, Oxidative DNA damage
Source: https://aopwiki.org/
Increase, Oxidative DNA damage
Source: https://aopwiki.org/
Inhibition, Cytochrome P450 enzyme (CYP17A1) activity
Source: https://aopwiki.org/
Reduction, 17-OH-pregnenolone conversion in DHEA
Source: https://aopwiki.org/
Reduction, 17-OH-progesterone conversion in androstenedione
Source: https://aopwiki.org/
Decrease, testosterone synthesis/level
Source: https://aopwiki.org/
Decrease, dihydrotestosterone (DHT) level
Source: https://aopwiki.org/
Decrease, dihydrotestosterone (DHT) level
Source: https://aopwiki.org/
Decrease, dihydrotestosterone (DHT) level
Source: https://aopwiki.org/
Decrease, dihydrotestosterone (DHT) level
Source: https://aopwiki.org/
Decrease, androgen receptor activation
Source: https://aopwiki.org/
Decrease, androgen receptor activation
Source: https://aopwiki.org/
Decrease, androgen receptor activation
Source: https://aopwiki.org/
Decrease, androgen receptor activation
Source: https://aopwiki.org/
Decrease, androgen receptor activation
Source: https://aopwiki.org/
Decrease, androgen receptor activation
Source: https://aopwiki.org/
Decrease, androgen receptor activation
Source: https://aopwiki.org/
Impaired inguinoscrotal testicular descent phase
Source: https://aopwiki.org/
Malformation, cryptorchidism - maldescended testis
Source: https://aopwiki.org/
Malformation, cryptorchidism - maldescended testis
Source: https://aopwiki.org/
Malformation, cryptorchidism - maldescended testis
Source: https://aopwiki.org/
Inhibition, 5α-reductase
Source: https://aopwiki.org/
Inhibition, 5α-reductase
Source: https://aopwiki.org/
Increase, DNA methyltransferase inhibition
Source: https://aopwiki.org/
Increase, DNA methyltransferase inhibition
Source: https://aopwiki.org/
Increase, DNA methyltransferase inhibition
Source: https://aopwiki.org/
Increase, DNA methyltransferase inhibition
Source: https://aopwiki.org/
Increase, DNA methyltransferase inhibition
Source: https://aopwiki.org/
Increase, DNA methyltransferase inhibition
Source: https://aopwiki.org/
Increase, DNA methyltransferase inhibition
Source: https://aopwiki.org/
Increase, DNA methyltransferase inhibition
Source: https://aopwiki.org/
Increase, DNA hypomethylation
Source: https://aopwiki.org/
Increase, DNA hypomethylation
Source: https://aopwiki.org/
Increase, DNA hypomethylation
Source: https://aopwiki.org/
Increase, Gene expression
Source: https://aopwiki.org/
Increase, Gene expression
Source: https://aopwiki.org/
Increase, Gene expression
Source: https://aopwiki.org/
Decrease, Transgenerational DNA methylation
Source: https://aopwiki.org/
Inhibition of tyrosinase
Source: https://aopwiki.org/
Reduction of L-Dopaquinone
Source: https://aopwiki.org/
Reduction in melanin level
Source: https://aopwiki.org/
Reduction of melanosome level
Source: https://aopwiki.org/
Reduction fo Pigmentation pattern
Source: https://aopwiki.org/
Increase in reactive oxygen and nitrogen species (RONS)
Source: https://aopwiki.org/
Increase in reactive oxygen and nitrogen species (RONS)
Source: https://aopwiki.org/
Increase in reactive oxygen and nitrogen species (RONS)
Source: https://aopwiki.org/
Increase in reactive oxygen and nitrogen species (RONS)
Source: https://aopwiki.org/
Increase in reactive oxygen and nitrogen species (RONS)
Source: https://aopwiki.org/
Increase, Oxidative damage to DNA
Source: https://aopwiki.org/
Increase, Oxidative damage to DNA
Source: https://aopwiki.org/
Increase, Oxidative damage to DNA
Source: https://aopwiki.org/
Increase, Oxidative damage to DNA
Source: https://aopwiki.org/
Increase, Oxidative damage to DNA
Source: https://aopwiki.org/
Retinaldehyde dehydrogenase inhibition
Source: https://aopwiki.org/
Altered, Photoreceptor patterning
Source: https://aopwiki.org/
Altered, Photoreceptor patterning
Source: https://aopwiki.org/
Decreased retinoic acid (RA) synthesis
Source: https://aopwiki.org/
Decreased plasma RA level
Source: https://aopwiki.org/
Altered, Visual function
Source: https://aopwiki.org/
Altered, Visual function
Source: https://aopwiki.org/
Altered, Visual function
Pathways: TPOi eye size
Source: https://aopwiki.org/
Altered, Visual function
Source: https://aopwiki.org/
Altered, Visual function
Source: https://aopwiki.org/
Chronic reactive oxygen species
Source: https://aopwiki.org/
Porcupine-induced Wnt secretion and Wnt signaling activation
Source: https://aopwiki.org/
beta-catenin activation
Source: https://aopwiki.org/
Epithelial-mesenchymal transition
Source: https://aopwiki.org/
Epithelial-mesenchymal transition
Source: https://aopwiki.org/
Treatment-resistant gastric cancer
Source: https://aopwiki.org/
Increase, S-adenosylmethionine depletion
Source: https://aopwiki.org/
Antagonism, Thyroid Receptor
Source: https://aopwiki.org/
Antagonism, Thyroid Receptor
Source: https://aopwiki.org/
Inhibition of cystathionine beta-synthase
Source: https://aopwiki.org/
Increased Homocysteine level
Source: https://aopwiki.org/
Increased, Plasma HCY level
Source: https://aopwiki.org/
Induced, dysfunction of microcirculation
Source: https://aopwiki.org/
Induced, dysfunction of microcirculation
Source: https://aopwiki.org/
Impaired,anterior-posterior axis development
Source: https://aopwiki.org/
Substance - lung surfactant interaction
Source: https://aopwiki.org/
Inhibition of lung surfactant function
Source: https://aopwiki.org/
Alveolar collapse
Source: https://aopwiki.org/
Alveolar reopening
Source: https://aopwiki.org/
Loss of barrier function
Source: https://aopwiki.org/
Blood extravasation into the lungs
Source: https://aopwiki.org/
Reduced tidal volume
Source: https://aopwiki.org/
Impaired oxygenation of the blood
Source: https://aopwiki.org/
Acute inhalation toxicity
Source: https://aopwiki.org/
Frustrated phagocytosis
Source: https://aopwiki.org/
Frustrated phagocytosis
Source: https://aopwiki.org/
Increased, DNA damage and mutation
Source: https://aopwiki.org/
Increased, DNA damage and mutation
Source: https://aopwiki.org/
Increased, DNA damage and mutation
Source: https://aopwiki.org/
Increased, DNA damage and mutation
Source: https://aopwiki.org/
Increased, DNA damage and mutation
Source: https://aopwiki.org/
Increased, DNA damage and mutation
Source: https://aopwiki.org/
Lung cancer
Source: https://aopwiki.org/
Lung cancer
Source: https://aopwiki.org/
Lung cancer
Source: https://aopwiki.org/
Lung cancer
Source: https://aopwiki.org/
Lung cancer
Source: https://aopwiki.org/
Inhibition, TBX1
Source: https://aopwiki.org/
Disruption, Neural crest cell migration
Source: https://aopwiki.org/
Disruption, Progenitor cells of second heart field
Source: https://aopwiki.org/
Disruption, Progenitor cells of second heart field
Source: https://aopwiki.org/
Impairment, Fourth pharyngeal arch development
Source: https://aopwiki.org/
Abnormalities, Cardiac outflow tract formation
Source: https://aopwiki.org/
Anomalies, Congenital cardiac conotruncal
Source: https://aopwiki.org/
decrease, transcription of genes by AR
Source: https://aopwiki.org/
decrease, transcription of genes by AR
Source: https://aopwiki.org/
decrease, transcription of genes by AR
Source: https://aopwiki.org/
anogenital distance (AGD), decreased
Source: https://aopwiki.org/
anogenital distance (AGD), decreased
Source: https://aopwiki.org/
anogenital distance (AGD), decreased
Source: https://aopwiki.org/
anogenital distance (AGD), decreased
Source: https://aopwiki.org/
Antagonism, Androgen receptor
Source: https://aopwiki.org/
Antagonism, Androgen receptor
Source: https://aopwiki.org/
Antagonism, Androgen receptor
Source: https://aopwiki.org/
Antagonism, Androgen receptor
Source: https://aopwiki.org/
Antagonism, Androgen receptor
Source: https://aopwiki.org/
Antagonism, Androgen receptor
Source: https://aopwiki.org/
Decrease, testosterone levels
Source: https://aopwiki.org/
Antagonism,LH receptor
Source: https://aopwiki.org/
Reduction, Progesterone synthesis
Source: https://aopwiki.org/
Reduction, Plasma progesterone concentration
Source: https://aopwiki.org/
Reduction, progesterone uptake, decresed maturation
Source: https://aopwiki.org/
Impaired ovulation
Source: https://aopwiki.org/
Decrease of egg production and cummulative fecundity
Source: https://aopwiki.org/
Decrease of egg production and cummulative fecundity
Source: https://aopwiki.org/
Decline, Population trajectory
Source: https://aopwiki.org/
Decline, Population trajectory
Source: https://aopwiki.org/
Increase, DNA methyltransferase expression
Source: https://aopwiki.org/
Increase, hypermethylation of the promotor region of gonadotropin releasing hormone receptor
Source: https://aopwiki.org/
Decrease, expression of gonadotropin releasing hormone receptor
Source: https://aopwiki.org/
Impaired coordination and movement
Source: https://aopwiki.org/
Stimulation, TLR7/8
Source: https://aopwiki.org/
Increase, IL-23 from matured dendritic cells
Source: https://aopwiki.org/
Th17 cell migration and inflammation induction
Source: https://aopwiki.org/
Th17 cell migration and inflammation induction
Source: https://aopwiki.org/
Psoriatic skin disease
Source: https://aopwiki.org/
Binding to estrogen receptor (ER)-α in immune cells
Source: https://aopwiki.org/
Induction of GATA3 expression
Source: https://aopwiki.org/
Increase of Th2 cells producing IL-4
Source: https://aopwiki.org/
Increase of anti-DNA antibody from autoreactive B cell
Source: https://aopwiki.org/
Exacerbation of systemic lupus erythematosus (SLE)
Source: https://aopwiki.org/
Inhibition of JAK3
Source: https://aopwiki.org/
Blockade of STAT5 phosphorylation
Source: https://aopwiki.org/
Suppression of STAT5 binding to cytokine gene promoters
Source: https://aopwiki.org/
Suppression of IL-4 production
Source: https://aopwiki.org/
Impairment of T-cell dependent antibody response
Source: https://aopwiki.org/
Trypsin inhibition
Source: https://aopwiki.org/
Increased intestinal monitor peptide level
Source: https://aopwiki.org/
Increased blood CCK level
Source: https://aopwiki.org/
Increased exocrine secretion from pancreatic acinar cells
Source: https://aopwiki.org/
Acinar cell proliferation
Source: https://aopwiki.org/
Pancreatic acinar cell tumors
Source: https://aopwiki.org/
Decreased, Mitochondrial Fatty Acid Beta Oxidation
Source: https://aopwiki.org/
Induced dysregulation of ACE2
Source: https://aopwiki.org/
Induced dysregulation of ACE2
Source: https://aopwiki.org/
Induced dysregulation of ACE2
Source: https://aopwiki.org/
Increased Angiotensin II
Source: https://aopwiki.org/
Increased Angiotensin II
Source: https://aopwiki.org/
Increased Angiotensin II
Source: https://aopwiki.org/
Increased Angiotensin II
Source: https://aopwiki.org/
Increase plasma Ang II
Source: https://aopwiki.org/
Increase plasma Ang II
Source: https://aopwiki.org/
Binding to ACE2
Source: https://aopwiki.org/
Binding to ACE2
Source: https://aopwiki.org/
Binding to ACE2
Source: https://aopwiki.org/
Binding to ACE2
Source: https://aopwiki.org/
Binding to ACE2
Source: https://aopwiki.org/
Binding to ACE2
Source: https://aopwiki.org/
Binding to ACE2
Source: https://aopwiki.org/
Binding to ACE2
Source: https://aopwiki.org/
Binding to ACE2
Source: https://aopwiki.org/
Binding to ACE2
Source: https://aopwiki.org/
Binding to ACE2
Source: https://aopwiki.org/
Binding to ACE2
Source: https://aopwiki.org/
Binding to ACE2
Source: https://aopwiki.org/
Binding to ACE2
Source: https://aopwiki.org/
Binding to ACE2
Source: https://aopwiki.org/
Binding to ACE2
Source: https://aopwiki.org/
SARS-CoV-2 cell entry
Source: https://aopwiki.org/
SARS-CoV-2 cell entry
Source: https://aopwiki.org/
SARS-CoV-2 cell entry
Source: https://aopwiki.org/
SARS-CoV-2 cell entry
Source: https://aopwiki.org/
SARS-CoV-2 cell entry
Source: https://aopwiki.org/
SARS-CoV-2 cell entry
Source: https://aopwiki.org/
SARS-CoV-2 cell entry
Source: https://aopwiki.org/
SARS-CoV-2 cell entry
Source: https://aopwiki.org/
SARS-CoV-2 cell entry
Source: https://aopwiki.org/
SARS-CoV-2 cell entry
Source: https://aopwiki.org/
Increased inflammatory immune responses
Source: https://aopwiki.org/
Increased inflammatory immune responses
Source: https://aopwiki.org/
Increase, the risk of acute respiratory failure
Source: https://aopwiki.org/
Increase, the risk of acute respiratory failure
Source: https://aopwiki.org/
Increase, the risk of acute respiratory failure
Source: https://aopwiki.org/
Reduce, Sperm count
Source: https://aopwiki.org/
Reduce, Sperm count
Source: https://aopwiki.org/
Decreased, plasma 11-ketotestosterone level
Source: https://aopwiki.org/
Decreased, plasma 11-ketotestosterone level
Source: https://aopwiki.org/
Decreased, plasma 11-ketotestosterone level
Source: https://aopwiki.org/
Impaired, Spermatogenesis
Source: https://aopwiki.org/
Impaired, Spermatogenesis
Source: https://aopwiki.org/
Increase, Protein oxidation
Source: https://aopwiki.org/
Increase, Protein oxidation
Source: https://aopwiki.org/
Increase, Abnormal osmoregulation
Source: https://aopwiki.org/
Increase, Abnormal osmoregulation
Source: https://aopwiki.org/
Increase, Body fluid overload
Source: https://aopwiki.org/
Decrease, Mitochondrial membrane potential
Source: https://aopwiki.org/
Decrease, Mitochondrial membrane potential
Source: https://aopwiki.org/
Decrease, Mitochondrial membrane potential
Source: https://aopwiki.org/
Decrease, Mitochondrial membrane potential
Source: https://aopwiki.org/
Increased, Lipid peroxidation
Source: https://aopwiki.org/
Increased, Lipid peroxidation
Source: https://aopwiki.org/
Increased, Lipid peroxidation
Source: https://aopwiki.org/
Increased, Lipid peroxidation
Source: https://aopwiki.org/
Increased, Lipid peroxidation
Source: https://aopwiki.org/
Increased, Lipid peroxidation
Source: https://aopwiki.org/
Decrease, Neutral lipids
Source: https://aopwiki.org/
Increase, DNA double-strand break
Source: https://aopwiki.org/
Increase, DNA double-strand break
Source: https://aopwiki.org/
Increase, DNA double-strand break
Source: https://aopwiki.org/
Increase, DNA double-strand break
Source: https://aopwiki.org/
Increase, Formation of DNA photoproducts
Source: https://aopwiki.org/
Increase, Cripto-1 expression
Source: https://aopwiki.org/
Inhibition, Activin signaling
Source: https://aopwiki.org/
Inhibition, Fin regeneration
Source: https://aopwiki.org/
Urothelial cell injury/death
Source: https://aopwiki.org/
Urothelial Tumor
Source: https://aopwiki.org/
Decrease, Global DNA methylation
Source: https://aopwiki.org/
Decrease, Global DNA methylation
Source: https://aopwiki.org/
Decrease, Global DNA methylation
Source: https://aopwiki.org/
Decrease, Global DNA methylation
Source: https://aopwiki.org/
Increase, Caspase transcription
Source: https://aopwiki.org/
Increase, Caspase transcription
Source: https://aopwiki.org/
Increase, Caspase transcription
Source: https://aopwiki.org/
Increase, Caspase transcription
Source: https://aopwiki.org/
Increase, Ovarian somatic cell apoptosis
Source: https://aopwiki.org/
Increase, Ovarian somatic cell apoptosis
Source: https://aopwiki.org/
Increase, Ovarian somatic cell apoptosis
Source: https://aopwiki.org/
Decrease, Heritable DNA methylation (F3)
Source: https://aopwiki.org/
Decrease, Heritable DNA methylation (F3)
Source: https://aopwiki.org/
Increase, Caspase transcription (F3)
Source: https://aopwiki.org/
Increase, Caspase transcription (F3)
Source: https://aopwiki.org/
Increase, Oocyte apoptosis (F3)
Source: https://aopwiki.org/
Decrease, Oogenesis (F3)
Source: https://aopwiki.org/
Decrease, Oogenesis (F3)
Source: https://aopwiki.org/
Decrease, Fecundity (F3)
Source: https://aopwiki.org/
Decrease, Fecundity (F3)
Source: https://aopwiki.org/
Increase, Ovarian somatic cell apoptosis (F3)
Source: https://aopwiki.org/
Increase, Ovarian follicle breakdown (F3)
Source: https://aopwiki.org/
Inhibition, Chitin synthase 1
Source: https://aopwiki.org/
Inhibition, Chitin synthase 1
Source: https://aopwiki.org/
Decrease, Cuticular chitin content
Source: https://aopwiki.org/
Decrease, Cuticular chitin content
Source: https://aopwiki.org/
Decrease, Cuticular chitin content
Source: https://aopwiki.org/
Decrease, Cuticular chitin content
Source: https://aopwiki.org/
Increase, Premature molting
Source: https://aopwiki.org/
Increase, Premature molting
Source: https://aopwiki.org/
Increase, Premature molting
Source: https://aopwiki.org/
Increase, Premature molting
Source: https://aopwiki.org/
Increase, Premature molting
Source: https://aopwiki.org/
Increase, Premature molting
Source: https://aopwiki.org/
Increase, Sulfonylurea receptor binding
Source: https://aopwiki.org/
Increase, Sulfonylurea receptor binding
Source: https://aopwiki.org/
Increase, Cell membrane depolarization
Source: https://aopwiki.org/
Increase, Cell membrane depolarization
Source: https://aopwiki.org/
Increase, Cell membrane depolarization
Source: https://aopwiki.org/
Increase, Cell membrane depolarization
Source: https://aopwiki.org/
Increase, Opening of voltage-dependent calcium channel
Source: https://aopwiki.org/
Increase, Opening of voltage-dependent calcium channel
Source: https://aopwiki.org/
Nipple retention (NR), increased
Source: https://aopwiki.org/
Reduction, 17beta-estradiol synthesis by the undifferentiated gonad
Source: https://aopwiki.org/
Reduction, 17beta-estradiol synthesis by the undifferentiated gonad
Source: https://aopwiki.org/
Increased, Differentiation to Testis
Source: https://aopwiki.org/
Increased, Differentiation to Testis
Source: https://aopwiki.org/
Increased, Male Biased Sex Ratio
Source: https://aopwiki.org/
Increased, Male Biased Sex Ratio
Source: https://aopwiki.org/
Toll-like receptor 4 activation
Source: https://aopwiki.org/
Activator protein 1 activation
Source: https://aopwiki.org/
Pin-1 activation
Source: https://aopwiki.org/
Latent Transforming growth Factor beta expression
Source: https://aopwiki.org/
Inhibition of 11β-HSD
Source: https://aopwiki.org/
11β-hydroxylase inhibition
Source: https://aopwiki.org/
Decreased spermatogenesis
Source: https://aopwiki.org/
Decreased spermatogenesis
Source: https://aopwiki.org/
Decreased spermatogenesis
Source: https://aopwiki.org/
Granulosa cell proliferation of gonadotropin-independent follicles, Reduced
Source: https://aopwiki.org/
Inhibition, Chitinase
Source: https://aopwiki.org/
Decrease, Digestion of old cuticle
Source: https://aopwiki.org/
Decrease, Digestion of old cuticle
Source: https://aopwiki.org/
Inhibition, Chitobiase
Source: https://aopwiki.org/
Decrease, ATP synthase activity
Source: https://aopwiki.org/
Decrease, ATP synthase activity
Source: https://aopwiki.org/
Increase, Tissue/organ damage
Source: https://aopwiki.org/
Increase, Tissue/organ damage
Source: https://aopwiki.org/
Increase, Tissue/organ damage
Source: https://aopwiki.org/
Increase, Tissue/organ damage
Source: https://aopwiki.org/
Increase, Tissue/organ damage
Source: https://aopwiki.org/
Increase, Tissue/organ damage
Source: https://aopwiki.org/
Increase, Tissue/organ damage
Source: https://aopwiki.org/
Decrease, Plasma membrane ATPase activity
Source: https://aopwiki.org/
Increase, Mitochondrial complex III dysfunction
Source: https://aopwiki.org/
Increase, Mitochondrial complex III dysfunction
Source: https://aopwiki.org/
Increase, Cytochrome c release
Source: https://aopwiki.org/
Increase, Cytochrome c release
Source: https://aopwiki.org/
Increase, Mitochondrial complex I dysfunction
Source: https://aopwiki.org/
Increase, Mitochondrial complex I dysfunction
Source: https://aopwiki.org/
benzoquinone imine and acylglucuronide metabolites
Pathways: Hepatitis
Source: https://aopwiki.org/
Mitochondrial dysfunction
Pathways: Hepatitis
Source: https://aopwiki.org/
Mitochondrial dysfunction
Pathways: tau-AOP
Source: https://aopwiki.org/
Mitochondrial dysfunction
Source: https://aopwiki.org/
Mitochondrial dysfunction
Source: https://aopwiki.org/
Mitochondrial dysfunction
Source: https://aopwiki.org/
Activation of ER stress
Pathways: Hepatitis
Source: https://aopwiki.org/
Activation of ER stress
Source: https://aopwiki.org/
Apoptotic cell death
Pathways: Hepatitis
Source: https://aopwiki.org/
Apoptotic cell death
Source: https://aopwiki.org/
Immune cell activation
Pathways: Hepatitis
Source: https://aopwiki.org/
IFNγ signaling
Pathways: Hepatitis
Source: https://aopwiki.org/
Immune mediated hepatitis
Pathways: Hepatitis
Source: https://aopwiki.org/
Decrease, Cell proliferation
Source: https://aopwiki.org/
Decrease, Cell proliferation
Source: https://aopwiki.org/
Decrease, Cell proliferation
Source: https://aopwiki.org/
Decrease, Cell proliferation
Source: https://aopwiki.org/
Decrease, Cell proliferation
Source: https://aopwiki.org/
Decrease, Cell proliferation
Source: https://aopwiki.org/
Decrease, Cell proliferation
Source: https://aopwiki.org/
Decrease, Cell proliferation
Source: https://aopwiki.org/
Maturation of TNF/iNOS-Producing Dendritic Cells
Source: https://aopwiki.org/
Decrease, Lipid storage
Source: https://aopwiki.org/
Decrease, Lipid storage
Source: https://aopwiki.org/
Decrease, Fatty acid β-oxidation
Source: https://aopwiki.org/
Increase, Cell death
Source: https://aopwiki.org/
Increase, Cell death
Source: https://aopwiki.org/
Increase, Cell death
Source: https://aopwiki.org/
Increase, Cell death
Source: https://aopwiki.org/
Increase, Cell death
Source: https://aopwiki.org/
Increase, Cell death
Source: https://aopwiki.org/
Increase, Cell death
Source: https://aopwiki.org/
Increase, Cell death
Source: https://aopwiki.org/
Increase, Cell death
Source: https://aopwiki.org/
Increase, Cell death
Source: https://aopwiki.org/
Increase, Cell death
Source: https://aopwiki.org/
Increase, Cell death
Source: https://aopwiki.org/
Increase, Cell death
Source: https://aopwiki.org/
Increase, Cell death
Source: https://aopwiki.org/
Increase, Cell death
Source: https://aopwiki.org/
Increase, Cell death
Source: https://aopwiki.org/
Increase, Oxygen consumption
Source: https://aopwiki.org/
Increase, Oxygen consumption
Source: https://aopwiki.org/
Increase, Oxygen consumption
Source: https://aopwiki.org/
Increase, Global DNA methylation
Source: https://aopwiki.org/
Increased, Thyroxine (T4) in serum
Source: https://aopwiki.org/
Altered, Thyroid hormone-dependent gene expression
Source: https://aopwiki.org/
Altered, Thyroid hormone-dependent gene expression
Source: https://aopwiki.org/
Altered, Thyroid hormone-dependent gene expression
Source: https://aopwiki.org/
Altered, Thyroid hormone-dependent gene expression
Source: https://aopwiki.org/
Displacement, Serum thyroxine (T4) from carrier protein
Source: https://aopwiki.org/
Displacement, Serum thyroxine (T4) from carrier protein
Source: https://aopwiki.org/
Binding, Thyroid binding globulin in serum
Source: https://aopwiki.org/
Impaired lung function
Source: https://aopwiki.org/
Decrease, Acyl-CoA dehydrogenases
Source: https://aopwiki.org/
impaired fertility
Source: https://aopwiki.org/
impaired fertility
Source: https://aopwiki.org/
Cortisol and 11β-(OH) testosterone decreased
Source: https://aopwiki.org/
Decreased plasma Cortisol level
Source: https://aopwiki.org/
decreased oocyte maturation
Source: https://aopwiki.org/
Testicular Cancer
Source: https://aopwiki.org/
Inhibition, cytochrome oxidase
Source: https://aopwiki.org/
Encephalitis
Source: https://aopwiki.org/
Encephalitis
Source: https://aopwiki.org/
Prolonged TLR9 activation
Source: https://aopwiki.org/
systemic inflammatory response syndrome
Source: https://aopwiki.org/
systemic inflammatory response syndrome
Source: https://aopwiki.org/
Multi Organ Failure involving Acute Respiratory Distress Syndrome
Source: https://aopwiki.org/
Toll Like Receptor (TLR) Dysregulation
Source: https://aopwiki.org/
Toll Like Receptor (TLR) Dysregulation
Source: https://aopwiki.org/
Toll Like Receptor (TLR) Dysregulation
Source: https://aopwiki.org/
Increased SARS-CoV-2 production
Source: https://aopwiki.org/
Increased SARS-CoV-2 production
Source: https://aopwiki.org/
Increased SARS-CoV-2 production
Source: https://aopwiki.org/
Increased SARS-CoV-2 production
Source: https://aopwiki.org/
Increased SARS-CoV-2 production
Source: https://aopwiki.org/
Increased SARS-CoV-2 production
Source: https://aopwiki.org/
Increased SARS-CoV-2 production
Source: https://aopwiki.org/
Increased SARS-CoV-2 production
Source: https://aopwiki.org/
Coagulation
Source: https://aopwiki.org/
Thrombosis and Disseminated Intravascular Coagulation
Source: https://aopwiki.org/
Thrombosis and Disseminated Intravascular Coagulation
Source: https://aopwiki.org/
Thrombosis and Disseminated Intravascular Coagulation
Source: https://aopwiki.org/
Impaired gustatory nerve
Source: https://aopwiki.org/
dysgeusia
Source: https://aopwiki.org/
Downregulation, ACE2
Source: https://aopwiki.org/
Downregulation, ACE2
Source: https://aopwiki.org/
Downregulation, ACE2
Source: https://aopwiki.org/
Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)
Source: https://aopwiki.org/
Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)
Source: https://aopwiki.org/
Increased activation, Nuclear factor kappa B (NF-kB)
Source: https://aopwiki.org/
Increased activation, Nuclear factor kappa B (NF-kB)
Source: https://aopwiki.org/
Increased activation, Nuclear factor kappa B (NF-kB)
Source: https://aopwiki.org/
Increased activation, Nuclear factor kappa B (NF-kB)
Source: https://aopwiki.org/
Induced, Angiotensin (Ang) II accumulation
Source: https://aopwiki.org/
Induced, Angiotensin (Ang) II accumulation
Source: https://aopwiki.org/
Increased Ang II type 1 receptor (AT1R)
Source: https://aopwiki.org/
Increased Ang II type 1 receptor (AT1R)
Source: https://aopwiki.org/
Hyperactivation of ACE/Ang-II/AT1R axis
Source: https://aopwiki.org/
Hyperactivation of ACE/Ang-II/AT1R axis
Source: https://aopwiki.org/
Dysregulation, ACE2 expression and activity
Source: https://aopwiki.org/
Dysregulation, ACE2 expression and activity
Source: https://aopwiki.org/
Dysregulation, ACE2 expression and activity
Source: https://aopwiki.org/
Imbalanced salty and sweet taste responses
Source: https://aopwiki.org/
Increased Sodium-sensitive hypertension
Source: https://aopwiki.org/
Increased viral transcription and replication
Source: https://aopwiki.org/
Increase, D1 protein deactivation
Source: https://aopwiki.org/
Decrease, Photosystem II efficiency
Source: https://aopwiki.org/
Decrease, Photosystem II efficiency
Source: https://aopwiki.org/
Decrease, Reproduction
Source: https://aopwiki.org/
Decrease, Reproduction
Source: https://aopwiki.org/
Decrease, Reproduction
Source: https://aopwiki.org/
Decrease, Reproduction
Source: https://aopwiki.org/
Decrease, Reproduction
Source: https://aopwiki.org/
Decrease, Reproduction
Source: https://aopwiki.org/
Decrease, Reproduction
Source: https://aopwiki.org/
Decrease, Reproduction
Source: https://aopwiki.org/
Increase, Programmed cell death
Source: https://aopwiki.org/
Increase, Oxygen-evolving complex damage
Source: https://aopwiki.org/
Diminished protective oxidative stress response
Source: https://aopwiki.org/
Diminished protective oxidative stress response
Source: https://aopwiki.org/
Diminished protective oxidative stress response
Source: https://aopwiki.org/
Diminished protective oxidative stress response
Source: https://aopwiki.org/
Diminished protective oxidative stress response
Source: https://aopwiki.org/
Fibrinolysis, decreased
Source: https://aopwiki.org/
Bradykinin system, hyperactivated
Source: https://aopwiki.org/
Hyperinflammation
Source: https://aopwiki.org/
Hyperinflammation
Source: https://aopwiki.org/
Hyperinflammation
Source: https://aopwiki.org/
Hyperinflammation
Source: https://aopwiki.org/
Sustentacular cells, decrease
Source: https://aopwiki.org/
olfactory sensory neurons, decrease
Source: https://aopwiki.org/
Olfactory epithelium degeneration
Source: https://aopwiki.org/
impaired olfactory function (anosmia)
Source: https://aopwiki.org/
blood brain barrier disruption
Source: https://aopwiki.org/
Cerebrovascular disease (stroke)
Source: https://aopwiki.org/
Altered, retinal layer structure
Source: https://aopwiki.org/
Decreased, Eye size
Pathways: TPOi eye size
Source: https://aopwiki.org/
Decreased, Eye size
Source: https://aopwiki.org/
Decreased, Population size
Source: https://aopwiki.org/
Bulky DNA adducts, increase
Source: https://aopwiki.org/
Inhibition of ALDH1A (RALDH)
Source: https://aopwiki.org/
Inhibition of ALDH1A (RALDH)
Source: https://aopwiki.org/
Decreased, all-trans retinoic acid (atRA) concentration
Source: https://aopwiki.org/
Decreased, all-trans retinoic acid (atRA) concentration
Source: https://aopwiki.org/
Disrupted meiotic initiation of fetal oogonia of the ovary
Source: https://aopwiki.org/
Reduced size of the ovarian follicle pool
Source: https://aopwiki.org/
Inhibition of Fyna
Source: https://aopwiki.org/
Inhibition of Plxna2
Source: https://aopwiki.org/
Overexpression of rasl11b
Source: https://aopwiki.org/
Increased (ectopic) all-trans retinoic acid concentration
Source: https://aopwiki.org/
Premature initiation of meiosis in fetal male germ cells
Source: https://aopwiki.org/
Decrease (loss of) fetal male germ cells
Source: https://aopwiki.org/
abnormal, placental labyrinth vasculature morphology
Source: https://aopwiki.org/
increase, placental insufficiency
Source: https://aopwiki.org/
increase, Preeclampsia
Source: https://aopwiki.org/
NLRP3 inflammasome activity, increased
Source: https://aopwiki.org/
NLRP3 inflammasome activity, increased
Source: https://aopwiki.org/
NLRP3 inflammasome activity, increased
Source: https://aopwiki.org/
Genomic instability
Source: https://aopwiki.org/
Genomic instability
Source: https://aopwiki.org/
increased MyD88 activation
Source: https://aopwiki.org/
increased release of danger/damage associated molecular patterns
Source: https://aopwiki.org/
increased platelet surface TLR9 expression
Source: https://aopwiki.org/
formation of neutrophil extracellular traps (NETs)
Source: https://aopwiki.org/
Platelet-neutrophil interactions, Increased
Source: https://aopwiki.org/
Platelet-neutrophil interactions, Increased
Source: https://aopwiki.org/
Repression of Gbx2 expression
Source: https://aopwiki.org/
foxi1 expression, increased
Source: https://aopwiki.org/
six1b expression, increased
Source: https://aopwiki.org/
eya1 expression, inhibited
Source: https://aopwiki.org/
Cystic Fibrosis Transmembrane Regulator Function, Decreased
Source: https://aopwiki.org/
Cystic Fibrosis Transmembrane Regulator Function, Decreased
Source: https://aopwiki.org/
Airway Surface Liquid Height, Decreased
Source: https://aopwiki.org/
Airway Surface Liquid Height, Decreased
Source: https://aopwiki.org/
Cilia Beat Frequency, Decreased
Source: https://aopwiki.org/
Cilia Beat Frequency, Decreased
Source: https://aopwiki.org/
Cilia Beat Frequency, Decreased
Source: https://aopwiki.org/
Mucociliary Clearance, Decreased
Source: https://aopwiki.org/
Mucociliary Clearance, Decreased
Source: https://aopwiki.org/
Mucociliary Clearance, Decreased
Source: https://aopwiki.org/
Mucus Viscosity, Increased
Source: https://aopwiki.org/
FOXJ1 Protein, Decreased
Source: https://aopwiki.org/
FOXJ1 Protein, Decreased
Source: https://aopwiki.org/
Motile Cilia Number/Length, Decreased
Source: https://aopwiki.org/
Motile Cilia Number/Length, Decreased
Source: https://aopwiki.org/
Endothelial cell dysfunction
Source: https://aopwiki.org/
Endothelial cell dysfunction
Source: https://aopwiki.org/
Platelet activation, Increased
Source: https://aopwiki.org/
Neutrophil activation, Increased
Source: https://aopwiki.org/
Thromboinflammation, Increased
Source: https://aopwiki.org/
Altered gene expression, NRF2 dependent antioxidant pathway
Source: https://aopwiki.org/
Altered gene expression, NRF2 dependent antioxidant pathway
Pathways: 1
Source: https://aopwiki.org/
Altered gene expression, NRF2 dependent antioxidant pathway
Source: https://aopwiki.org/
Altered gene expression, TGF-β dependent fibrosis pathway
Source: https://aopwiki.org/
Altered gene expression, NF-kB dependent Interleukin-6 pathway
Source: https://aopwiki.org/
Altered gene expression, NF-kB dependent Interleukin-6 pathway
Source: https://aopwiki.org/
Altered gene expression, AHR nuclear translocator (ARNT)-dependent pathway
Source: https://aopwiki.org/
Altered gene expression, AHR nuclear translocator (ARNT)-dependent pathway
Source: https://aopwiki.org/
Increased, Reactive metabolites production
Source: https://aopwiki.org/
Altered gene expression, P53 dependent apoptosis pathway
Source: https://aopwiki.org/
altered, inner ear development
Source: https://aopwiki.org/
Increased, Interleukin-6 production
Source: https://aopwiki.org/
Myocardial Infarction
Source: https://aopwiki.org/
Angiotensin (1-7) levels diminished
Source: https://aopwiki.org/
Angiotensin II degradation reduced
Source: https://aopwiki.org/
ADAM17 expression induction
Source: https://aopwiki.org/
ACE2 increased shedding
Source: https://aopwiki.org/
Intestinal barrier, disruption
Source: https://aopwiki.org/
Intestinal barrier, disruption
Source: https://aopwiki.org/
Gastrointestinal disorders
Source: https://aopwiki.org/
Gastrointestinal disorders
Source: https://aopwiki.org/
Interferon-I antiviral response, antagonized by SARS-CoV-2
Source: https://aopwiki.org/
Interferon-I antiviral response, antagonized by SARS-CoV-2
Source: https://aopwiki.org/
Interferon-I antiviral response, antagonized by SARS-CoV-2
Source: https://aopwiki.org/
Interferon-I antiviral response, antagonized by SARS-CoV-2
Source: https://aopwiki.org/
Interferon-I antiviral response, antagonized by SARS-CoV-2
Source: https://aopwiki.org/
Viral infection and host-to-host transmission, proliferated
Source: https://aopwiki.org/
Hyperphosphorylation of Tau
Pathways: tau-AOP
Source: https://aopwiki.org/
Dysfunctional Autophagy
Pathways: tau-AOP
Source: https://aopwiki.org/
Dysfunctional Autophagy
Source: https://aopwiki.org/
Accumulation, Cytosolic toxic Tau oligomers
Pathways: tau-AOP
Source: https://aopwiki.org/
Synaptic dysfunction
Pathways: tau-AOP
Source: https://aopwiki.org/
Synaptic dysfunction
Source: https://aopwiki.org/
Synaptic dysfunction
Source: https://aopwiki.org/
Memory Loss
Pathways: tau-AOP
Source: https://aopwiki.org/
Impaired mechanotransduction of pericytes
Source: https://aopwiki.org/
Pericyte dysfunction
Source: https://aopwiki.org/
Increased ACE2 expression
Source: https://aopwiki.org/
Increases in cellular reactive oxygen species
Source: https://aopwiki.org/
Increase, TNF
Source: https://aopwiki.org/
Decrease, GLUT4
Source: https://aopwiki.org/
Decrease, Glucose uptake
Source: https://aopwiki.org/
Abnormal, Glucose homeostasis
Source: https://aopwiki.org/
Gestational diabetes mellitus
Source: https://aopwiki.org/
Gut microbiota, alteration
Source: https://aopwiki.org/
Gut microbiota, alteration
Source: https://aopwiki.org/
Acute Myeloid Leukemia
Source: https://aopwiki.org/
Binding to hERG channel
Source: https://aopwiki.org/
hERG channel biogenesis interference
Source: https://aopwiki.org/
Direct hERG channel blockage
Source: https://aopwiki.org/
Induction of hERG trafficking defects
Source: https://aopwiki.org/
Inhibition of Ikr
Source: https://aopwiki.org/
Prolongation of Action Potential Duration
Source: https://aopwiki.org/
Prolongation of QT interval
Source: https://aopwiki.org/
Torsades de Pointes
Source: https://aopwiki.org/
Sudden cardiac death
Source: https://aopwiki.org/
Pyroptosis
Source: https://aopwiki.org/
Increase, Pollen abnormal
Source: https://aopwiki.org/
Inhibition, Mitochondrial Electron Transport Chain Complexes
Source: https://aopwiki.org/
Inhibition, Mitochondrial Electron Transport Chain Complexes
Source: https://aopwiki.org/
Inhibition, Mitochondrial Electron Transport Chain Complexes
Source: https://aopwiki.org/
Inhibition, Mitochondrial Electron Transport Chain Complexes
Source: https://aopwiki.org/
Increase, Mitochondrial Dysfunction
Source: https://aopwiki.org/
Increase, Mitochondrial Dysfunction
Source: https://aopwiki.org/
Increase, Mitochondrial Dysfunction
Source: https://aopwiki.org/
Increase, Mitochondrial Dysfunction
Source: https://aopwiki.org/
Increase, Mitochondrial Dysfunction
Source: https://aopwiki.org/
Increase, Oxidative Stress
Source: https://aopwiki.org/
Increase, Oxidative Stress
Source: https://aopwiki.org/
Increase, Oxidative Stress
Source: https://aopwiki.org/
Increase, Oxidative Stress
Source: https://aopwiki.org/
Increase, Oxidative Stress
Source: https://aopwiki.org/
Increase, Oxidative Stress
Source: https://aopwiki.org/
Increase, Oxidative Stress
Source: https://aopwiki.org/
transposition of the great arteries
Source: https://aopwiki.org/
Increased, tumor growth
Source: https://aopwiki.org/
Increased, Steroidogenic acute regulatory protein (StAR)
Source: https://aopwiki.org/
Increased, estrogens
Source: https://aopwiki.org/
Increased, estrogens
Source: https://aopwiki.org/
Activation of Tumor Protein 53
Source: https://aopwiki.org/
premature cell differentiation
Source: https://aopwiki.org/
microcephaly
Source: https://aopwiki.org/
Disruption of sodium channel gating kinetics
Source: https://aopwiki.org/
Disruption of sodium channel gating kinetics
Source: https://aopwiki.org/
Increase risk, microcephaly
Source: https://aopwiki.org/
Premature cell differentiation
Source: https://aopwiki.org/
Increased microRNA expression
Source: https://aopwiki.org/
Decreased SIRT1 expression
Source: https://aopwiki.org/
metastatic breast cancer
Source: https://aopwiki.org/
Disruption, action potential
Source: https://aopwiki.org/
Agonism, Estrogen Receptor alpha
Source: https://aopwiki.org/
Increased, Kisspeptin signalling
Source: https://aopwiki.org/
Decreased, Gonadotropins
Source: https://aopwiki.org/
Decreased, Androgen and Progestin
Source: https://aopwiki.org/
Decreased, Maturation Inducing Steroid Surge by Granulosa cells
Source: https://aopwiki.org/
Impaired, Oocyte maturation and ovulation
Source: https://aopwiki.org/
Increased, Oocyte Atresia
Source: https://aopwiki.org/
Impaired, Reproduction
Source: https://aopwiki.org/
Altered neurotransmission in development
Source: https://aopwiki.org/
Secondary genotoxicity
Source: https://aopwiki.org/
Non-coding RNA expression profile alteration
Source: https://aopwiki.org/
Activation of inflammation pathway
Source: https://aopwiki.org/
Activation of inflammation pathway
Source: https://aopwiki.org/
Activation of inflammation pathway
Source: https://aopwiki.org/
Pulmonary inflammation
Source: https://aopwiki.org/
Pulmonary inflammation
Source: https://aopwiki.org/
Emphysema
Source: https://aopwiki.org/
Fibroblast proliferation and differentiation
Source: https://aopwiki.org/
Airway remodeling
Source: https://aopwiki.org/
Chronic obstructive pulmonary disease
Source: https://aopwiki.org/
Viable offspring, decreased
Source: https://aopwiki.org/
protein-coupled estrogen receptor 1 (GPER) activation
Source: https://aopwiki.org/
Abnormal lipid metabolism
Source: https://aopwiki.org/
Activation, PARP1
Source: https://aopwiki.org/
Releasing, Apoptosis-Inducing Factor (AIF)
Source: https://aopwiki.org/
Altered function of the brain
Source: https://aopwiki.org/
Inhibition of Ceramide Synthase
Source: https://aopwiki.org/
Reduced complex sphingolipids
Source: https://aopwiki.org/
Affected folate transporter
Source: https://aopwiki.org/
decreased folate uptake
Source: https://aopwiki.org/
Increased sphingolipid-1-phosphate
Source: https://aopwiki.org/
Endoplasmic reticulum stress
Source: https://aopwiki.org/
Endoplasmic reticulum stress
Source: https://aopwiki.org/
Insulin resistance
Source: https://aopwiki.org/
Insulin resistance
Source: https://aopwiki.org/
Insulin resistance
Source: https://aopwiki.org/
Non-alcoholic fatty liver disease
Source: https://aopwiki.org/
Increase, slincR expression
Source: https://aopwiki.org/
Increase, slincR expression
Source: https://aopwiki.org/
Decrease, sox9 expression
Source: https://aopwiki.org/
Decrease, sox9 expression
Source: https://aopwiki.org/
Antagonism, Smoothened receptor
Source: https://aopwiki.org/
Decrease, GLI1/2 translocation to nucleus
Source: https://aopwiki.org/
Decrease, GLI1/2 translocation to nucleus
Source: https://aopwiki.org/
liver dysfunction
Source: https://aopwiki.org/
Activation of metabotropic glutamate receptor
Source: https://aopwiki.org/
Inositol triphosphate receptor activation
Source: https://aopwiki.org/
Inositol triphosphate receptor activation
Source: https://aopwiki.org/
Inhibition GABAA receptor
Source: https://aopwiki.org/
Activation of calpain signalling
Source: https://aopwiki.org/
Decrease, GLI1/2 target gene expression
Source: https://aopwiki.org/
Decrease, GLI1/2 target gene expression
Source: https://aopwiki.org/
Decrease, GLI1/2 target gene expression
Source: https://aopwiki.org/
Decrease, palatal shelf outgrowth
Source: https://aopwiki.org/
Decrease, palatal shelf outgrowth
Source: https://aopwiki.org/
Decrease, palatal shelf outgrowth
Source: https://aopwiki.org/
Orofacial clefting
Source: https://aopwiki.org/
Orofacial clefting
Source: https://aopwiki.org/
Orofacial clefting
Source: https://aopwiki.org/
Decrease, Sonic Hedgehog second messenger production
Source: https://aopwiki.org/
Decrease, Sonic Hedgehog second messenger production
Source: https://aopwiki.org/
Decrease, Sonic Hedgehog second messenger production
Source: https://aopwiki.org/
Decrease, Smoothend relocation and activation
Source: https://aopwiki.org/
Increase, Alcohol dehydrogenase
Source: https://aopwiki.org/
Increase, Vitellogenin mRNA
Source: https://aopwiki.org/
Delay, Ovarian maturation
Source: https://aopwiki.org/
Increase, Body volume of female adults
Source: https://aopwiki.org/
Increase, sex ratio (F/M)
Source: https://aopwiki.org/
Increase, developmental abnormalities
Source: https://aopwiki.org/
Increase, developmental abnormalities
Source: https://aopwiki.org/
Decrease, Tyrosine
Source: https://aopwiki.org/
Decrease, dopa decarboxylase
Source: https://aopwiki.org/
Increase, Defects in tanning of new cuticle
Source: https://aopwiki.org/
Increase, impairment of cuticle sclerotization
Source: https://aopwiki.org/
Increase, pigmentation
Source: https://aopwiki.org/
Increase, delay in oviposition
Source: https://aopwiki.org/
Decrease, hatching of egg
Source: https://aopwiki.org/
Decrease, 20-hydroxyecdysone
Source: https://aopwiki.org/
Decrease, knickkopf gene
Source: https://aopwiki.org/
Decrease, Chitin laminar organization
Source: https://aopwiki.org/
Decrease, Prevent chitin degradation by chitinases
Source: https://aopwiki.org/
Weak, Procuticle protection
Source: https://aopwiki.org/
Decrease, New cuticle secretion
Source: https://aopwiki.org/
Increase, Cytosolic calcium
Source: https://aopwiki.org/
Inhibition, Fatty acid oxidation
Source: https://aopwiki.org/
Altered Signaling Pathways
Source: https://aopwiki.org/
Altered Signaling Pathways
Source: https://aopwiki.org/
Altered Signaling Pathways
Source: https://aopwiki.org/
Altered, Nitric Oxide Levels
Source: https://aopwiki.org/
Increase, Endothelial Dysfunction
Source: https://aopwiki.org/
Vascular remodeling
Source: https://aopwiki.org/
Occurrence, Vascular Remodeling
Source: https://aopwiki.org/
Increase, Glycolysis
Source: https://aopwiki.org/
Decrease, Glucose pool
Source: https://aopwiki.org/
Increase, Mitochondrial swelling
Source: https://aopwiki.org/
increase oxidation of the di-copper moiety of the hemocyanin active site
Source: https://aopwiki.org/
Decreased, oxygen binding capacity by hemocyanin
Source: https://aopwiki.org/
Cognitive, sensed as hypoxic/low oxygen environment
Source: https://aopwiki.org/
Increase, hemocyanin mRNA
Source: https://aopwiki.org/
Increase, pulmonate breathing
Source: https://aopwiki.org/
Loss of drebrin
Source: https://aopwiki.org/
Loss of drebrin
Source: https://aopwiki.org/
Increased, glycolipid levels
Source: https://aopwiki.org/
Impaired, blood testis barrier
Source: https://aopwiki.org/
Increased Modified Proteins
Source: https://aopwiki.org/
Occurrence of Cataracts
Source: https://aopwiki.org/
Increase, Cardiac remodelling
Source: https://aopwiki.org/
Pulmonary epithelial injury
Source: https://aopwiki.org/
Airway inflammation
Source: https://aopwiki.org/
Increased incidence of respiratory disease
Source: https://aopwiki.org/
Dysfunction of respiratory system
Source: https://aopwiki.org/
Hypospadias, increased
Source: https://aopwiki.org/
Altered Bone Cell Homeostasis
Source: https://aopwiki.org/
Increase, Bone Remodeling
Source: https://aopwiki.org/
Occurrence, bone loss
Source: https://aopwiki.org/
Promotion, Ovarian Cancer
Source: https://aopwiki.org/
Brain thyroid hormone (T4/T3) decreased
Source: https://aopwiki.org/
Abnormal, neuroblast migration
Source: https://aopwiki.org/
Periventricular heterotopia formation
Source: https://aopwiki.org/
Occurrence, (Micro)vascular dysfunction
Source: https://aopwiki.org/
Increase, Pro-Inflammatory Mediators
Source: https://aopwiki.org/
Increase, Neural Remodeling
Source: https://aopwiki.org/
hERG channel blockade
Source: https://aopwiki.org/
Inhibition of rapid delayed rectifying potassium current
Source: https://aopwiki.org/
Increased,Cardiac Dysregulation
Source: https://aopwiki.org/
Decreased, thyroid hormone binding to thyroid hormone receptor
Source: https://aopwiki.org/
Decreased, myelin basic protein expression in oligodendrocytes
Source: https://aopwiki.org/
Impaired, oligodendrocyte maturation
Source: https://aopwiki.org/
Hypomyelination
Source: https://aopwiki.org/
Hypomyelination
Source: https://aopwiki.org/
Hypomyelination
Source: https://aopwiki.org/
Hypomyelination
Source: https://aopwiki.org/
Altered, white brain matter
Source: https://aopwiki.org/
Altered, white brain matter
Source: https://aopwiki.org/
Altered, white brain matter
Source: https://aopwiki.org/
Altered, white brain matter
Source: https://aopwiki.org/
Binding, extracellular matrix protein laminin
Source: https://aopwiki.org/
Disrupted binding, laminin-beta1-integrin receptors with laminin
Source: https://aopwiki.org/
Decreased, neural progenitor cell adhesion to laminin
Source: https://aopwiki.org/
Disturbed, radial glia cell alignment and migration
Source: https://aopwiki.org/
Decreased, radial glia cell density
Source: https://aopwiki.org/
Disturbed, cortical architecture
Source: https://aopwiki.org/
Altered, cholesterol metabolism
Source: https://aopwiki.org/
Decreased, oligodendrocyte differentiation
Source: https://aopwiki.org/
Decreased, oligodendrocyte differentiation
Source: https://aopwiki.org/
Decreased, oligodendrocyte differentiation
Source: https://aopwiki.org/
Increase, goblet cell number
Source: https://aopwiki.org/
Activation, Microglia
Source: https://aopwiki.org/
Succinate dehydrogenase, inhibited
Source: https://aopwiki.org/
Superoxide generation, increased
Source: https://aopwiki.org/
Insulin resistance, increased
Source: https://aopwiki.org/
decreased, Bcl-2 expression
Source: https://aopwiki.org/
increased, Bax expression
Source: https://aopwiki.org/
decreased, Intellectual Quotient
Source: https://aopwiki.org/
increased, Economic Burden
Source: https://aopwiki.org/
Increased adipocyte size
Source: https://aopwiki.org/
Increased adipocyte numbers
Source: https://aopwiki.org/
Metabolically unhealthy Obesity
Source: https://aopwiki.org/
Conjugation, GSH
Source: https://aopwiki.org/
Estrogen receptor alpha inactivation
Source: https://aopwiki.org/
Estrogen receptor alpha inactivation
Source: https://aopwiki.org/
Increased fat mass
Source: https://aopwiki.org/
increased lipid accumulation
Source: https://aopwiki.org/
Increased pro-inflammatory cytokine expression
Source: https://aopwiki.org/
Increase, Glucuronidation of T4
Source: https://aopwiki.org/
Increase, Androgen receptor
Source: https://aopwiki.org/
prostatic intraepithelial neoplasia
Source: https://aopwiki.org/
Prostate cancer
Source: https://aopwiki.org/
Increase, Gonadotropins concentration in plasma
Source: https://aopwiki.org/
Reduction,Testosterone concentration in plasma
Source: https://aopwiki.org/
Reduction, the ratio of 17beta-estradiol/11-Keto Testosterone in plasma
Source: https://aopwiki.org/
Decreased spawning and cumulative fecundity, decreased gonadosomatic index
Source: https://aopwiki.org/
Disruption, Estrogen receptor
Source: https://aopwiki.org/
Depletion, Ectoplasmic specialization (ES)
Source: https://aopwiki.org/
Increased, gene expression of AR
Source: https://aopwiki.org/
Impaired insulin signaling
Source: https://aopwiki.org/
Metabolic syndrome
Source: https://aopwiki.org/
Decreased, Viable Offspring
Source: https://aopwiki.org/
Increased LCN2/iron complex binds to SLC22A17 receptor in neuron
Source: https://aopwiki.org/
Increased intracelluar Iron accumulation
Source: https://aopwiki.org/
Increased intracelluar Iron accumulation
Source: https://aopwiki.org/
Neurological disorder
Source: https://aopwiki.org/
Neurological disorder
Source: https://aopwiki.org/
Neurological disorder
Source: https://aopwiki.org/
Opening, voltage-gated calcium channels
Source: https://aopwiki.org/
Activation, caspases
Source: https://aopwiki.org/
Increase, CNS Neural cell death
Source: https://aopwiki.org/
Decrease, elavl3
Source: https://aopwiki.org/
Decrease, sox10
Source: https://aopwiki.org/
Decrease, mbp
Source: https://aopwiki.org/
Disruption, neurotransmitter release
Source: https://aopwiki.org/
Disruption, neurotransmitter release
Source: https://aopwiki.org/
Decreased, Ionotropic GABA receptor chloride channel conductance
Source: https://aopwiki.org/
Ryanodine receptor activation
Source: https://aopwiki.org/
Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2
Source: https://aopwiki.org/
Activation of mitogen-activated protein kinase kinase, extracellular signal-regulated kinase 1/2
Source: https://aopwiki.org/
Epigenetic modification process
Source: https://aopwiki.org/
Expression of factors ruling proliferation, modified
Source: https://aopwiki.org/
Uterine adenocarcinoma (endometrioid adenocarcinoma Type I)
Source: https://aopwiki.org/
Inhibition of Sulfotransferase E1 (SULT1E1)
Source: https://aopwiki.org/
Influenza A Virus (IAV) binds sialic acid glycan receptor
Source: https://aopwiki.org/
Influenza A virus (IAV) cell entry
Source: https://aopwiki.org/
Influenza A Virus production increased
Source: https://aopwiki.org/
Immune mechanisms antagonized by viral proteins
Source: https://aopwiki.org/
Influenza A Virus (IAV) budding
Source: https://aopwiki.org/
Influenza A Virus (IAV) shedding and transmission
Source: https://aopwiki.org/
increased,Vascular endothelial dysfunction
Source: https://aopwiki.org/
increased,Vascular endothelial dysfunction
Source: https://aopwiki.org/
increased,Vascular endothelial dysfunction
Source: https://aopwiki.org/
increased,Vascular endothelial dysfunction
Source: https://aopwiki.org/
increased,Vascular endothelial dysfunction
Source: https://aopwiki.org/
Angiogenesis dysfunction
Source: https://aopwiki.org/
Angiogenesis dysfunction
Source: https://aopwiki.org/
Angiogenesis dysfunction
Source: https://aopwiki.org/
Angiogenesis dysfunction
Source: https://aopwiki.org/
Angiogenesis dysfunction
Source: https://aopwiki.org/
Increase, Vascular disrupting effects
Source: https://aopwiki.org/
Increase, Vascular disrupting effects
Source: https://aopwiki.org/
Increase, Vascular disrupting effects
Source: https://aopwiki.org/
Increase, Vascular disrupting effects
Source: https://aopwiki.org/
Increase, Vascular disrupting effects
Source: https://aopwiki.org/
Activation, HIF1α
Source: https://aopwiki.org/
Activation Sema6A
Source: https://aopwiki.org/
Activation, Dll4-Notch pathway
Source: https://aopwiki.org/
Activation, Dll4-Notch pathway
Source: https://aopwiki.org/
Activation of PPAR
Source: https://aopwiki.org/
Abnormal expression of NO
Source: https://aopwiki.org/
Activation of MMP-2 MMP-9
Source: https://aopwiki.org/
Activation of angiopoietin like protein 4
Source: https://aopwiki.org/
Activation of Angiogenic cytokines
Source: https://aopwiki.org/
Activated ANG/Tie2 pathway
Source: https://aopwiki.org/
Activated BMP/TGF-beta pathway
Source: https://aopwiki.org/
Activated Wnt/Frizzled pathway
Source: https://aopwiki.org/
Activated AKT/ERK/PI3K pathway
Source: https://aopwiki.org/
Inhibition VEGF/VEGFR pathway
Source: https://aopwiki.org/
Vascular barrier disruption
Source: https://aopwiki.org/
Impaired Platelet Aggregation
Source: https://aopwiki.org/
Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
Source: https://aopwiki.org/
Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
Source: https://aopwiki.org/
Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)
Source: https://aopwiki.org/
Inhibition, NADH-ubiquinone oxidoreductase (complex I)
Source: https://aopwiki.org/
Inhibition, NADH-ubiquinone oxidoreductase (complex I)
Source: https://aopwiki.org/
Inhibition, NADH-ubiquinone oxidoreductase (complex I)
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
N/A, Mitochondrial dysfunction 1
Source: https://aopwiki.org/
Impaired, Proteostasis
Source: https://aopwiki.org/
Impaired, Proteostasis
Source: https://aopwiki.org/
Neuroinflammation
Source: https://aopwiki.org/
Neuroinflammation
Source: https://aopwiki.org/
Neuroinflammation
Source: https://aopwiki.org/
Neuroinflammation
Source: https://aopwiki.org/
Neuroinflammation
Source: https://aopwiki.org/
Neuroinflammation
Pathways: tau-AOP
Source: https://aopwiki.org/
Neuroinflammation
Source: https://aopwiki.org/
Neuroinflammation
Source: https://aopwiki.org/
Neuroinflammation
Source: https://aopwiki.org/
Degeneration of dopaminergic neurons of the nigrostriatal pathway
Source: https://aopwiki.org/
Degeneration of dopaminergic neurons of the nigrostriatal pathway
Source: https://aopwiki.org/
Parkinsonian motor deficits
Source: https://aopwiki.org/
Parkinsonian motor deficits
Source: https://aopwiki.org/
Parkinsonian motor deficits
Source: https://aopwiki.org/
Increase, Ecdysone receptor agonism
Source: https://aopwiki.org/
Increase, Nuclear receptor E75b gene expression
Source: https://aopwiki.org/
Increase, Fushi tarazu factor-1 gene expression
Source: https://aopwiki.org/
Decrease, Circulating ecdysis triggering hormone
Source: https://aopwiki.org/
Decrease, Circulating crustacean cardioactive peptide
Source: https://aopwiki.org/
Decrease, Ecdysis motoneuron bursts
Source: https://aopwiki.org/
Decrease, Excitatory postsynaptic potential
Source: https://aopwiki.org/
Decrease, Abdominal muscle contraction
Source: https://aopwiki.org/
Increase, Incomplete ecdysis
Source: https://aopwiki.org/
Increase, Incomplete ecdysis
Source: https://aopwiki.org/
Increase, Incomplete ecdysis
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
Increase, Mortality
Source: https://aopwiki.org/
reduction in ovarian granulosa cells, Aromatase (Cyp19a1)
Source: https://aopwiki.org/
reduction in ovarian granulosa cells, Aromatase (Cyp19a1)
Source: https://aopwiki.org/
Reduction, Plasma 17beta-estradiol concentrations
Source: https://aopwiki.org/
Reduction, Plasma 17beta-estradiol concentrations
Source: https://aopwiki.org/
Reduction, Plasma 17beta-estradiol concentrations
Source: https://aopwiki.org/
Reduction, Plasma 17beta-estradiol concentrations
Source: https://aopwiki.org/
Reduction, Plasma 17beta-estradiol concentrations
Source: https://aopwiki.org/
Reduction, Plasma 17beta-estradiol concentrations
Source: https://aopwiki.org/
Reduction, Plasma 17beta-estradiol concentrations
Source: https://aopwiki.org/
Reduction, Plasma 17beta-estradiol concentrations
Source: https://aopwiki.org/
Reduction, Plasma 17beta-estradiol concentrations
Source: https://aopwiki.org/
Reduction, 17beta-estradiol synthesis by ovarian granulosa cells
Source: https://aopwiki.org/
Reduction, 17beta-estradiol synthesis by ovarian granulosa cells
Source: https://aopwiki.org/
Reduction, 17beta-estradiol synthesis by ovarian granulosa cells
Source: https://aopwiki.org/
Reduction, 17beta-estradiol synthesis by ovarian granulosa cells
Source: https://aopwiki.org/
Reduction, 17beta-estradiol synthesis by ovarian granulosa cells
Source: https://aopwiki.org/
Reduction, 17beta-estradiol synthesis by ovarian granulosa cells
Source: https://aopwiki.org/
impaired, Fertility
Source: https://aopwiki.org/
impaired, Fertility
Source: https://aopwiki.org/
impaired, Fertility
Source: https://aopwiki.org/
impaired, Fertility
Source: https://aopwiki.org/
impaired, Fertility
Source: https://aopwiki.org/
impaired, Fertility
Source: https://aopwiki.org/
impaired, Fertility
Source: https://aopwiki.org/
impaired, Fertility
Source: https://aopwiki.org/
impaired, Fertility
Source: https://aopwiki.org/
impaired, Fertility
Source: https://aopwiki.org/
irregularities, ovarian cycle
Source: https://aopwiki.org/
irregularities, ovarian cycle
Source: https://aopwiki.org/
Activation, Pregnane-X receptor, NR1l2
Source: https://aopwiki.org/
Induction, Upregulation of glucuronyltransferase activity
Source: https://aopwiki.org/
Induction, Upregulation of glucuronyltransferase activity
Source: https://aopwiki.org/
Induction, Upregulation of glucuronyltransferase activity
Source: https://aopwiki.org/
Induction, Upregulation of glucuronyltransferase activity
Source: https://aopwiki.org/
Increase, Biliary excretion TH glucuronide
Source: https://aopwiki.org/
Increase, Biliary excretion TH glucuronide
Source: https://aopwiki.org/
Increase, Biliary excretion TH glucuronide
Source: https://aopwiki.org/
Increase, Biliary excretion TH glucuronide
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Pathways: TPOi eye size
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in serum, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in neuronal tissue, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in neuronal tissue, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in neuronal tissue, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in neuronal tissue, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in neuronal tissue, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in neuronal tissue, Decreased
Source: https://aopwiki.org/
Thyroxine (T4) in neuronal tissue, Decreased
Source: https://aopwiki.org/
Hippocampal gene expression, Altered
Source: https://aopwiki.org/
Hippocampal gene expression, Altered
Source: https://aopwiki.org/
Hippocampal gene expression, Altered
Source: https://aopwiki.org/
Hippocampal gene expression, Altered
Source: https://aopwiki.org/
Hippocampal gene expression, Altered
Source: https://aopwiki.org/
Hippocampal gene expression, Altered
Source: https://aopwiki.org/
Hippocampal gene expression, Altered
Source: https://aopwiki.org/
Hippocampal anatomy, Altered
Source: https://aopwiki.org/
Hippocampal anatomy, Altered
Source: https://aopwiki.org/
Hippocampal anatomy, Altered
Source: https://aopwiki.org/
Hippocampal anatomy, Altered
Source: https://aopwiki.org/
Hippocampal anatomy, Altered
Source: https://aopwiki.org/
Hippocampal anatomy, Altered
Source: https://aopwiki.org/
Hippocampal Physiology, Altered
Source: https://aopwiki.org/
Hippocampal Physiology, Altered
Source: https://aopwiki.org/
Hippocampal Physiology, Altered
Source: https://aopwiki.org/
Hippocampal Physiology, Altered
Source: https://aopwiki.org/
Hippocampal Physiology, Altered
Source: https://aopwiki.org/
Hippocampal Physiology, Altered
Source: https://aopwiki.org/
Hippocampal Physiology, Altered
Source: https://aopwiki.org/
Hippocampal Physiology, Altered
Source: https://aopwiki.org/
Loss, Cochlear function
Source: https://aopwiki.org/
Binding of antagonist, PPAR alpha
Source: https://aopwiki.org/
stabilization, PPAR alpha co-repressor
Source: https://aopwiki.org/
Decreased, PPARalpha transactivation of gene expression
Source: https://aopwiki.org/
Not Increased, Circulating Ketone Bodies
Source: https://aopwiki.org/
Increased, Catabolism of Muscle Protein
Source: https://aopwiki.org/
Decreased, Body Weight
Source: https://aopwiki.org/
Fatty Acid Beta Oxidation, Decreased
Source: https://aopwiki.org/
Decreased, Ketogenesis (production of ketone bodies)
Source: https://aopwiki.org/
Binding at picrotoxin site, iGABAR chloride channel
Source: https://aopwiki.org/
Reduction, Ionotropic GABA receptor chloride channel conductance
Source: https://aopwiki.org/
Reduction, Neuronal synaptic inhibition
Source: https://aopwiki.org/
Generation, Amplified excitatory postsynaptic potential (EPSP)
Source: https://aopwiki.org/
Occurrence, A paroxysmal depolarizing shift
Source: https://aopwiki.org/
Occurrence, Epileptic seizure
Source: https://aopwiki.org/
Activation, PXR/SXR
Source: https://aopwiki.org/
Activation, PXR/SXR
Source: https://aopwiki.org/
Binding of antagonist, NMDA receptors
Source: https://aopwiki.org/
Binding of antagonist, NMDA receptors
Source: https://aopwiki.org/
Inhibition, NMDARs
Source: https://aopwiki.org/
Inhibition, NMDARs
Source: https://aopwiki.org/
17beta-estradiol synthesis by ovarian granulosa cells, reduction
Source: https://www.effectopedia.org/
17beta-estradiol synthesis by ovarian granulosa cells, reduction
Source: http://www.effectopedia.org/
17beta-estradiol synthesis by ovarian granulosa cells, reduction
Source: https://www.effectopedia.org/
Accumulating Risk for Cardiopathy
Source: https://www.effectopedia.org/
Accumulating Risk for Cardiopathy
Source: http://www.effectopedia.org/
Accumulating Risk for Cardiopathy
Source: https://www.effectopedia.org/
Accumulation of beta-catenin
Source: http://www.effectopedia.org/
Accumulation of beta-catenin
Source: https://www.effectopedia.org/
Accumulation of beta-catenin
Source: https://www.effectopedia.org/
AChE binding
Source: http://www.effectopedia.org/
AChE binding
Source: https://www.effectopedia.org/
AChE binding
Source: https://www.effectopedia.org/
Activation of Voltage operated calcium channels (pre-synaptic) and direct depolarisation (post-synaptic)
Source: http://www.effectopedia.org/
Activation of Voltage operated calcium channels (pre-synaptic) and direct depolarisation (post-synaptic)
Source: http://www.effectopedia.org/
Activation of Voltage operated calcium channels (pre-synaptic) and direct depolarisation (post-synaptic)
Source: https://www.effectopedia.org/
Activation of Voltage operated calcium channels (pre-synaptic) and direct depolarisation (post-synaptic)
Source: https://www.effectopedia.org/
Activation of Voltage operated calcium channels (pre-synaptic) and direct depolarisation (post-synaptic)
Source: https://www.effectopedia.org/
Activation of Voltage operated calcium channels (pre-synaptic) and direct depolarisation (post-synaptic)
Source: https://www.effectopedia.org/
Activation of Wnt target genes
Source: https://www.effectopedia.org/
Activation of Wnt target genes
Source: https://www.effectopedia.org/
Activation of Wnt target genes
Source: http://www.effectopedia.org/
Alteration of Anal fin papillae
Source: http://www.effectopedia.org/
Alteration of Anal fin papillae
Source: http://www.effectopedia.org/
Alteration of Anal fin papillae
Source: https://www.effectopedia.org/
Alteration of Anal fin papillae
Source: https://www.effectopedia.org/
Alteration of Anal fin papillae
Source: https://www.effectopedia.org/
Alteration of Anal fin papillae
Source: https://www.effectopedia.org/
Alteration of cell proliferation and differentiation of androgen dependent organs
Source: https://www.effectopedia.org/
Alteration of cell proliferation and differentiation of androgen dependent organs
Source: http://www.effectopedia.org/
Alteration of cell proliferation and differentiation of androgen dependent organs
Source: https://www.effectopedia.org/
Alteration of Gonadal morphology
Source: https://www.effectopedia.org/
Alteration of Gonadal morphology
Source: https://www.effectopedia.org/
Alteration of Gonadal morphology
Source: https://www.effectopedia.org/
Alteration of Gonadal morphology
Source: https://www.effectopedia.org/
Alteration of Gonadal morphology
Source: http://www.effectopedia.org/
Alteration of Gonadal morphology
Source: http://www.effectopedia.org/
Alteration of neurotrasmitter release such as dopamine, norepinephrine, serotonin
Source: https://www.effectopedia.org/
Alteration of neurotrasmitter release such as dopamine, norepinephrine, serotonin
Source: https://www.effectopedia.org/
Alteration of neurotrasmitter release such as dopamine, norepinephrine, serotonin
Source: http://www.effectopedia.org/
Alteration of neurotrasmitter release such as dopamine, norepinephrine, serotonin
Source: http://www.effectopedia.org/
Alteration of neurotrasmitter release such as dopamine, norepinephrine, serotonin
Source: https://www.effectopedia.org/
Alteration of neurotrasmitter release such as dopamine, norepinephrine, serotonin
Source: https://www.effectopedia.org/
Alteration of proliferation and differentiation of several androgen dependent tissues
Source: https://www.effectopedia.org/
Alteration of proliferation and differentiation of several androgen dependent tissues
Source: http://www.effectopedia.org/
Alteration of proliferation and differentiation of several androgen dependent tissues
Source: https://www.effectopedia.org/
Altered Calicium Signaling
Source: http://www.effectopedia.org/
Altered Calicium Signaling
Source: https://www.effectopedia.org/
Altered Calicium Signaling
Source: https://www.effectopedia.org/
Altered Expression of ETC Proteins
Source: https://www.effectopedia.org/
Altered Expression of ETC Proteins
Source: https://www.effectopedia.org/
Altered Expression of ETC Proteins
Source: http://www.effectopedia.org/
Altered sex ratios
Source: http://www.effectopedia.org/
Altered sex ratios
Source: http://www.effectopedia.org/
Altered sex ratios
Source: https://www.effectopedia.org/
Altered sex ratios
Source: https://www.effectopedia.org/
Altered sex ratios
Source: https://www.effectopedia.org/
Altered sex ratios
Source: https://www.effectopedia.org/
Altered Sychronization of Calcium in Myocytes
Source: http://www.effectopedia.org/
Altered Sychronization of Calcium in Myocytes
Source: https://www.effectopedia.org/
Altered Sychronization of Calcium in Myocytes
Source: https://www.effectopedia.org/
Altered TR mediated proteints
Source: https://www.effectopedia.org/
Altered TR mediated proteints
Source: https://www.effectopedia.org/
Altered TR mediated proteints
Source: http://www.effectopedia.org/
Androgen receptor, agonism
Source: http://www.effectopedia.org/
Androgen receptor, agonism
Source: https://www.effectopedia.org/
Androgen receptor, agonism
Source: https://www.effectopedia.org/
Antagonism of the androgen receptor
Source: http://www.effectopedia.org/
Antagonism of the androgen receptor
Source: https://www.effectopedia.org/
Antagonism of the androgen receptor
Source: https://www.effectopedia.org/
Apoptosis
Source: https://www.effectopedia.org/
Apoptosis
Source: https://www.effectopedia.org/
Apoptosis
Source: https://www.effectopedia.org/
Apoptosis
Source: https://www.effectopedia.org/
Apoptosis
Source: http://www.effectopedia.org/
Apoptosis
Source: http://www.effectopedia.org/
Apoptosis
Source: http://www.effectopedia.org/
Apoptosis
Source: http://www.effectopedia.org/
Apoptosis
Source: https://www.effectopedia.org/
Apoptosis
Source: https://www.effectopedia.org/
Apoptosis
Source: https://www.effectopedia.org/
Apoptosis
Source: https://www.effectopedia.org/
Behavioral Changes
Source: https://www.effectopedia.org/
Behavioral Changes
Source: http://www.effectopedia.org/
Behavioral Changes
Source: https://www.effectopedia.org/
Binding of nicotine to nicotinic receptors alpha4Beta2 and alpha7 (agonism)
Source: http://www.effectopedia.org/
Binding of nicotine to nicotinic receptors alpha4Beta2 and alpha7 (agonism)
Source: http://www.effectopedia.org/
Binding of nicotine to nicotinic receptors alpha4Beta2 and alpha7 (agonism)
Source: https://www.effectopedia.org/
Binding of nicotine to nicotinic receptors alpha4Beta2 and alpha7 (agonism)
Source: https://www.effectopedia.org/
Binding of nicotine to nicotinic receptors alpha4Beta2 and alpha7 (agonism)
Source: https://www.effectopedia.org/
Binding of nicotine to nicotinic receptors alpha4Beta2 and alpha7 (agonism)
Source: https://www.effectopedia.org/
Binding to AR
Source: http://www.effectopedia.org/
Binding to AR
Source: https://www.effectopedia.org/
Binding to AR
Source: https://www.effectopedia.org/
Binding to ER
Source: https://www.effectopedia.org/
Binding to ER
Source: https://www.effectopedia.org/
Binding to ER
Source: https://www.effectopedia.org/
Binding to ER
Source: https://www.effectopedia.org/
Binding to ER
Source: http://www.effectopedia.org/
Binding to ER
Source: http://www.effectopedia.org/
Binding to GR
Source: http://www.effectopedia.org/
Binding to GR
Source: https://www.effectopedia.org/
Binding to GR
Source: https://www.effectopedia.org/
Binding to MR
Source: https://www.effectopedia.org/
Binding to MR
Source: https://www.effectopedia.org/
Binding to MR
Source: http://www.effectopedia.org/
Binding to PR
Source: http://www.effectopedia.org/
Binding to PR
Source: https://www.effectopedia.org/
Binding to PR
Source: https://www.effectopedia.org/
Binding to the GABA A receptor
Source: http://www.effectopedia.org/
Binding to the GABA A receptor
Source: https://www.effectopedia.org/
Binding to the GABA A receptor
Source: https://www.effectopedia.org/
Binding to the nACh receptor
Source: https://www.effectopedia.org/
Binding to the nACh receptor
Source: https://www.effectopedia.org/
Binding to the nACh receptor
Source: http://www.effectopedia.org/
Binding to the NMDA receptor
Source: http://www.effectopedia.org/
Binding to the NMDA receptor
Source: https://www.effectopedia.org/
Binding to the NMDA receptor
Source: https://www.effectopedia.org/
Binding to the retinoic acid receptor (agonism)
Source: http://www.effectopedia.org/
Binding to the retinoic acid receptor (agonism)
Source: https://www.effectopedia.org/
Binding to the retinoic acid receptor (agonism)
Source: https://www.effectopedia.org/
Binding to Thyroid Peroxidase (TPO)
Source: https://www.effectopedia.org/
Binding to Thyroid Peroxidase (TPO)
Source: https://www.effectopedia.org/
Binding to Thyroid Peroxidase (TPO)
Source: http://www.effectopedia.org/
Calcium influx, Decreased
Source: https://www.effectopedia.org/
Calcium influx, Decreased
Source: http://www.effectopedia.org/
Calcium influx, Decreased
Source: https://www.effectopedia.org/
Calcium-Induced Cell Death in Myocytes
Source: https://www.effectopedia.org/
Calcium-Induced Cell Death in Myocytes
Source: http://www.effectopedia.org/
Calcium-Induced Cell Death in Myocytes
Source: https://www.effectopedia.org/
Calcium-Induced MPT
Source: https://www.effectopedia.org/
Calcium-Induced MPT
Source: http://www.effectopedia.org/
Calcium-Induced MPT
Source: https://www.effectopedia.org/
Cell death, N/A
Source: https://www.effectopedia.org/
Cell death, N/A
Source: http://www.effectopedia.org/
Cell death, N/A
Source: https://www.effectopedia.org/
chloride-permeable ion channels
Source: http://www.effectopedia.org/
chloride-permeable ion channels
Source: https://www.effectopedia.org/
chloride-permeable ion channels
Source: https://www.effectopedia.org/
Congestive Heart Failure
Source: http://www.effectopedia.org/
Congestive Heart Failure
Source: https://www.effectopedia.org/
Congestive Heart Failure
Source: https://www.effectopedia.org/
Convolutions
Source: http://www.effectopedia.org/
Convolutions
Source: http://www.effectopedia.org/
Convolutions
Source: https://www.effectopedia.org/
Convolutions
Source: https://www.effectopedia.org/
Convolutions
Source: https://www.effectopedia.org/
Convolutions
Source: https://www.effectopedia.org/
Death
Source: http://www.effectopedia.org/
Death
Source: http://www.effectopedia.org/
Death
Source: http://www.effectopedia.org/
Death
Source: http://www.effectopedia.org/
Death
Source: http://www.effectopedia.org/
Death
Source: http://www.effectopedia.org/
Death
Source: http://www.effectopedia.org/
Death
Source: https://www.effectopedia.org/
Death
Source: https://www.effectopedia.org/
Death
Source: https://www.effectopedia.org/
Death
Source: https://www.effectopedia.org/
Death
Source: https://www.effectopedia.org/
Death
Source: https://www.effectopedia.org/
Death
Source: https://www.effectopedia.org/
Death
Source: https://www.effectopedia.org/
Death
Source: https://www.effectopedia.org/
Death
Source: https://www.effectopedia.org/
Death
Source: https://www.effectopedia.org/
Death
Source: https://www.effectopedia.org/
Death
Source: https://www.effectopedia.org/
Death
Source: https://www.effectopedia.org/
Decrease in conversion of testosterone to oestradiol
Source: http://www.effectopedia.org/
Decrease in conversion of testosterone to oestradiol
Source: https://www.effectopedia.org/
Decrease in conversion of testosterone to oestradiol
Source: https://www.effectopedia.org/
Decrease in dihydrotestosterone conversion from testosterone
Source: https://www.effectopedia.org/
Decrease in dihydrotestosterone conversion from testosterone
Source: https://www.effectopedia.org/
Decrease in dihydrotestosterone conversion from testosterone
Source: http://www.effectopedia.org/
Decrease in transcription of androgen dependent genes
Source: http://www.effectopedia.org/
Decrease in transcription of androgen dependent genes
Source: https://www.effectopedia.org/
Decrease in transcription of androgen dependent genes
Source: https://www.effectopedia.org/
Decrease in transcription of androgen-dependent genes
Source: https://www.effectopedia.org/
Decrease in transcription of androgen-dependent genes
Source: https://www.effectopedia.org/
Decrease in transcription of androgen-dependent genes
Source: http://www.effectopedia.org/
Decrease in transcription of oestrogen receptor genes
Source: http://www.effectopedia.org/
Decrease in transcription of oestrogen receptor genes
Source: https://www.effectopedia.org/
Decrease in transcription of oestrogen receptor genes
Source: https://www.effectopedia.org/
Decrease levels of serum T4 and T3
Source: https://www.effectopedia.org/
Decrease levels of serum T4 and T3
Source: https://www.effectopedia.org/
Decrease levels of serum T4 and T3
Source: http://www.effectopedia.org/
Decreased AChE in neurons
Source: http://www.effectopedia.org/
Decreased AChE in neurons
Source: https://www.effectopedia.org/
Decreased AChE in neurons
Source: https://www.effectopedia.org/
Decreased channel open time
Source: https://www.effectopedia.org/
Decreased channel open time
Source: https://www.effectopedia.org/
Decreased channel open time
Source: http://www.effectopedia.org/
Decreased levels of TPO
Source: http://www.effectopedia.org/
Decreased levels of TPO
Source: https://www.effectopedia.org/
Decreased levels of TPO
Source: https://www.effectopedia.org/
Delayed adult mail mortality
Source: http://www.effectopedia.org/
Delayed adult mail mortality
Source: http://www.effectopedia.org/
Delayed adult mail mortality
Source: https://www.effectopedia.org/
Delayed adult mail mortality
Source: https://www.effectopedia.org/
Delayed adult mail mortality
Source: https://www.effectopedia.org/
Delayed adult mail mortality
Source: https://www.effectopedia.org/
Dendritic morphology, Aberrant
Source: https://www.effectopedia.org/
Dendritic morphology, Aberrant
Source: http://www.effectopedia.org/
Dendritic morphology, Aberrant
Source: https://www.effectopedia.org/
Deregulation and Increase of mt Calcium Loading
Source: https://www.effectopedia.org/
Deregulation and Increase of mt Calcium Loading
Source: http://www.effectopedia.org/
Deregulation and Increase of mt Calcium Loading
Source: https://www.effectopedia.org/
De-repression of the Wnt/beta-catenin signalling pathway
Source: https://www.effectopedia.org/
De-repression of the Wnt/beta-catenin signalling pathway
Source: http://www.effectopedia.org/
De-repression of the Wnt/beta-catenin signalling pathway
Source: https://www.effectopedia.org/
Developmental toxicity by antagonism of the androgen receptor
Source: https://www.effectopedia.org/
Developmental toxicity by antagonism of the androgen receptor
Source: http://www.effectopedia.org/
Developmental toxicity by antagonism of the androgen receptor
Source: https://www.effectopedia.org/
Developmental toxicity by inhibition of the 5-alpha reductase enzyme
Source: https://www.effectopedia.org/
Developmental toxicity by inhibition of the 5-alpha reductase enzyme
Source: http://www.effectopedia.org/
Developmental toxicity by inhibition of the 5-alpha reductase enzyme
Source: https://www.effectopedia.org/
Developmental toxicity by inhibition of the aromatase enzyme with letrozole
Source: https://www.effectopedia.org/
Developmental toxicity by inhibition of the aromatase enzyme with letrozole
Source: http://www.effectopedia.org/
Developmental toxicity by inhibition of the aromatase enzyme with letrozole
Source: https://www.effectopedia.org/
Developmental toxicity of retinoic acid
Source: https://www.effectopedia.org/
Developmental toxicity of retinoic acid
Source: http://www.effectopedia.org/
Developmental toxicity of retinoic acid
Source: https://www.effectopedia.org/
Dialated CardioMyopathy
Source: http://www.effectopedia.org/
Dialated CardioMyopathy
Source: https://www.effectopedia.org/
Dialated CardioMyopathy
Source: https://www.effectopedia.org/
Disruption of homeostasis of neuronal networks
Source: https://www.effectopedia.org/
Disruption of homeostasis of neuronal networks
Source: http://www.effectopedia.org/
Disruption of homeostasis of neuronal networks
Source: https://www.effectopedia.org/
ER Transcription Factors
Source: http://www.effectopedia.org/
ER Transcription Factors
Source: http://www.effectopedia.org/
ER Transcription Factors
Source: https://www.effectopedia.org/
ER Transcription Factors
Source: https://www.effectopedia.org/
ER Transcription Factors
Source: https://www.effectopedia.org/
ER Transcription Factors
Source: https://www.effectopedia.org/
Excitability
Source: http://www.effectopedia.org/
Excitability
Source: https://www.effectopedia.org/
Excitability
Source: https://www.effectopedia.org/
Facilitated Inhibitory Transmission Cortex-Thalamus
Source: https://www.effectopedia.org/
Facilitated Inhibitory Transmission Cortex-Thalamus
Source: https://www.effectopedia.org/
Facilitated Inhibitory Transmission Cortex-Thalamus
Source: http://www.effectopedia.org/
Gene expression for Vtg production
Source: http://www.effectopedia.org/
Gene expression for Vtg production
Source: http://www.effectopedia.org/
Gene expression for Vtg production
Source: https://www.effectopedia.org/
Gene expression for Vtg production
Source: https://www.effectopedia.org/
Gene expression for Vtg production
Source: https://www.effectopedia.org/
Gene expression for Vtg production
Source: https://www.effectopedia.org/
Gonadotropins, circulating concentrations, reduction
Source: http://www.effectopedia.org/
Gonadotropins, circulating concentrations, reduction
Source: https://www.effectopedia.org/
Gonadotropins, circulating concentrations, reduction
Source: https://www.effectopedia.org/
Headache and fatigue
Source: http://www.effectopedia.org/
Headache and fatigue
Source: http://www.effectopedia.org/
Headache and fatigue
Source: https://www.effectopedia.org/
Headache and fatigue
Source: https://www.effectopedia.org/
Headache and fatigue
Source: https://www.effectopedia.org/
Headache and fatigue
Source: https://www.effectopedia.org/
Heart Failure
Source: https://www.effectopedia.org/
Heart Failure
Source: https://www.effectopedia.org/
Heart Failure
Source: https://www.effectopedia.org/
Heart Failure
Source: https://www.effectopedia.org/
Heart Failure
Source: https://www.effectopedia.org/
Heart Failure
Source: https://www.effectopedia.org/
Heart Failure
Source: https://www.effectopedia.org/
Heart Failure
Source: https://www.effectopedia.org/
Heart Failure
Source: http://www.effectopedia.org/
Heart Failure
Source: http://www.effectopedia.org/
Heart Failure
Source: http://www.effectopedia.org/
Heart Failure
Source: http://www.effectopedia.org/
Hydrophobic binding to proteins and membranes
Source: http://www.effectopedia.org/
Hydrophobic binding to proteins and membranes
Source: https://www.effectopedia.org/
Hydrophobic binding to proteins and membranes
Source: https://www.effectopedia.org/
Hyperpolarized mitochondrial membrane potential
Source: http://www.effectopedia.org/
Hyperpolarized mitochondrial membrane potential
Source: https://www.effectopedia.org/
Hyperpolarized mitochondrial membrane potential
Source: https://www.effectopedia.org/
Increased channel open time
Source: http://www.effectopedia.org/
Increased channel open time
Source: https://www.effectopedia.org/
Increased channel open time
Source: https://www.effectopedia.org/
Increased metabolism
Source: https://www.effectopedia.org/
Increased metabolism
Source: https://www.effectopedia.org/
Increased metabolism
Source: https://www.effectopedia.org/
Increased metabolism
Source: http://www.effectopedia.org/
Increased metabolism
Source: http://www.effectopedia.org/
Increased metabolism
Source: http://www.effectopedia.org/
Increased metabolism
Source: https://www.effectopedia.org/
Increased metabolism
Source: https://www.effectopedia.org/
Increased metabolism
Source: https://www.effectopedia.org/
Increased mitochondrial reactive oxygen species formation
Source: https://www.effectopedia.org/
Increased mitochondrial reactive oxygen species formation
Source: https://www.effectopedia.org/
Increased mitochondrial reactive oxygen species formation
Source: http://www.effectopedia.org/
Increased mitochondrial reactive oxygen species formation
Source: http://www.effectopedia.org/
Increased mitochondrial reactive oxygen species formation
Source: https://www.effectopedia.org/
Increased mitochondrial reactive oxygen species formation
Source: https://www.effectopedia.org/
Increased residence time of AChE
Source: http://www.effectopedia.org/
Increased residence time of AChE
Source: https://www.effectopedia.org/
Increased residence time of AChE
Source: https://www.effectopedia.org/
Increased Sensitivity to Calcium Loading/ROS in Myocytes
Source: http://www.effectopedia.org/
Increased Sensitivity to Calcium Loading/ROS in Myocytes
Source: https://www.effectopedia.org/
Increased Sensitivity to Calcium Loading/ROS in Myocytes
Source: https://www.effectopedia.org/
Inhibited DNA Replication
Source: https://www.effectopedia.org/
Inhibited DNA Replication
Source: https://www.effectopedia.org/
Inhibited DNA Replication
Source: http://www.effectopedia.org/
Inhibition of ATP synthase
Source: http://www.effectopedia.org/
Inhibition of ATP synthase
Source: https://www.effectopedia.org/
Inhibition of ATP synthase
Source: https://www.effectopedia.org/
Inhibition of ATP-dependent cellular functions
Source: https://www.effectopedia.org/
Inhibition of ATP-dependent cellular functions
Source: https://www.effectopedia.org/
Inhibition of ATP-dependent cellular functions
Source: https://www.effectopedia.org/
Inhibition of ATP-dependent cellular functions
Source: https://www.effectopedia.org/
Inhibition of ATP-dependent cellular functions
Source: https://www.effectopedia.org/
Inhibition of ATP-dependent cellular functions
Source: https://www.effectopedia.org/
Inhibition of ATP-dependent cellular functions
Source: http://www.effectopedia.org/
Inhibition of ATP-dependent cellular functions
Source: http://www.effectopedia.org/
Inhibition of ATP-dependent cellular functions
Source: http://www.effectopedia.org/
Inhibition of complex I
Source: http://www.effectopedia.org/
Inhibition of complex I
Source: https://www.effectopedia.org/
Inhibition of complex I
Source: https://www.effectopedia.org/
Inhibition of complex II
Source: http://www.effectopedia.org/
Inhibition of complex II
Source: https://www.effectopedia.org/
Inhibition of complex II
Source: https://www.effectopedia.org/
Inhibition of complex III
Source: https://www.effectopedia.org/
Inhibition of complex III
Source: https://www.effectopedia.org/
Inhibition of complex III
Source: http://www.effectopedia.org/
Inhibition of complex IV
Source: http://www.effectopedia.org/
Inhibition of complex IV
Source: https://www.effectopedia.org/
Inhibition of complex IV
Source: https://www.effectopedia.org/
Inhibition of histone deacetylases (HDACs) class I
Source: http://www.effectopedia.org/
Inhibition of histone deacetylases (HDACs) class I
Source: https://www.effectopedia.org/
Inhibition of histone deacetylases (HDACs) class I
Source: https://www.effectopedia.org/
Inhibition of the aromatase enzyme
Source: http://www.effectopedia.org/
Inhibition of the aromatase enzyme
Source: https://www.effectopedia.org/
Inhibition of the aromatase enzyme
Source: https://www.effectopedia.org/
Inhibition of the electron transport chain
Source: https://www.effectopedia.org/
Inhibition of the electron transport chain
Source: http://www.effectopedia.org/
Inhibition of the electron transport chain
Source: https://www.effectopedia.org/
Inhibition of the enzyme 5-alpha reductase type 2
Source: https://www.effectopedia.org/
Inhibition of the enzyme 5-alpha reductase type 2
Source: https://www.effectopedia.org/
Inhibition of the enzyme 5-alpha reductase type 2
Source: http://www.effectopedia.org/
Inhibition of Topoisomerase II
Source: https://www.effectopedia.org/
Inhibition of Topoisomerase II
Source: http://www.effectopedia.org/
Inhibition of Topoisomerase II
Source: https://www.effectopedia.org/
Interaction (VSGCs)
Source: http://www.effectopedia.org/
Interaction (VSGCs)
Source: https://www.effectopedia.org/
Interaction (VSGCs)
Source: https://www.effectopedia.org/
Interaction with inner mitochondrial membrane & non-covalent perturbation
Source: https://www.effectopedia.org/
Interaction with inner mitochondrial membrane & non-covalent perturbation
Source: https://www.effectopedia.org/
Interaction with inner mitochondrial membrane & non-covalent perturbation
Source: http://www.effectopedia.org/
Intercalation with Nuclear and mt DNA
Source: http://www.effectopedia.org/
Intercalation with Nuclear and mt DNA
Source: https://www.effectopedia.org/
Intercalation with Nuclear and mt DNA
Source: https://www.effectopedia.org/
Learning and memory, Impairment
Source: http://www.effectopedia.org/
Learning and memory, Impairment
Source: https://www.effectopedia.org/
Learning and memory, Impairment
Source: https://www.effectopedia.org/
Learning impairment
Source: https://www.effectopedia.org/
Learning impairment
Source: https://www.effectopedia.org/
Learning impairment
Source: http://www.effectopedia.org/
ligand-gated chloride channels
Source: http://www.effectopedia.org/
ligand-gated chloride channels
Source: https://www.effectopedia.org/
ligand-gated chloride channels
Source: https://www.effectopedia.org/
Loss of consciousness
Source: https://www.effectopedia.org/
Loss of consciousness
Source: https://www.effectopedia.org/
Loss of consciousness
Source: https://www.effectopedia.org/
Loss of consciousness
Source: https://www.effectopedia.org/
Loss of consciousness
Source: http://www.effectopedia.org/
Loss of consciousness
Source: http://www.effectopedia.org/
Mixed sex gonads
Source: http://www.effectopedia.org/
Mixed sex gonads
Source: http://www.effectopedia.org/
Mixed sex gonads
Source: https://www.effectopedia.org/
Mixed sex gonads
Source: https://www.effectopedia.org/
Mixed sex gonads
Source: https://www.effectopedia.org/
Mixed sex gonads
Source: https://www.effectopedia.org/
Movement Impariment
Source: http://www.effectopedia.org/
Movement Impariment
Source: https://www.effectopedia.org/
Movement Impariment
Source: https://www.effectopedia.org/
Necrosis
Source: https://www.effectopedia.org/
Necrosis
Source: https://www.effectopedia.org/
Necrosis
Source: https://www.effectopedia.org/
Necrosis
Source: https://www.effectopedia.org/
Necrosis
Source: http://www.effectopedia.org/
Necrosis
Source: http://www.effectopedia.org/
Neuronal membrane potential disruption
Source: http://www.effectopedia.org/
Neuronal membrane potential disruption
Source: https://www.effectopedia.org/
Neuronal membrane potential disruption
Source: https://www.effectopedia.org/
Neuronal network function, Decreased
Source: https://www.effectopedia.org/
Neuronal network function, Decreased
Source: http://www.effectopedia.org/
Neuronal network function, Decreased
Source: https://www.effectopedia.org/
Nicotine exposure developmental outcome
Source: http://www.effectopedia.org/
Nicotine exposure developmental outcome
Source: http://www.effectopedia.org/
Nicotine exposure developmental outcome
Source: https://www.effectopedia.org/
Nicotine exposure developmental outcome
Source: https://www.effectopedia.org/
Nicotine exposure developmental outcome
Source: https://www.effectopedia.org/
Nicotine exposure developmental outcome
Source: https://www.effectopedia.org/
NMDARs, Binding of antagonist
Source: http://www.effectopedia.org/
NMDARs, Binding of antagonist
Source: https://www.effectopedia.org/
NMDARs, Binding of antagonist
Source: https://www.effectopedia.org/
NMDARs, Inhibition
Source: http://www.effectopedia.org/
NMDARs, Inhibition
Source: https://www.effectopedia.org/
NMDARs, Inhibition
Source: https://www.effectopedia.org/
Nonspecific Protein Binding
Source: https://www.effectopedia.org/
Nonspecific Protein Binding
Source: https://www.effectopedia.org/
Nonspecific Protein Binding
Source: http://www.effectopedia.org/
Oxidation of hemoglobin (methemoglobin)
Source: https://www.effectopedia.org/
Oxidation of hemoglobin (methemoglobin)
Source: http://www.effectopedia.org/
Oxidation of hemoglobin (methemoglobin)
Source: https://www.effectopedia.org/
Oxidative stress in red blood cells
Source: http://www.effectopedia.org/
Oxidative stress in red blood cells
Source: https://www.effectopedia.org/
Oxidative stress in red blood cells
Source: https://www.effectopedia.org/
Paralysis
Source: http://www.effectopedia.org/
Paralysis
Source: http://www.effectopedia.org/
Paralysis
Source: https://www.effectopedia.org/
Paralysis
Source: https://www.effectopedia.org/
Paralysis
Source: https://www.effectopedia.org/
Paralysis
Source: https://www.effectopedia.org/
Population reduction
Source: https://www.effectopedia.org/
Population reduction
Source: https://www.effectopedia.org/
Population reduction
Source: https://www.effectopedia.org/
Population reduction
Source: https://www.effectopedia.org/
Population reduction
Source: https://www.effectopedia.org/
Population reduction
Source: https://www.effectopedia.org/
Population reduction
Source: https://www.effectopedia.org/
Population reduction
Source: https://www.effectopedia.org/
Population reduction
Source: https://www.effectopedia.org/
Population reduction
Source: http://www.effectopedia.org/
Population reduction
Source: http://www.effectopedia.org/
Population reduction
Source: http://www.effectopedia.org/
Population reduction
Source: http://www.effectopedia.org/
Population reduction
Source: http://www.effectopedia.org/
Population reduction
Source: http://www.effectopedia.org/
Population reduction
Source: http://www.effectopedia.org/
Population reduction
Source: http://www.effectopedia.org/
Population reduction
Source: http://www.effectopedia.org/
Population reduction
Source: https://www.effectopedia.org/
Population reduction
Source: https://www.effectopedia.org/
Population reduction
Source: https://www.effectopedia.org/
Population reduction
Source: https://www.effectopedia.org/
Population reduction
Source: https://www.effectopedia.org/
Population reduction
Source: https://www.effectopedia.org/
Population reduction
Source: https://www.effectopedia.org/
Population reduction
Source: https://www.effectopedia.org/
Population reduction
Source: https://www.effectopedia.org/
Presynaptic release of glutamate, Reduced
Source: https://www.effectopedia.org/
Presynaptic release of glutamate, Reduced
Source: http://www.effectopedia.org/
Presynaptic release of glutamate, Reduced
Source: https://www.effectopedia.org/
Reduced ATP formation
Source: http://www.effectopedia.org/
Reduced ATP formation
Source: http://www.effectopedia.org/
Reduced ATP formation
Source: http://www.effectopedia.org/
Reduced ATP formation
Source: https://www.effectopedia.org/
Reduced ATP formation
Source: https://www.effectopedia.org/
Reduced ATP formation
Source: https://www.effectopedia.org/
Reduced ATP formation
Source: https://www.effectopedia.org/
Reduced ATP formation
Source: https://www.effectopedia.org/
Reduced ATP formation
Source: https://www.effectopedia.org/
Reduced ATP-depndent functions
Source: https://www.effectopedia.org/
Reduced ATP-depndent functions
Source: https://www.effectopedia.org/
Reduced ATP-depndent functions
Source: https://www.effectopedia.org/
Reduced ATP-depndent functions
Source: https://www.effectopedia.org/
Reduced ATP-depndent functions
Source: https://www.effectopedia.org/
Reduced ATP-depndent functions
Source: https://www.effectopedia.org/
Reduced ATP-depndent functions
Source: http://www.effectopedia.org/
Reduced ATP-depndent functions
Source: http://www.effectopedia.org/
Reduced ATP-depndent functions
Source: http://www.effectopedia.org/
Reduced Calcium Loading Capacity of Mitochondria
Source: https://www.effectopedia.org/
Reduced Calcium Loading Capacity of Mitochondria
Source: http://www.effectopedia.org/
Reduced Calcium Loading Capacity of Mitochondria
Source: https://www.effectopedia.org/
Reduced eggs per female
Source: https://www.effectopedia.org/
Reduced eggs per female
Source: https://www.effectopedia.org/
Reduced eggs per female
Source: https://www.effectopedia.org/
Reduced eggs per female
Source: https://www.effectopedia.org/
Reduced eggs per female
Source: http://www.effectopedia.org/
Reduced eggs per female
Source: http://www.effectopedia.org/
Reduced Excitatory of the Hippocampus
Source: http://www.effectopedia.org/
Reduced Excitatory of the Hippocampus
Source: https://www.effectopedia.org/
Reduced Excitatory of the Hippocampus
Source: https://www.effectopedia.org/
Reduced Excitatory Transmition
Source: https://www.effectopedia.org/
Reduced Excitatory Transmition
Source: https://www.effectopedia.org/
Reduced Excitatory Transmition
Source: http://www.effectopedia.org/
Reduced Fertility
Source: http://www.effectopedia.org/
Reduced Fertility
Source: http://www.effectopedia.org/
Reduced Fertility
Source: https://www.effectopedia.org/
Reduced Fertility
Source: https://www.effectopedia.org/
Reduced Fertility
Source: https://www.effectopedia.org/
Reduced Fertility
Source: https://www.effectopedia.org/
Reduced Growth
Source: https://www.effectopedia.org/
Reduced Growth
Source: https://www.effectopedia.org/
Reduced Growth
Source: https://www.effectopedia.org/
Reduced Growth
Source: https://www.effectopedia.org/
Reduced Growth
Source: http://www.effectopedia.org/
Reduced Growth
Source: http://www.effectopedia.org/
Reduced membrane current
Source: http://www.effectopedia.org/
Reduced membrane current
Source: https://www.effectopedia.org/
Reduced membrane current
Source: https://www.effectopedia.org/
Reduced mitochondrial membrane potential
Source: https://www.effectopedia.org/
Reduced mitochondrial membrane potential
Source: http://www.effectopedia.org/
Reduced mitochondrial membrane potential
Source: https://www.effectopedia.org/
Reduced mitochondrial oxygen consumption
Source: https://www.effectopedia.org/
Reduced mitochondrial oxygen consumption
Source: https://www.effectopedia.org/
Reduced mitochondrial oxygen consumption
Source: http://www.effectopedia.org/
Reduced mitochondrial oxygen consumption
Source: http://www.effectopedia.org/
Reduced mitochondrial oxygen consumption
Source: https://www.effectopedia.org/
Reduced mitochondrial oxygen consumption
Source: https://www.effectopedia.org/
Reduced oxygen supply and hypoxia
Source: https://www.effectopedia.org/
Reduced oxygen supply and hypoxia
Source: https://www.effectopedia.org/
Reduced oxygen supply and hypoxia
Source: http://www.effectopedia.org/
Reduction of all cell functions
Source: http://www.effectopedia.org/
Reduction of all cell functions
Source: https://www.effectopedia.org/
Reduction of all cell functions
Source: https://www.effectopedia.org/
Release of BDNF, Reduced
Source: https://www.effectopedia.org/
Release of BDNF, Reduced
Source: http://www.effectopedia.org/
Release of BDNF, Reduced
Source: https://www.effectopedia.org/
Repression of the Wnt signalling pathway
Source: http://www.effectopedia.org/
Repression of the Wnt signalling pathway
Source: https://www.effectopedia.org/
Repression of the Wnt signalling pathway
Source: https://www.effectopedia.org/
Repression of Wnt signalling
Source: https://www.effectopedia.org/
Repression of Wnt signalling
Source: https://www.effectopedia.org/
Repression of Wnt signalling
Source: http://www.effectopedia.org/
Respiration changes
Source: https://www.effectopedia.org/
Respiration changes
Source: https://www.effectopedia.org/
Respiration changes
Source: http://www.effectopedia.org/
Respiratory Failure
Source: http://www.effectopedia.org/
Respiratory Failure
Source: http://www.effectopedia.org/
Respiratory Failure
Source: http://www.effectopedia.org/
Respiratory Failure
Source: http://www.effectopedia.org/
Respiratory Failure
Source: https://www.effectopedia.org/
Respiratory Failure
Source: https://www.effectopedia.org/
Respiratory Failure
Source: https://www.effectopedia.org/
Respiratory Failure
Source: https://www.effectopedia.org/
Respiratory Failure
Source: https://www.effectopedia.org/
Respiratory Failure
Source: https://www.effectopedia.org/
Respiratory Failure
Source: https://www.effectopedia.org/
Respiratory Failure
Source: https://www.effectopedia.org/
Reversible decrease of organ functions
Source: http://www.effectopedia.org/
Reversible decrease of organ functions
Source: https://www.effectopedia.org/
Reversible decrease of organ functions
Source: https://www.effectopedia.org/
Sedation
Source: http://www.effectopedia.org/
Sedation
Source: https://www.effectopedia.org/
Sedation
Source: https://www.effectopedia.org/
Seizures
Source: https://www.effectopedia.org/
Seizures
Source: https://www.effectopedia.org/
Seizures
Source: https://www.effectopedia.org/
Seizures
Source: https://www.effectopedia.org/
Seizures
Source: https://www.effectopedia.org/
Seizures
Source: https://www.effectopedia.org/
Seizures
Source: http://www.effectopedia.org/
Seizures
Source: http://www.effectopedia.org/
Seizures
Source: http://www.effectopedia.org/
Sex reversal
Source: http://www.effectopedia.org/
Sex reversal
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Sex reversal
Source: https://www.effectopedia.org/
Sex reversal
Source: https://www.effectopedia.org/
Sex reversal
Source: https://www.effectopedia.org/
Sex reversal
Source: https://www.effectopedia.org/
Signaling disruption
Source: https://www.effectopedia.org/
Signaling disruption
Source: https://www.effectopedia.org/
Signaling disruption
Source: https://www.effectopedia.org/
Signaling disruption
Source: https://www.effectopedia.org/
Signaling disruption
Source: http://www.effectopedia.org/
Signaling disruption
Source: http://www.effectopedia.org/
Synaptic malformation and altered function
Source: http://www.effectopedia.org/
Synaptic malformation and altered function
Source: https://www.effectopedia.org/
Synaptic malformation and altered function
Source: https://www.effectopedia.org/
Synaptogenesis, Decreased
Source: https://www.effectopedia.org/
Synaptogenesis, Decreased
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Synaptogenesis, Decreased
Source: https://www.effectopedia.org/
Testosterone synthesis by ovarian theca cells, reduction
Source: https://www.effectopedia.org/
Testosterone synthesis by ovarian theca cells, reduction
Source: http://www.effectopedia.org/
Testosterone synthesis by ovarian theca cells, reduction
Source: https://www.effectopedia.org/
Transcription of retinoic acid regulated genes
Source: https://www.effectopedia.org/
Transcription of retinoic acid regulated genes
Source: http://www.effectopedia.org/
Transcription of retinoic acid regulated genes
Source: https://www.effectopedia.org/
Tremors
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Tremors
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Tremors
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Tremors
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Tremors
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Tremors
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Tumor Cell Death and Regression
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Tumor Cell Death and Regression
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Tumor Cell Death and Regression
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Upreregulated Gene Transcription in the liver tissue
Source: http://www.effectopedia.org/
Upreregulated Gene Transcription in the liver tissue
Source: http://www.effectopedia.org/
Upreregulated Gene Transcription in the liver tissue
Source: https://www.effectopedia.org/
Upreregulated Gene Transcription in the liver tissue
Source: https://www.effectopedia.org/
Upreregulated Gene Transcription in the liver tissue
Source: https://www.effectopedia.org/
Upreregulated Gene Transcription in the liver tissue
Source: https://www.effectopedia.org/
Valproic acid exposure developmental outcome
Source: https://www.effectopedia.org/
Valproic acid exposure developmental outcome
Source: http://www.effectopedia.org/
Valproic acid exposure developmental outcome
Source: https://www.effectopedia.org/
voltage-gated calcium channels
Source: http://www.effectopedia.org/
voltage-gated calcium channels
Source: https://www.effectopedia.org/
voltage-gated calcium channels
Source: https://www.effectopedia.org/

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